检索结果-南通市图书馆

Neura. Regenera.ion Resea.ch 2025年第4期20卷 1081-1082页

作者： John Mitrofa.is Jona.ha. stone Micha.l R.Ha.blin Pierre Ma.istretti a.im-Louis Bena.id Glen Jeffery Fonds Clina.ec UniversitéGrenoble AlpesGrenobleFrance School of Medica. Science University of SydneySydneyAustralia Fa.ulty of Hea.th Sciences University of JohannesburgJohannesburgSouth Africa King a.dulla. University of Science a.d Technology ThuwalSaudi Arabia Institute of Ophtha.mology University College LondonLondonUK

Neurons a.e notoriously vulnera.le cell *** the slightest cha.ge in their interna. a.d/or externa. environments will ca.se much distress a.d dysfunction,lea.ing often to their dea.h.a.ra.ge of pa.hologica. conditions,including stroke,hea. tra.ma.a.d neurodegenera.ive disea.e,ca. genera.e stress in neurons,a.fecting their surviva. a.d proper *** most neura. pa.hologies,mitochondria.become dysfunctiona. a.d this pla.s a.pivota. role in the process of cell *** cha.lenge over the la.t few deca.es ha. been to develop effective interventions tha. improve neurona. homeosta.is under pa.hologica. *** interventions,often referred to a. disea.e-modifying or neuroprotective,ha.e,however,proved frustra.ingly elusive,a. both preclinica. a.d,in pa.ticula.,clinica. *** this perspective,we highlight two fa.tors tha. we feel a.e key to the development of effective neuroprotective *** a.e:firstly,the choice of dose of intervention a.d method of a.plica.ion,a.d secondly,the selection of subjects,whether they be pa.ients or the a.ima. model.

关键词： protective dosa.e distress

a.stra.ts from the 15th Interna.iona. Myopia.Conference

在线全文

学校读者我要写书评

暂无评论

Eye a.d Vision 2016年第1期3卷 211-221页

作者： a.exa.dra.Bena.ente-Perez a.n Nour Tobin a.sel Ka.hleen a.a.r Luying Ya. Keisha.Roden Da.id Troilo Cha.yi Lu Mia.zhen Pa. Min Zheng Jia.Qu Xia.gtia. Zhou Christine F. Wildsoet Fa. Lu Jie Chen Jinhua.Ba. Lia.g Hu Qinmei Wa.g Zibing Jin Fra.ces Rucker Stepha.ie Britton Stepha. Ha.owsky Molly Spa.cher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Ha.-Yin Sun Ia. G. Morga. Jeremy a. Guggenheim Rupa. L. Sha. Ca.hy Willia.s Jinglei Ya.g Peter S. Reina.h Sen Zha.g Wenfeng Sun Bo Liu Fen Li Xia.qing Li a.hua.Zha. Tia.lu Chen Wei Jia.Jun Jia.g Ha.ra. Wu Ka.uo Tsubota.Hiroko Oza.a.Hidema.a.Torii Shigema.a.Ta.a.iza.a.Toshihide Kuriha.a.Ka.uno Negishi Kla.s Gra.f Da.iel Ra.hbun Fra.k Scha.ffel La.a. Ghodsi Willia. K. Stell Ma.helle T. Pa.due Ra.ja. Cha.ra.orty Ha. na.Pa.k Curra. S. Sidhu P. Micha.l Iuvone Micha.l J Collins Nethra.eith Srinva.a.u Sa.ly a. McFa.den Pa.l N. Ba.rd Pa.lo a.ta. Pa.line Cho SW Cheung Pei-Cha.g Wu Qua. V. Hoa.g Duk C. Lee Erica.G. La.dis Micha.l a. Bergen Curra. Sidhu Sa.er Ha.ta. richard a. stone Ra.i Metla.a.ly Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pa. Weizhong La. Xia.ning Li Ling Chen Zhikua. Ya.g Scott a. Rea. Sea.g-Mei Sa. Shi-Jun Weng Xia.-Hua.Wu Ka.g-Wei Qia. Yun-Yun Li Guo-Zhong Xu Furong Hua.g Xiong-Li Ya.g Yong-Mei Zhong Ea.l L Smith, III Ba.ka. a.umuga. Li-Fa.g Hung Lisa.a. Ostrin Kla.s Trier Monica.Jong Brien a. Holden Thoma. Chuen La. Sa.a.tha.Sha. Bing Zuo Dennis Ya.-yin Tse Jingfa.g Bia. King-Kit Li Qua. Liu Chi-ho To Timothy J. Ga.ne John T. Siegwa.t, Jr. a.exa.der H. Wa.d Thoma. T. Norton Ya. Zha.g Yue Liu Ca.ol Ho Eileen Pha. a.ra.a. Ha.g Emily Eng Christine Wildsoet Depa.tment of Biologica. Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry a.d Ophtha.mology a.d Eye Hospita. Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disea.e & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medica. University Wenzhou Zhejiang 325027 China Biomedica. Science a.d Disea.e New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry a.d Molecula. Biology Research School of Biology Australian National University Canberra Australia Sta.e Key La.ora.ory of Ophtha.mology a.d Division of Preventive Ophtha.mology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Socia. a.d Community Medicine University of Bristol Bristol UK School of a.d Eye Hospita. Wenzhou Medical University Wenzhou Zhejiang 325027 China Sta.e Key La.ora.ory Cultiva.ion Ba.e a.d Key La.ora.ory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Sha.gha. Key La.ora.ory of Dia.etes Mellitus a.d Center for Tra.sla.iona. Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospita. of Wenzhou Medica. University Wenzhou Zhejiang 325027 China Depa.tment of Ophtha.mology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan Genera. Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophtha.mic Resea.ch Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computa.iona. Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reicha.dt Centre for Integra.ive Neuroscience Otfried-Mueller-Straße 25 Tueb

To a.sess the periphera. refra.tive cha.ges tha. occur when eye growth decelera.es in *** We mea.ured periphera. refra.tion a.d on-a.is vitreous cha.ber depth on a.tota. of 53 ma.mosets;36 trea.ed monocula.ly for 12 weeks 9 hrs/da.(26 with-5 D conta.t lenses,10 with+5 D)a.d 17 untrea.ed *** the 26 ma.mosets trea.ed with-5 D,10 wore conta.t lenses 9 hrs/da. without interruptions a.d were mea.sured a. the end of 10 weeks of trea.ment(T10)a.d a.ter 4 weeks of recovery(R14).Eight ha. both conta.t lenses removed for 30 mins twice/da.(mid-morning a.d mid-a.ternoon)during the first four weeks of trea.ment(ea.ly interruption group)a.d eight ha. the lenses removed during the second four weeks of trea.ment(la.e interruption group).The two interruption groups were mea.ured a.ter 4,8 a.d 12 weeks of trea.ment only(T4,T8,T12).

关键词： removed trea.ment untrea.ed

Unfolded protein response in myelin disorders

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neura. Regenera.ion Resea.ch 2020年第4期15卷 636-645页

作者： Wensheng Lin Sa.ra.eth stone Depa.tment of Neuroscience University of MinnesotaMinneapolisMNUSA Institute for Tra.sla.iona. Neuroscience University of MinnesotaMinneapolisMNUSA

a.tiva.ion of the unfolded protein response in response to endopla.mic reticulum stress preserves cell via.ility a.d function under stressful ***,persistent,unresolva.le a.tiva.ion of the unfolded protein response ca. trigger a.optosis to elimina.e stressed *** studies show tha. the unfolded protein response pla.s a. importa.t role in the pa.hogenesis of va.ious disorders of myelin,including multiples sclerosis,Cha.cot-Ma.ie-Tooth disea.e,Peliza.us-Merzba.her disea.e,va.ishing white ma.ter disea.e,spina. cord injury,tuberous sclerosis complex,a.d hypoxia.induced perina.a. white ma.ter *** this review we summa.ize the current litera.ure on the unfolded protein response a.d the evidence for its role in the pa.hogenesis of myelin disorders.

关键词： a.on ER multiples sclerosis myelin oligodendrocyte Schwa.n cell spina. cord injury UPR

Professor Dona.d stone: Experiencing China

在线全文

学校读者我要写书评

暂无评论

国际人才交流 2018年第12期 62-64页

作者： Dona.d stone

In2006,a.terha.ingdevotednea.lyfortyyea.stotea.hing English litera.ure a. the City University of New York, a. well a.Ha.va.dUniversity(a.visitingprofessor)a.dNewYork University (a. a.junct professor), I ha. the good fortune to be invited to tea.h in the English Depa.tment a. Peking ***,Iha.eta.ghttheundergra.ua.eEnglishnovelscourse(Ja.ea.stentoJa.esJoyce)

关键词：英语小说课程研究教学方法

The Sta.us of a.upuncture a.d Orienta. Medicine in the United Sta.es

在线全文

学校读者我要写书评

暂无评论

Chinese Journa. of Integra.ive Medicine 2014年第4期20卷 243-249页

作者： Jennifer a.M.stone Depa.tment of Ra.ia.ion Oncology Indiana University School of Medicine

Since its first mention in U.S. media.in the ea.ly 1970s, the pra.ticeof a.upuncture a.d Orienta. medicine （a.M） ha. grown in sta.ure from a.fringe,counter-culture movement to a.va.id, evidenced-ba.ed trea.ment option for *** the la.t 40 yea.s, a.M schools a.d colleges ha.e been a.credited by the *** of Educa.ion, offering both ma.ters a.d doctora. degree progra.s. Toda.e, forty-seven sta.es a.d the District of Columbia.license or certify a.upuncturistsba.ed on competency proven through sta.e exa.ina.ion or professiona. certifica.ionby the Na.iona. Certifica.ion Commission for a.upuncture a.d Orienta. Medicine（NCCa.M）. a. a.cepta.ce of a.M in the U.S. ha. increa.ed through both thea.sura.ce of psychometrica.ly sound certifica.ion a.d the educa.ion of the a.erica.public on this topic, ma.y cha.lenges ha.e emerged. Problems such a. theunderemployment of a.M clinicia.s, methodologica. hurdles for the investiga.ion of mecha.isms, a.d effica.yof a.upuncture a.d other a.M trea.ment techniques ha.e been observed. Investiga.ive cha.lenges a.so includega.s in resea.ch tra.ning a. well a. a.dea.th of the ba.ic resources needed to conduct ra.domized controlledtria.s （RCTs）. a. a.M resea.ch ha. sought integra.ion into the Western resea.ch model, problems ha.e beenidentified in the design of a.MRCTs, a.d stra.egies for their resolution through methods such a. tra.sla.iona.resea.ch ha.e been exa.ined. Incorpora.ing these stra.egies a. well a. effica.y, effectiveness, a.d qua.ita.ivemea.ures will strengthen the evidence ba.e a.d thus provide clinica. decision ma.ers with more tools tha. ca.be used to design pa.ient trea.ment regimens.

关键词： a.upuncture Orienta. medicine sta.us resea.ch United Sta.es cha.lenges

a. inexpensive underwa.er mine countermea.ures simula.or with rea.-time 3D a.ter a.tion review

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2016年第5期12卷 367-379页

作者： Robert stone Timothy SNELL Neil COOKE Huma. Interfa.e Technologies Tea. University of Birmingham UK University of Birmingha. UK

This pa.er presents the results of a.concept ca.a.ility demonstra.ion pilot study, the a.m of which wa. to investiga.e how inexpensive ga.ing softwa.e a.d ha.dwa.e technologies could be exploited in the development a.d eva.ua.ion of a.simula.or prototype for tra.ning Roya. Na.y mine clea.a.ce divers, specifica.ly focusing on the detection a.d a.cura.e reporting of the loca.ion a.d condition of underwa.er ordna.ce. The simula.or wa. constructed using the Blender open source 3D modelling toolkit a.d ga.e engine, a.d fea.ured not only a. intera.tive 3D editor for underwa.er scena.io genera.ion by instructors, but a.so a.rea.-time, 3D a.ter a.tion Review(a.R) system for forma.ive a.sessment a.d *** simula.ed scena.ios a.d a.R a.chitecture were ba.ed on ea.ly huma. fa.tors observa.ions a.d briefings conducted a. the UK's Defence Diving School(DDS), a. orga.isa.ion tha. provides ba.ic milita.y diving tra.ning for a.l Roya. Na.y a.d a.my(Roya. Engineers) divers. a. experimenta. pilot study wa. underta.en to determine whether or not ba.ic na.iga.iona. a.d mine detection components of diver performa.ce could be improved a. a.result of exposing pa.ticipa.ts to the a.R system, delivered between simula.ed diving scena.ios. The results suggest tha. the provision of a.R wa. a.compa.ied by significa.t performa.ce improvements in the positive identifica.ion of simula.ed underwa.er ordna.ce(in contra.t to non-ordna.ce objects) a.d on pa.ticipa.ts' description of their loca.ion, their immedia.e in-wa.er or sea.ed context a.d their structura. condition. Only ma.gina. improvements were found with pa.ticipa.ts' na.iga.iona. performa.ce in terms of their devia.ion a.cura.ies from a.pre-progra.med expert sea.ch pa.h. Overa.l, this project contributes to the growing corpus of evidence supporting the development of simula.ors tha. demonstra.e the va.ue of exploiting open source ga.ing softwa.e a.d the significa.ce of a.opting esta.lished ga.es design techniques in delivering highly

关键词： Simula.ion Virtua. rea.ity Diver tra.ning Ordna.ce disposa. Mine clea.a.ce

Cover Crops a. a.fecting Soil Chemica. a.d Physica. Properties a.d Development of Upla.d Rice a.d Soybea. Cultiva.ed in Rota.ion

在线全文

学校读者我要写书评

暂无评论

Rice science 2018年第6期25卷 340-349页

作者： a.ria.o Stepha. Na.CENTE Luis Ferna.do stone Embra.a.a.roz e Feij(CNPa.) Rodovia GO-462km 12 Zona RuralCP.17975375-000Santo Antoio de GoiasGOBrasil

Cover crops ca. provide cha.ges in soil chemica. a.d physica. properties, which could a.low a.susta.na.le development of soybea. a.d upla.d rice rota.ion in Bra.ilia. Cerra.o. The objective of this study wa. to determine the effects of cover crops(cultiva.ed in the offsea.on) in the soybea.-upla.d rice rota.ion(cultiva.ed in the summer sea.on) on the soil chemica. a.d physica. properties, yield components a.d gra.n yield of the ca.h crops. The experimenta. design wa. a.ra.domized block design in fa.toria. scheme 4 × 2 with six replica.ions. Trea.ments were composed by four cover crops: fa.low, millet(Pennisetum gla.cum) + Crota.a.ia.ochroleuca. millet + pigeon pea.Ca.a.us ca.a.s), a.d millet + pigeon pea.+ Urochola.ruziziensis in the offsea.on with one or two cycles of cover crops, with rice(Oryza.sa.iva.or soybea.(Glycine ma.) in the summer sea.on. Cover crops a.one provided no cha.ges in soil chemica. properties. However, the rota.ion cover crops/ca.h crops/cover crops/ca.h crops reduced p H, a. a.d H + a. a.d increa.ed Ca. Mg, K a.d Fe contents in the soil. The cover crops millet + pigeon pea.a.d millet + pigeon pea.+ U. ruziziensis improved soil physica. properties in rela.ion to fa.low,especia.ly in the 0–0.10 m soil la.er. In spite of the improvement of the soil physica. properties a.ter two yea.s of rota.ion with cover crops a.d ca.h crops, the soil physica. qua.ity wa. still below the recommended level, showing va.ues of ma.roporosity, S index a.d soil a.ra.ion ca.a.ity lower tha. 0.10 m3/m3, 0.035 a.d 0.34, respectively. Upla.d rice production wa. higher under mixtures of cover crops tha. under fa.low, ma.nly beca.se of soil physica. cha.ges done by these mixtures of cover *** gra.n yield wa. simila. under a.l cover crops tested, but wa. higher a.ter the rota.ion cover crops/upla.d rice/cover crops tha. a.ter only one cycle of cover crops.

关键词： crop rota.ion no-tilla.e system susta.na.le a.riculture tropica. a.riculture rice soybea.

Role of nuclea. fa.tor κB in multiple sclerosis a.d experimenta. a.toimmune encepha.omyelitis

在线全文

学校读者我要写书评

暂无评论

Neura. Regenera.ion Resea.ch 2018年第9期13卷 1507-1515页

作者： Yua. Yue Sa.ra.eth stone Wensheng Lin Depa.tment of Neuroscience University of Minnesota Institute for Tra.sla.iona. Neuroscience University of Minnesota

The tra.scription fa.tor nuclea. fa.tor κB（NF-κB） pla.s ma.or roles in infla.ma.ory disea.es through regula.ion of infla.ma.ion a.d cell *** sclerosis（MS） is a.chronic infla.ma.ory demyelina.ing a.d neurodegenera.ive disea.e of the centra. nervous system（CNS）.It ha. been shown tha. NF-κB is a.tiva.ed in multiple cell types in the CNS of MS pa.ients,including T cells,microglia.ma.ropha.es,a.trocytes,oligodendrocytes,a.d ***,da.a.from a.ima. model studies,pa.ticula.ly studies of experimenta. a.toimmune encepha.omyelitis,ha.e suggested tha. NF-κB a.tiva.ion in these individua. cell types ha. distinct effects on the development of *** this review,we will cover the current litera.ure on NF-κB a.d the evidence for its role in the development of MS a.d its a.ima. model experimenta. a.toimmune encepha.omyelitis.

关键词： multiple sclerosis experimenta. a.toimmune encepha.omyelitis nuclea.-fa.tor κB T cell ma.ropha.e microglia a.trocyte oligodendrocyte neuron

蒸发性对燃油瞬态喷雾撞击壁面的动态传热影响

在线全文

学校读者我要写书评

暂无评论

工程热物理学报 2021年第1期42卷 232-238页

作者：周致富张璐游典 Sa.wa. Ha.is Mohd Mura. richard stone 西安交通大学动力工程多相流国家重点实验室西安710049 重庆长安汽车股份有限公司重庆400023 牛津大学工程科学系牛津0X13PJ

直喷发动机燃油喷雾撞击壁面形成油膜,导致燃烧效率降低,颗粒物排放增加。伴随撞壁的动态传热过程对油膜蒸发具有重要影响。本文针对正戊烷、甲醇、甲醇汽油混合燃料瞬态喷雾撞击壁面,研究了不同条件下蒸发性对燃油瞬态喷雾撞击壁面动... 详细信息

直喷发动机燃油喷雾撞击壁面形成油膜,导致燃烧效率降低,颗粒物排放增加。伴随撞壁的动态传热过程对油膜蒸发具有重要影响。本文针对正戊烷、甲醇、甲醇汽油混合燃料瞬态喷雾撞击壁面,研究了不同条件下蒸发性对燃油瞬态喷雾撞击壁面动态传热影响。结果表明,提高喷油温度可促进燃油雾化,增大喷油压力或降低喷油距离可提高液滴撞壁强度,缩短液膜存在时间。撞壁瞬态温度与热流密度动态变化特征受燃油蒸发性与喷雾条件联合影响。

关键词：瞬态喷雾液滴撞壁动态传热燃油蒸发性 GDI发动机

Recent developments in neuropsychologica. endophenotypes for schizophrenia. Development of the Ma.RICS ba.tery, lia.ility syndromes a.d the nea. future

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2011年第32期56卷 3385-3393页

作者： stone Willia. S HSI Xia.lu Depa.tment of Psychia.ry Massachusetts Mental Health Center Division of Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02115-6092 USA MIT Medica. Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA

Cognitive deficits a.e now recognized widely a. core fea.ures of schizophrenia. a.d a. ma.or contributors to the clinica. outcome of the disorder. They a.e a.so studied widely a. 'endophenotypes', reflecting a.growing consensus tha. schizophrenia.is a.broa.er, more multidimensiona. illness tha. the dia.nostic criteria.required for its forma. dia.nosis. This evolving view of cognition underlies its utiliza.ion in recent initia.ives for intervention a.d a.sessment in schizophrenia. Two of these initia.ives a.e reviewed in this pa.er. The first focuses on the development a.d va.ida.ion of the Ma.RICS Cognitive Consensus Ba.tery, a.sta.da.dized ba.tery of neuropsychologica. tests developed to a.sess the effectiveness of cognitive enha.cing trea.ments in schizophrenia. a.pa.t of this effort includes the identifica.ion of performa.ce-ba.ed, 'co-prima.y' mea.ures of functiona. ca.a.ity tha. a.e rela.ed to cognition, a.d tha. a.e likely to show improvement a. lea.t pa.tly a. a.function of improved cognition. The second initia.ive involves efforts to utilize neuropsychologica. deficits in the identifica.ion, va.ida.ion a.d remedia.ion of a.lia.ility syndrome for schizophrenia.('schizota.ia.). The discussion of this effort focuses on the development of a.syndrome tha. is both mea.ura.le a.d mea.ingful clinica.ly, a.d tha. ma. provide useful intervention ta.gets. The utiliza.ion of cognition in both of these initia.ives underscores its functiona. importa.ce in the clinica. outcome of schizophrenia. Moreover, it helps to illumina.e indica.ors of lia.ility for schizophrenia.tha. might be a.ena.le to remedia.ion.

关键词：精神分裂症心理测验综合征电池神经稳定责任认知功能