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NON-INVASIVE MEASUREMENT OF DEEP TISSUE TEMPERATURE CHANGES CAUSED BY APOPTOSIS DURING BREAST CANCER NEOADJUVANT CHEMOTHERAPY:A CASE STUDY

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 361-372页

作者： SO HYUN CHUNG rita MEHTA BRUCE J.TROMBERG A.G.YODH Department of Physics and Astronomy University of Pennsylvania 209 S.33rd StPhiladelphiaPA 19104USA Department of Medicine UC Irvine Healthcare 101 The City Drive SouthOrangeCA 92868USA Beckman Laser Institute Department of Biomedical Engineering University of CaliforniaIrvine1002 Health Sciences Rd IrvineCA 92612USA

Treatment-induced apoptosis of cancer cells is one goal of cancer ***,more heat is generated by mitochondria during apoptosis,especially the uncoupled apoptotic state,^(1,2) compared to the resting *** this case study,we explore these thermal effects by longitudinally measuring temperature variations in a breast lesion of a pathological complete responder during neoadjuvant chemotherapy(NAC).Diffuse Optical Spectroscopic Imaging(DOSI)was employed to derive absolute deep tissue temperature using subtle spectral features of the water peak at 975 nm.^(3)A significant temperature increase was observed in time windows during the anthracycline and cyclophosphamide(AC)regimen but not in the paclitaxel and bevacizumab *** concentration changes generally did not follow temperature,suggesting the measured temperature increases were likely due to mitochondrial uncoupling rather than a direct vascular effect.A simultaneous increase of tissue oxygen saturation with temperature was observed,suggesting that oxidative stress also contributes to *** preliminary,this study indicates longitudinal DOSI tissue temperature monitoring provides information that can improve our understanding of the mechanisms of tissue response during NAC.

关键词： Deep tissue temperature Diffuse Optical Spectroscopic Imaging apoptosis neoadjuvant chemotherapy breast cancer Bound Water Index NIR water absorption spectrum

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Laparoscopic fundoplication for gastroesophageal reflux disease

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World Journal of Gastroenterology 2014年第39期20卷 14272-14279页

作者： Marzio Frazzoni Micaela Piccoli rita Conigliaro Leonardo Frazzoni Gianluigi Melotti Digestive Pathophysiology Unit Baggiovara Hospital 41100 Modena Italy Digestive Endoscopy Unit Baggiovara Hospital 41100 Modena Italy Department of General Surgery Baggiovara Hospital 41100 Modena Italy

Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor (PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total (360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior (Toupet) fundoplication, and the anterior (Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard.

关键词： Gastroesophageal reflux disease Refractory gastroesophageal reflux disease Laparoscopic fundoplication Impedance-pH monitoring Proton pump inhibitors

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To compute or not to compute?

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第1期6卷 85-93页

作者： Alessandra Fiore Ivo Vanzi Camillo Nuti Cristoforo Demartino rita Greco Bruno Briseghella Department of Engineering and Geology University of Chieti-Pescara "G.d'Annunzio" DICAR Department of Civil Engineering and Architecture Polytechnic University of Bari College of Civil Engineering Fuzhou University Department of Architecture Roma Tre University College of Civil Engineering Nanjing Tech University DICATECH Department of Civil Engineering Environment Territory Building and Chemical Polytechnic University of Bari

In a previous paper "to retrofit or not to retrofit?"(Nuti and Vanzi, 2003) a straightforward procedure able to forecast the economic return of seismic structural upgrading was presented. More recently, the authors realized that the final mathematical results can be much simplified so as to allow back-of-an-envelope computation. The title of this paper tries to highlight precisely this aspect, namely that for many a regular seismic structural upgrading cases, nearly no computation is needed(apart from one subtraction and one multiplication) to assess their economic convenience. These findings are presented and discussed in this paper, together with a state of the art on the cost-studies available in literature and technical codes. The mathematical formulation leading to the proposed approximation is suitably explained, underlining its applicability field and comparing it with the rigorous solution. Also a table and a formula are furnished that alternatively allows to calculate the maximum estimation errors, in order to obtain an upper and lower bound for the maximum amount of money which should be allocated for seismic structural upgrading.

关键词： Seismic retrofitting Structural reliability Safety Optimization Cost minimization

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Presence of Mycoplasma *** Patients with Asthma or Allergic Rhinitis

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Advances in Microbiology 2014年第11期4卷 720-725页

作者： Munoz-Zurita Guillermo Paz martínez David Yánez Santos Jorge Antonio Gil Juárez Constantino Cedillo Ramírez María Lilia Alumno de Doctorado del Posgrado en Ciencias Ambientales Benemérita Universidad Autónoma de PueblaPueblaMexico Hospital Universitario de Puebla Benemérita Universidad Autónoma de PueblaPueblaMexico Facultad de Estomatología Benemérita Universidad Autónoma de PueblaPueblaMexico Centro de Investigaciones en Ciencias Microbiológicas Benemérita Universidad Autónoma de PueblaPueblaMexico Centro de Detección Biomolecular VIEPBenemérita Universidad Autónoma de PueblaPueblaMexico

Objective: To compare the presence of Mycoplasma spp. in pharyngeal swabs of patients with asthma, allergic rhinitis and controls, also to compare the reactivity to allergens in the three groups. Material and Methods: Throat swabs of 120 patients with asthma, 211 allergic rhinitis patients and 171 healthy persons were cultured in E media. Positive cultures were identified by PCR. Susceptibility of patients positive for isolation of Mycoplasma spp. to indoor, forest and undergrowth allergens were determined. Results: Mycoplasma spp. was isolated in 26.6% of samples from asthmatic patients, 36% in patients with allergic rhinitis and 2.9% in the group of healthy persons. Positive patients for Mycoplasma with asthma and allergic rhinitis showed susceptibility tomite, grass and thunder mainly. Conclusion: There is a higher incidence of Mycoplasma spp. in asthmatic and allergic rhinitis patients than healthy persons. Only patients with asthma or allergic rhinitis showed reactivity to environmental allergens.

关键词： Asthma Allergic Rhinitis Allergens Mycoplasma Spp.

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Formation and control of nitrogenous DBPs from Western Australian source waters: Investigating the impacts of high nitrogen and bromide concentrations

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Journal of Environmental Sciences 2017年第8期29卷 102-115页

作者： Ina Kristiana Deborah Liew rita K.Henderson Cynthia A.Joll Kathryn L.Linge Curtin Water Quality Research Centre Department of Chemistry Curtin University School of Chemical Engineering University of New South Wales

We studied the formation of four nitrogenous DBPs（N-DBPs） classes（haloacetonitriles,halonitromethanes, haloacetamides, and N-nitrosamines）, as well as trihalomethanes and total organic halogen（TOX）, after chlorination or chloramination of source waters. We also evaluated the relative and additive toxicity of N-DBPs and water treatment options for minimisation of N-DBPs. The formation of halonitromethanes, haloacetamides, and N-nitrosamines was higher after chloramination and positively correlated with dissolved organic nitrogen or total nitrogen. N-DBPs were major contributors to the toxicity of both chlorinated and chloraminated waters. The strong correlation between bromide concentration and the overall calculated DBP additive toxicity for both chlorinated and chloraminated source waters demonstrated that formation of brominated haloacetonitriles was the main contributor to toxicity. Ozone–biological activated carbon treatment was not effective in removing N-DBP precursors. The occurrence and formation of N-DBPs should be investigated on a case-by-case basis, especially where advanced water treatment processes are being considered to minimise their formation in drinking waters, and where chloramination is used for final disinfection.

关键词： Haloacetonitriles Haloacetamides Halonitromethanes N-nitrosamines Chlorination Chloramination

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Recent Advances in Dissecting Stress-Regulatory Crosstalk in Rice

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Molecular Plant 2013年第2期6卷 250-260页

作者： rita Sharma David De Vleesschauwer Manoj K. Sharma Pamela C. Ronald Department of Plant Pathology and Genome Center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94710 USA Laboratory of Phytopathology Faculty of Bioscience Engineering Ghent University B-9000 Ghent Belgium Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea

Biotic and abiotic stresses impose a serious limitation on crop productivity worldwide. Prior or simultaneous exposure to one type of stress often affects the plant response to other stresses, indicating extensive overlap and cross-talk between stress-response signaling pathways. Systems biology approaches that integrate large genomic and prot-eomic data sets have facilitated identification of candidate genes that govern this stress-regulatory crosstalk. Recently, we constructed a yeast two-hybrid map around three rice proteins that control the response to biotic and abiotic stresses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae; NH1, the rice ortholog of NPR1, a key regulator of systemic acquired resistance; and the ethylene-responsive transcription factor, SUBIA, which confers tolerance to submergence stress. These studies coupled with transcriptional profiling and co-expression analyses identified a suite of proteins that are positioned at the interface of biotic and abiotic stress responses, including mitogen-activated protein kinase 5 （OsMPK5）, wall-associated kinase 25 （WAK25）, sucrose non-fermenting-l-related protein kinase-1 （SnRK1）, SUBIA binding protein 23 （SAB23）, and several WRKY family tran- scription factors. Emerging evidence suggests that these genes orchestrate crosstalk between biotic and abiotic stresses through a variety of mechanisms, including regulation of cellular energy homeostasis and modification of synergistic and/or antagonistic interactions between the stress hormones salicylic acid, ethylene, jasmonic acid, and abscisic acid.

关键词： abiotic biotic crosstalk defense response hormone systems biology stress.

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Futibatinib:new targeted therapy in intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 923-926页

作者： rita Khoury Nadine Khalife Rebecca Ibrahim Khalil Saleh International Department Gustave Roussy Cancer CampusVillejuifFrance Head and Neck Oncology Department Gustave Roussy Cancer CampusVillejuifFrance

Biliary tract tumors are a heterogenous group of cancers that includes extrahepatic cholangiocarcinoma,hilar cholangiocarcinoma,gallbladder tumor as well as intrahepatic cholangiocarcinoma(ICCA)(1).Biliary tract tumors are uncommon tumors representing 2%of all newly diagnosed cancers in the United *** incidence of ICCA is increasing worldwide and associated with a dismal prognosis,and the 5-year overall survival(OS)rate is not exceeding 8%(1).

关键词： Futibatinib RLY-4008 infigratinib pemigatinib cholangiocarcinoma

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Remote Sensing Data Processing Process Scheduling Based on Reinforcement Learning in Cloud Environment

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 1965-1979页

作者： Ying Du Shuo Zhang Pu Cheng rita Yi Man Li Xiao-Guang Yue School of Computer and Information Engineering Henan UniversityKaifeng475004China Henan Province Engineering Research Center of Spatial Information Processing Henan UniversityKaifeng475004China School of Software Henan UniversityKaifeng475004China Department of Economics and Finance/Sustainable Real Estate Research Center Hong Kong Shue Yan UniversityHong Kong999077China Department of Computer Science and Engineering European University CyprusNicosia1516Cyprus CIICESI-ESTG Politécnico do PortoFelgueiras4610-156Portugal

Task scheduling plays a crucial role in cloud computing and is a key factor determining cloud computing *** solve the task scheduling problem for remote sensing data processing in cloud computing,this paper proposes a workflow task scheduling algorithm—Workflow Task Scheduling Algorithm based on Deep Reinforcement Learning(WDRL).The remote sensing data process modeling is transformed into a directed acyclic graph scheduling ***,the algorithm is designed by establishing a Markov decision model and adopting a fitness calculation ***,combine the advantages of reinforcement learning and deep neural networks to minimize make-time for remote sensing data processes from *** experiment is based on the development of CloudSim and Python and compares the change of completion time in the process of remote sensing *** results showthat compared with several traditionalmeta-heuristic scheduling algorithms,WDRL can effectively achieve the goal of optimizing task scheduling efficiency.

关键词： Cloud computing reinforcement learning remote sensing task scheduling

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Epiretinal membrane following pars plana vitrectomy for rhegmatogenous retinal detachment repair

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1872-1877页

作者： Ruti Sell Amir Sternfeld Ivan Budnik Ruth Axer-Siegel rita Ehrlich Departm ent of Ophthalmology Rabin Medical Center-Beilinson HospitalPetach Tikva 4941492Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6997801Israel Department of Pathophysiology Sechenov First Moscow State Medical UniversityMoscow 119146Russia

AIM: To determine the rate and possible contributors for post-pars plana vitrectomy(PPV) epiretinal membrane(ERM) in patients treated for rhegmatogenous retinal detachment(RRD). METHODS: This prospective, nonrandomized study comprised 47 consecutive patients(47 eyes) with acute RRD treated with 23 G post-PPV. All participants were followed prospectively for 6 mo for the development of ERM using spectral domain optical coherence tomography. Preoperative and intraoperative data were collected by questionnaires to surgeons. Main outcome measure was the percentage of the ERM formation following post-PPV for RRD. RESULTS: ERM developed postoperatively in 23 eyes(48.9%), none necessitated surgical removal. There was a statistically significant difference between patients with and without ERM postoperatively in preoperative best corrected visual acuity(median log MAR 1.9 vs 0.3, respectively;P=0.003) rate of macula-off(69.6% vs 37.5%, respectively, P=0.028), and rate of ≥5 cryo-applications(55.6% and 18.8%, respectively, P=0.039). ERM developed mainly between the 1st and 3rd months of follow-up. Macula-off status increased the risk of ERM, with the odds ratio of 3.81(P=0.031). CONCLUSION: ERM is a frequent post RRD finding, and its development is associated with macula-off RRD.

关键词： epiretinal membrane pars plana vitrectomy rhegmatogenous retinal detachment cryotherapy macula-off

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Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment

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Cancer Drug Resistance 2020年第4期3卷 775-790页

作者： Maria rita Fabbrizi Jason L.Parsons Cancer Research Centre Department of Molecular and Clinical Cancer MedicineUniversity of LiverpoolLiverpool L39TAUnited Kingdom Clatterbridge Cancer Centre NHS Foundation Trust Clatterbridge RoadBebington CH634JYUnited Kingdom

Incidences of head and neck squamous cell carcinoma(HNSCC)have been on the rise in the last few decades,with a significant risk factor being human papillomavirus(HPV)type-16/18 infection,particularly in the development of oropharyngeal ***(RT)is an important treatment modality for HNSCC,where it promotes extensive cellular DNA damage leading to the therapeutic *** has been well-established that HPV-positive HNSCC display better response rates and improved survival following RT compared to HPV-negative *** differential radiosensitivity has been largely associated with altered cellular DNA damage response mechanisms in HPV-positive HNSCC,and particularly with the signaling and repair of DNA double strand ***,other factors,particularly hypoxia present within the solid cancer,have a major impact on relative ***,recent approaches aimed at enhancing the radiosensitivity of HNSCC have largely centered on targeting key proteins involved in DNA repair,DNA damage checkpoint activation,and hypoxia *** studies have utilised in vitro and in vivo models of HPV-positive and HPV-negative HNSCC and examined the impact of specific inhibitors against the targets in combination with radiation in suppressing HNSCC cell growth and ***,accumulating evidence has shown that targeting enzymes including poly(ADP-ribose)polymerase,ataxia telangiectasia and Rad-3 related,DNA-dependent protein kinase catalytic subunit,and checkpoint kinase 1 can radiosensitise HNSCC cells which should be taken forward in further preclinical studies,with the goal of optimizing the future effective RT treatment of HNSCC.

关键词： DNA damage DNA repair head and neck cancer ionising radiation proton beam therapy radiobiology radiotherapy

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