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The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs-disulfiram and ritonavir

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Chinese Journal of Cancer 2015年第4期34卷 161-165页

作者： richard e Kast International Initiative for Accelerated Improvement of Glioblastoma Care Study Center

Based on reporting in the last several years,an impressive but dismal list of cytotoxic chemotherapies that fail to prolong the median overall survival of patients with glioblastoma has prompted the development of treatment protocols designed to interfere with growth-facilitating signaling systems by using non-cytotoxic,non-oncology *** recognition of the pro-mobility stimulus,interleukin-18,as a driver of centrifugal glioblastoma cell migration allows potential treatment adjuncts with disulfiram and *** and ritonavir are well-tolerated,non-cytotoxic,non-oncology chemotherapeutic drugs that are marketed for the treatment of alcoholism and human immunodeficiency virus(HIV) infection,*** drugs exhibit an interleukin-18—inhibiting *** the favorable tolerability profile of disulfiram and ritonavir,the unlikely drug-drug interaction with temozolomide,and the poor prognosis of glioblastoma,trials of addition of disulfiram and ritonavir to current standard initial treatment of glioblastoma would be warranted.

关键词：白细胞介素-18 胶质细胞治疗方案人类免疫缺陷病毒硫病理细胞毒性治疗药物

established and experimental techniques to improve phalloplasty outcomes/optimization of a hypercomplex surgery

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Plastic and Aesthetic Research 2020年第6期7卷 50-64页

作者： erin e.Carter Curtis N.Crane richard A.Santucci Department of Urology Boston University School of MedicineBostonMA 02119USA The Crane Center for Transgender Surgery AustinTX 78746USA

An increasing number of transgender and gender non-conforming patients are seeking genital gender affirming surgeries in order to better align their physical characteristics with their innate gender identity and treat gender *** is the most complex of these surgeries,and this complexity creates a wide range of potential *** of the most common complications and therefore,targets for improvement in outcomes,concern neourethral fistula/stricture,efficacy of reinnervation of the phalloplasty flap,postoperative flap monitoring,and donor site *** the setting of no established"gold standard",this review seeks to describe the components and staging of phalloplasty,with an emphasis on established and experimental solutions to the most common and vexing problems.

关键词： Phalloplasty transgender female to male transmasculine surgical complications radial forearm flap anterolateral thigh flap genital gender confirmation

A framework for quantifying properties of 3-dimensional movement-based signals

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Current Zoology 2010年第3期56卷 327-336页

作者： Shaun TD NeW richard A PeTeRS ARC Centre of excellence in Vision Science Division of EvolutionEcology & GeneticsResearch School of BiologyThe Australian National University

Understanding how signal properties are optimized for the reliable transmission of information requires accurate de- scription of the signal in time and space. For movement-based signals where movement is restricted to a single plane, measure- ments from a single viewpoint can be used to consider a range of viewing positions based on simple geometric calculations. However, considerations of signal properties from a range of viewing positions for movements extending into three-dimensions （3D） are more problematic. We present here a new framework that overcomes this limitation, and enables us to quantify the extent to which movement-based signals are view-specific. To illustrate its application, a Jacky lizard tail flick signal was filmed with synchronized cameras and the position of the tail tip digitized for both recordings. Camera aligmnent enabled tl^e construction of a 3D display action pattern profile. We analyzed the profile directly and used it to create a detailed 3D animation. In the virtual environment, we were able to film the same signal from multiple viewing positions and using a computational motion analysis algorithm （gradient detector model） to measure local image velocity in order to predict view dependent differences in signal properties. This approach will enable consideration of a range of questions concerning movement-based signal design and evolu- tion that were previously out of reach [Current Zoology 56 （3）： 327-336, 2010].

关键词： Signal evolution Sensory ecology Movement-based signal 3D Display Action Pattern

Drosophila seizure disorders： genetic suppression of seizure susceptibility

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Frontiers in Biology 2016年第2期11卷 96-108页

作者： Arunesh Saras Laura e. Simon Harlan J. Brawer richard e. Price Mark A. Tanouye Division of Organismal Biology Department of Environmental Science Policy and Management University of California Berkeley CA 94720 USA Department of Molecular and Cell Biology University of California Berkeley CA 94720 USA Helen Wills Neuroscience Institute University of California Berkeley CA 94720 USA

Various Drosophila models of human disease have recently received increased interest. The main goal is to uncover the fundamental biological basis for human pathology taking advantage of the power of Drosophila genetics. This review examines a set of Drosophila seizure-sensitive mutations that model human seizure disorders, especially epilepsy. Also described is a novel set of mutations that act as seizure-suppressors that ameliorate epilepsy phenotypes in double mutant combinations.

关键词： Drosophila epilepsy seizure disorders sodium channel seizttre-suppressor genes

Optical read-out and modulation of peripheral nerve activity

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Neural Regeneration Research 2018年第1期13卷 58-61页

作者： Arjun K.Fontaine Hans e.Anderson John H.Caldwell richard F.Weir Department of Bioengineering University of Colorado – Anschutz Medical Campus Department of Cell and Developmental Biology University of Colorado – Anschutz Medical Campus

Numerous clinical and research applications necessitate the ability to interface with peripheral nerve fibers to read and control relevant neural pathways. Visceral organ modulation and rehabilitative prosthesis are two areas which could benefit greatly from improved neural interfacing approaches. Therapeutic neural interfacing, or ‘bioelectronic medicine’, has potential to affect a broad range of disorders given that all the major organs of the viscera are neurally innervated. However, a better understanding of the neural pathways that underlie function and a means to precisely interface with these fibers are required. existing peripheral nerve interfaces, consisting primarily of electrode-based designs, are unsuited for highly specific （individual axon） communication and/or are invasive to the tissue. Our laboratory has explored an optogenetic approach by which optically sensitive reporters and actuators are targeted to specific cell （axon） types. The nature of such an approach is laid out in this short perspective, along with associated technologies and challenges.

关键词： peripheral nerve interface optogenetics bioelectronic medicine prosthesis control adeno-associated virus GCaMP

Fluid mechanics 5th ed.

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B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

丛书名： McGraw-Hill series in mechanical engineering

2003年

作者： Frank M white

来源：畅想之星图书光盘版（南... 评论

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Cellular & Molecular Immunology 2021年第6期18卷 1503-1511页

作者： Sadiye Amcaoglu Rieder Jingya Wang Natalie white Ariful Qadri Catherine Menard Geoffrey Stephens Jodi LKarnell Christopher eRudd Roland Kolbeck Present address:Viela Bio GaithersburgMDUSA Universite de Montreal MontrealQCCanada MedImmune/AstraZeneca GaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA View author publications

Modulation of T-cell responses has played a key role in treating cancers and autoimmune ***,understanding how different receptors on T cells impact functional outcomes is *** influence of B7-H7(HHLA2)and CD28H(TMIGD2)on T-cell activation remains *** we examined global transcriptomic changes in human T cells induced by *** through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 *** transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine ***,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 *** inhibitory activity was comparable to that observed with ***,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break *** work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.

关键词： T cell inhibition Checkpoint pathway T cell transcriptomics

The essay and the essayist

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英语自学 2000年第5期 7-8页

作者： e.B.white 李勤

The essayist is a self-liberated man,sus-tained by the childish belief that everything hethinks about,everything that happens to him,is of general *** is a fellow who thor-oughly enjoys his work,just as people whotake... 详细信息

关键词：英语自学 The essay and the essayist 评论家约翰逊

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