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PIEZO1 channels in cutaneous free nerve endings:novel insights into itch-scratch-mechanisms

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Signal Transduction and Targeted Therapy 2023年第2期8卷 319-320页

作者： Manuel Pedro pereira Henning Wiegmann Sonja Ständer Department of Dermatology and Center for Chronic Pruritus University Hospital Münster48149MünsterGermany

A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive ***,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP... 详细信息

关键词： ZO1 insight scratch

Evaluation of the Genotoxicity of Polymeric Microparticles Containing Ametryn Herbicide

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Journal of Environmental Science and Engineering(A) 2012年第4期1卷 553-565页

作者： Renata de Lima Leandro O. Feitosa renato Grillo Anderson E.S. pereira Leonardo FernandesFraceto Department of Biotechnology University of Sorocaba Sorocaba 18023-000 Brazil Federal University of Sao Carlos Sorocaba 18052-780 Brazil Department of Environmental Engineering UNESP-Univ. Estadual Paulista Sorocaba 18087-180 Brazil Department of Biochemistry Institute of Biology UNICAMP Campinas 18083-862 Brazil

Agrochemicals have been used throughout the ages to eradicate weeds and pests. Use of agrochemicals is now commonplace, serving as an aid in farming procedures and contributing to greater agricultural production. However, the indiscriminate use of agrochemicals is a cause for concern because they can exert toxic effects on the environment and hence on living beings. This work involved a genotoxic analysis of controlled release formulations of the herbicide ametryn encapsulated in microspheres of poly（hydroxybutyrate） and poly（hydroxybutyrate-co^valerate）. Genotoxicity was analyzed using cytogenetic, micronucleus, comet and Allium cepa assays, as well as molecular analysis. The results showed that the rate of chromosome breakdown caused by unencapsulated ametryn was much higher than that caused by ametryn encapsulated in the polymer microspheres （p 〈 0.05）. This indicates that controlled release delivery systems employing the polymer formulations should be significantly safer for the environment and for living beings.

关键词： Ametryn controlled release environmental chemistry genotoxicity.

Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Implications for preclinical testing

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Cellular & Molecular Immunology 2023年第11期20卷 1328-1338页

作者： Tertuliano Alves pereira Neto John Sidney Alba Grifoni Alessandro Sette Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology(LJI)La JollaCA92037USA Department of Medicine Division of Infectious Diseases and Global Public HealthUniversity of CaliforniaSan DiegoLa JollaCA92037USA

Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex(MHC)molecules,and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccine testing are yet to be fully *** this study,we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase(IEDB)*** first analyzed SARS-CoV-2 spike(S)and nucleoprotein(N),which are two common targets of the immune response and well studied in both human and mouse *** observed a weak but statistically significant correlation between human and H-2^(b)mouse T-cell responses(CD8 S specific(r=0.206,p=1.37×10^(−13));CD4 S specific(r=0.118,p=2.63×10^(−5))and N specific(r=0.179,p=2.55×10^(−4))).Due to intrinsic differences in MHC molecules across species,we also investigated the association between the immunodominance of common Human Leukocyte Antigen(HLA)alleles for which HLA transgenic mice are available,namely,A*02:01,B*07:02,DRB1*01:01,and DRB1*04:01,and found higher significant correlations for both CD8 and CD4(maximum r=0.702,p=1.36×10^(−31)and r=0.594,p=3.04−122,respectively).Our results further indicated that some regions are commonly immunogenic between humans and mice(either H-2^(b)or HLA transgenic)but that others are human ***,we noted a significant correlation between CD8 and CD4 S-(r=0.258,p=7.33×10^(21))and N-specific(r=0.369,p=2.43×10^(14))responses,suggesting that discrete protein subregions can be simultaneously recognized by T *** findings were confirmed in other viral systems,providing general guidance for the use of murine models to test T-cell immunogenicity of viral antigens destined for human use.

关键词： T cells SARS-CoV-2 Vaccine Animal testing HLA

Quantitative hazard assessment system(Has-Q) for open pit mine slopes

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International Journal of Mining Science and Technology 2019年第3期29卷 419-427页

作者： Tatiana Barreto dos Santos Milene Sabino Lana Tiago Martins pereira Ismet Canbulat Mining Engineering Department Universidade Estadual de Minas GeraisJoao Monlevade 35930314Brazil Mining Engineering Department Universidade Federal de Ouro PretoOuro Preto 35400000Brazil Statistical Department Universidade Federal de Ouro PretoOuro Preto 35400000Brazil School of Minerals and Energy Resources Engineering University of New South WalesSydneyNSW 2052Australia

Rock slope hazard assessment is an important part of risk analysis for open pit *** main parameters that can lead to rock slope failures are the parameters traditionally used in geomechanical classifications,the slope geometrical parameters and external factors like rainfall and *** paper presents a methodology for a hazard assessment system for open pit mine slopes based on 88 cases collated around the world using principal components analysis,discriminant analysis and confidence *** historical cases used in this study included copper,gold,iron,diamond,lead and zinc,platinum and claystone *** variables used in the assessment methodology are uniaxial compressive strength of intact rock;spacing,persistence,opening,roughness,infilling and orientation of the main discontinuity set;weathering of the rock mass;groundwater;blasting method;and height and inclination of the *** principal component analysis was used to quantify the data,the discriminant analysis was used to establish a rule to classify new slopes about its stability *** provide a practical hazard assessment system,confidence ellipses were used to propose a hazard graph and generate the *** discriminant rule developed in this research has a high discrimination capacity with an error rate of 11.36%.

关键词： Hazard assessment Risk analysis Open pit mine slopes Multivariate statistics

Quantification of displacement and particle crushing around a penetrometer tip

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Geoscience Frontiers 2020年第2期11卷 389-399页

作者： Eshan Ganju Fei Han Monica Prezzi Rodrigo Salgado Juliana Spohr pereira Lyles School of Civil Engineering Purdue University

Particle crushing occurs near the tip of a penetrometer and influences the development of the tip *** study particle crushing near a penetrometer tip,a cone penetrometer was monotonically jacked and then load-tested in medium dense and dense silica sand samples prepared in a halfcylindrical calibration chamber with viewing *** the tests,images of the advancing penetrometer and the surrounding soil were taken using digital cameras and analyzed to obtain the displacement and strain fields around the penetrometer using the Digital Image Correlation(DIC)***,soil samples were collected near the tip of the penetrometer using a novel agarimpregnation technique and digitized using an X-ray *** digitized samples were analyzed to reconstruct the three-dimensional models of individual particles,generating the gradation and relative breakage parameters of the sand around the cone penetrometer.

关键词： Crushing DIC Penetrometer X-ray CT

Delineation of sensitive coastal zone of northern Ramanathapuram coast,Tamilnadu,India,using a GIS approach

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Geodesy and Geodynamics 2022年第5期13卷 456-463页

作者： Gurugnanam Balasubramanian Sreechitra Suresh Santonu Goswami Bairavi Swaminathan Glitson Francis pereira Centre for Applied Geology The Gandhigram Rural Institute-Deemed to Be UniversityDindigulTamil NaduIndia National Remote Sensing Centre India

This research aims to assess the sensitive coastal zones by analyzing the shoreline changes such as accretion and erosion in the eastern coastal part of Ramanathapuram District,Tamil Nadu,*** study focused on Mandapam,Pirappanvalsai,Enmanamcondam,Nagachi,Terbogi,Athyuthu,Chitrakkottai,Pathengal,Attangarai,Alagankulam,and Devipattinam *** of these areas are distinguished as highly sensitive ecological *** erosion of an area leads to irreplaceable disturbances to ***,erosion and accretion studies are top priorities when studying the coastal *** addition to GIS technology,which has been widely used in the past 20 years,the End Point Rate(EPR)and Linear Regression Rate(LRR)analyses were conducted to better understand the shoreline *** stability of the coastal region was analyzed by observing the slope variations of the beach during the profile *** the study,we analyzed that the Quaternary deposits of sand are the dominant geological feature of the study *** reefs and salt pans are highly distributed along the coastal *** coast of Mandapam village has been detected as a highly sensitive region,with an average erosion rate of-3.1 m/yr and an average accretion rate of 1.22 m/yr,resulting in high erosion and low *** coast is a steep coast with an average slope angle of 0.24°.This study provides insight into sustainable coastal zone management.

关键词： End point rate Linear regression rate Geographic information system Beach profile Ramanathapuram

An illustrated checklist of macrofaunal molluscs from soft-sediments of the Abrolhos Parcel(northeastern,Brazil)with 15 new records

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Journal of Oceanology and Limnology 2021年第2期39卷 671-682页

作者： Flávia Maria pereira da COSTA Ana Maria Setubal PIRES-VANIN Departamento de Oceanografi a Biológica Instituto Oceanográfi coUniversidade de São PauloSão Paulo 05508-120Brazil

Comprehensive understanding of marine biodiversity is essential for conservation,especially for vulnerable *** this paper,we implemented and illustrated a checklist of molluscs from the Abrolhos Parcel,Brazil,the most important coralline area in South Atlantic *** list features 100 species belonging to 4 classes and 85 genera,of which 15 are new records for Bahia State,northeast *** results highlight the potential for new records in the *** species came from 54 unconsolidated sediment samples collected from the bottom of the reef with a 0.042-m^(2) van Veen *** the listed species,Curveulima sp.,Notarchus *** Guyanella clenchi are new records for the South Atlantic,while Caecum metamorphosicum,Eratoidea janeiroensis,Volvarina serrei,Solemya notialis,Solariorbis shimeri,and Amphithalamus glabrus are endemic to Brazilian waters.A comparison of our results with those obtained in other reef environments indicates that the Abrolhos Parcel has a rich malacofauna and suggests that many more species can still be found with more samplings.

关键词： Bivalvia Gastropoda micromolluscs Scaphopoda Solenogastres southwest Atlantic

Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo Antonio Marenco Saul Alfredo Antezana-Vera Daniela pereira Dias Luiz Antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

To supervise or to self‑supervise:a machine learning based comparison on credit supervision

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Financial Innovation 2021年第1期7卷 562-582页

作者： JoséAmérico pereira Antunes Central Bank of Brazil Av Presidente Vargas730Rio de Janeiro 20231‑044Brazil

This study investigates the need for credit supervision as conducted by on-site banking *** builds on a real bank on-site credit examination to compare the performance of a hypothetical self-supervision approach,in which banks themselves assess their loan portfolios without external intervention,with the on-site banking supervision approach of the Central Bank of *** experiment develops two machine learning classification models:the first model is based on good and bad ratings informed by banks,and the second model is based on past on-site credit portfolio examinations conducted by banking *** findings show that the overall performance of the on-site supervision approach is consistently higher than the performance of the self-supervision approach,justifying the need for on-site credit portfolio examination as conducted by the Central Bank.

关键词： Bank supervision Machine learning Loan loss provisions On-site credit supervision