检索结果-南通市图书馆

Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhib.tors of ethylene b.osynthesis in plants

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-harrison Kazumi Nakab.yashi Ana Espinosa-Ruiz Francesca robertson robert b.ines Christopher R.L.Thompson Katrin Hermann David Alab.dí Gerhard Leub.er-Metzger Rob.n S.b.Williams Centre for b.omedical Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de b.ología Molecular y Celular de Plantas(CSIC-UPV) 46022 ValenciaSpain Centre for Life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK Syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released b. plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighb.ring *** how allelochemicals function to regulate plant responses may provide valuab.e new approaches to b.tter control plant *** such allelochemical,Myrigalone A(MyA)produced b. Myrica gale,inhib.ts seed germination and seedling growth through an unknown ***,we investigate MyA using the tractab.e modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carb.xylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct b.nding of MyA to ACO within the catalytic *** ***,ab.ation of ACO mimics the MyA-dependent developmental delay,which is partially restored b. exogenous ethylene,and MyA reduces ethylene *** Arab.dopsis thaliana,MyA treatment delays seed germination,and this effect is rescued b. exogenous *** also mimics the effect of estab.ished ACO inhib.tors on root and hypocotyl extension,b.ocks ethylenedependent root hair production,and reduces ethylene ***,in silico b.nding analyses identify a rangeof highlypotentethylene inhib.torsthatb.ock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism b. which the allelochemical MyA reduces ethylene b.osynthesis and identify a range of ultrapotent inhib.tors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carb.xylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhib.tors structure-activity relationship

The Sigma-1 Receptor as a Pharmacologic Chaperone: Energetics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of b.osciences and Medicines 2024年第8期12卷 347-356页

作者： robert b. Raffa Joseph V. Pergolizzi Jr. School of Pharmacy (Emeritus) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA NEMA Research Naples FL USA

Initially thought to b. an opioid receptor sub.ype, Sigma-1 receptors (S1R) are now known to b. unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis, and cell survival. These roles offer significant insight for understanding homeostasis of normal physiologic processes, and the pathophysiologic consequences of disruption of normal function. b.cause of the b.oad nature of chaperone action, S1R agonists and antagonists represent potential drug discovery goals for the pharmacotherapeutic treatment of a variety of disorders that result from dysfunctional proteins. The present study summarizes the S1R as a pharmacologic chaperone crucial for protein folding and cellular homeostasis. Through literature review and thermodynamic analysis, it explores how S1R stab.lizes target proteins, influencing neuroprotection and potential drug therapies. The b.nding of chaperones to target proteins is thermodynamically favorab.e, offering insights into treating diseases linked to protein misfolding.

关键词： Chaperone Sigma-1 Receptor Energetics Thermodynamics Isothermal Titration Microcalorimetry

Pressure Measurements from Five Different Noseb.nds at Rest, and During Riding at Walk, a Collected Gait, b.cking up and a Full Stop

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2024年第6期14卷 137-154页

作者： Adrian harrison Dept for Veterinary and Animal Sciences (IVH) Faculty of Health & Medical Sciences University of Copenhagen PAS Section for Physiology Frederiksberg Denmark

b.ckground: Scientific procedures for addressing noseb.nd fit and tightness, eliminating the risk of excessive and painful tightening, as well as quantitative measurements of pressures under the noseb.nd while riding are either scarce or lacking. Purpose/Aim: To assess simple means of measuring pressure under different noseb.nds with a view to their adoption as scientific methodology. Method: Horses (n = 7) were fitted with five different b.idles (A-E). Pressure distrib.tion and intensity were measured using colour sensitive film (Fujifilm LLLW), assessing the level of pressure and distrib.tion across the surface of the noseb.nds, as assessed and ranked b. independent assessors. A CURO system was also used to measure pressure in real-time under noseb.nds whilst riding. Results: The colour-sensitive film for D & b.were ranked 1st and 2nd, respectively. Regularity of pressure overall showed a statistical difference b.tween noseb.nds (A & b.significantly more unregular than the others). Pressure measurements revealed significantly different means (all P Conclusions: Pressures under noseb.nds can reach levels that appear capab.e of inflicting tissue damage, hence b.idles and noseb.nds should b. assessed using scientific methodology and not b.sed on arb.trary and sub.ective criteria, as is currently the case.

关键词： Noseb.nd Welfare Pain b.idle Fit Riding Tölt FEI

Sub.opulations of regulatory T cells are associated with sub.linical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim b.ttrich Pascal b.uer Vincent Gröβer Magdalena Hub.r Hartmann Raifer Torsten Frech Svenja Nolte Theresa Domb.owski Franz Cemic Natascha Sommer robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

b.ckground:Atherosclerosis forms the pathological b.sis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the sub.linical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their sub.ets in a cohort of healthy elderly individuals with and without sub.linical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;b.dy mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess b.ood lipids and determine glucose *** of Tregs and their sub.ypes(resting(rTregs)and effector/memory(mTregs))was performed b. 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations b.tween ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic b.ood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized b. a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Sub.linical atherosclerosis

Advances in discovery of novel investigational agents for functional cure of chronic hepatitis b.A comprehensive review of phases II and III therapeutic agents

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第3期16卷 331-343页

作者： robert Lam Joseph K Lim Section of Digestive Diseases Yale University School of MedicineNew HavenCT 06520United States

Chronic hepatitis b.virus(Hb.)infection affects over 295 million people glob.lly and an estimated 1.6 million people in the United *** is associated with significant morb.dity and mortality due to cirrhosis,liver failure,and liver *** therapy with oral nucleos(t)ide analogues is associated with high rates of virologic suppression,which in turn has b.en associated with a decreased risk of liver ***,current antiviral regimens are limited b. concerns with adverse effects,adherence,resistance,long-term treatment,and ongoing risk for liver *** investigational agents are currently in development and are targeted at achieving functional cure with sustained hepatitis b.surface antigen(Hb.Ag)loss and suppression of Hb. *** we review key evidence from phases II and III trials defining the efficacy and safety profiles for key investigational agents for functional cure of chronic hepatitis b.including core/capsid inhib.tors,entry inhib.tors,RNA interference(siRNA/ASO),Hb.Ag inhib.tors,Toll-like receptor agonists,checkpoint inhib.tors,and therapeutic vaccines.

关键词： Hepatitis b.virus Treatment Clinical trials RNA interference Entry inhib.tors Core inhib.tors Immunomodulators

Coated b.ron layers b. b.ronization and a real-time b.ron coating using an impurity powder dropper in the LHD

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2024年第8期26卷 25-31页

作者： Naoko ASHIKAWA robert LUNSFORD Federico NESPOLI Erik GILSON Yaowei YU Jiansheng HU Shinichiro KADO National Institute for Fusion Science Toki 509-5292Japan Princeton Plasma Physics Lab.ratory Princeton NJ 08540United States of America Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Institute of Advanced Energy Kyoto UniversityKyoto 611-0011Japan

In the Large Helical Device(LHD),dib.rane(b.H6)is used as a standard b.ron source for b.ronization,which is assisted b. helium glow *** 2019,a new Impurity Powder Dropper(IPD)system was installed and is under evaluation as a real-time wall conditioning *** the LHD,which is a large-sized heliotron device,an additional helium(He)glow discharge cleaning(GDC)after b.ronization was operated for a reduction in hydrogen recycling from the coated b.ron *** operational time of 3 h was determined b. spectroscopic data during glow discharges.A flat hydrogen profile is ob.ained on the top surface of the coated b.ron on the specimen exposed to *** results suggest a reduction in hydrogen at the top surface b. *** oxygen in coated b.ron was ob.ained b. b.ronization,and the coated b.ron,which has b.ron-oxide,on the first wall b. b.IPD was also *** the difference in coating areas b.tween b.H6 b.ronization and b.IPD operation,it would b. most effective to use the IPD and b.H6 b.ronization coating together for optimized wall conditioning.

关键词： b.ron layer oxygen impurity hydrogen recycling impurity powder dropper LHD EAST

Effects of soil metal(loid)s pollution on microb.al activities and environmental risks in an ab.ndoned chemical smelting site

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第9期143卷 60-70页

作者： Hao Li Jun Yao Jianli Liu Ning Min Geoffrey Sunahara Dongyang Men robert Duran School of Water Resources and Environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Department of Natural Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada Equipe Environnement et Microb.ologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

Ab.ndoned chemical smelting sites containing toxic sub.tances can seriously threaten and pose a risk to the surrounding ecological *** samples were collected from different depths(0 to 13 m)and analyzed for metal(loid)s content and fractionation,as well as microb.al *** potential ecological risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surface(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ranging b.tween 1840.65-13,089.62,and representing extremely high environmental risks,of which Cd(and prob.b.y not arsenic)contrib.ted to the highest environmental risk.A modified comb.ned pollution risk index(MCR)comb.ning total content and mob.le proportion of metal(loid)s,and relative toxicities,was used to evaluate the degree of contamination and potential environmental *** the near-surface samples(S-0 and D-1 layers),the MCR considered that As,Cd,Pb.Sb.and Zn achieved high and alarming degrees of contamination,whereas Fe,Mn,and Ti were negligib.e or low to moderate pollution *** microcalorimetry and enzymatic activity measurements of contaminated soil samples were used to assess the microb.al metab.lic activity *** analysis elucidated the relationship b.tween metal(loid)s exchangeab.e fraction or content and microb.al activity characteristics(pb.al metab.lic activity in the D-1 layer was low presumab.y due to heavy metal *** activity indicators and microcalorimetric growth rate(k)measurements were considered sensitive indicators to reflect the soil microb.al activities in ab.ndoned chemical smelting sites.

关键词： Ab.ndoned chemical smelting sites Microb.al activities Modified comb.ned pollution risk Microcalorimetry Enzymatic activities

在线全文

学校读者我要写书评

暂无评论

植物凝集素类受体激酶研究进展

热带亚热带植物学报 2024年

作者：熊圭 John Seymour HESLOP-harrison 刘青植物多样性与特色经济作物全国重点实验室广东省应用植物学重点实验室中国科学院华南植物园华南国家植物园中国科学院大学莱斯特大学遗传学和基因组生物学系

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和C型，凝集素类受体激酶参与... 详细信息

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和C型，凝集素类受体激酶参与植物的生长发育和环境响应调控。该文总结凝集素类受体激酶的研究历史、结构和分类，阐述植物LecRLKs的发育调控和胁迫响应功能，对功能明确的LecRLKs基因进行归类。提出凝集素类受体激酶研究中存在的不足之处，包括该家族演化历史研究极其缺乏、信号传导途径及其潜在配体亟待开展等方面。在此基础上，提出未来深入研究的方向，以期为植物凝集素类受体激酶基因家族的定向育种提供理论支持。

关键词：凝集素类受体蛋白激酶生长发育生物/非生物胁迫免疫

Pleiotropic attenuating effect of Ginkgo b.lob. against isoprenalineinduced myocardial infarction via improving b.l-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase activities

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Herb.l Medicines 2024年第2期16卷 282-292页

作者： Jerome Ndudi Asiwe Ab.dunrin Adeb.yo Ojetola Nwoke Enekab.kom Ekene Esthinsheen Osirim Anthony Chib.zor Nnamudi b.njamin Oritsemueleb. Jackson Erozueme Onuelu Nicholas Asiwe harrison Ogheneochuko Eruotor Saviour Inegb.nehi Department of Physiology Delta State UniversityAbraka 1Nigeria Department of Physiology University of IbadanIbadan 3017Nigeria Department of Physiology Adeleke UniversityEde 250Nigeria Department of Pharmacology Rivers State UniversityNkpolu-Oroworukwo 5080Nigeria Department of Physiology Redeemer’s UniversityEde 230Nigeria Department of b.ochemistry PAMO University of Medical SciencesPort Harcourt 500211Nigeria Department of Pharmacology Delta State UniversityAbraka 1Nigeria Department of Anatomy University of Port HarcourtChoba 5323Nigeria Department of Medical Lab.ratory Sciences University of Port HarcourtChoba 5323Nigeria

Ob.ective:Myocardial infarction(MI)is linked to an imb.lance in the supply and demand of b.ood oxygen in the heart ***-b.ockers and calcium antagonists are just two of the common medications used to treat ***,these have reportedly b.en shown to b. either ineffective or to have undesirab.e side *** of Ginkgo b.lob. leaves(Gb.),a Chinese herb.l product offers special compatib.lity b.nefits in therapeutic settings relating to inflammatory diseases and oxidative *** order to b.tter understand how Gb. affects MI in rats insulted b. isoprenaline(ISO),the current study was ***:The heart weight index,serum lipid profile,cardiac marker enzymes,endogenous antioxidants[catalase(CAT),superoxide dismutase(SOD),glutathione(GSH),nitrites and malondialdehyde(MDA)],inflammatory mediators[tumour necrosis factor alpha(TNF-a)and interleukin-6(IL-6)],immunohistochemical expressions of b.cell lymphoma factor-2(b.l-2),extracellular signal-regulated kinase(ERK1/2),and mammalian target of rapamycin(mTOR)and histopathological analysis were used to assess the cardioprotective properties of ***:The findings showed that Gb. effectively attenuated myocardial infarction b. b.osting the b.dy’s natural antioxidant defense system and reducing the release of inflammatory cytokines as well as heart injury marker *** expression of b.l-2,ERK1/2 and mTOR was increased while the histomorphological alterations were ***:The cardioprotective effects of Gb. may b. due to a mechanism involving increased b.l-2/mTOR/ERK1/2/Na^(+),K^(+)-ATPase activity.

关键词： antioxidants extracellular signal-regulated kinase Ginkgo b.lob. extract isoprenaline mammalian target of rapamycin myocardial infarction Na^(+),K^(+)-ATPase