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Role of regulatory T cell in the pathogenesis of inflammatorybowel disease

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World Journal of Gastroenterology 2016年第7期22卷 2195-2205页

作者： akiko yamada rieko arakaki masako saito takaaki tsunematsu yasusei kudo naozumi ishimaru Department of Oral Molecular Pathology Tokushima University Graduate SchoolTokushima 770-8504Japan

Regulatory T(Treg) cells play key roles in various immune responses. For example, Treg cells contribute to the complex pathogenesis of inflammatory bowel disease(IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. Many animal models of IBD have been used to investigate factors such as pathogenic cytokines, pathogenic bacteria, and T-cell functions, including those of Treg cells. In addition, analyses of patients with IBD facilitate our understanding of the precise mechanism of IBD. This review article focuses on the role of Treg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports.

关键词： Inflammatory bowel disease Regulatory Tcell Animal model Therapy

Usefulness of Newly Devised Clomiphene Citrate Administration Method Compared with the Conventional Method in Ovulation and Pregnancy

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 637-649页

作者： Makoto Kawamura Misaki Akiyama Remi Nakajima Eri Satoi Yoko Ogaki rieko Kanda Department of Obstetrics and Gynecology Kohseichuo General Hospital Tokyo Japan

Objective: Since not all women wish to conceive a child through aggressive treatment, we investigated the usefulness of modified repeated intracyclic clomiphene citrate (CC) therapy (repeated CC therapy) as a newly devised administration method. Methods: We evaluated the effects of CC administration on menstrual cycle length and retrospectively compared ovulation and pregnancy in 220 women who received CC at our hospital. Patients in the conventional method group received 50 mg per day for five days, starting on the fifth day of menstruation (withdrawal bleeding). Groups with and without menstrual cycle shortening after conventional CC administration were compared. The repeated CC therapy group was also compared with the non-shortened group. Repeated CC therapy was administered for the first five days as in the conventional method, and a second five-day repeat treatment was administered after an interval of five to seven days. Pregnancy rates, including indirect pregnancies, were evaluated by three different methods. Results: Ovulation and pregnancy rates were significantly better in the shortened group than in the non-shortened group (P < 0.001 and P = 0.010, respectively). Even in the non-shortened group, ovulation and pregnancy rates including indirect pregnancies were significantly improved when ovulation was observed with repeated CC therapy (P < 0.001 and P = 0.022, respectively). Conclusions: For patients whose menstrual cycle was not improved or shortened, repeated CC therapy as the newly devised CC administration method is useful as the next step after the conventional CC administration method.

关键词： Clomiphene Citrate Infertility Menstrual Cycle Ovulation Induction

Adult-Type Granulosa Cell Tumor with Similar Clinical Findings Seen during Ovarian Cystectomy Performed at the Same Time as Laparoscopic Ovarian Drilling for Polycystic Ovarian Syndrome: An Extremely Rare Case

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1197-1206页

作者： Remi Nakajima Risa Kobayashi Marie Kawai Eriko Sakamoto Miho Matsuda rieko Kanda Makoto Kawamura Department of Obstetrics and Gynecology Kohseichuo General Hospital. Tokyo Japan

Polycystic ovary syndrome (PCOS) is a major cause of anovulatory infertility. Laparoscopic ovarian drilling (LOD) is a treatment for PCOS that allows the laparoscopic identification of other intra-abdominal lesions and the provision of diagnostic treatment. This study reports a case of PCOS with an ovarian mass in which LOD was aggressively used and a granulosa cell tumor (GCT) was found. A 34-year-old woman with secondary amenorrhea and irregular menstrual cycles presented to the emergency department with abdominal pain of unknown etiology. Imaging studies revealed a 6-cm left ovarian mass with an internal appearance suggestive of a hemorrhage. The patient’s secondary amenorrhea was subsequently diagnosed as PCOS, and LOD was performed to preserve her fertility. Simultaneously, a cystectomy was performed to evaluate the tumor in the left ovary;the diagnosis was adult-type GCT. Although concomitant GCT and PCOS are extremely rare, the two conditions have similar clinical manifestations. In women of reproductive age, the impact of surgery on future fertility should be considered, and the initial surgical technique should be chosen carefully.

关键词： Polycystic Ovary Syndrome Laparoscopic Ovarian Drilling Granulosa Cell Tumor

Preparation and incubation conditions affect the DNA integrity of ejaculated human spermatozoa

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Asian Journal of Andrology 2010年第5期12卷 753-759页

作者： rieko Matsuura Takumi Takeuchi Atsumi Yoshida The Reproduction Center Kiba Park Clinic Tokyo 135-0042 Japan

Appropriate semen processing and assessment are critical for successful infertility treatment. We investigated whether laboratory procedures including semen preparation and incubation affect sperm DNA integrity. A total of 153 infertile men were involved. Conventional semen parameters and sperm chromatin structure assay （SCSA） parameters, that is, DNA fragmentation index （%DFI） and high DNA stainability （%HDS）, were assessed on the flesh ejaculated semen samples, which were treated and incubated under different conditions. Negative correlations were identified between the %DFI and sperm concentration, motility, progressive motility and morphology. A lower percentage of DFI was detected in spermatozoa when density gradient centrifugation （DGC） was followed by swimup treatment in comparison with DGC alone （P 〈 0.01）. Although the %DFI increased in a time-dependent manner with incubation both at room temperature （RT） and at 37℃ in air, the %DFI after 24 h at RT was significantly lower than that at 37℃ （P 〈 0.05）. Incubation with 5% CO2 was effective in maintaining sperm motility （P 〈 0.01）; however, it induced further elevation of %DFI （P 〈 0.001）. Thus, sperm DNA damage was associated with longer incubation periods. Interestingly, common culture conditions, such as maintaining pH and temperature, compromised the sperm DNA integrity.

关键词： density gradient centrifugation DNA damage male infertility sperm chromatin structure assay spermatozoa

Fulminant hepatic failure resulting from small-cell lung cancer and dramatic response of chemotherapy

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World Journal of Gastroenterology 2006年第15期12卷 2466-2468页

作者： Kyoichi Kaira Atsushi Takise rieko Watanabe Masatomo Mori Department of Respiratory Medicine Maebashi Red Cross Hospital 3-21-36 Asahi-choMaebashiGunma 371-0014Japan Department of Medicine and Molecular ScienceGunma University Graduate School of MedicineShowa-machiMaebashiGunma 371-8511Japan Department of Respiratory Medicine Maebashi Red Cross Hospital 3-21-36 Asahi-choMaebashiGunma 371-0014Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Showa-machiMaebashiGunma 371-8511Japan

Prompt treatment in tumor-associated encephalopathy may prolong survival. We describe a 69-year-old male patient who was presented with fulminant hepatic failure, secondary to small-cell lung carcinoma with rapidly progressing encephalopathy. Both symptoms remitted following chemotherapy, suggesting swift diagnosis and administration of chemotherapy to be effective in treatment of fulminant hepatic failure and encephalopathy.

关键词： Small-cell lung carcinoma Fulminant hepatic failure Chemotherapy

Transcriptional regulation of human polo-like kinases and early mitotic inhibitors

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Journal of Genetics and Genomics 2008年第4期35卷 215-224页

作者： Moe Tategu Hiroki Nakagawa Kaori Sasaki rieko Yamauchi Sota Sekimachi Yuka Suita Naoko Watanabe Kenichi Yoshida Department of Life Sciences Meiji University School of Agriculture 1-1-1 Higashimita Tama-ku Kawasaki Kanagawa 214-8571 Japan

Human polo-like kinases （PLK1-PLK4） have been implicated in mitotic regulation and carcinogenesis. PLK1 phosphorylates early mitotic inhibitor 1 （Emil） to ensure mitosis entry, whereas Emi2 plays a key role during the meiotic cell cycle. Transcription factor E2F is primarily considered to regulate the G1/S transition of the cell cycle but its involvement in the regulation of mitosis has also been recently suggested. A gap still exists between the molecular basis of E2F and mitotic regulation. The present study was designed to characterize the transcriptional regulation of human PLK and Emi genes. Adenoviral overexpression of E2F1 increased PLK1 and PLK3 mRNA levels in A549 cells. A reporter gene assay revealed that the putative promoter regions of PLK1, PLK3, and PLK4 genes were responsive to activators E2F, E2F1-E2F3. We further characterized the putative promoter regions of Emil and Emi2 genes, and these could be regulated by activators E2F and E2F1-E2F4, respectively. Finally, PLK1-PLK4, Emil, and Emi2 mRNA expression levels in human adult, fetal tissues, and several cell lines indicated that each gene has a unique expression pattern but is uniquely expressed in common tissues and cells such as the testes and thymus. Collectively, these results indicate that E2F can integrate G1/S and G2/M to oscillate the cell cycle by regulating mitotic genes PLK and Emi, leading to determination of the cell fate.

关键词： polo-like kinase early mitotic inhibitor cell cycle E2F promoter gene regulation

Coptidis Rhizoma Water Extract Stimulates 5'-AMP-Activated Protein Kinase in Rat Skeletal Muscle

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中国天然药物 2011年第3期9卷 215-221页

作者： Tatsuro Egawa rieko Oshima Eriko Kurogi Hiroko Tanabe Satoshi Tsuda Tatsuya Hayashi Laboratory of Sports and Exercise Medicine Graduate School of Human and Environmental StudiesKyoto University

AIM:Coptidis Rhizoma(CR),the dried rhizomes of Asian herbs(including Coptis chinensis Franch),has been used to treat diabetes mellitus for thousands of *** explored the possibility that CR acts directly on skeletal muscle,the major organ responsible for glucose homeostasis,and activates 5'-AMP-activated protein kinase(AMPK),a signaling intermediary leading to metabolic enhancement of skeletal ***:Isolated rat epitrochlearis and soleus muscles were incubated in a buffer containing a CR water extract(CE),and activation of AMPK and related events were ***:In response to CE treat-ment,phosphorylation of Thr172 at the catalyticαsubunit of AMPK,an essential step for full kinase activation,increased in both *** of Ser79 of acetyl CoA carboxylase(ACC),an endogenous substrate of AMPK,increased *** of isoform-specific AMPK activity revealed that CE activated both the α1 and α2 isoforms of the catalytic ***,the maximal effect of CE on AMPK phosphorylation was significantly greater than that of berberine(BBR),indicating that the action of CE is not totally ascribed to ***:We propose that CE is an acute activator of AMPK in both fast-and slow-twitch skeletal muscles.

关键词： Coptidis Rhizoma Coptis chinensis 5’-AMP-activated protein kinase Skeletal muscle Berberine

A Cultural Comparison of Conflict-Solution Styles Displayed in the Japanese, French, and German School Texts

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Psychology Research 2012年第12期2卷 719-728页

作者： rieko Tomo Doshisha Women's College Kyoto Japan

The purpose of this study is to examine the ways how to solve the conflicts between parents and children by statistical analyses displayed in Japanese, French, and German school texts published in 2000. The results were as follows: (1) Japanese parents and children acting in those texts have much more compromising tendency to avoid conflicts than French and German ones. Japanese children are much more expected to behave in harmony with others by avoidance of any conflicts, whereas French and German ones by presenting their opinions for their solution; and (2) French and German parents and children use a much more verbal communication style than Japanese ones do. Those children are expected to express their own opinions much more than Japanese children. These results show that the solution styles of parent-child conflicts would be an interesting indicator reflecting culture and society.

关键词：文化比较教科书显示日语学校德语统计分析日本

Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

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World Journal of Gastroenterology 2017年第39期23卷 7150-7159页

作者： Akira Yokoyama Kenro Hirata rieko Nakamura Tai Omori Takeshi Mizukami Junko Aida Katsuya Maruyama Tetsuji Yokoyama National Hospital Organization Kurihama Medical and Addiction Center Division of Gastroenterology and Hepatology Department of Internal Medicine School of Medicine Keio University Department of Health Promotion National Institute of Public HealthSaitama Endoscopy Center Kawasaki Municipal Ida Hospital Research Team for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology

AIM To determine whether the presence of columnar-lined esophagus(CLE) is associated with the presence of esophageal varices(EVs) in male Japanese alcoholics. METHODS The subjects were 1614 Japanese alcohol-dependent men(≥ 40 years of age) who had undergone upper gastrointestinal endoscopic screening. Digitalized records of high-quality endoscopic images that included the squamocolumnar junction and esophagogastric junction were retrospectively jointly reviewed by four expert endoscopists for the purpose of diagnosing CLE. The authors investigated whether and to what extent there were associations between the presence of CLE and the presence of EVs, especially in the group with liver cirrhosis(LC).RESULTS CLE ≥ 5 mm in length was found in 355 subjects(≥ 30 mm in 6 of them), LC without EVs in 152 subjects, LC with EVs in 174 subjects, and EVs without LC in 6 subjects. Advanced EVs, i.e., nodular, large or coiled forms, red color sign, or post-treatment, were found in 88 subjects. The incidence of CLE ≥ 5 mm decreased in the following order(P < 0.0001): 23.3% in the group without EVs, 17.4% in the group with small and straight EVs, and 5.7% in the group with advanced EVs. The multivariate ORs(95%CI) for EVs and advanced EVs in the group with LC were lower when CLE ≥ 5 mm was present [0.46(0.23-0.93) and 0.24(0.08-0.74), respectively, vs 0-4 mm CLE]. CONCLUSION The presence of CLE in male Japanese alcoholics was negatively associated with the presence of EVs.

关键词： Alcohol Columnar-lined esophagus Hiatal hernia Liver cirrhosis Portal hypertension Esophageal varices