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The effect of EMG magnitude on the masseter vestibular evoked myogenic potential(mVEMP)

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Journal of Otology 2022年第4期17卷 203-210页

作者： Daniel J.Romero Gary P.Jacobson richard A.roberts Department of Hearing and Speech Sciences Division of Vestibular SciencesVanderbilt University Medical Center121521st Ave.South6308 Medical Center EastNashvilleTN37232-8718USA

Introduction:The masseter vestibular evoked myogenic potential(mVEMP)is a bilaterally generated,electromyographically(EMG)-mediated response innervated by the trigeminal *** purpose of the present investigation was to 1)determine whether subjects could accurately achieve and maintain a range of EMG target levels,2)to examine the effects of varied EMG levels on the latencies and amplitudes of the mVEMP,and 3)to investigate the degree of side-to-side asymmetry and any effects of EMG ***:Subjects were nine neurologically and otologically normal young adults.A high-intensity tone burst was presented monaurally while subjects were seated upright and asked to match a range of EMG target levels by clenching their *** were made from the ipsilateral and contralateral masseter muscles referenced to the ear being monaurally ***:We found that the tonic EMG target had no effect on mVEMP ***,although mVEMP amplitudes“scaled”to the EMG target,there was a tendency for the subjects’EMG level to“undershoot”the EMG target levels greater than 50 *** some individuals did generate differences in EMG activation between sides,there were no significant differences on average EMG activation between ***,while average corrected amplitude asymmetry was similar across EMG targets,some individuals demonstrated large,corrected amplitude asymmetry ***:The results of this investigation suggest that,as with cVEMP recordings,the underlying EMG activation may vary between subjects and could impact mVEMP amplitudes,yet could be mitigated by amplitude correction *** it is important to be aware that even young normal subjects have difficulty maintaining large,tonic EMG activity during the mVEMP recording.

关键词： Vestibular evoked myogenic potentials (VEMPs) Masseter VEMPs Electromyography(EMG) Vestibulomasseteric reflex(VMR) EMG target Level

A factor analytic assessment of the English translation of the neuropsychological vertigo inventory(NVI)

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Journal of Otology 2020年第2期15卷 45-49页

作者： Gary P.Jacobson Erin G.Piker Kelsey Hatton richard A.roberts Vanderbilt University Medical Center NashvilleTNUSA James Madison University HarrisonburgVAUSA

Purpose:Vestibular impairments have been associated with a variety of cognitive deficits,most notably deficits in visuo-spatial *** Neuropsychological Vertigo Inventory(NVI)was developed to measure self-reported cognitive deficits in patients with dizziness and/or *** original French language version of the NVI includes 28 items and 7 *** purpose of the present investigation was to determine whether the statistical assessment of an English language version supported the presence of the same cognitive constructs as the French version of the ***:The English language adaptation of the NVI(referred to here as the NVIe)was administered to an unselected sample of 280 patie nts that were being evaluated for dizziness and/or vertigo in a tertiary care dizziness *** individual item scores from the NVIe were subjected to an exploratory factor analysis(EFA).Results:The results of the data analysis supported a 22-item NVIe consisting of 4 constructs:affective state,temporal memory,spatial memory,visual spatial ***:The NVIe is a new tool for screening cognitive constructs that may be affected by vestibular *** to clinical implementation of the NVIe,additional studies of reliability and convergent validity are needed.

关键词： Cognition Vestibular Construct validity

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一路平安

中国全科医学 2013年第19期16卷 2191-2192页

作者： richard roberts roberts 邵钧(翻译) 美国威斯康辛州 Wisconsin大学医学和公共卫生学院家庭医学系中国全科医学杂志社

我不善于说＂拜拜＂.在担任WONCA主席的三年里,我无数次地对我的家人、患者、诊所同事、工作中视察的家庭医生说＂拜拜＂.这从来不是一件容易的事.每当我走进当地机场的停机楼,离开家人的忧伤就席卷我的全身.每次和患者、诊所同事谈起... 详细信息

我不善于说＂拜拜＂.在担任WONCA主席的三年里,我无数次地对我的家人、患者、诊所同事、工作中视察的家庭医生说＂拜拜＂.这从来不是一件容易的事.每当我走进当地机场的停机楼,离开家人的忧伤就席卷我的全身.每次和患者、诊所同事谈起我下一次的旅行,我就深感内疚.我担心我不在的时候会发生什么我不该错过或本该预料到的事.

关键词：家庭医学家庭医生医生病人关系

Surgical management of the diabetic foot:The current evidence

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World Journal of Orthopedics 2024年第5期15卷 404-417页

作者： richard Henry Randall roberts Gareth Rhys Davies-Jones James Brock Vaishnav Satheesh Greg AJ robertson Department of Trauma and Orthopaedics Wrexham Maelor HospitalWrexham LL137TDUnited Kingdom Department of Trauma and Orthopaedics The Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY107AGUnited Kingdom

The prevalence of diabetes mellitus and its associated complications,particularly diabetic foot pathologies,poses significant healthcare challenges and economic burdens *** review synthesises current evidence on the surgical management of the diabetic foot,focusing on the interplay between neuropathy,ischemia,and infection that commonly culminates in ulcers,infections,and,in severe cases,*** escalating incidence of diabetes mellitus underscores the urgency for effective management strategies,as diabetic foot complications are a leading cause of hospital admissions among diabetic patients,significantly impacting morbidity and mortality *** review explores the pathophysiological mechanisms underlying diabetic foot complications and further examines diabetic foot ulcers,infections,and skeletal pathologies such as Charcot arthropathy,emphasising the critical role of early diagnosis,comprehensive management strategies,and interdisciplinary care in mitigating adverse *** addressing surgical interventions,this review evaluates conservative surgeries,amputations,and reconstructive procedures,highlighting the importance of tailored approaches based on individual patient profiles and the specific characteristics of foot *** integration of advanced diagnostic tools,novel surgical techniques,and postoperative care,including offloading and infection control,are discussed in the context of optimising healing and preserving limb function.

关键词： Diabetes Diabetic foot Charcot Osteomyelitis Amputation Diabetic foot attack Conservative surgery

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英国全科医学的起伏

中国全科医学 2013年第7期16卷 715-716页

作者： richard roberts 李月威斯康辛大学医学和公共卫生学院家庭医学系美国威斯康辛州53715 中国全科医学杂志社

从1828年英国诞生第一家免费医疗诊所开始,到1948年二战结束后由英国政府支持的国民卫生服务体系(NHS)正式确立,直到今天,英国的免费国民医疗保健已经走过了一个半世纪的道路。NHS以提供"所有人都能享受的、以需要而非支付能力为基础的... 详细信息

从1828年英国诞生第一家免费医疗诊所开始,到1948年二战结束后由英国政府支持的国民卫生服务体系(NHS)正式确立,直到今天,英国的免费国民医疗保健已经走过了一个半世纪的道路。NHS以提供"所有人都能享受的、以需要而非支付能力为基础的免费全面服务"为准则,是全球最早、最廉价和最公平的国民医疗卫生保障体系。为了削减初级卫生保健信托机构(此类机构长期负责管理并给社区诊所拨付医疗经费)数量,英国政府对NHS实行改革,将国民保健服务预算的75%,即健康资金预算权都交给全科医生直接管理,并允许全科医生向私人医疗服务机构购买服务,新组成一个委员会负责监管全科医生。卫生政策专家警告新的改革幅度太大,且存在私人医疗机构通过贿赂全科医生引起资金外流等制度设计缺陷。NHS改革引起了专业人士和普通民众的关注。本文由Wonca主席richard roberts撰写,对英国全科医学及NHS的改革等问题进行了探讨,以期帮助读者更深入地了解NHS和英国全科医学的发展形势。

关键词：英国全科医学英国国民卫生服务体系改革

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整体大于部分之和

中国全科医学 2013年第16期16卷 1819-1820页

作者： richard roberts 邵钧 Wisconsin大学医学和公共卫生学院家庭医学系世界家庭医生组织中国全科医学杂志社

有些真理常常需要通过不同的表达方式来重复，直到我们更好地理解。最近的一次计划开展家庭医生共病工作坊的会议使我再次想到了这句话。会议由糖尿病和抑郁症小组（DDD）组织，规划会议在根特大学召开，由JandeMacseneer教授主持。DDD... 详细信息

有些真理常常需要通过不同的表达方式来重复，直到我们更好地理解。最近的一次计划开展家庭医生共病工作坊的会议使我再次想到了这句话。会议由糖尿病和抑郁症小组（DDD）组织，规划会议在根特大学召开，由JandeMacseneer教授主持。DDD是在2007年发起的一个多学科小组，旨在改善糖尿病和抑郁症共病患者的照顾和结局。世界家庭医生组织（WONCA）是DDD的创始成员之一。DDD计划为全世界的糖尿病医生、家庭医生、初级保健工作者、护士、精神卫生工作者提供一系列糖尿病和抑郁症共病工作坊。

关键词：家庭医学家庭医生家庭医生工作坊共病

前列腺癌筛查：调和初级保健和专科的视角矛盾

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中国全科医学 2013年第13期16卷 1451-1452页

作者： richard M.Hoffman Michael J.Barry richard G.roberts Harold C.Sox 邵钧(翻译) New Mexico大学医学院家庭医学和社区医学系美国新墨西哥州 Harvard医学院马萨诸塞州 Wisconsin大学医学和公共卫生学院家庭医学系威斯康辛州 Dartmouth医学院 Dartmouth研究所新罕布什尔州中国全科医学杂志社

当初级保健医生实施专科医生制定的筛查指南时,两者可能因视角不同而产生分歧。两则由专科机构最近发布的临床指南就足以说明这一问题。美国泌尿学会(AUA)指南小组和美国国家综合癌症网络(NCCN)建议,具有前列腺癌一般患病风险的男性在4... 详细信息

当初级保健医生实施专科医生制定的筛查指南时,两者可能因视角不同而产生分歧。两则由专科机构最近发布的临床指南就足以说明这一问题。美国泌尿学会(AUA)指南小组和美国国家综合癌症网络(NCCN)建议,具有前列腺癌一般患病风险的男性在40岁对前列腺特异性抗原筛查风险和好处进行咨询,而此前建议的年龄是50岁。不过,目前没有直接证据证明此建议对前列腺癌死亡率有具体影响。为了不妨碍初级保健医生为患者提供好处和价值已被证实的服务,专业机构在制定指南时应遵循适当的标准。初级保健协会和医疗系统也应该对现有证据进行评估,以判断临床建议实施的可行性和适用性。

关键词：前列腺特异性抗原癌症早期检测指南话题循证医学

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DNA序列分析与计算机的应用

中国生物工程杂志 1981年第3期 24-29页

作者： Thomas R.Gingcras richard J.roberts 阮可三中国科学院生物物理所二室

研究核酸结构和功能相互关系的各种规律,这是科学工作者的基本目标。对分子生物学家来说,这意味着去弄清核酸序列中所包含的信息。这就是说要去分析和介绍这些序列的真正含义。由于大部分DNA分子实在太长,长期以来严重地妨害了我们对DN... 详细信息

研究核酸结构和功能相互关系的各种规律,这是科学工作者的基本目标。对分子生物学家来说,这意味着去弄清核酸序列中所包含的信息。这就是说要去分析和介绍这些序列的真正含义。由于大部分DNA分子实在太长,长期以来严重地妨害了我们对DNA分子进一步研究的种种努力。幸而,人们发现了限制性内切酶,这种酶可以把DNA大分

关键词：序列分析领域全序列长序列序列数据计算机 DNA

The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges

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BioDesign Research 2020年第1期2020卷 1-8页

作者： Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly richard J.roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang Department of Biomedical Engineering and Program in Bioinformatics College of EngineeringBoston UniversityBoston MA 02215USA The NOVIM Group Kohn HallUC Santa BarbaraCA 93106USA Climate Institute WashingtonDCUSA Department of Energy WashingtonDCUSA Center for Health Law Ethics&Human Rights at the Boston University School of Public HealthSchool of MedicineBoston UniversityUSA Department of Bioengineering University of CaliforniaBerkeley CAUSA Department of Genetics Harvard Medical SchoolCambridge MAUSA School for the Future of Innovation in Society Arizona State UniversityBarrett&O’Connor Washington Center1800 I StreetNWWashingtonDC 20006USA Sloan School of Management MITCambridge MAUSA Department of Chemical Engineering University of WashingtonSeattle WashingtonUSA The Ecosystems Center of the Marine Biological Laboratory in Woods Hole MAUSA Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovotIsrael Department of Soil and Crop Sciences Colorado State UniversityFort Collins CO 80523USA MIT Joint Program on the Science and Policy of Global Change MITCambridge MAUSA New England Biolabs Beverly MAUSA Department of Biology and Program in Bioinformatics Boston UniversityBoston MA 02215USA Department of Earth Atmospheric and Planetary SciencesMITCambridge MAUSA Soil and Crop Sciences Section School of Integrated Plant SciencesCornell UniversityIthaca NYUSA Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA

The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory *** and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric *** participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,richard ***,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and *** include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed.

关键词： Synthetic roberts enable