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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： xiang ren tan Mary C.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee Ivan C.C.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance Centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore Campus for Research Excellence and Technological Enterprise(CREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity Cognition Heat stress Hyperthermia Motor function

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge Wen-Ying Zhuang Gang Hu ren xiang tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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解密baccatin Ⅲ生物合成途径,奠定紫衫烷可持续获取途径

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Science Bulletin 2024年第9期69卷 1182-1184页

作者：谭仁祥陈晓亚 State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

The characterization and reconstitution of Taxus enzymes leading to taxoids (diterpenoids with the taxane skeleton seen in the taxol molecule)[1–5] are exciting and may tempt researchers to update the episode about t... 详细信息

关键词： prescribed skeleton baccatin

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Post-ingestion conversion of dietary indoles into anticancer agents

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National Science Review 2022年第4期9卷 128-138页

作者： Li Ping Lin Dan Liu Jia Cheng Qian Liang Wu Quan Zhao ren xiang tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing University State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine

There are health benefits from consuming cruciferous vegetables that release indole-3-carbinol(I3 C), but the in vivo transformation of I3 C-related indoles remains underinvestigated. Here we detail the post-ingestion conversion of I3 C into antitumor agents, 2-(indol-3-ylmethyl)-3,3′-diindolylmethane(LTr1) and 3,3′-diindolylmethane(DIM), by conceptualizing and materializing the reaction flux derailing(RFD) approach as a means of unraveling these stepwise transformations to be non-enzymatic but p H-dependent and gut microbe-sensitive. In the upper(or acidic) gastrointestinal tract, LTr1 is generated through Michael addition of 3-methyleneindolium(3 MI, derived in situ from I3 C) to DIM produced from I3 C via the formaldehyde-releasing(major) and CO-liberating(minor) pathways. In the large intestine,‘endogenous’ I3 C and DIM can form, respectively, from couplings of formaldehyde with one and two molecules of indole(a tryptophan catabolite). Acid-producing gut bacteria such as Lactobacillus acidophilus facilitate the H+-promotable steps. This work updates our understanding of the merits of I3 C consumption and identifies LTr1 as a drug candidate.

关键词： indole-3-carbinol reaction flux derailing (RFD) approach 2-(indol-3-ylmethyl)-3 3′-diindolylmethane (LTr1) anticancer Lactobacillus acidophilus

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Carbon-nitrogen bond formation to construct novel polyketide-indole hybrids from the indole-3-carbinol exposed culture of Daldinia eschscholzii

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Synthetic and Systems Biotechnology 2022年第2期7卷 750-755页

作者： Li Ping Lin Min Wu Nan Jiang Wei Wang ren xiang tan State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing210023China State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing210023China Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing211166China Key Laboratory of Marine Drugs Ministry of EducationOcean University of ChinaQingdao266003China

A plenty of cytochrome P450s have been annotated in the Daldinia eschosholzii *** by the fact that some P450s have been reported to catalyze the carbon-nitrogen(C-N)bond formation,we were curious about whether hybrids through C-N bond formation could be generated in the indole-3-carbinol(I3C)exposed culture of *** expected,two skeletally undescribed polyketide-indole hybrids,designated as indolpolyketone A and B(1 and 2),were isolated and assigned to be constructed through C-N bond *** structures were elucidated by 1D and 2D NMR *** absolute configurations of 1 and 2 were determined by comparing the recorded and calculated electronic circular dichroism(ECD)***,the plausible biosynthetic pathways for 1 and 2 were *** 1 and 2 exhibited significant antiviral activity against H1N1 with IC_(50) values of 45.2 and 31.4μM,*** brief,compounds 1 and 2 were reported here for the first time and were the first example of polyketide-indole hybrids pieced together through C-N bond formation in the I3C-exposed culture of ***,this study expands the knowledge about the chemical production of *** through precursor-directed biosynthesis(PDB).

关键词： Polyketide-indole hybrids Daldinia eschosholzii Indole-3-carbinol C-N bond formation P450 Precursor-directed biosynthesis

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Discovery of daspyromycins A and B,2-aminovinyl-cysteine containing lanthipeptides,through a genomics-based approach

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Chinese Chemical Letters 2022年第1期33卷 511-515页

作者： Jing Shi Jia-Qi Ma Yong-Chao Wang Zi-Fei Xu Bo Zhang Rui-Hua Jiao ren-xiang tan Hui-Ming Ge State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China Chemistry and Biomedicine Innovation Center(ChemBIC) Nanjing UniversityNanjing 210023China

Lanthipeptides are one of the largest groups of ribosomally synthesized and post-translationally modified peptides(RiPPs)and are characterized by the presence of lanthionine(Lan)or methyllanthionine residues(MeLan).Only very few lanthipeptides contain a C-terminal 2-aminovinyl-cysteine(AviCys)motif,but all of them show potent antibacterial *** advances of genome sequencing led to the rapid accumulation of new biosynthetic gene clusters(BGCs)for *** this study,through our genome mining strategy,we found the AviCys containing lanthipeptides are widespread in the bacterial kingdom.A lanthipeptide-type biosynthetic gene cluster was identified from public bacterial genome *** new lanthipeptides,daspyromycins A and B(1 and 2)containing AviCys motif,along with two degraded products,daspyromycins C and D(3 and 4),were obtained after heterologous expression of the gene cluster in Streptomyces albus *** A and B showed potent antimicrobial activity against a spectrum of Gram-positive and-negative bacteria including methicillin-resistant Staphylococcus aureus(MRSA)and vancomycin-resistant Enterococci(VRE).

关键词： Lanthipeptides Genomics-based approach Daspyromycin RiPPs 2-Aminovinyl-cysteine motif

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Bioactive Alkaloids from Indole-3-carbinol Exposed Culture of Daldinia eschscholzii

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Chinese Journal of Chemistry 2018年第8期36卷 749-753页

作者： Li Ping Lina ren xiang tan State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese Medicine Nanjing Jiangsu 210023 China Institute of Functional Biomolecules State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Nanjing Jiangsu 210023 China

Two new and rare bioactive indoles named dalesindoloids A （1） and B （3）, along with 3-（1H-indole-3ylmethyl）-2-oxindole （2）, were characterized from the indole-3-carbinot （13C）-exposed culture of Daldinia eschscholzii. The absolute configuration of 2 was determined by quantum chemical calculations of the electronic circular dichroism （ECD） spectrum. Dalesindoloids A and B were cytotoxic against the leukemia HL-60 cell line with the IC50 values of 1.0 and 7.4 μmol/L, respectively, with the former being inhibitory on Staphylococcus aureus （MIC： 9.1 μmol/L）. The simultaneous characterization of the alkaloids from the 13C-exposed fungal culture highlighted that the 2,3-epoxyindoline motif can be transformed into both lactam and indolin-3-one moieties. This is the first-time description of the 2,3-epoxyindoline chemical versatility and Wagner-Meerwein rearrangement （WMR） reaction in the microbial culture.

关键词： indole alkaloids indole-3-carbinol Daldinia eschscholzii anticancer antibacterial

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A New Jatrophane Diterpenoid Ester from Euphorbia turczaninowii

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Chinese Chemical Letters 2006年第2期17卷 201-203页

作者： Li Gen LIU ren xiang tan You Ming GONG China Pharmaceutical University Nanjing 210009 Nanjing University Nanjing 210093

A new jatrophane diterpenoid ester （2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R） - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6（17）, 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. ＆ Kit.. ... 详细信息

关键词： Euphorbia turczaninowii Kar. & Kit. jatrophane diterpenoid ester ( 2S 3S 4R 5R 7S,8R 13R 15R)-3 5 7 8 15-pentaacetoxy-9 14-dioxojatropha-6(17) llE-diene.

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A New Antimicrobial Flavonol Glycoside from Alchornea davidii

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Chinese Chemical Letters 2003年第2期14卷 179-180页

作者： Gui You CUI Jun Yan LIU ren xiang tan Institute of Functional Biomolecules School of Life SciencesNanjing UniversityNanjing 210093

A new flavonol glycoside, isorhamnetin-3-O-b-D-xyloside, was isolated from the extract of leaves and twigs of Alchornea davidii (Euphorbiaceae). Its structure was established on the basis of the spectral analysis and chemical degradation. Antimicrobial assay showed that it moderately inhibited the growth of test bacteria (Staphylococcus aureus, Bacillus subtilis and Pseudomonas fluorescens) and fungi (Candida albicans, Aspergillus niger and Trichophyton rubrum) with MICs at 50 g/mL.

关键词： Alchornea davidii Euphorbiaceae flavonol glycoside antimicrobial activity.

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Antiosteoporotic Tetrahydroxanthone Dimers from Aspergillus brunneoviolaceus FB-2 Residing in Human Gut

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Chinese Journal of Chemistry 2021年第6期39卷 1580-1586页

作者： Xiao-Jing Lv Fei Ding Ying-Jie Wei ren-xiang tan State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjingJiangsu 210023China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjingJiangsu 210023China

A complex community of human-associated microorganisms plays diversely important roles in maintaining health,and the metabolites help to define whether a particular human-associated microbe is a friend or a *** work shows that Aspergillus brunneoviolaceus FB-2,derived from the stool of a healthy individual,produces a family of antiosteoporotic xanthone dinners including penibishexahydroxanthone A(1)and brunneoxanthones A-E(2-6,undescribed previously).The structures of 1-6 were elucidated by MS and NMR spectroscopic analysis,and the absolute configuration of 2 was established by X-ray *** 4-6 are relatively rare examples of highly oxidized heterodimeric xanthones with an 8-ketone ***,the prednisolone-induced osteoporotic zebrafish enabled our demonstration that the antiosteoporotic effects of 1-6 are dose-dependent.

关键词： Aspergillus brunneoviolaceus Gut-associated fungus Natural products Structure elucidation Biological activity

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