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Electrophysiology and heart rhythm disorders in older adults

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Journal of Geriatric Cardiology 2016年第8期13卷 645-651页

作者： Parag Goyal Michael W rich Division of Cardiology Weill Cornell Medical College New York USA Cardiovascular Division Washington University School of Medicine St. Louis USA

1 Introduction Heart rhythm disorders, including bradyarrhythmias, atrial fibrillation （AF）, and ventricular arrhythmias, become increasingly common with aging and represent important causes of morbidity and mortality among older adults.[1-3] Older adults are particularly predisposed to these conditions due to the high prevalence of cardiovascular disease in con- junction with age-related changes that occur in the heart and cardiac conduction system.

关键词： Arrhythmia Atrial fibrillation Bradycardia The aged Ventricular tachycardia

Perioperative care in older adults

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Journal of Geriatric Cardiology 2015年第5期12卷 465-469页

作者： Giselle A Baquero Michael W rich Penn State College of Medicine Hershey PA USA Washington University School of Medicine St. Louis MO USA

1 Background Over the last 20 years, the number of older adults requiring surgical interventions has substantially increased and will continue to escalate as the population ages. Perioperative management of older patients poses challenges not encountered in younger individuals. People over 70 years of age are more likely to have multiple comorbidities, physical and cognitive impairments, and reduced cardiac, pulmonary, and renal reserve. These factors predispose older patients to increased risk for perioperative complications and prolonged length of hospital stay, which in turn increase risk for iatrogenesis, nosocomial infections, and perioperative mortality.

关键词： Aging Cardiovascular disease Perioperative care Surgery The elderly

Distributed Beamforming Based Wireless Power Transfer:Analysis and Realization

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Tsinghua Science and Technology 2020年第6期25卷 758-775页

作者： Xiaoran Fan Han Ding Yanyong Zhang Wade Trappe Zhu Han rich Howard the Wireless Information Network Laboratory(WINLAB) Rutgers UniversityNew BrunswickNJ 08901USA the Department of Computer Science and Technology Xi'an Jiaotong UniversityXi'an 710049China the Department of Computer Science and Technology University of Science and Technology of ChinaHefei 230052China the Department of Electrical and Computer Engineering University of HoustonHoustonTX 77004USA.

This paper presents a new Wireless Power Transfer(WPT)approach by aligning the phases of a group of spatially distributed Radio Frequency(RF)transmitters(TX)at the target receiver(RX)*** approach can transfer energy over tens of meters and even to targets blocked by *** to popular beamforming based WPTs,our approach leads to a drastically different energy density distribution:the energy density at the target receiver is much higher than the energy density at other *** to this unique energy distribution pattern,our approach offers a safer WPT solution,which can be potentially scaled up to ship a higher level of energy over longer ***,we model the energy density distribution and prove that our proposed system can create a high energy peak exactly at the target *** we conduct detailed simulation studies to investigate how the actual energy distribution is impacted by various important system parameters,including number/topology of transmitters,transmitter antenna directionality,the distance between receiver and transmitters,and environmental ***,we build an actual prototype with 17 N210 and 4 B210 Universal Software Radio Peripheral(USRP)nodes,through which we validate the salient features and performance promises of the proposed system.

关键词： Wireless Power Transfer(WPT) distributed beamforming wireless network

An acoustofluidic scanning nanoscope using enhanced image stacking and processing

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Microsystems & Nanoengineering 2022年第4期8卷 191-198页

作者： Geonsoo Jin Joseph rich Jianping Xia Albert JHe Chenglong Zhao Tony Jun Huang Thomas Lord Department of Mechanical Engineering and Material Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Physics University of Dayton300 College ParkDaytonOH 45469USA Department of Electro-Optics and Photonics University of Dayton300 College ParkDaytonOH 45469USA

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas,such as semiconductor fabrication,biomedical imaging,and nanoscale material *** scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view;however,those scanning microscopes still rely upon fluorescence labeling and complex optical *** overcome these limitations,we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm(alphablending process).This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and ***,the number of images required to capture the entire field of view(200×200μm)by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous ***,the image quality is also greatly improved by applying an alpha-blending imaging technique,which is critical for accurately depicting and identifying nanoscale objects or *** dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view.

关键词： image overcome stacking

Acoustofluidic scanning fluorescence nanoscopy with a large field of view

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Microsystems & Nanoengineering 2024年第3期10卷 159-167页

作者： Geonsoo Jin Neil Upreti Joseph rich Jianping Xia Chenglong Zhao Tony Jun Huang Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA The MITRE Corporation McLeanVA 22102USA

Large-field nanoscale fluorescence imaging is invaluable for many applications,such as imaging subcellular structures,visualizing protein interactions,and high-resolution tissue ***,conventional fluorescence microscopy requires a trade-off between resolution and field of view due to the nature of the optics used to form the *** overcome this barrier,we developed an acoustofluidic scanning fluorescence nanoscope that simultaneously achieves superior resolution,a large field of view,and strong fluorescent *** acoustofluidic scanning fluorescence nanoscope utilizes the superresolution capabilities of microspheres that are controlled by a programmable acoustofluidic device for rapid fluorescence enhancement and *** acoustofluidic scanning fluorescence nanoscope resolves structures that cannot be resolved with conventional fluorescence microscopes with the same objective lens and enhances the fluorescent signal by a factor of~5 without altering the field of view of the *** improved resolution realized with enhanced fluorescent signals and the large field of view achieved via acoustofluidic scanning fluorescence nanoscopy provides a powerful tool for versatile nanoscale fluorescence imaging for researchers in the fields of medicine,biology,biophysics,and biomedical engineering.

关键词： field resolution utilize

A national longitudinal cohort study of factors contributing to UK medical students’mental ill-health symptoms

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General Psychiatry 2023年第2期36卷 92-105页

作者： Asta Medisauskaite Milou E W M Silkens Antonia rich Medical School UCLLondonUK Department of Health Services Research and Management City University of LondonLondonUK

Background The mental health of current medical students is predictive of their mental health as future *** prevalence of anxiety,depression and burnout is high among medical students,but less is known about the occurrence of other mental ill-health symptoms,such as eating or personality disorders,and factors contributing to mental ***(1)To explore the prevalence of various mental ill-health symptoms in medical students and(2)to investigate what medical school factors and students’attitudes contribute to these mental ill-health *** Between November 2020 and May 2021,medical students from nine geographically spread medical schools in the UK participated by completing online questionnaires at two points in time,approximately 3 months *** Of the 792 participants who filled in the questionnaire at baseline,over half experienced medium to high somatic symptoms(50.8%;402)and drank alcohol at hazardous levels(62.4%;494).Adjusted longitudinal data analysis of 407 students who completed the follow-up questionnaire demonstrated that less supportive educational climates that were more competitive and less centralised around the students,lower feelings of belongingness,greater stigma towards mental ill-health and lower intentions to seek help for mental ill-health,all contributed to students’mental ill-health *** Medical students experience a high prevalence of various mental ill-health *** study suggests that medical school factors and students’attitudes towards mental ill-health are significantly associated with students’mental health.

关键词： filled doctor competitive

A 3D-printed platform for modular neuromuscular motor units

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Microsystems & Nanoengineering 2017年第1期3卷 251-259页

作者： Caroline Cvetkovic Max H.rich Ritu Raman Hyunjoon Kong Rashid Bashir Department of Bioengineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Micro and Nanotechnology Laboratory University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

A complex and functional living cellular system requires the interaction of one or more cell types to perform specific tasks,such as sensing,processing,or force *** and flexible platforms for fabrication of such multi-cellular modules and their characterization have been ***,we present a modular cellular system,made up of multi-layered tissue rings containing integrated skeletal muscle and motor neurons(MNs)embedded in an extracellular *** MNs were differentiated from mouse embryonic stem cells through the formation of embryoid bodies(EBs),which are spherical aggregations of cells grown in a suspension *** EBs were integrated into a tissue ring with skeletal muscle,which was differentiated in parallel,to create a co-culture amenable to both cell *** multi-layered rings were then sequentially placed on a stationary three-dimensionalprinted hydrogel structure resembling an anatomical muscle–tendon–bone *** demonstrate that the site-specific innervation of a group of muscle fibers in the multi-layered tissue rings allows for muscle contraction via chemical stimulation of MNs with glutamate,a major excitatory neurotransmitter in the mammalian nervous system,with the frequency of contraction increasing with glutamate *** addition of tubocurarine chloride(a nicotinic receptor antagonist)halted the contractions,indicating that muscle contraction was MN *** a bio-fabricated system permitting controllable mechanical and geometric attributes in a range of length scales,our novel engineered cellular system can be utilized for easier integration of other modular“building blocks”in living cellular and biological machines.

关键词： 3D printing neuromuscular junction skeletal muscle stereolithography tissue engineering

Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation

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Microsystems & Nanoengineering 2022年第2期8卷 149-159页

作者： Zeyu Wang Joseph rich Nanjing Hao Yuyang Gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side ***,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading ***,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome *** synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is *** final product consists of drug-loaded silica nanocarriers that are encased within an exosomal *** drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the ***,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of *** exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell *** utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications.

关键词： exosome loading simultaneous

SURVIVAL TRENDS IN CHILDHOOD HEMATOLOGICAL MALIGNANCIES

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International Journal of Biomathematics 2012年第6期5卷 95-103页

作者： STEPHANIE rich SHIHAB ALI GEOFFREY W. CALKINS JAMES S. MICHAELSON Laboratory of Quantitative Medicine Massachusetts General Hospital 65 Landsdowne Street Suite 200Cambridge Massachusetts 02139 USA Laboratory of Quantitative Medicine and Departments of Surgery and Pathology Massachusetts General Hospital 65 Landsdowne Street Suite 200Cambridge Massachusetts 02139 USA

Survival of patients with childhood hematological malignancies has increased markedly in the past decades. To examine the finescale details of how this progress has occurred, we carried out KaplanMeier causespecific survival analysis using the Surveillance Epi demiology and End Results （SEER） dataset for patients with childhood hematologi cal malignancies Hodgkin＇s Lymphoma, NonHodgkin＇s Lymphoma, Lymphoblastic Leukemia and Myeloid Leukemia diagnosed in five eras： 1983-1987; 1988-1992; 1993-1997; 1998-2002 and 2003-2007. We generated KaplanMeier estimates of survival for each of the first 24 years after diagnosis. These figures agree with previously reported five and tenyear values and attest to the remarkable increase in survival that has occurred over the past three decades of medical progress. The trend towards progres sively increasing survival shows no sign of slowing, suggesting that we may expect further increases in survival in the years ahead. Most of the increase in survival for childhood hematological malignancies has occurred by reducing the risk of death in the first two years after diagnosis. This may be largely explained by the fact that this is the time period when patients are at highest risk of death.

关键词： Childhood hematological malignancies survival trends.