PIEZO1 channels in cutaneous free nerve endings:novel insights into itch-scratch-mechanisms

作     者：Manuel Pedro Pereira Henning Wiegmann Sonja Ständer Manuel Pedro Pereira;Henning Wiegmann;Sonja Ständer

作者机构：Department of Dermatology and Center for Chronic PruritusUniversity Hospital Münster48149MünsterGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第2期

页      面：319-320页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：Open Access funding enabled and organized by Projekt DEAL 

主　　题：ZO1 insight scratch 

摘      要：A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive ***,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP)*** is defined as an unpleasant sensation leading to the desire to scratch.