Unfolded protein response in myelin disorders

作     者：Wensheng Lin Sarrabeth Stone Wensheng Lin;Sarrabeth Stone

作者机构：Department of NeuroscienceUniversity of MinnesotaMinneapolisMNUSA Institute for Translational NeuroscienceUniversity of MinnesotaMinneapolisMNUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第4期

页      面：636-645页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Institutes of Health(NS094151 and NS105689 both to WL) 

主　　题：axon ER multiples sclerosis myelin oligodendrocyte Schwann cell spinal cord injury UPR 

摘      要：Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful ***,persistent,unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed *** studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin,including multiples sclerosis,Charcot-Marie-Tooth disease,Pelizaeus-Merzbacher disease,vanishing white matter disease,spinal cord injury,tuberous sclerosis complex,and hypoxia-induced perinatal white matter *** this review we summarize the current literature on the unfolded protein response and the evidence for its role in the pathogenesis of myelin disorders.