检索结果-南通市图书馆

Cellular senescence in musculoskeletal homeostasis,diseases,and regeneration

Bone Research 2021年第4期9卷 444-455页

作者： Mei Wan Elise F.Gray-Gaillard Jennifer h.Elisseeff Department of Orthopaedic Surgery The Johns Hopkins University School of MedicineBaltimoreMDUSA Translational Tissue Engineering Center Wilmer Eye Institute and the Department of Biomedical EngineeringThe Johns Hopkins UniversityBaltimoreMDUSA

Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders,which represent the leading global cause of *** senescence was initially described by hayflick et *** 1961 as an irreversible nondividing state in in vitro cell culture *** now know that cellular senescence can occur in vivo in response to various stressors as a heterogeneous and tissue-specific cell state with a secretome phenotype acquired after the initial growth *** the past two decades,compelling evidence from preclinical models and human data show an accumulation of senescent cells in many components of the musculoskeletal *** senescence is therefore a defining feature of age-related musculoskeletal disorders,and targeted elimination of these cells has emerged recently as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration of the skeleton and skeletal *** this review,we summarize evidence of the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders,including osteoporosis,osteoarthritis,and *** highlight the diversity of the senescent cells in the microenvironment of bone,joint,and skeletal muscle tissue,as well as the mechanisms by which these senescent cells are involved in musculoskeletal *** addition,we discuss how identifying and targeting senescent cells might positively affect pathologic progression and musculoskeletal system regeneration.

关键词： skeletal homeostasis dividing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

美国儿童家庭寄养制度的变革与借鉴——基于自由主义与国家干预主义的福利辨析

引用

华东理工大学学报（社会科学版） 2015年第1期30卷 15-21页

作者：满小欧 richard P.Barth 东北大学文法学院辽宁沈阳110819 美国马里兰大学社会工作学院巴尔的摩21230

美国是世界上最早开展家庭寄养的国家之一,可以追溯到18世纪的殖民时代。在三个多世纪的发展历程中,美国儿童家庭寄养制度在"自由主义"与"国家干预主义"两种价值取向交织下不断向前发展,国家与社会的福利供给角色也不断发生改变。发展至... 详细信息

美国是世界上最早开展家庭寄养的国家之一,可以追溯到18世纪的殖民时代。在三个多世纪的发展历程中,美国儿童家庭寄养制度在"自由主义"与"国家干预主义"两种价值取向交织下不断向前发展,国家与社会的福利供给角色也不断发生改变。发展至今,形成了以永久家庭安置为核心的政府主导、社会强制报告、专业社工服务为一体的家庭寄养体系,在"自由"与"干预"之间实现了平衡,为我国在适度普惠儿童福利背景下,从政府主导、保护主体多元化、提供预防服务方面建设完善困境儿童救助与家庭支持福利制度给予了有益启示。

关键词：家庭寄养自由主义国家干预主义儿童福利

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The ecological scale mediates whether trees experience drought legacies in radial growth

引用

Forest Ecosystems 2023年第3期10卷 298-306页

作者： héctor hernández-Alonso Jaime Madrigal-González Fernando Silla Area of Ecology Faculty of BiologyUniversidad de SalamancaE-37007SalamancaSpain iuFOR-EiFAB Campus de SoriaUniversidad de ValladolidE-42004SoriaSpain

The impact of lag effects produced by disturbances on primary production has been a major concern among ecologists during the last *** and extreme climatic events are imposing drastic reductions in radial growth of trees as evidenced in tree-rings series Dendrochronological samples are obtained at tree level but analyzed at an aggregated scale(i.e.,mean chronologies),although aggregating tree-ring chronology on a regional scale may reduce the possibility of studying the variability of individual tree response to drought,by amplifying the average population ***,we conducted experimental research in which 370 trees of 5 species were analyzed to assess the potential statistical and scaling issues that may occur when using regressionbased methods to analyze ecosystem responses to *** legacy effects were quantified using individual and aggregated ***,lag effects were validated using confidence and prediction intervals to identify values falling outside the certainty of the climate-growth model Individual scale legacy effects contrasted with confidence intervals were commonly distributed across species but were scarce when compared with prediction *** analysis of aggregated scale legacies detected significant growth reductions when validated using prediction intervals;however,individual scale legacy lag effects were not *** finding directly contrasts the results obtained when using an aggregated *** results provide empirical evidence on how aggregating ecological data to infer processes that emerge from an individual scale can lead to distorted *** therefore encourage the use of individual based statistical and ecological procedures to analyze tree rings as a means of further understanding the ecosystem responses to disturbances.

关键词： Legacy effects Drought disturbances Tree growth Tree-ring width Dendrochronology Individual scale Mountainous forests

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-scale defects in powder-based additively manufactured metals and alloys

引用

Journal of Materials Science & Technology 2022年第27期122卷 165-199页

作者： J.Fu h.Li X.Song M.W.Fu Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Mechanical and Automation Engineering Chinese University of Hong KongShatinHong KongChina

Defect formation is a critical challenge for powder-based metal additive manufacturing(AM).Current understanding on the three important issues including formation mechanism,influence and control method of metal AM defects should be *** this review paper,multi-scale defects in AMed metals and alloys are identified and for the first time classified into three categories,including geometry related,surface integrity related and microstructural *** particular,the microstructural defects are further divided into internal cracks and pores,textured columnar grains,compositional defects and dislocation *** root causes of the multi-scale defects are *** key factors that affect the defect formation are identified and *** detection methods and modeling of the multi-scale defects are briefly *** effects of the multi-scale defects on the mechanical properties especially for tensile properties and fatigue performance of AMed metallic components are *** control and mitigation methods for the corresponding defects,include process parameter control,post processing,alloy design and hybrid AM techniques,are summarized and *** research aspect,current research gaps and future prospects from three important aspects of the multi-scale AM defects are identified and delineated.

关键词： Metal additive manufacturing Multi-scale defects Detection and modeling Mechanical properties Defect control and mitigation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection of Nh_(2) Radical in Ammonia Radio-Frequency Plasmas by Laser-Induced Resonance Fluorescence

引用

Chinese Physics Letters 2001年第7期18卷 939-941页

作者： GONG Xue-Yu X.R.Duan h.Lange A.A.Meyer-Plath Department of Technological Physics Nanhua UniversityHengyang 421001 Institute of Low Temperature Plasma Physics Greifswald17489 Germany

By means of one photon absorption laser-induced resonance fluorescence at 599.5 nm the relative concentrations of amidogen(Nh_(2))radical in the ammonia(Nh_(3))radio-frequency(rf)plasma source were measured under different discharge pressures and rf *** time dependence of the fluorescence which comes from the radiation 101-211 of the P-branches of the Σ vibronic sub-bands can be described by a single-exponential *** decay time of Nh_(2)(A2A1)Σ(0,9,0)rovibronic state was *** spatial dependence of the Nh_(2) density in discharge tube was measured.

关键词： decay Ammonia Fluorescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Land Quality Assessment and Monitoring:The Next Challenge for Soil Science

引用

Pedosphere 2003年第1期13卷 1-10页

作者： h.ESWARAN J.KIMBLE U.S.DepartmentofAgriculture NaturalResourcesConservationServicePOBox2890WashingtonDC20013（USA） U.S.DepartmentofAgriculture NaturalResourcesConservationServicePOBox2890Washington

Sustainable land management (SLM) is the key to harmonizing environmental and ecological concernsof society with the economic realities of producing adequate food and fiber of high quality and ensuring abasic minimal quality of life. The aim of SLM is to maintain the integrity of the biophysical land resourcebase, but it can only be realized if land users understand the impacts of land management options on theirlands but also on other off-site areas and can optimize the socioeconomic and environmental benefits of theirchoice. To facilitate this, the contribution of soil survey organizations would be through the assessment andmonitoring of land quality. Land quality is a measure of the ability of land to perform specific functions and isderived by an integration of soil survey information with other environmental, and if necessary, socioeconomicinformation. The desired reliability influences the operational scale of the assessment. Such an assessmentwould assist in: 1) locating homologous areas for research sites or for transferring technologies; 2) providingthe geographic basis for systems analysis (e.g. by modeling); 3) serving as a basis for local, national andglobal resource assessment and monitoring; 4) providing an ecosystem context for land use, assessments oftemporal and spatial variability, and impact of human interventions; 5) serving as a framework for moredetailed assessment for all levels of interest; and 6) evaluating global issues such as food security, impacts ofclimate change, biodiversity monitoring, and addressing *** on an evaluation of the progress made in soil resource inventories and considering the demandsof the environment focused world, the paper considers the need for countries to mount such a program. Theauthors believe that this is the next demand of soil science and that we can fulfill our social contract byperiodically providing such information on the state of a nation's land resource.

关键词： degradation land quality monitoring of soils sustainable landmanagement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Does deep sedation impact the results of 48 hours catheterless ph testing?

引用

World Journal of Gastroenterology 2011年第10期17卷 1304-1307页

作者： Vineet Korrapati Jay P Babich Anil Balani James h Grendell, Kavita R Kongara Anil Balani James h Grendell Kavita R Kongara Department of Gastroenterology and hepatology Win-throp University Hospital Mineola NY 11501 United States Department of Gastroenterology and hepatology UMDNJ-RWJ Medical School New Brunswick NJ 08901United States

AIM： To study a cohort of patients undergoing 48 h Bravo ph testing receiving deep sedation with propofol. METhODS： We retrospectively reviewed the charts of 197 patients （81 male, 116 female） who underwent Bravo esophageal ph monitoring from July 2003 to January 2008. All patients underwent Bravo ph probe placement via esophagogastroduodenoscopy （EGD） and received propofol for sedation. Patients on a proton pump inhibitor （89 patients） were excluded. Acid reflux variables measured included the total, upright, and supine fractions of time at ph 〈 4 and DeMeester score, and were compared between day I and day 2. RESULTS： Of the 108 patients that were included in the study, the most common indication for Bravo ph monitoring was heartburn, with chest pain being the second most common. A signed rank test revealed no statistically significant difference between day I and day 2 reflux episodes. CONCLUSION： Patients who received propofol for sedation for EGD with Bravo ph capsule placement did not experience any significant difference in reflux episodes from day 1 to day 2.

关键词： Esophagus Bravo study Propofol ph cap-sule Gastroesophageal reflux disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

EFFECT OF VACUUM hEAT TREATMENT ON OXIDATION BEhAVIOR OF SPUTTERED NiCrAlY COATING

引用

Acta Metallurgica Sinica(English Letters) 2002年第1期15卷 61-66页

作者： M.h. Li X.F. Sun Z.Y. Zhang h.R. Guan W.Y. hu Z.Q Institute of Metal Research The Chinese Academy of Sciences Shenyang 110016 China

A bond coat for thermal barrier coating (TBC), NiCrAlY coating, is subjected to vac-uum heat treatment in order to remove internal stress before ceramic top coat is de-posited. The effect of vacuum heat treatment on the oxidation behavior of the sputtered NiCrAlY coating has been investigated. The as-sputtered NiCrAlY coating consists of γ-Ni and b-NiAl phases. After vacuum heat treatment, the sputtered NiCrAlY coating mainly consists of γ'-Ni3Al, β-NiAl, γ-Ni, and trace of α-Al2O3 phases. The isothermal oxidation of sputtered NiCrAlY coating with and without vacuum heat treatment has been performed at 1000℃. It is shown that a-Al2O3 formed during vacuum heat treatment acts as nuclei for the formation of a-Al2O3, and the protective a-Al2O3 scale is formed more rapidly on the vacuum heat treated NiCrAlY coating than that formed on the untreated coating. Also the a-Al2O3 scale has a better adherence to the vacuum heat treated NiCrAlY coating. Therefore the vacuum heat treatment improves the oxidation resistance of sputtered NiCrAlY coating.

关键词： vacuum heat treatment oxidation sputtered NiCrAlY coating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Performance Description of Brushless Doubly-Fed Induction Machine in Its Asynchronous and Variable Speed Synchronous Modes

引用

Journal of Electromagnetic Analysis and Applications 2011年第12期3卷 490-511页

作者： hamed Gorginpour hashem Oraee richard A. McMahon 不详

Brushless Doubly-Fed Machine has attracted considerable attention in recent years due to its advantages. It has the robustness of the squirrel cage induction machine, and the speed and power factor controllability of the synchronous machine as well as the absence of brushes and slip rings, and using a fractionally rated frequency converter. hence, there are considerable benefits over the conventional machines, when the machine is applied to applications such as a wind turbine generator or high power adjustable speed drive. however, these benefits are obtained in slightly more complex structure, higher cost and larger dimensions in comparison to the conventional induction machine. This paper presents fundamental aspects of the three modes of operation of brushless doubly fed machine, i.e. simple induction mode, cascade induction mode, and synchronous mode. The investigation is performed by analyzing the spatial harmonic contents of the rotor magnetic flux density. The direct cross couplings between stator and rotor fields as well as, indirect cross coupling between stator fields by the special rotor of this machine is described. Furthermore, loss analysis of the machine in various modes is presented and the torque-speed curves for asynchronous modes are obtained. A 2-D magnetodynamic finite element model based on the D-180 4/8 pole prototype machine is extracted and simulated to verify the results.

关键词： Brushless Doubly Fed Machine (BDFM) Cascade Induction Mode Direct and Indirect Cross Coupling Nested Loop Rotor Simple Induction Mode Spatial harmonic Synchronous Mode

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar

引用

Journal of Pharmaceutical Analysis 2016年第4期6卷 268-275页

作者： Emilia Sawicki Michel J.hillebrand hilde Rosing Jan h.M.Schellens Bastiaan Nuijen Jos h.Beijnen Department of Pharmacy & Pharmacology The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital Division of Clinical Pharmacology Department of Medical OncologyThe Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital Division of Pharmacoepidemiology & Clinical Pharmacology.Department of Pharmaceutical Sciences Faculty of Science.Utrecht University

Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as P-glycoprotein and Breast Cancer Resistance *** is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of many anticancer ***,a clinical formulation of elacridar is unavailable and therefore the pharmaceutical development of a drug product is highly *** also necessitates the availability of an analytical method for its quality control.A reverse-phase high-performance liquid chromatographic method with ultraviolet detection was developed for the pharmaceutical quality control of products containing elacridar as the active pharmaceutical *** analytical method was validated for linearity,accuracy,precision,selectivity,carry-over,stability of stock and reference solutions,stability of the final extract,stability-indicating capability and impurity *** found that elacridar is unstable in aqueous solutions that are exposed to light because a hydroxylation product of elacridar is ***,sample solutions with elacridar must be protected from light.

关键词： GF120918 Solid dispersion Dissolution hydroxylation hPLC-UV

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：