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Separability Analysis of Atlantic Forest Patches by Comparing Parametric and Non-Parametric Image Classification Algorithms

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Journal of Geographic Information System 2019年第5期11卷 567-578页

作者： Marcos Roberto Martines Mariana de Paula Garcia Lúcio Alexandre D. M. Cavagis Marcel Fantin ricardo vicente ferreira Matheus Oliveira Alves Rogério Hartung Toppa Federal University of So Carlos UFSCar/NEEPC So Carlos So Paulo Brazil Federal University of So Carlos UFSCar/DFQM So Carlos So Paulo Brazil University of So Paulo USP So Carlos So Paulo Brazil Federal University of Triangulo Mineiro Minas Gerais Brazil Faculdades Associadas de Uberaba FAZU Minas Gerais Brazil.

The aim of this work was to differentiate Atlantic Forest patches, as well as their spatial distribution, from other tree covers that compose the landscape, by comparing three methods of digital images classification, using techniques of geoprocessing and remote sensing. The study area was a sub-basin of the Iperó River, tributary of the Iperó-Mirim stream, Sarapuí River basin, in Araçoiaba da Serra, State of São Paulo, Brazil. This research has been developed on a Geographic Information System environment platform, using medium resolution images from Sentinel-2 Satellite. Three image classification algorithms: Maximum Likelihood Classification (MLC), Support Vector Machines (SVM) and Random Tree (RT) were applied to verify the separability of forest patches, forestry and other uses. The results were analyzed by means of a confusion matrix, accuracy and kappa index, thus showing that the three algorithms were able to successfully differentiate the targets, with the higher efficiency attributed to MLC and the lowest to RT. Overall, the three classifiers presented errors, but specifically for the forest patches, the highest accuracy was obtained from SVM.

关键词： Atlantic Forest Land Cover Image Classification

ISOPERIMETRIC PROBLEMS OF THE CALCULUS OF VARIATIONS WITH FRACTIONAL DERIVATIVES

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Acta Mathematica Scientia 2012年第2期32卷 619-630页

作者： ricardo Almeida Rui A.C.ferreira Delfim F.M.Torres Center for Research and Development in Mathematics and Applications Department of MathematicsUniversity of Aveiro3810-193 AveiroPortugal Department of Mathematics Faculty of Engineering and Natural SciencesLusophone University of Humanities and Technologies1749-024 LisbonPortugal

In this article, we study isoperimetric problems of the calculus of variations with left and right Riemann-Liouville fractional derivatives. Both situations when the lower bound of the variational integrals coincide a... 详细信息

关键词： Calculus of variations fractional derivatives isoperimetric problems

New evidence-based practice:Artificial intelligence as a barrier breaker

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World Journal of Methodology 2023年第5期13卷 384-389页

作者： ricardo Maia ferreira Department of Sports and Exercise Polytechnic Institute of Maia(N2i)Maia 4475-690PortoPortugal Department of Physioterapy Polytechnic Institute of CoimbraCoimbra Health SchoolCoimbra 3046-854CoimbraPortugal Department of Physioterapy Polytechnic Institute of Castelo BrancoDr.Lopes Dias Health SchoolCastelo Branco 6000-767Castelo BrancoPortugal Sport Physical Activity and Health Research&Innovation Center Polytechnic Institute of Viana do CasteloMelgaço4960-320Viana do CasteloPortugal

The concept of evidence-based practice has persisted over several years and remains a cornerstone in clinical practice,representing the gold standard for optimal patient ***,despite widespread recognition of its significance,practical application faces various challenges and barriers,including a lack of skills in interpreting studies,limited resources,time constraints,linguistic competencies,and ***,we have witnessed the emergence of a groundbreaking technological revolution known as artificial *** artificial intelligence has become increasingly integrated into our daily lives,some reluctance persists among certain segments of the *** article explores the potential of artificial intelligence as a solution to some of the main barriers encountered in the application of evidence-based *** highlights how artificial intelligence can assist in staying updated with the latest evidence,enhancing clinical decision-making,addressing patient misinformation,and mitigating time constraints in clinical *** integration of artificial intelligence into evidence-based practice has the potential to revolutionize healthcare,leading to more precise diagnoses,personalized treatment plans,and improved doctor-patient *** proposed synergy between evidencebased practice and artificial intelligence may necessitate adjustments to its core concept,heralding a new era in healthcare.

关键词： Evidence Clinicians Patients Artificial intelligence Evidence-based practice

Cannabinoid Modulation of Monoamine Levels in Mouse Brain:Unveiling Neurochemical Dynamics through an Innovative High‑performance Liquid Chromatography‑Fluorescence Detection Bioanalysis

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Journal of Analysis and Testing 2024年第3期8卷 300-314页

作者： Fonseca Carla Cunha Susana ferreira ricardo Lapo Pais Mariana Goncalves Joana Camins Antoni Ettcheto Miren Barbosa Rui Fortuna Ana Laboratory of Pharmacology Faculty of PharmacyUniversity of CoimbraPolo das Ciencias da SaudeAzinhaga de Santa CombaCoimbra 3000‑548Portugal CIBIT/ICNAS-Coimbra Institute for Biomedical Imaging and Translational Research University of CoimbraCoimbra 3000‑548Portugal Department of Pharmacology Toxicology and Therapeutic ChemistryFaculty of Pharmacy and Food ScienceUniversitat de BarcelonaBarcelona 08028Spain Institute of Neurosciences Universitat de BarcelonaBarcelona 08035Spain Faculty of Sciences and Technology Doctoral Program in Biomedical EngineeringUniversity of CoimbraCoimbra 3004‑516Portugal Biomedical Research Networking Centre in Neurodegenerative Diseases(CIBERNED) Carlos Ⅲ Health InstituteMadrid 28031Spain Institut d’Investigacio Sanitaria Pere Virgili(IISPV) Reus 43204Spain CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbra 3004-504Portugal

Homeostasis of monoaminergic pathways is compromised in aging and neurodegenerative/neurological diseases such as Alzheimer’s disease and *** the other hand,their modulation has also been linked to the mechanism of action of several ***,monitoring the levels of noradrenaline(NA),adrenaline(AD),dopamine(DA),and serotonin(5-HT),as well as those of tryptophan(TRYP),the precursor of 5-HT,and DA metabolites,namely 3,4-dihydroxyphenylacetic acid(DOPAC)and homovanillic acid(HVA),is fundamental for assessing disease severity and *** work aimed to develop and validate the first High-Performance Liquid Chromatography(HPLC)coupled with fluorescence detector(FLD)method that simultaneously and accurately quantifies NA,AD,DA,DOPAC,HVA,5-HT and TRYP in mouse brain and prefrontal cortex(PFC)*** sample preparation by protein precipitation was required to extract the *** curves were plotted using the background subtraction approach to reduce the interference of the endogenous *** and inter-day accuracy and precision were within the ranges defined by ICH(The International Council for Harmonisation)guideline for bioanalytical method *** validation,the impact of cannabidiol(CBD),cannabigerol(CBG),and cannabidivarin(CBDV)was explored in mice brains post-administration,revealing significant alterations in specific neurotransmitter levels upon cannabinoid exposure and shedding light on the complex modulation of neurochemical dynamics by *** research highlights the fit-for-purpose of the HPLC-FLD method and provides insights into potential mechanisms underlying phytocannabinoid actions in the central nervous system(CNS).

关键词： Neurotransmitter HPLC Mice Brain Prefrontal cortex Cannabinoid

Trophic niche changes associated with the eradication of invasive mammals in an insular lizard: an assessment using isotopes

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Current Zoology 2022年第2期68卷 211-219页

作者： Sara F.NUNES Mario MOTA-ferreira Marta SAMPAIO Joana ANDRADE Nuno OLIVEIRA Rui REBELO ricardo ROCHA Faculty of Sciences Centre for EcologyEvolution and Environmental ChangesUniversity of LisbonLisbon1749-016Portugal CIBI0-lnBI0 Research Center in Biodiversity and Genetic ResourcesUniversity of PortoVairao4485-661Portugal CIBI0-lnBI0 Research Center in Biodiversity and Genetic ResourcesInstitute of AgronomyUniversity of LisbonLisbon1349-017Portugal Sociedade Portuguesa Para o Estudo das Aves Av.Columbano Bordalo Pinheiro873°AndarLisboa1070-062Portugal

Invasive species are a major threat to island biodiversity,and their eradications have substantially contributed to the conservation of island ***,the consequences of eradications on the trophic ecology of native taxa are largely ***,we used the eradication of invasive black rats Rattus rattus and European rabbits Oryctolagus cuniculus from the Berlenga Island,in the western coast of Portugal,as a whole-ecosystem experiment to investigate the effects of the eradication of invasive mammals on the trophic niche and body dimensions of the island-restricted Berlenga wall lizard Podarcis carbonelli berlengensis over a 2-year *** results suggest an expansion of the isotopic niche and an intensification of the sexual dimorphism of the lizard following mammal ***,we found considerable variability in isotopic niche across the island and detected evidence of sex-specific and season-modulated nutritional requirements of this threatened *** findings support that the eradication of 2 of the planets most problematic invasive vertebrates led to changes in the lizard trophic niche and sexual dimorphism in just 2 *** suggests that the ecological pressuresfor example,prey availability and habitat structureto which lizards are exposed have substantially changed *** study emphasizes the scientific value of island eradications as experiments to address a wide range of ecological questions and adds to the increasing body of evidence supporting substantial conservation gains associated with these restoration interventions.

关键词： food-webs invasive species eradication Oryctolagus cuniculus Podarcis carbonelli berlengensis Rattus rattus

Is There an Absolute Scale for Speed?

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Journal of Modern Physics 2022年第8期13卷 1184-1196页

作者： ricardo B. ferreira Joã o B. ferreira Instituto Superior de Agronomia University of Lisbon Lisbon Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil Lisbon Portugal

Except for the speed of photons in vacuum, all speeds are relative. Could we develop an absolute scale for speed in which relative values for speed may be arbitrarily positioned and compared in absolute terms? The currently accepted definition for the meter as the distance covered by photons in vacuum during 1/299,792,458 s, and the view that the greater a material particle is accelerated towards c, the greater time dilation and length contraction will be, suggest that anything disturbing one of the four spacetime dimensions may affect the other three as well. One hypothetical experiment, one real experiment performed in the 1970s, and one experiment from a different field of science are discussed to propose that both time and velocity are only partially relative. In the first experiment, person A is standing still on the Earth’s surface, and person B is onboard a train passing by person A at the constant speed of 60 km/h (as measured by person B on the train’s speedometer). Persons A and B define two distinct inertial frames of reference, which correspond to two different spacetime conditions and which are therefore characterized by comparatively different lengths of the meter and durations of the second, as predicted by the Lorentz factor. Therefore, if person B onboard the train measures the train’s speed relative to person A as 60 km/h, a simple calculation will show that person A will perceive the train passing by at 59.99999999999981455834 km/h. If we consider the speed of photons in vacuum (c = 299,792,458 m/s) as a universal reference, and if we consider that the greater a material particle is accelerated towards c, the greater time dilation and length contraction will be, then person C, occupying an independent, distinct inertial frame of reference, will be unable to determine persons A and B’s absolute speeds, but may infer which one is moving at a speed closer to c by comparing, with his own meter and second, the durations of the second and the lengths of

关键词： Spacetime Relativity Speed of Light Space Time

Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche

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Bioactive Materials 2024年第4期34卷 311-325页

作者： Emanuel Quartin Susana Rosa Sara Gonzalez-Anton Laura Mosteo Lopez Vitor Francisco Delfim Duarte Cristina Lo Celso ricardo Pires das Neves Lino ferreira CNC-Center for Neuroscience and Cell Biology CIBB-Centre for Innovative Biomedicine and BiotechnologyUniversity of Coimbra3004-517CoimbraPortugal IIIUC-Institute of Interdisciplinary Research University of Coimbra3004-517CoimbraPortugal Faculty of Medicine University of Coimbra3004-517CoimbraPortugal Department of Life Sciences Imperial College LondonSouth Kensington CampusThe Francis Crick InstituteLondonUK Haematopoietic Stem Cell Laboratory The Francis Crick InstituteLondonUK Instituto de Investigação e Inovação em Saúde(i3S) University of PortoPortoPortugal Department of Biomedicine Faculdade de Medicina da Universidade do Porto(FMUP)PortoPortugal Department of Onco-Hematology Instituto Português de Oncologia(IPO)-PortoPortoPortugal

More effective approaches are needed in the treatment of blood cancers,in particular acute myeloid leukemia(AML),that are able to eliminate resistant leukemia stem cells(LSCs)at the bone marrow(BM),after a chemotherapy session,and then enhance hematopoietic stem cell(HSC)engraftment for the re-establishment of the HSC ***,we investigate whether light-activatable nanoparticles(NPs)encapsulating all-trans-retinoic acid(RA^(+)NPs)could solve both *** in vitro results show that mouse AML cells transfected with RA^(+)NPs differentiate towards antitumoral M1 macrophages through RIG.1 and OASL gene *** in vivo results further show that mouse AML cells transfected with RA^(+)NPs home at the BM after transplantation in an AML mouse *** photo-disassembly of the NPs within the grafted cells by a blue laser enables their differentiation towards a macrophage *** macrophage activation seems to have systemic anti-leukemic effect within the BM,with a significant reduction of leukemic cells in all BM compartments,of animals treated with RA^(+)NPs,when compared with animals treated with empty *** a separate group of experiments,we show for the first time that normal HSCs transfected with RA^(+)NPs show superior engraftment at the BM niche than cells without treatment or treated with empty *** is the first time that the activity of RA is tested in terms of long-term hematopoietic reconstitution after transplant using an in situ activation approach without any exogenous priming or genetic conditioning of the transplanted ***,the approach documented here has the potential to improve consolidation therapy in AML since it allows a dual intervention in the BM niche:to tackle resistant leukemia and improve HSC engraftment at the same time.

关键词： Light Nanoparticles Retinoic acid Leukemia M1 macrophages Drug delivery

Scientometric Analysis of Research Output from Brazil in Response to the Zika Crisis Using e-Lattes

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Journal of Data and Information Science 2020年第4期5卷 137-146页

作者： ricardo Barros Sampaio Antônio de Abreu Batista-Jr Bruno Santos ferreira Mauricio LBarreto Jesús PMena-Chalco Regional Board of Brasília Fiocruz Distrito FederalBrazil Department of Informatics Federal University of Maranhão São LuísMABrazil Department of Teaching and Learning Studies Laval UniversityQuébecCanada Center of Integrated Data and Knowledge about Health(CIDACS) SalvadorBrazil Center for Mathematics Computation and CognitionFederal University of ABC Santo AndréSPBrazil

Purpose:This paper aims to test the use of e-Lattes to map the Brazilian scientific output in a recent research health subject:Zika ***/methodology/approach:From a set of Lattes CVs of Zika researchers registered on the Lattes Platform,we used the e-Lattes to map the Brazilian scientific response to the Zika ***:Brazilian science articulated quickly during the public health emergency of international concern(PHEIC)due to the creation of mechanisms to streamline funding of scientific *** limitations:We did not assess any dimension of research quality,including the scientific impact and societal *** implications:e-Lattes can provide useful guidelines for different stakeholders in research groups from Lattes CVs of ***/value:The information included in Lattes CVs permits us to assess science from a broader perspective taking into account not only scientific research production but also the training of human resources and scientific collaboration.

关键词： e-Lattes Zika virus Lattes Platform Brazilian research output Brazilian science

Does landscape context affect pollinationrelated functional diversity and richness of understory flowers in forest fragments of Atlantic Rainforest in southeastern Brazil?

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Ecological Processes 2020年第1期9卷 737-748页

作者： Karoline Baptista de Lima Patrícia Alves ferreira Milton Groppo Renato Goldenberg Emerson ricardo Pansarin Roxana Cardoso Barreto Guilherme Peres Coelho Yago Barros-Souza Danilo Boscolo Biology Department Faculty of PhilosophySciences and LettersUniversity of São PauloRibeirão PretoSP 14040-901Brazil National Institute of Science and Technology in Interdisciplinary and Transdisciplinary Studies in Ecology and Evolution(IN-TREE) SalvadorBrazil Botany Department Biological Science SectorParanáFederal UniversityCuritibaPR 81531-970Brazil Botany Department Biological Science CenterPernambuco Federal UniversityRecifePE 50670-420Brazil Institute of Bioscience Rio Grande do Sul Federal UniversityPorto AlegreRS 90040-060Brazil Botany Department Federal University of São CarlosSão CarlosSP 13565-905Brazil.

Background:How landscape modifications affect functional diversity of floral characteristics pertinent to pollinators is poorly *** possess functional traits that sometimes coevolved with pollinators,crucial for the maintenance of both pollinator and plant *** evaluated how richness and functional diversity of available understory flowers respond to forest cover and landscape heterogeneity in a multiscale *** in bloom were sampled from 25 landscapes in the understory of Atlantic Forest fragments in *** were classified into functional groups regarding flower characteristics relevant to *** heterogeneity and forest cover were measured in buffers ranging from 200 to 2000 m from sampling units and their correlation with plant richness and functional diversity was assessed using generalized linear models and further model selection through Akaike’s second-order information ***:Plants’richness and functional diversity were affected negatively by forest *** former responded to forest cover at a regional scale while the latter responded at a local *** landscape heterogeneity increased richness and functional ***:Our results showed that forest cover and landscape heterogeneity are important to support biodiversity related to pollination,mostly due to the availability of diversified resources and nesting sites associated to different land-uses for pollinators and flowering plant *** findings should highlight,along with forest cover,landscape heterogeneity as an environmental management priority in rural tropical areas for mitigating the loss of plant biodiversity and enhancing ecosystem functioning.

关键词： Functional diversity Pollination Landscape heterogeneity Forest cover Understory plant community