检索结果-南通市图书馆

母体卡托普利治疗可持续改善肠-脑轴并减轻雄性后代的高血压

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2020年第5期28卷 456-456页

作者：周卫(译) 叶鹏(校) Li H Yang T richards em Pepine CJ Raizada MK 不详

母胎相互作用在后代的远期健康及跨代高血压的发生中发挥作用。然而,目前对于母体对后代肠道及肠道微生物环境的影响在后代高血压控制中的作用仍知之甚少。此研究旨在检验母体对后代肠-脑轴产生影响,继而影响后代高血压发生这一假设。... 详细信息

母胎相互作用在后代的远期健康及跨代高血压的发生中发挥作用。然而,目前对于母体对后代肠道及肠道微生物环境的影响在后代高血压控制中的作用仍知之甚少。此研究旨在检验母体对后代肠-脑轴产生影响,继而影响后代高血压发生这一假设。本研究选用卡托普利进行实验,卡托普利是一种具有抗菌特性的血管紧张素转换酶抑制剂。在整个怀孕和哺乳期间,对怀孕的自发性高血压母鼠和正常血压的母鼠(WKY组)给予卡托普利水[100 mg/(kg·d)]或无菌水。

关键词：正常血压高血压控制卡托普利治疗血管紧张素转换酶抑制剂自发性高血压肠道微生物无菌水持续改善

在线全文

学校读者我要写书评

暂无评论

患者肠道微生物群失调与肠上皮屏障功能障碍

中华高血压杂志 2018年第9期26卷 864-864页

作者： Kim S Goel R Kumar A Qi Y Lobaton G Hosaka K Mohammed M Handberg em richards em Pepine CJ Raizada MK 刘青叶鹏

最近的证据表明，在动物模型中，肠道病理学和微生物组与高血压之间存在联系。然而，这种关联在人类中是否存在尚不清楚。因此，该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预... 详细信息

最近的证据表明，在动物模型中，肠道病理学和微生物组与高血压之间存在联系。然而，这种关联在人类中是否存在尚不清楚。因此，该研究的目的是检验高血压患者具有明显特异的肠道微生物组以及肠上皮屏障功能标记物和微生物组组成可以预测收缩压变化的假设。研究者通过鸟枪法宏基因组学分析粪便样本显示微生物分类和功能变化，结果显示高血压患者和对照受试者之间丁酸盐产生存在差异。

关键词：肠道微生物高血压患者微生物群功能障碍上皮屏障失调动物模型屏障功能

Risk Factors for Cardiovascular Disease among Hotel Workers, Bohicon, Benin

在线全文

学校读者我要写书评

暂无评论

Occupational Diseases and Environmental Medicine 2024年第2期12卷 130-141页

作者： Mênonli Adjobimey Rose Mikponhoué eméline Gbaguidi Esdras Hountohotegbè Hélène Sacca Paul Ayélo Vikkey Antoine Hinson Unité de Recherche et d&#8217Enseignement en Sant&#233 au Travail et Environnement FSS Cotonou Cotonou Benin Service de Santé au Travail du Centre National Hospitalier Universitaire de Pneumo Phtisiologie de Cotonou Cotonou Benin Laboratoire d’ Epid&#233miologie des Maladies Chroniques et Neurologiques FSS Cotonou Benin

Introduction: Non-communicable diseases (NCDs) are on the increase in several sectors of activity. The aim of the study was to determine the frequencies of cardiovascular risk factors (CVRF) and factors associated with hypertension among hotel workers in the city of Bohicon. Methods: This was a descriptive and analytical cross-sectional study conducted in the period from December 2018 to January 2019. The variables studied were sociodemographic, occupational, anthropometric and behavioral. Participant recruitment was exhaustive. A standardized questionnaire inspired by the STEPS-WHO questionnaire was used for data collection. After the descriptive analysis, a bivariate analysis was performed using Pearson’s Chi-square test or Fisher’s test at the 5% threshold. Results: A total of 101 workers, 53 (52.47%) of them male, participated in the study. The mean age was 30.60 ± 8.20 years, with extremes of 18 and 55 years. The frequencies of the main risk factors were: 68.32% sitting position > 6 hours/day;38.61% shift work;21.78% high psychological demand, 82.18% low decision latitude, 24.75% low social support, 21.78% occupational stress;7 (6.93%) harmful alcohol consumption;6.93% tobacco consumption;48.51% insufficient physical activity;98.02% insufficient fruit and vegetable consumption;59.41% overweight;14.85% HTA. Factors associated with hypertension were: sex, age and marital status. Conclusion: Occupational factors need to be taken into account when assessing CVRFs. NCD control programs are needed in all sectors of activity. A larger study is needed in the hotel sector.

关键词： FDRCV Occupational Factors Hypertension Hotels Benin

Relationship between Inter Canine Width and Inter Alar Width, Inter Commissural Width, and Inter Canthal Distance: A Pilot Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Stomatology 2024年第6期14卷 279-290页

作者： Grevisse Bindele Ndombolo Augustin Mantshumba Milolo Fidele Nyimi Bushabu em Kalala Kazadi Pierrot Kumpanya Ntumba Jean Marie Kayembe Bukama Elias Lubadi Tshilumba Jean Paul Sekele Isouradi Department of Prosthodontics Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo National Center of Research in Dental Sciences Kinshasa Democratic Republic of the Congo Department of Oral and Maxillofacial Surgery Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo Department of Periodontology Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo Department of Operative Dentistry Teaching Hospital of Kinshasa University Kinshasa Democratic Republic of the Congo

The aim of this study was to determine the relationship between inter canine width (ICW) and inter alar width (IAW), inter commissural width (ICoW), and inter canthal distance (ICaD) in Bantu population. Materials and Methods: It was a pilot study included all participants who were aged at least 18 years, without a history of orthodontics treatment from Prosthodontics Department, Faculty of Dental Medicine, University of Kinshasa. The Ethics committee of the National Center of Research for Dental Sciences in DR Congo approved the study protocol (CNRSB 1504.218). The participants medical records were obtained from the interview and dental examination. Nature of the study was explained with participant information sheet, and an informed consent of all participants was obtained. The inclusion criteria were no missing maxillary and mandibular teeth, no diastema, and no anterior restorations, 18 years old before enrollment in the study. The exclusion criteria were inability to meet the above requirements, pregnancy, and refusal to participate in the study. The inter-canine width (ICW), inter alar width (IAW), inter canthal distance (ICaD) and inter-commissural width (ICoW) of each participant were measured with a digital Vernier caliper (Mitutoyo, UK Ltd.,) (0.01 mm) three times and the average value was recorded. The inter canthal distance (ICaD) was measured without applying pressure by bringing the recording parts of the caliper just in contact with the medial angle. The inter alar width (IAW) was marked with a fine marked pencil on the widest outer surface of the alae of the nose on either side or width. Those two points were measured without applying pressure by bringing the recording parts of the caliper just in contact with the outer surface. The participant was told to stop breathing shortly to avoid any change in shape of the nose. The inter-commissural width (ICoW) was determined by measuring the maxillary lip vermilion from commissure to commissure without the

关键词： Relationship Inter-Canine Width Inter Alar Width Inter Canthal Distance Inter Commissural Width

Extrapolation-Based Acceleration of Iterative Solvers:Application to Simulation of 3D Flows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2011年第3期9卷 607-626页

作者： Leopold Grinberg George em Karniadakis Division of Applied Mathematics Brown UniversityProvidence 02912USA

We investigate the effectiveness of two extrapolation-based methods aiming to approximate the initial state required by an iterative solver in simulations of unsteady flow *** methods lead to about a ten-fold reduction in the iteration count while requiring only negligible computational *** are particularly suitable for parallel computing since they are based almost exclusively on data stored locally on each *** has been evaluated in simulations of turbulent flow in a stenosed carotid artery and also in laminar flow in a very large domain containing the human intracranial arterial tree.

关键词： High-order methods POD CFD low-energy preconditioner

A Scalable Domain Decomposition Method for Ultra-Parallel Arterial Flow Simulations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2008年第10期4卷 1151-1169页

作者： Leopold Grinberg George em Karniadakis Division of Applied Mathematics Brown UniversityProvidence 02912USA

Ultra-parallel flow simulations on hundreds of thousands of processors require new multi-level domain decomposition *** we present such a new two-level method that has features both of discontinuous and continuous Galerkin ***,at the coarse level the domain is subdivided into several big patches and within each patch a spectral element discretization(fine level)is *** interface conditions for the Navier-Stokes equations are developed to connect the patches,relaxing the C0 continuity and minimizing data transfer at the patch *** perform several 3D flow simulations of a benchmark problem and of arterial flows to evaluate the performance of the new method and investigate its accuracy.

关键词： Bioflows spectral elements discontinuous Galerkin parallel computing

Efficient and Accurate Numerical Methods Using the Accelerated Spectral Deferred Correction for Solving Fractional Differential Equations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical Mathematics(Theory,Methods and Applications) 2022年第4期15卷 876-902页

作者： Xuejuan Chen Zhiping Mao George em Karniadakis School of Science Jimei UniversityXiamen 361021China School of Mathematical Sciences Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific ComputingXiamen UniversityXiamenChina Division of Applied Mathematics Brown UniversityProvidenceRI 02912USA

We develop an efficient and accurate spectral deferred correction(SDC)method for fractional differential equations(FDEs)by extending the algorithm in[14]for classical ordinary differential equations(ODEs).Specifically,we discretize the resulted Picard integral equation by the SDC method and accelerate the convergence of the SDC iteration by using the generalized minimal residual algorithm(GMRES).We first derive the correction matrix of the SDC method for FDEs and analyze the convergence region of the SDC *** then present several numerical examples for stiff and non-stiff FDEs including fractional linear and nonlinear ODEs as well as fractional phase field models,demonstrating that the accelerated SDC method is much more efficient than the original SDC method,especially for stiff ***,we resolve the issue of low accuracy arising from the singularity of the solutions by using a geometric mesh,leading to highly accurate solutions compared to uniform mesh solutions at almost the same computational ***,for long-time integration of FDEs,using the geometric mesh leads to great computational savings as the total number of degrees of freedom required is relatively small.

关键词： Stiff problem generalized minimal residual geometric mesh refinement long time evolution fractional phase field models

Predicting the aquatic risk of realistic pesticide mixtures to species assemblages in Portuguese river basins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第5期27卷 12-20页

作者： emília Silva Michiel A.Daam Maria José Cerejeira Centro de Engenharia dos Biossistemas (CEER) Instituto Superior de Agronomia (ISA) University of Lisbon (UL) Tapada da Ajuda1349-017 Lisbon Portugal

Although pesticide regulatory tools are mainly based on individual substances, aquatic ecosystems are usually exposed to multiple pesticides from their use on the variety of crops within the catchment of a river. This study estimated the impact of measured pesticide mixtures in surface waters from 2002 and 2008 within three important Portuguese river basins（＇Mondego＇, ＇Sado＇ and ＇Tejo＇） on primary producers, arthropods and fish by toxic pressure calculation. Species sensitivity distributions（SSDs）, in combination with mixture toxicity models, were applied. Considering the differences in the responses of the taxonomic groups as well as in the pesticide exposures that these organisms experience, variable acute multi-substance potentially affected fractions（ms PAFs） were obtained. The median msP AF for primary producers and arthropods in surface waters of all river basins exceeded 5%, the cut-off value used in the prospective SSD approach for deriving individual environmental quality standards. A ranking procedure identified various photosystem II inhibiting herbicides, with oxadiazon having the relatively largest toxic effects on primary producers, while the organophosphorus insecticides, chlorfenvinphos and chlorpyrifos, and the organochloride endosulfan had the largest effects on arthropods and fish, respectively. These results ensure compliance with European legislation with regard to ecological risk assessment and management of pesticides in surface waters.

关键词： Pesticides Mixtures Risk assessment Multi-substance potentially affected fraction Surface waters

When to pull the trigger in nonazoospermic infertile men undergoing intracytoplasmic sperm injection?

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2020年第4期22卷 439-440页

作者： Sandro C Esteves Sheena em Lewis ANDROFERT Andrology and Human Reproduction ClinicReferral Center for Male Reproduction13075-460 CampinasSPBrazil Department of Surgery(Division of Urology) University of Campinas(UNICAMP)13083-887 CampinasSPBrazil Faculty of Health Aarhus University8000 AarhusDenmark Queens University Belfast Northern Ireland BT71NNUK Examenlab Ltd. Weavers Court Business ParkLinfield RoadBelfastNorthern Ireland BT125GHUK

Before the era of intracytoplasmic sperm injection(ICSI),few options were available for men with severe infertility to father a biological *** in 1992 as a modification of conventional in vitro fertilization,ICSI has enabled men with low sperm quantity and quality to have their own biological offspring.[1]Among nonazoospermic infertile men,ICSI has been traditionally carried out with ejaculated *** contrast,methods to harvest sperm from the epididymides and testes are used for ICSI in men with azoospermia-related infertility.

关键词： injection infertility traditionally