Abnormal volumetric brain morphometry and cerebral blood flow in adolescents with depression
作者机构：Department of Radiologythe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychiatrythe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of RadiologyChongqing HongRen Yi HospitalChongqing 408400China Department of RadiologyWest China HospitalChengdu 610041Sichuan ProvinceChina
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2023年第13卷第6期
页 面：386-396页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：Supported by The Project of Scientific Research and Innovative Experiment for College Students in Chongqing Medical University,No.202215 the Provincial Project of University Students Innovation and Entrepreneurship Training Program,No.202210631015
主 题：Voxel-based morphometry Cerebral blood flow Arterial spin labeling Adolescent Depression The right percental gyrus
摘 要：BACKGROUND Prior research has demonstrated that the brains of adolescents with depression exhibit distinct structural ***,preliminary studies have documented the pathophysiological changes in certain brain regions,such as the cerebellum,highlighting a need for further research to support the current understanding of this *** To study brain changes in depressed *** This study enrolled 34 adolescents with depression and 34 age-,sex-,and education-level-matched healthy control(HC)*** and functional alterations were identified when comparing the brains of these two participant groups through voxel-based morphometry and cerebral blood flow(CBF)analysis,*** between identified brain alterations and the severity of depressive symptoms were explored through Pearson correlation *** The cerebellum,superior frontal gyrus,cingulate gyrus,pallidum,middle frontal gyrus,angular gyrus,thalamus,precentral gyrus,inferior temporal gyrus,superior temporal gyrus,inferior frontal gyrus,and supplementary motor areas of adolescents with depression showed an increase in brain volume compared to HC *** patients with depression further presented with a pronounced drop in CBF in the left pallidum(group=98,and peak t=-4.4324),together with increased CBF in the right percental gyrus(PerCG)(group=90,and peak t=4.5382).In addition,17-item Hamilton Depression Rating Scale scores were significantly correlated with the increased volume in the opercular portion of the left inferior frontal gyrus(r=-0.5231,P0.01).CONCLUSION The right PerCG showed structural and CBF changes,indicating that research on this part of the brain could offer insight into the pathophysiological causes of impaired cognition.
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