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Individua. consistency a.d sex differences in migra.ion stra.egies of Scopoli＇s shea.wa.ers Ca.onectris diomedea.despite yea. differences

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Current Zoology 2014年第5期60卷 631-641页

作者： Ma.tina.S. MULLER Bruno Ma.Sa.richard a. phillips Gia.omo DELL Gra.ua.e School of Environmenta. Studies Nagoya University Japan University of Pa.ermo Department of Agriculture and Forest Sciences Italy British a.ta.ctic Survey Natural Environment Research Council Cambridge CB3 0ET UK Ornis ita.ica Rome Italy

Recently-developed ca.a.ilities for tra.king the movements of individua. birds over the course of a.yea. or longer ha. provided increa.ing evidence for consistent individua. differences in migra.ion schedules a.d destina.ions. This ra.ses questions a.out the rela.ive importa.ce of individua. consistency versus flexibility in the evolution of migra.ion stra.egies, a.d ha. implica.ions for the a.ility of popula.ions to respond to clima.ic cha.ge. Using geoloca.ors, we tra.ked the migra.ions of Scopoli＇s shea.wa.ers Ca.onectris diomedea.breeding in Linosa.（Ita.y） a.ross three yea.s, a.d a.a.ysed timing a.d spa.ia. a.pects of their movements. Birds showed rema.ka.le va.ia.ion in their ma.n wintering destina.ion a.ong the western coa.t of a.rica. We found significa.t individua. consistency in the tota. dista.ce tra.eled, time spent in tra.sit, a.d time tha. individua.s spent in the win- tering a.ea.. We found extensive sex differences in scheduling, dura.ion, dista.ces a.d destina.ions of migra.ory journeys. We a.so found sex differences in the degree of individua. consistency in a.pects of migra.ion beha.iour. Despite strong evidence for individua. consistency, which indica.es tha. migra.ion journeys from the sa.e bird tended to be more simila. tha. those of dif- ferent birds, there rema.ned substa.tia. intra.individua. va.ia.ion between yea.s. Indeed, we a.so found clea. a.nua. differences in depa.ture da.es, return da.es, wintering period, the tota. dista.ce tra.eled a.d re^rn routes from wintering grounds ba.k to the colony. These findings show tha. this popula.ion flexibly shifts migra.ion schedules a. well a. routes between yea.s in response to direct or indirect effects of heterogeneity in the environment, while ma.nta.ning consistent individua. migra.ion stra.egies [Current Zoology 60 （5）： 631-641, 2014].

关键词： a.ia. migra.ion GLS loggers Repea.a.ility Individua. stra.egies

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Thermodyna.ics Properties of Mesoscopic Qua.tum Na.owire Devices

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Chinese Physics Letters 2007年第5期24卷 1339-1341页

作者： a.tia.a. a.a.a.la.a.el H. phillips Depa.tment of Physics Faculty of Science Beni-Suef University Beni-Suef Egypt Depa.tment of Physics a.d Depa.tment of Ma.hema.ics Faculty of Engineering Ain Shams University Egypt

We investiga.e the thermodyna.ics properties of mesoscopic qua.tum na.owire devices, such a. the effect of electron-phonon rela.a.ion time, Peltier coefficient, ca.rier concentra.ion, frequency of this field, a.d cha.nel width. The influence of time-va.ying fields on the tra.sport through such device ha. been ta.en into considera.ion. This device is modelled a. na.owires connecting to two reservoirs. The two-dimensiona. electron ga. in a.Ga.s- a.Ga.s heterojunction ha. a.Fermi wa.e length which is a.hundred times la.ger tha. tha. in a.meta.. The results show the oscilla.ory beha.iour of dependence of the thermo power on frequency of the induced field. These results a.ree with the existing experiments a.d ma. be importa.t for electronic na.odevices.

关键词： THERMOPOWER TRa.SPORT

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Therma. 9hot Noise through Bounda.y Roughness of Ca.bon Na.otube Qua.tum Dots

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Chinese Physics Letters 2011年第1期28卷 186-189页

作者： a.tia.a. a.a.a.la.a.el H. phillips Depa.tment of Physics Faculty of Science Beni-Suef University Beni-Suef Egypt Depa.tment of Engineering Physics a.d Ma.hema.ics Faculty of Engineering Ain Shams University Cairo Egypt

Therma. shot noise, therma. volta.e a.d thermo power a.e studied through a.ca.bon na.otube qua.tum dot coupled to two lea.s with ra.dom roughness of a.plitude on ea.h of the two bounda.ies, under the effect of microwa.e field, a.d ma.netic field. The expressions for the therma. shot noise a.d therma. energy a.e deduced when the ba.rier strength a.d conta.t a.ea.a.e ta.en into considera.ion. a.model for such mesoscopic devices is proposed a. a.ca.bon na.otube qua.tum dot coupled to two lea.s with ra.dom roughness of a.plitude on ea.h of the two bounda.ies. The results show oscilla.ory beha.iors of the dependence of the therma. shot noise on the studied pa.a.eters. The thermopower oscilla.es with the va.ia.ion of the conta.t a.ea. a.d the pea. heights decrea.e linea.ly with the conta.t a.ea.a.d increa.es with tempera.ure. This trend of beha.ior is due to the interpla. of the induced microwa.e photons a.d the tunneling ra.e through the side ba.ds. This resea.ch is importa.t for using a.model a. a.high-frequency shot noise detector a.d the thermopower is sensitive to the energy dependence of the conducta.ce.

关键词： Noise Energy Ca.bon Lea. Ca.bona.es Ca.bona.ion Models Bounda.ies Fields

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a.erra.t cytokine milieu a.d signa.ing a.fect immune cell phenotypes a.d functions in tuberculosis pa.hology:Wha. ca. we lea.n from this phenomenon for a.plica.ion to infla.ma.ory syndromes?

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Cellula. & Molecula. Immunology 2021年第8期18卷 2062-2064页

作者： Ernest a.a.kwa. Julia.Seyfa.th richard phillips Ma.c Ja.obsen Depa.tment of Genera. Pedia.rics Medical FacultyUniversity Hospital DüsseldorfHeinrich-Heine-UniversityDüsseldorfGermany Depa.tment of Medica. Dia.nostics College of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Depa.tment of Medicine School of Medicine and DentistryCollege of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Kuma.i Centre for Colla.ora.ive Resea.ch in Tropica. Medicine(KCCR) KumasiGhana

Our previous study published in Cellula.&Molecula. Immunology(Ha.ling et a..1)described a.erra.t immunologica. fea.ures in the pa.hogenesis of ***,we provided evidence supporting a. impa.t cha.n rega.ding a.erra.t high interleukin(IL)-6 a.d IL-10 cytokine expression a.d respective receptor signa.ing a.fecting T-cell functions in a.ute *** STa.3 phosphoryla.ion,high expression of its key regula.or suppressor of cytokine signa.ing(SOCS)3 a.d sponta.eous IL-6/IL-10 secretion cha.a.terized CD4^(+)T cells from tuberculosis pa.ients.

关键词： tuberculosis cytokine STa.3

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应用CRISP清单,提升我国全科医学和基本医疗研究报告的质量

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中国全科医学 2025年第4期28卷 393-401页

作者：杨辉汪洋陈庆奇刘晨曦顾杰赵洋秦江梅曹新阳 Eliza.eth Sturgiss Willia. R.phillips 许岩丽 Mona.h大学公共卫生与预防医学学院澳大利亚墨尔本市VIC 3168 上海市全科医学与社区卫生发展研究中心 200090 同济大学附属杨浦医院全科医学科上海市200090 香港大学家庭医学及基层医疗学系中国香港特别行政区999077 华中科技大学同济医学院医药卫生管理学院湖北省武汉市430000 复旦大学附属中山医院全科医学科上海市200032 复旦大学附属中山医院国际医疗部上海市200032 新南威尔士大学乔治全球健康研究院澳大利亚悉尼2050 墨尔本大学人口与全球健康学院澳大利亚墨尔本3010 国家卫生健康委卫生发展研究中心北京市100044 《中国全科医学》杂志社有限公司北京市100053 School of Prima.y a.d a.lied Hea.th Ca.e Monash UniversityMelbourneVictoriaAustraliaVIC 3168 University of Wa.hington SeattleWashington98195

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全... 详细信息

基本医疗(初级保健)研究报告内容的条目共识(CRISP)工作组于2023年提出了CRISP清单,以支持改善上述领域研究报告的质量、实用性和传播性。《中国全科医学》英文版的学术编辑团队对CRISP清单进行了中文翻译,并通过这篇述评,在回顾我国全科医学和基本医疗研究的内涵和发展现状的基础上,归纳了该领域的科研报告中目前存在的主要问题,如“以作者为中心”“过度重视塑造权威性”“盲目生搬国际经验”“缺乏对方法学的透明报告”“在论文中压入大量冗繁信息”以及“遮蔽关键信息”等。最后,编辑团队推荐和鼓励中国的全科医学和基本医疗服务研究的作者、编辑和学术评议专家尝试使用CRISP清单,在改善中国全科医学和基本医疗研究报告质量的同时,进一步完善该工具在学科发展研究、临床研究、卫生服务研究、卫生政策研究、教育和培训研究以及社区流行病学研究等亚领域中的应用。

关键词：全科医学基本医疗研究报告内容共识

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a.cura.y of ultra.ound to identify chronic liver disea.e

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World Journa. of Ga.troenterology 2010年第28期16卷 3510-3520页

作者： richard a.la. Kerry Thoirs Ma.reen phillips Division of Medica. Ima.ing Flinders Medical CentreFlinders DriveBedford Pk5042South Australia Australia School of Hea.th Sciences University of South AustraliaCity East CampusNorth TerraceAdelaide5000South AustraliaAustralia Interna.iona. Centre of a.lied Hea.th Evidence University of South AustraliaCity East CampusNorth TerraceAdelaide5000South AustraliaAustralia

a.M:To identify a.d a.sess studies reporting the dia.nostic performa.ce of ultra.ound ima.ing for identifying chronic liver disea.e(CLD)in a.high risk popula.ion. METHODS:a.sea.ch wa. performed to identify studies investiga.ing the dia.nostic a.cura.y of ultra.ound ima.ing for *** a.thors independently used the qua.ity a.sessment of dia.nostic a.cura.y studies(QUa.a.)checklist to a.sess the methodologica. qua.ity of the selected ***-observer relia.ility of the QUa.a. tool wa. a.sessed by mea.uring the degree of a.reement(percent a.reement,κsta.istic)between the reviewers for ea.h a.sessment prior to a.*** cha.a.teristics of ea.h study popula.ion, sensitivity a.d specificity results for the index tests, a.d results of a.y testing for observer a.reement were extra.ted from the *** Opera.or Cha.a.teristic plots were genera.ed using Microsoft Excel 2003 softwa.e a.d used to gra.hica.ly displa. the dia.nostic performa.ce da.a.a.d to explore the rela.ionships between the reported ultra.ound techniques a.d study cha.a.teristics,a.d methodology qua.ity. RESULTS:Twenty-one studies published between 1991 a.d 2009 were reta.ned for da.a.extra.tion,a.a.ysis a.d a.sessment for methodologica. *** of methodology qua.ity wa. performed on the 21 selected studies by two independent reviewers(Ra.KT) using the QUa.a. a.sessment *** a.l studies the mea. number of responses within the QUa.a. a.sessment tool wa. 10(ra.ge 7-13)for"Yes",1(ra.ge 0-3)for"No"a.d 3(ra.ge 0-6)for"unclea.".Interra.er a.reement for a.sessment of methodology qua.ity wa. significa.tly grea.er tha. cha.ce when a.sessing for representa.ive spectrum,clea. selection criteria. a.propria.e dela. between reference a.d index tests, a.equa.e descriptions of the index a.d reference tests, reference a.d index test blinding,a.d if releva.t clinica. informa.ion wa. *** studies reported modera.e to high observer a.reement for ultra.ound ***

关键词： Chronic liver disea.e Liver surfa.e Systema.ic review Ultra.onogra.hy

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Tra.sport Cha.a.teristics of Mesoscopic Ra.io-Frequency Single Electron Tra.sistor

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Chinese Physics Letters 2008年第1期25卷 250-253页

作者： a. H. phillips N. a. I. a.y K. Kira. H. E. El-Sa.es Fa.ulty of Engineering Ain-Shams University Cairo Egypt Higher Technologica. Institute Ramadan Tenth City Egypt

The tra.sport property of a.qua.tum dot under the influence of externa. time-dependent field is investiga.ed. The mesoscopic device is modelled a. semiconductor qua.tum dot coupled wea.ly to superconducting lea.s via.a.ymmetric double tunnel ba.riers of different heights. a. expression for the current is deduced by using the La.da.er-Buttiker formula. ta.ing into considera.ion of both the Coulomb blocka.e effect a.d the ma.netic field. It is found tha. the periodic oscilla.ion of the current with the ma.netic field is controlled by the ra.io of the frequency of the a.plied a.-field to the electron cyclotron frequency. Our results show tha. the present device opera.es a. a.ra.io-frequency single electron tra.sistor.

关键词： pulsa.s x-ra. spectra rela.ivity a.d gra.ita.ion redshift

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a.huma.ized mouse model to study huma. immune response in xenotra.spla.ta.ion

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2012年第5期11卷 494-498页

作者： Peta.phillips Center for Tra.spla.t a.d Rena. Resea.ch Westmead Millennium InstituteWestmead HospitalWestmeadNSW Sydney 2145Australia

Ba.KGROUND: a.ma.or ba.rier to the clinica. a.plica.ion of xenotra.spla.ta.ion a. a.trea.ment option for pa.ients is T cell-media.ed rejection. Studies ba.ed on experimenta. rodent models of xenogra.t tolera.ce or rejection in vivo ha.e provided useful informa.ion a.out the role of T cell immune response in xenotra.spla.ta.ion. However not a.l observa.ions seen in rodents fa.thfully reca.itula.e the huma. situa.ion This study a.med to esta.lish a.huma.ized mouse model of xenotra.spla.ta.ion, which mimics xenogra.t rejection in the context of the huma. immune system. METHODS: NOD-SCID IL2rγ -/- mice were tra.spla.ted with neona.a. porcine islet cell clusters (NICC) followed by reconstitution of huma. periphera. blood mononuclea. cells (PBMC). Huma. leukocyte engra.tment a.d islet xenogra.t rejection were confirmed by flow cytometric a.d histologica. a.a.yses. RESULTS: In the a.sence of huma. PBMC, porcine NICC tra.spla.ted into NOD-SCID IL2rγ -/- mice revea.ed excellent gra.t integrity a.d endocrine function. Huma. PBMC demonstra.ed a.high level of engra.tment in NOD-SCID IL2rγ -/- mice. Reconstitution of NICC recipient NOD-SCID IL2rγ -/- mice with huma. PBMC led to the ra.id destruction of NICC xenogra.ts in a.PBMC number-dependent ma.ner. CONCLUSIONS: Huma. PBMC-reconstituted NOD-SCID IL2rγ -/- mice provide a. idea. model to study huma. immune responses in xenotra.spla.ta.ion. Studies ba.ed on this huma.ized mouse model will provide insight for improving the outcomes of clinica. xenotra.spla.ta.ion.

关键词： huma.ized mice xenotra.spla.ta.ion neona.a. porcine islet cell cluster xenorejection tolera.ce

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Fluorescence lifetime ima.ing of molecula. rotors to ma. microviscosity in cells

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Chinese Optics Letters 2010年第10期8卷 926-930页

作者： Ja.es a. Levitt Ma.ina.K. Kuimova.Gokha. Ya.ioglu Pei-Hua.Chung Kla.s Suhling Da.id phillips Depa.tment of Physics King's College London Depa.tment of Chemistry Imperial College London PhotoBiotics Ltd.

Fluorescence liftime ima.ing （FLIM） of modified hydrophobic bodipy dyes tha. a.t a. fluorescent molecula. rotors shows tha. the fluorescence lifetime of these probes is a.function of the microviscosity of their environment. Incuba.ing cells with these dyes, we find a.puncta.e a.d continuous distribution of the dye in cells. The viscosity va.ue obta.ned in wha. a.pea.s to be endocytotic vesicles in living cells is a.ound 100 times higher tha. tha. of wa.er a.d of cellula. ***-resolved fluorescence a.isotropy mea.urements a.so yield rota.iona. correla.ion times consistent with la.ge microviscosity va.ues. In this wa., we successfully develop a.pra.tica. a.d versa.ile a.proa.h to ma. the microviscosity in cells ba.ed on ima.ing fluorescent molecula. rotors.

关键词： Fluorescence lifetime ima.ing of molecula. rotors to ma. microviscosity in cells

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Progress in TILLING a. a.tool for functiona. genomics a.d improvement of crops

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Journa. of Integra.ive Pla.t Biology 2014年第5期56卷 425-443页

作者： Lia.g Chen Liugen Ha. Ma.tin a. J. Pa.ry a.drew L. phillips Yin-Ga.g Hu Sta.e Key La.ora.ory of Crop Stress Biology in a.id a.ea. a.d College of a.ronomy Northwest A&F University Depa.tment of Pla.t Biology a.d Crop Science Rothamsted Research Institute of Wa.er Sa.ing a.riculture in a.id Regions of China Northwest A&F University

Food security is a.globa. concern a.d substa.tia. yield increa.es in crops a.e required to feed the growing world popula.ion. Muta.enesis is a. importa.t tool in crop improvement a.d is free of the regula.ory restrictions imposed on genetica.ly modified orga.isms. Ta.geting Induced Loca. Lesions in Genomes（TILLING）, which combines tra.itiona. chemica. muta.enesis with high‐throughput genome‐wide screening for point muta.ions in desired genes, offers a.powerful wa. to crea.e novel muta.t a.leles for both functiona. genomics a.d improvement of crops. TILLING is genera.ly a.plica.le to genomes whether sma.l or la.ge, diploid or evena.lohexa.loid, a.d shows grea. potentia. to a.dress the ma.or cha.lenge of linking sequence informa.ion to the function of genes a.d to modula.e key tra.ts for pla.t breeding. TILLING ha. been successfully a.plied in ma.y crop species a.d recent progress in TILLING is summa.ized below, especia.ly on the developments in muta.ion detection technology, a.plica.ion of TILLING in gene functiona. studies a.d crop breeding. The potentia. of TILLING/EcoTILLING for functiona. genetics a.d crop improvement is a.so discussed. Furthermore, a.sma.l‐sca.e forwa.d stra.egy including ba.kcross a.d selfing wa. conducted to relea.e the potentia. muta.t phenotypes ma.ked in M2（or M3） pla.ts.

关键词： Crop breeding functiona. genomics muta.ion detection TILLING

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