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Abnormal volumetric brain morphometry and cerebral blood flow in adolescents with depression

World Journal of Psychiatry 2023年第6期13卷 386-396页

作者： yu-Jia Fu Xiao Liu Xing-yu Wang Xiao Li Lin-Qi Dai Wen-yu ren Yong-Ming Zeng Zhen-Lin Li ren-qiang yu Department of Radiology the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychiatry the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Radiology Chongqing HongRen Yi HospitalChongqing 408400China Department of Radiology West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Prior research has demonstrated that the brains of adolescents with depression exhibit distinct structural ***,preliminary studies have documented the pathophysiological changes in certain brain regions,such as the cerebellum,highlighting a need for further research to support the current understanding of this *** To study brain changes in depressed *** This study enrolled 34 adolescents with depression and 34 age-,sex-,and education-level-matched healthy control(HC)*** and functional alterations were identified when comparing the brains of these two participant groups through voxel-based morphometry and cerebral blood flow(CBF)analysis,*** between identified brain alterations and the severity of depressive symptoms were explored through Pearson correlation *** The cerebellum,superior frontal gyrus,cingulate gyrus,pallidum,middle frontal gyrus,angular gyrus,thalamus,precentral gyrus,inferior temporal gyrus,superior temporal gyrus,inferior frontal gyrus,and supplementary motor areas of adolescents with depression showed an increase in brain volume compared to HC *** patients with depression further presented with a pronounced drop in CBF in the left pallidum(group=98,and peak t=-4.4324),together with increased CBF in the right percental gyrus(PerCG)(group=90,and peak t=4.5382).In addition,17-item Hamilton Depression Rating Scale scores were significantly correlated with the increased volume in the opercular portion of the left inferior frontal gyrus(r=-0.5231,P<0.01).CONCLUSION The right PerCG showed structural and CBF changes,indicating that research on this part of the brain could offer insight into the pathophysiological causes of impaired cognition.

关键词： Voxel-based morphometry Cerebral blood flow Arterial spin labeling Adolescent Depression The right percental gyrus

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Resting-state functional magnetic resonance imaging and support vector machines for the diagnosis of major depressive disorder in adolescents

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World Journal of Psychiatry 2024年第11期14卷 1696-1707页

作者： Zhi-Hui yu ren-qiang yu Xing-yu Wang Wen-yu ren Xiao-Qin Zhang Wei Wu Xiao Li Lin-Qi Dai Ya-Lan Lv Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China School of Medical Informatics Chongqing Medical UniversityChongqing 400016China

BACKGROUND Research has found that the amygdala plays a significant role in underlying pathology of major depressive disorder(MDD).However,few studies have explored machine learning-assisted diagnostic biomarkers based on amygdala functional connectivity(FC).AIM To investigate the analysis of neuroimaging biomarkers as a streamlined approach for the diagnosis of MDD in *** Forty-four adolescents diagnosed with MDD and 43 healthy controls were enrolled in the *** resting-state functional magnetic resonance imaging,the FC was compared between the adolescents with MDD and the healthy controls,with the bilateral amygdala serving as the seed point,followed by statistical analysis of the *** support vector machine(SVM)method was then applied to classify functional connections in various brain regions and to evaluate the neurophysiological characteristics associated with *** Compared to the controls and using the bilateral amygdala as the region of interest,patients with MDD showed significantly lower FC values in the left inferior temporal gyrus,bilateral calcarine,right lingual gyrus,and left superior occipital ***,there was an increase in the FC value in *** SVM analysis revealed that the reduction in the FC value in the right lingual gyrus could effectively differentiate patients with MDD from healthy controls,achieving a diagnostic accuracy of 83.91%,sensitivity of 79.55%,specificity of 88.37%,and an area under the curve of 67.65%.CONCLUSION The results showed that an abnormal FC value in the right lingual gyrus was effective as a neuroimaging biomarker to distinguish patients with MDD from healthy controls.

关键词： Major depressive disorder Adolescent Support vector machine Machine learning Resting-state functional magnetic resonance imaging Neuroimaging Biomarker

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Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora

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World Journal of Gastroenterology 2017年第44期23卷 7830-7839页

作者： Ce Qi Ya Li ren-qiang yu Sheng-Li Zhou Xing-Guo Wang Guo-Wei Le Qing-Zhe Jin Hang Xiao Jin Sun The Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan University School of Food Science and Technology Jiangnan University Wuxi Maternal and Child Health Hospital Quality of Research and Development Department COFCO Fortune Food Sales&Distribution Co.Ltd. Department of Food Science University of Massachusetts 不详

AIM To demonstrate that specific bacteria might release bacterial extracellular DNA(e DNA) to exert immunomodulatory functions in the mouse small *** Extracellular DNA was extracted using phosphate buffered saline with 0.5 mmol/L dithiothreitol combined with two phenol extractions. TOTO-1 iodide, a cell-impermeant and high-affinity nucleic acid stain, was used to confirm the existence of e DNA in the mucus layers of the small intestineand colon in healthy Male C57 BL/6 mice. Composition difference of e DNA and intracellular DNA(i DNA) of the small intestinal mucus was studied by Illumina sequencing and terminal restriction fragment length polymorphism(T-RFLP). Stimulation of cytokine production by e DNA was studied in RAW264.7 cells in *** TOTO-1 iodide staining confirmed existence of e DNA in loose mucus layer of the mouse colon and thin surface mucus layer of the small intestine. Illumina sequencing analysis and T-RFLP revealed that the composition of the e DNA in the small intestinal mucus was significantly different from that of the i DNA of the small intestinal mucus bacteria. Illumina Miseq sequencing showed that the e DNA sequences came mainly from Gram-negative bacteria of Bacteroidales S24-7. By contrast, predominant bacteria of the small intestinal flora comprised Grampositive bacteria. Both e DNA and i DNA were added to native or lipopolysaccharide-stimulated Raw267.4 macrophages, respectively. The e DNA induced significantly lower tumor necrosis factor-α/interleukin-10(IL-10) and IL-6/IL-10 ratios than i DNA, suggesting the predominance for maintaining immune homeostasis of the *** Our results indicated that degraded bacterial genomic DNA was mainly released by Gram-negative bacteria, especially Bacteroidales-S24-7 and Stenotrophomonas genus in gut mucus of mice. They decreased pro-inflammatory activity compared to total gut flora genomic DNA.

关键词： Bacterial extracellular DNA Flora Immunestimulatory property Gut microbiota Mouse Small intestine

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Antidepressants combined with psychodrama improve the coping style and cognitive control network in patients with childhood trauma-associated major depressive disorder

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World Journal of Psychiatry 2022年第8期12卷 1016-1030页

作者： ren-qiang yu Huan Tan Er-Dong Wang Jie Huang Pei-Jia Wang Xiao-Mei Li Han-Han Zheng Fa-Jin Lv Hua Hu Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China College of Art Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 40016China

BACKGROUND The use of antidepressant therapy alone has a limited efficacy in patients with childhood trauma-associated major depressive disorder(MDD).However,the effectiveness of antidepressant treatment combined with psychodrama in these patients is *** To evaluate the effectiveness of antidepressant treatment combined with *** Patients with childhood trauma-associated MDD treated with antidepressants were randomly assigned to either the psychodrama intervention(observation group)or the general health education intervention(control group)and received combination treatment for 6 *** observation group received general health education given by the investigator together with the“semi-structured group intervention model”of Yi Shu psychodrama.A total of 46 patients were recruited,including 29 cases in the observation group and 17 cases in the control *** of depression and anxiety as well as coping style and resting-state functional magnetic resonance imaging were assessed before and after the *** Symptoms of depression and anxiety,measured by the Hamilton Depression Scale,Beck Depression Inventory,and Beck Anxiety Inventory,were reduced after the intervention in both groups of *** coping style of the observation group improved significantly in contrast to the control group,which did *** addition,an interaction between treatment and time in the right superior parietal gyrus node was ***,functional connectivity between the right superior parietal gyrus and left inferior frontal gyrus in the observation group increased after the intervention,while in the control group the connectivity *** This study supports the use of combined treatment with antidepressants and psychodrama to improve the coping style of patients with childhood trauma-associated *** connectivity between the superior parietal gyrus and inferior frontal gyrus was increased after this combined treatmen

关键词： Major depressive disorder Childhood trauma Yi Shu psychodrama Cognitive control network Coping style

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神经元电生理模型的建模方法

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中国生物医学工程学报 2011年第5期30卷 787-795页

作者：任玉强柴新禹任秋实李丽明上海交通大学生物医学工程学院上海200240 北京大学工学院生物医学工程系北京100871

建立神经元电生理模型是神经科学研究中的一个重要组成部分。神经元电生理模型是从已知的生物物理学数据出发模拟神经元的结构及功能,研究神经元的电生理学特性及信息编码功能。文中对从单个神经元建模到神经元网络建模的方法进行了介绍... 详细信息

建立神经元电生理模型是神经科学研究中的一个重要组成部分。神经元电生理模型是从已知的生物物理学数据出发模拟神经元的结构及功能,研究神经元的电生理学特性及信息编码功能。文中对从单个神经元建模到神经元网络建模的方法进行了介绍,并讨论了相关方法的研究进展以及常用建模工具。

关键词：神经元电生理模型建模方法建模工具

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian yu Jane Howe Kaiwen Chen Ning Yan Hao ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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浅析中国诗与中国画评价标准分歧的原因

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和田师范专科学校学报 2006年第1期26卷 116-117页

作者：任玉强西南师范大学中国新诗研究所重庆400715

中国传统诗歌与中国传统绘画的评价标准存在分歧,本文试图从三个方面来分析造成这一分歧的原因。一是诗与画功能上的不同;二是中国传统文化的制约;三是主体需求的影响。

关键词：中国诗中国画南宗北宗

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对当前“先锋口语诗”的反思

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涪陵师范学院学报 2006年第3期22卷 118-121页

作者：任玉强西南大学中国新诗研究所重庆400715

中国当代诗坛存在的“先锋口语诗”在诗歌语言的选择和运用上具有散漫无际和口语化的特征,这使得诗失去了应有的内涵与韵味,同时又背离了现代汉语的本质特征,从而导致了诗意的缺失。

关键词：先锋口语诗现代汉语背离反思

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宗白华、闻一多新诗“绘画美”理论的比较分析

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太原大学学报 2006年第3期7卷 12-13,36页

作者：任玉强西南大学中国新诗研究所重庆400715

二十世纪二十年代,针对中国新诗如何创作问题,宗白华和闻一多先后提出了新诗“绘画美”理论。虽然两者有着明显的继承关系,但不同也是显而易见的。二者的不同主要表现在理论渊源的不同、由本体向主体的转变、以及思维方式的不同等三个... 详细信息

二十世纪二十年代,针对中国新诗如何创作问题,宗白华和闻一多先后提出了新诗“绘画美”理论。虽然两者有着明显的继承关系,但不同也是显而易见的。二者的不同主要表现在理论渊源的不同、由本体向主体的转变、以及思维方式的不同等三个方面。

关键词：宗白华闻一多绘画美

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

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