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Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

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Neural Regeneration Research 2024年第5期19卷 935-936页

作者： ricardo Gómez-oliva Pedro Nunez-Abades Carmen Castro Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investigación e Innovación en Biomedicina de Cádiz CadizSpain Departamento de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic *** is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)*** neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the ***,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate *** latter are cells that maintain a proliferative phenotype while in an immature ***,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational Neurodegeneration 2017年第1期6卷 310-323页

作者： Rafael Lazo-gomez ricardo Tapia División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(SIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)into the rat spinal cord *** and resveratrol were co-infused with AMPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AMPA[1 mM]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AMPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective SIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism,and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： Motor neuron disorder Quercetin Resveratrol Sirtuin Excitotoxicity

Another Undiagnosed Pheochromocytoma Causes Hypertensive Crisis in the Operating Room—What about a Rapid Blood Metanephrine Test?

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Open Journal of Anesthesiology 2013年第2期3卷 93-96页

作者： Carrie Rosenberg ricardo gomez Department of Anesthesiology New Mexico Veterans Affairs Health Care System Albuquerque USA

Undiagnosed pheochromocytoma is a cause of hypertension intraoperatively. Hypertension from pheochromocytoma catecholamine secretion is potentially fatal and requires immediate treatment with cardiac afterload reduction and preload augmentation for end-organ protection. Diagnosis and management in the acute period can be complex in the context of co-existing disease, other possible causes of hypertension, and the anesthetized patient who is unable to provide historical clues. This case report highlights the plausibility that pheochromocytomas may be more likely to present sub-clinically in elderly patients with severe vascular disease, so we suggest the potential utility of studying whether reduced vascular responsiveness is protective in any way to catecholamine load. Above all, as an increasing number of case reports of pheochromocytoma discovery intra-operatively emerge, many with catastrophic outcomes, the development value and feasibility of a rapid, on-site blood metanephrine test should be considered. Existing diagnostic methods of pheochromocytoma are relatively time-consuming and not useful in the acute situation.

关键词： Pheochromocytoma Metanephrines Catecholamines Perioperative Hypertension

Engineering Geological Investigations for the Foundations of Large Structures-Examples of a Concrete Dam and a long Bridge in Portugal

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Journal of Mountain Science 2011年第2期8卷 296-306页

作者： ricardo OLIVEIRA COBA and New University of Lisbon Portugal

The safety of large structures requires adequate foundations, which implies a good knowledge of the geological and geotechnical conditions of the respective ground. In general, that is only possible through engineering geological studies which include proper site investigation techniques, adapted to the nature of the ground (rock mass or soil) and to the associated engineering problems. The paper illustrates the studies carried out for the design of the foundations of Ribeiradio 76 m high concrete gravity dam in a difficult rock mass and of Vasco da Gama Bridge, 13 km long, crossing the Tagus River in Lisbon, Portugal, through piles 75 m deep.

关键词： Geological investigation Foundations Concrete dam Bridge

Deduction and Validation of an Eulerian-Eulerian Model for Turbulent Dilute Two-Phase Flows by Means of the Phase Indicator Function-Disperse Elements Probability Density Function

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Chinese Journal of Chemical Engineering 2000年第3期8卷 189-202页

作者： Santiago Laín ricardo Aliod MVT-UST Fachbereich Ingenieurwissenschaften Martin-Luther-UniversitatHalle-WittenbergD-06099Halle(Saale)GermanyFluid Mechanica DepartmentE.U.Politecnica de Huesca.University of ZaragozaCarretera Zaragoza km.6722071 HuescaSpain

A statistical formalism overcoming some conceptual and practical difficulties arising in existing two-phase flow (2PHF) mathematical modelling has been applied to propose a model for dilute 2PHF turbulent Hows. Phase interaction terms with a clear physical meaning enter the equations and the formalism provides some guidelines for the avoidance of closure assumptions or the rational approximation of these terms. Continuous phase averaged continuity, momentum, turbulent kinetic energy and turbulence dissipation rate equations have been rigorously and systematically obtained in a single step. These equations display a structure similar to that for single-phase flows. It is also assumed that dispersed phase dynamics is well described by a probability density function (pdf) equation and Eulerian continuity, momentum and fluctuating kinetic energy equations for the dispersed phase are deduced. An extension of the standard k-e turbulence model for the continuous phase is used. A gradient transport model is adopted for the dispersed phase fluctuating fluxes of momentum and kinetic energy at the non-colliding, large inertia limit. This model is then used to predict the behaviour of three axisymmetric turbulent jets of air laden with solid particles varying in size and concentration. Qualitative and quantitative numerical predictions compare reasonably well with the three different sets of experimental results, studying the influence of particle size, loading ratio and flow confinement velocity.

关键词： two-phase flow turbulence phase indicator function pdf ensemble average jet

Review of the El Soplao Amber Outcrop,Early Cretaceous of Cantabria,Spain

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 959-976页

作者： María NAJARRO Enrique PENALVER ricardo PEREZ-DE LA FUENTE Jaime ORTEGA-BLANCO Cesar MENOR-SALVAN Eduardo BARRON Carmen SORIANO Idoia ROSALES Rafael LOPEZ DEL VALLE Francisco VELASCO Fernando TORNOS Véronique DAVIERO-gomez Bernard gomez Xavier DELCLOS Instituto Geologico y Minero de Espana E-28003MadridSpain Departament d'Estratigrafia Paleontologia i Geociencies MarinesFacultat de GeologiaUniversitat de BarcelonaE-08071BarcelonaSpain Centro de Astrobiologia(CSIC-INTA) E-28850Torrejon de ArdozSpain European Synchrotron Radiation Facilities F-38000 GrenobleFrance/Geosciences Rennes-Universite de Rennes 1F-35042 RennesFrance El Soplao S.L. Prao El CollaoE-39553CantabriaSpain Universidad del Pais Vasco Dpto.Mineralogia y PetrologiaE-48080 BilbaoSpain CNRS-UMR 5125 PEPS Universite Lyon 1GeodeF-69622 VilleurbanneFrance

El Soplao outcrop, an Early Cretaceous amber deposit recently discovered in northern Spain （Cantabria）, has been shown to be the largest site of amber with arthropod inclusions that has been found in Spain so far. Relevant data provided herein for biogeochemistry of the amber, palynology, taphonomy and arthropod bioinclusions complement those previously published. This set of data suggests at least two botanical sources for the amber of El Soplao deposit. The first （type A amber） strongly supports a source related to Cheirolepidiaceae, and the second （type B amber） shows non-specific conifer biomarkers. Comparison of molecular composition of type A amber with Frenelopsis leaves （Cheirolepidiaceae） strongly suggests a biochemical affinity and a common botanical origin. A preliminary palynological study indicates a regional high taxonomical diversity, mainly of pteridophyte spores and gymnosperm pollen grains. According to the preliminary palynological data, the region was inhabited by conifer forests adapted to a dry season under a subtropical climate. The abundant charcoalified wood associated with the amber in the same beds is evidence of paleofires that most likely promoted both the resin production and an intensive erosion of the litter, and subsequent great accumulation of amber plus plant cuticles. In addition, for the first time in the fossil record, charcoalified plant fibers as bioinclnsions in amber are reported. Other relevant taphonomic data are the exceptional presence of serpulids and bryozoans on the surfaces of some amber pieces indicating both a long exposure on marine or brackish-water and a mixed assemblage of amber. Lastly, new findings of insect bioiuclusions, some of them uncommon in the fossil record or showing remarkable adaptations, are reported. In conclusion, a documented scenario for the origin of the El Soplao amber outcrop is provided.

关键词： fossil resin chemotaxonomy paleobotany charcoal arthropod bioinclusions taphonomy EarlyAlbian

Synthesis identification analysis for closed loop system

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Journal of Systems Engineering and Electronics 2021年第4期32卷 939-946页

作者： WANG Jianhong ricardo A.Ramirez-Mendoza School of Electronic Engineering and Automation Jiangxi University of Science and TechnologyGanzhou 343100China School of Engineering and Sciences Tecnologico de MonterreyMonterrey 64849Mexico

The existing theories for closed loop identification with the linear feedback controller are very *** apply the existed theories directly in the control field,we propose a new idea about replacing the original unknown and nonlinear feedback controller with one approximated linear controller,while guaranteeing the equivalent property for the obtained closed loop *** on some statistical correlation functions,one condition is derived to show the equivalent property between the approximated linear controller and the original nonlinear *** detailed explicit form,corresponding to the approximated linear controller,is also ***,to give a complete analysis for closed loop identification,the cost function is rewritten as one extended expression,being convenient to *** spectral estimation is introduced to identify the unknown plant in the closed loop ***,the proposed theories are verified by one simulation example.

关键词： synthesis analysis closed loop system simplified function equivalent controller

Comprehensive Euler/Lagrange modelling including particle erosion for confined gas-solid flows

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Particuology 2024年第1期84卷 209-235页

作者： Guiherme A.Novelletto ricardo Martin Sommerfeld Multiphase Flow Systems Institute of Process EngineeringOtto-von-Guericke-University MagdeburgHoher Weg 7b06120Halle(Saale)Germany

The present research aims to assess the capability of a comprehensive Euler/Lagrange approach for predicting gas-solid flows and the associated solid particle *** open-source code OpenFOAM®4.1 was used to carry out the numerical simulations,where the standard Lagrangian libraries were substantially extended to account for all necessary *** are tracked considering both translational and rotational motion as well as all relevant forces,such as gravity/buoyancy,drag and transverse lift due to shear and particle *** tracking time step was dynamically adapted ac-cording to the locally relevant time scales,which drastically reduces computational *** approaches are adopted to model particle turbulent dispersion,particle collisions with rough walls and particle-particle *** solid particle erosion models,available in the literature,were considered to estimate pipe bend *** study cases are provided to validate the adopted nu-merical approach and erosion models *** first case intends to evaluate the ability of the extended CFD code to predict the behaviour of gas-solid flows in pneumatic conveying *** goal is achieved by comparing the numerical results with the experimental data obtained by Huber(1997)and Huber and Sommerfeld(1994,1998)in a pneumatic conveying ***,the importance of considering inter-particle collisions and surface roughness for predicting particle velocity,mass flux and mean diameter distributions in gas-solid flows is *** second and third case intend to evaluate the ability of the erosion models in estimating bend erosion in diluted gas-solid *** erosion data obtained experimentally by Mazumder et al.(2008)and Solnordal et al.(2015)in very dilut pneumatic conveying systems is used for validating the numerical results,neglecting now inter-particle collisions and two-way *** a comprehensive analysis of the different influential properti

关键词： Pneumatic conveying Pipe bend Numerical calculation(CFD) Euler/Lagrange approach Erosion models Wall roughness

A comprehensive review on biomarkers associated with painful temporomandibular disorders

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International Journal of Oral Science 2021年第3期13卷 230-242页

作者： Mayank Shrivastava ricardo Battaglino Liang Ye Department of Diagnostic and Biological Sciences School of DentistryUniversity of MinnesotaMinneapolisMNUSA Department of Rehabilitation Medicine Medical SchoolUniversity of MinnesotaMinneapolisMNUSA

Pain of the orofacial region is the primary complaint for which patients seek *** all the orofacial pain conditions,one condition that possess a significant global health problem is temporomandibular disorder(TMD).Patients with TMD typically frequently complaints of pain as a *** can occur due to complex interplay between peripheral and central sensitization,endogenous modulatory pathways,and cortical *** diagnosis of TMD pain a descriptive history,clinical assessment,and imaging is ***,due to the complex nature of pain an additional step is needed to render a definitive TMD *** this review we explicate the role of different biomarkers involved in painful *** painful TMD conditions,the role of biomarkers is still *** believe that the identification of biomarkers associated with painful TMD may stimulate researchers and clinician to understand the mechanism underlying the pathogenesis of TMD and help them in developing newer methods for the diagnosis and management of ***,to understand the potential relationship of biomarkers,and painful TMD we categorize the biomarkers as molecular biomarkers,neuroimaging biomarkers and sensory *** addition,we will briefly discuss pain genetics and the role of potential microRNA(miRNA)involved in TMD pain.

关键词： diagnosis endogenous facial