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Advances in Bioscience and Biotechnology 2012年第1期3卷 92-100页

作者： rishi k. vishwakarma Sameer Srivastava Somesh Singh Bashir M. k.an Plant Tissue Culture Division National Chemical Laboratory Maharashtra India

Leucaena leucocephala is fast growing leguminous tree species, acclimatized to variety of soil and climatic conditions. It is widely used for pulp production in India. Pulp mainly consists of cellulose, which is a simple polymer of unbranched β-1, 4-link.d glucan chains. The polymerization of glucose residues into a β-1, 4-link.d back.one is catalysed by the enzyme cellulose synthase (CesA). Here, cDNAs encoding CesA genes from Leucaena were isolated and characterized. The two complete cDNAs of 3.228 k. and 3.222 k. encoding CesA gene from L. leucocephala were designated as Ll-7CesA (FJ871987) and Ll-8CesA (GQ267555) respectively. In-silico studies showed that Ll-7CesA has 95.2% identities and Ll- 8CesA has 95.8% identities with Acacia mangium CesA2. Phylogenetic analysis revealed significant similarity with k.own dicot CesA genes. The deduced amino acid sequence of both CesA genes contained the conserved D, D, D, QxxRW motif, eight membrane spanning regions and a putative zinc binding domain, which are characteristic of glycosyltransferases. DNA blot analysis suggested, CesA gene to be in multiple copies in Leucaena genome. Semi quantitative and quantitative real-time PCR expression analysis of Ll-7CesA gene showed more expression in stem than leaf and not detected in root where as Ll-8CesA gene was expressed more in stem than leaf and root. Overall Ll-8CesA was expressed in all tested tissues and could be involved in active cellulose biosynthesis.

关键词： Cellulose Biosynthesis Cellulose Synthase Expression Analysis Leucaena leucocephala Tree Species

Home-based Detection and Prediction of Diabetic Foot Ulcers at Early Stage Using Sensor Technology and Supervised Learning

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 26-37页

作者： k.masamudram Bhavya Sai rishi Raghu Sai Surya Varshith Nuk.la Jayashree Jayaraman Vijayashree Jayaraman School of Computer Science and Engineering Vellore Institute of TechnologyVellore 632014India

For years,foot ulcers link.d with diabetes mellitus and neuropathy have significantly impacted diabetic patients’ health-related quality of life(HRQoL). Diabetes foot ulcers impact15% of all diabetic patients at some point in their lives. The facilities and resources used for DFU detection and treatment are only available at hospitals and clinics,which results in the unavailability of feasible and timely detection at an early stage. This necessitates the development of an at-home DFU detection system that enables timely predictions and seamless communication with users,thereby preventing amputations due to neglect and severity. This paper proposes a feasible system consisting of three major modules:an IoT device that work. to sense foot nodes to send vibrations onto a foot sole,a machine learning model based on supervised learning which predicts the level of severity of the DFU using four different classification techniques including XGBoost,k.SVM,Random Forest,and Decision tree,and a mobile application that acts as an interface between the sensors and the patient. Based on the severity levels,necessary steps for prevention,treatment,and medications are recommended via the application.

关键词： diabetic foot ulcer podiatry diabetes mellitus healthcare footcare internet of things machine learning human⁃computer interaction

Inflammation and dry eye disease——where are we?

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 820-827页

作者： Srinivas k.Rao rishi Mohan Nik.il Gok.ale Himanshu Matalia Paras Mehta Darshan Eye Care&Surgical Centre ChennaiTamil NaduIndia MM Eyetech Institute of Ophthalmology New DelhiIndia Gok.ale Eye Hospital MumbaiMaharashtraIndia Narayana Nethralaya Electronic CityBangaloreKarnatakaIndia Sameep Eye Hospital and Corneal Center VadodaraGujaratIndia

The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear *** also affects the health of meibomian glands and their secretions which further aggravates ocular surface *** article reviews current k.owledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,mark.rs that identify the presence of inflammation on the ocular surface and current treatment options are discussed.

关键词： dry eye disease inflammation meibomian gland dysfunction vicious cycle ocular surface disease

Numerical simulation and experimental validation of arc welding of DMR-249A steel

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Defence Technology（防务技术） 2016年第4期12卷 305-315页

作者： rishi PAMNANI M. VASUDEVAN T. JAYAk.MAR R VASANTHARAJA k.C. GANESH Prototype Training Centre Kalpakkam Tamil Nadu 603 127 India IGCAR Tamil Nadu 603 102 India Metallurgical and Materials Engg Dept NIT Warangal 506 004 India Dept of Mech Engg NITT Tiruchirappalli 620 015 India

The thermo-mechanical attributes of DMR-249 A steel weld joints manufactured by shielded metal arc welding(SMAW) and activated gas tungsten arc welding(A-GTAW) processes were studied using Finite Element Model(FEM) simulation. The thermal gradients and residual stresses were analyzed with SYSWELD software using double ellipsoidal heat source distribution model. The numerically estimated temperature distribution was validated with online temperature measurements using thermocouples. The predicted residual stresses profile across the weld joints was compared with the values experimentally measured using non-destructive techniques. The measured and predicted thermal cycles and residual stress profile was observed to be comparable. The residual stress developed in double sided A-GTAW joint were marginally higher in comparison to five pass SMAW joint due to phase transformation associated with high heat input per weld pass for A-GTAW process. The present investigations suggest the applicability of numerical modeling as an effective approach for predicting the thermo-mechanical properties influenced by welding techniques for DMR-249 A steel weld joints. The tensile, impact and micro-hardness tests were carried to compare the *** benefits of high productivity and savings of labor and cost associated with A-GTAW compared to SMAW process, the minor variation in residual stress build up of A-GTAW joint can be neglected to develop A-GTAW as qualified alternative welding technique for DMR-249 A steel.? 2016 China Ordnance Society. Production and hosting by Elsevier B.V. All rights reserved.

关键词： DMR-249A A-GTAW SMAW FEM SYSWELD Thermo-mechanical Simulation

Pea3 expression promotes the invasive and metastatic potential of colorectal carcinoma

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World Journal of Gastroenterology 2014年第46期20卷 17376-17387页

作者： Aruz Mesci Samira Taeb Xiaoyong Huang rishi Jairath Darshan Sivaloganathan Stanley k.Liu Faculty of Medicine University of TorontoToronto M5S 1A8Canada Sunnybrook.Health Sciences Centre Sunnybrook Research InstituteToronto M4N 3M5Canada Department of Medical Biophysics University of TorontoToronto M4N 3M5Canada Department of Radiation Oncology University of TorontoToronto M5S 3E2Canada

AIM: To investigate the function of Pea3 in colorectal carcinoma (CRC) invasion and metastatic potential.

关键词： Colorectal cancer Pea3 Epithelial-mesenchymal transition Liver metastasis

Stress-rupture measurements of cast magnesium strengthened by in-situ production of ceramic particles

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Journal of Magnesium and Alloys 2017年第2期5卷 225-230页

作者： Nagaraj M.Chelliah Sudarshan Lisa k.aemer Harpreet Singh M.k.Surappa rishi Raj Department of Mechanical Engineering University of Colorado BoulderBoulderCO 80302USA Department of Mechanical Engineering Indian Institute of TechnologyRopar 140001India Erich Schmid Institute of Material Science Austrian Academy of SciencesLeobenA-8700Austria Department of Materials Engineering Indian Institute of ScienceBangalore 560012India

We have introduced a polymer precursor into molten magnesium and then in-situ pyrolyzed to produce castings of metal matrix composites(P-MMCs)containing silicon-carbonitride(SiCNO)ceramic ***-rupture measurements of as-cast P-MMCs was performed at 350 ℃(0.69TM)to 450 ℃(0.78TM)under dead load condition corresponding to tensile stress of 2.5 MPa to 20 *** time-to-fracture data were analyzed using the classical Monk.an–Grant *** time-to-fracture is thermally activated and follows a power-law stress exponent exhibiting dislocation *** analysis revealed that while pure magnesium appears to fracture by dislocation slip,the P-MMCs fail from the nucleation and growth of voids at the grain boundaries.

关键词： Stress-rupture Polymer derived ceramics Magnesium Dispersion strengthened alloys High temperature Light-weight materials

Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells

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Journal of Pharmaceutical Analysis 2021年第6期11卷 799-807页

作者： Ebony Nottingham Elizabeth Mazzio Sunil k.mar Surapaneni Shallu k.tlehria Arindam Mondal Ramesh Badisa Stephen Safe Arun k.rishi Mandip Singh Department of Pharmaceutics College of Pharmacy and Pharmaceutical SciencesFlorida A&M UniversityTallahasseeFL32307USA Department of Veterinary Physiology and Pharmacology College of Veterinary MedicineTexas A&M UniversityCollege StationTX77843USA John D.Dingell VA medical Center and Department of Oncology Wayne State UniversityDetroitMI48201USA

Non-small cell lung cancer(NSCLC)is often characterized by an underlying mutation in the epidermal growth factor receptor(EGFR),contributing to aggressive metastatic *** 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate(CDODA-Me),a glycyrrhetinic acid derivative,reportedly improves the therapeutic response to erlotinib(ERL),an EGFR tyrosine k.nase *** the present study,we performed a series of studies to demonstrate the efficacy of CDODA-Me(2μM)in sensitizing HCC827 R(ERL-resistant)cells to ***,we first established the selectivity of ERL-induced drug resistance in the HCC827 R cells,which was sensitized when ERL was combined with CDODA-Me(2μM),shifting the IC50 from 23.48μM to 5.46μ***,whole transcriptomic microarray expression data demonstrated that the combination of ERL+CDODA-Me elicited 210 downregulated genes(0.44%of the whole transcriptome(WT))and 174 upregulated genes(0.36%of the WT),of which approximately 80%were unique to the ERL+CDODA-Me *** effects centered on losses to cell cycle progression transcripts,a reduction of minichromosome maintenance complex components(MCM2-7),all k.y components of the Cdc45·MCM2-7 GINS(CMG)complex,and replicative helicases;these effects were tantamount to the upregulation of processes associated with the nuclear factor erythroid 2 lik. 2 translational response to oxidative stress,including sulfiredoxin 1,heme oxygenase 1,and stress-induced growth inhibitor ***,these findings indicate that the synergistic therapeutic effects of ERL+CDODA-Me on resistant NSCLC cells are mediated via the inhibition of mitosis and induction of oxidative stress.

关键词： Transcriptomic analysis Combination therapy Drug resistance Erlotinib Epidermal growth factor receptor

Duality for a Control Problem Involving Support Functions

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Applied Mathematics 2014年第21期5卷 3525-3535页

作者： I. Husain Abdul Raoof Shah rishi k. Pandey Department of Mathematics Jaypee University of Engineering and Technology Guna India Department of Statistics University of Kashmir Srinagar India

Mond-Weir type duality for control problem with support functions is investigated under generalized convexity conditions. Special cases are derived. A relationship between our results and those of nonlinear programmin... 详细信息

关键词： Control Problem Support Function Generalize Convexity Converse Duality Nonlinear Programming

Oral eplerenone for the management of chronic central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 310-314页

作者： rishi P Singh Jonathan E Sears Rumneek.Bedi Andrew P Schachat Justis P Ehlers Peter k.k.iser Cole Eye Institute 9500 Euclid Avenue i-32 Cleveland Clinic

AIM: To examine eplerenone(Inspra, Pfizer), a mineralocorticoid receptor antagonist, as a treatment option for chronic central serous chorioretinopathy(CSCR).METHODS: A retrospective consecutive case series was conducted for patients receiving oral eplerenone for chronic CSCR. At baseline and each follow-up visit,spectral domain optical coherence tomography(SD-OCT)imaging was performed, including manual measurements of the height and diameter size of subretinal fluid. The primary outcome measure was the reduction in subretinal fluid following initiation of ***: A total of 17 eyes of 13 patients treated with25 and 50 mg of oral eplerenone per day were *** fluid(SRF) decreased over time following eplerenone therapy(P = 0.007 and P =0.002, diameter and height respectively). Maximum SRF height decreased from a mean of 131.5 μm at baseline to 15.3 μm at day181+. SRF diameter decreased from an average of 2174.4μm at baseline to 46.9 μm at day 181 +. Log MAR visual acuity improved from 0.42(Snellen equivalent: 20/53) at baseline to 0.29(Snellen equivalent: 20/39) at day 181 +(P = 0.024). Central subfield thick.ess(CST) decreased from 339.5 μm at baseline to 270.3 μm at day 181+(P = 0.029).CONCLUSION: Eplerenone therapy resulted in significant anatomic and visual improvements in eyes with chronic CSCR.

关键词： central serous chorioretinopathy central serous retinopathy eplerenone subretinal fluid

Emerging therapies in gastrointestinal cancers

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World Journal of Gastroenterology 2006年第46期12卷 7440-7450页

作者： Jyoti Nautiyal Arun k.rishi Adhip PN Majumdar k.rmanos Cancer Institute Detroit MI 48201United States k.rmanos Cancer Institute Veterans Affairs Medical Center Departments of Internal Medicineand Wayne State University Detroit MI 48201 United States

Members of the receptor tyrosine k.nase family, that include EGFR, ErbB-2/HER-2, ErbB-3/HER-3 and ErbB-4/ HER-4, are frequently implicated in experimental models of epithelial cell neoplasia as well as in human cancers. Therefore, interference with the activation of these growth factor receptors represents a promising strategy for de- velopment of novel and selective anticancer therapies. Indeed, a number of inhibitors that target either EGFR or HER-2, with the exception of a few that target both; have been developed for treatment of epithelial cancers. Since most solid tumors express different ErbB receptors and/or their ligands, identification of inhibitor(s), targeting multiple EGFR family members may provide a therapeutic benefit to a broader patient population. Here we describe the significance of an ErbB family of receptors in epithelial cancers, and summarize different available therapeutics targeting these receptors. It also emphasizes the need to develop pan-ErbB inhibitors and discusses EGF-Receptor Related Protein, a recently isolated negative regulator of EGFR as a potential pan-ErbB therapeutic for a wide vari- ety of epithelial cancers.

关键词： Gastrointestinal cancers Carcinogenesis Targeted therapies Pan-ErbB family EGF-Receptor Related Protein