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Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis:A prospective study

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World Journal of Gastroenterology 2021年第30期27卷 5112-5125页

作者： Mar Riveiro-Barciela Cristina Marcos-Fosch Fernando Martinez-Valle Fabrizio Bronte Olimpia Orozco Isidro Sanz-Pérez Daniele Torres Maria-Teresa Salcedo Salvatore petta Rafael Esteban antonio Craxi Maria Buti Department of Medicine of the UAB Hospital Universitari Vall d’HebronBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos IIIMadrid 28029Spain Systemic Autoimmune Diseases Unit Internal Medicine DepartmentHospital Universitari Vall d'HebronBarcelona 08035Spain Sezione di Gastroenterologia Di.Bi.M.I.SUniversity of PalermoPalermo 90133Italy Pathology Department Hospital Universitari Vall d'HebronBarcelona 08035Spain

BACKGROUND There is an increased risk of atherosclerosis in patients with chronic hepatitis C or human immunodeficiency virus,but there is scarce data on hepatitis B virus *** hypothesis of this study is that hepatitis B virus infection increases the risk of carotid plaques and subclinical atherosclerosis in naïve hepatitis B e antigen(HBeAg)negative *** To assess the rate of carotid plaques and subclinical atherosclerosis in naïve HBeAg negative subjects in comparison with a cohort of healthy *** Prospective case-control collaborative study conducted in two tertiary *** hundred and two subjects prospectively recruited at the outpatient clinic were included from May 2016 to April 2017:201 naïve HBeAg-negative hepatitis B virus-infected[49 chronic hepatitis B(CHB)and 152 inactive carriers(ICs)]and 201 healthy *** and metabolic measures,liver stiffness and carotid Doppler ultrasound were *** atherosclerosis was established on an intima-media thickness increase of≥1.2 mm and/or the presence of carotid *** distributed quantitative variables were compared with the Student t test and those with a non-normal distribution with the Mann-Whitney U *** variables were compared between groups using theχ2 or Fisher exact *** Carotid plaques were found more often in CHB(32.7%)than ICs(17.1%)or controls(18.4%)(P=0.048).Subclinical atherosclerosis was also increased in CHB(40.8%)vsICs(19.1%)or controls(19.4%)(P=0.003).No differences in the risk of atherosclerosis were observed between controls and *** factors independently associated with the presence of carotid plaques were age[odds ratio(OR)1.43,P<0.001]and CHB(OR 1.18,P=0.004)and for subclinical atherosclerosis,age(OR 1.45,P<0.001),CHB(OR 1.23,P<0.001)and diabetes(OR 1.13,P=0.028).In the subset of young subjects(<50 years),carotid plaques(12.5%vs 1.1%,P=0.027)and subclinical atherosclerosis(12.5%vs 2.2%,P=0.058

关键词： Hepatitis B virus Carotid plaques Subclinical atherosclerosis Cardiovascular risk Endothelial dysfunction Intima-media thickness

Feasibility of Wind Power Generation for the Reduction of Power Costs in Residential Buildings

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Journal of Energy and Power Engineering 2014年第7期8卷 1203-1209页

作者： Romulo Monteiro Callado Joao reinaldo Imbiriba da Rocha Junior antonio Felisberto P. Amorim Department of Electronic Engineering Edson Queir6z Foundation Fortaleza University Fortaleza Ceara 60810-260 Brazil

The installation of wind power generators on buildings located in areas with regular winds may be a suitable investment in a renewable power source. Brazil has a high eolic potential, where the annual mean wind speed may reach over eight meters per second. This case study is aimed to assess the economic feasibility of the installation of small wind power plants in urban areas. This work evaluates a project for the installation of a vertical axis wind turbine in three buildings （15-, 22-, and 26-story） including the following stages：（1） installation of a real-time power meter in the 15-store unit; （2） demand analysis of the 26-store building＇s power consumption; （3） winds survey along the coast of the State of Ceara; （4） analysis of the wind turbines available in the market; （5） simulation aimed to choose the system. Vertical wind power generators offer better conditions of use in urban areas. The turnover time was established to be between four and six years in the three studied units. The installation of a wind power generator on buildings in regions with an adequate eolic regimen reaches a financial return of the investment before the end of the equipment＇s lifespan.

关键词： Wind power generator wind energy power consumption renewable energy power plants in urban areas.

Aqueous extract of Ocimum tenuiflorum decreases levels of blood glucose in induced hyperglycemic tilapia(Oreochromis niloticus)

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Asian Pacific Journal of Tropical Medicine 2012年第8期5卷 634-637页

作者： Amilcar Arenal Leonardo Martín Nestor M Castillo Dainier de la Torre Ubaldo Torres reinaldo Gonzlez Biochemistry Laboratory Department of Morphophysiology University of Camagüey Km 51/2 74650Cuba Biochemistry Laboratory Department of BiochemistryUniversity of HavanaCuba Center for Genetic Engineering and Biotechnology.P.O.Box 387 Camagüey 70100 Policlinic "Julio antonio Mella" CamagüeyCuba Biochemistry Laboratory Department of Morphophysiology University of Camagüey Km 5 1/2 74650Cuba

Objective:To evaluate,in hyperglycemic tilapia[Oreochromis niloticus(***)].the effect of this aqueous extract on blood glucose ***:The hyperglycemia in *** was induced by adding glucose to fish pond *** aqueous extract of Ocimum tenuiflorum (***) was prepared by boiling fresh leaves and the doses of 0,40,80,200 and 400 mg per liter of pond water were ***:The blood sugar concentration for tilapia with hyperglycemic induced was an average of 50%higher than the control *** blood glucose levels in tilapia after the induction of hyperglycemia were higher than the control group for 90 min after the *** treatment with the aqueous extract of *** dropped the serum glucose level of hyperglycemic tilapia until it was similar to that of the control group and was dose ***:The results indicated that *** was endowed with anti-hyperglycemic *** our knowledge,this is the first report on the use of fish as a diabetes model to test natural extracts from plants.

关键词： Ocimum tenuiflorum Fish model Diabetes mellilus Phytotherapy Tilapi

Chemical Characterization and Cytotoxic Activity of Antarctic Macroalgae Extracts against Colorectal Cancer

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Advances in Biological Chemistry 2019年第5期9卷 167-177页

作者： Rafaele Frassini Yeslei Paulino da Silva Sidnei Moura Leonardo Zambotti Villela Aline Paternostro Martins Pio Colepicolo Mutue Toyota Fujii Nair S.Yokoya Claudio Martin Pereira de Pereira Vagner reinaldo Zingalli Bueno Pereira Joao antonio Pegas Henriques Mariana Roesch-Ely Laboratory of Genomics Proteomics and DNA RepairUniversity of Caxias do SulCaxias do SulRSBrazil Laboratory of Biosynthetic and Natural Products of Caxias do Sul Caxias do SulRSBrazil Laboratory of Biochemistry and Molecular Biology of Algae University of Sao PauloSao PauloSPBrazil Phycologycal Research Institute of BotanySao PauloSPBrazil Laboratory of Lipidomics and Biorganic—LLipidomicaBio Federal University of PelotasPelotasRSBrazil General Hospital University of Caxias do SulCaxias do SulRSBrazil

Background/Aim: Antarctic seaweeds are considered a promising source of compounds with anticancer activity. Colorectal cancer (CRC) is one of the most incident cancers with high mortality rates worldwide. This work aimed to characterize chemically extracts of the Antarctic macroalgae Iridaea cordata, Cystosphaera jacquinotii and Desmarestia anceps and to evaluate the cytotoxic effects against human colon cancer HCT 116 cell line. Materials and Methods: The extracts were obtained by depletion using an ultrasound probe and were identified by High-Performance Liquid Chromatography (HPLC) and Gas Chromatography coupled with Mass Spectrometry (GC-MS). Cell viability was determined by MTT assay. Results: Hexanic and chloroform extracts of the I. cordata and the hexanic, chloroform and methanolic extracts of D. anceps were able to inhibit growth of colorectal cancer cells in the three different incubation times (24, 48 and 72 h). Through GC analysis, 01 compounds were identified in the hexane extract and 02 compounds in the chloroform extract of the algae I. cordata. The hexane extract of D. anceps macroalgae presented 5 compounds, chloroform extract 10 and methanolic extract 3 respectively, with special highlight to fucosterol. Carotenoid analysis by HPLC identified β-carotene in all species, while zeaxanthin was present in the spectrum of I. cordata and C. jacquinotii. Fucoxanthin and violaxanthin were confirmed in the brown seaweeds C. jacquinotii and D. anceps. Conclusion: Extracts of macroalgae I. Cordata and D. anceps may be a source of therapeutic agents against CRC.

关键词： Antarctic Seaweeds Antitumor Activity Colorectal Cancer

Reappraisal of Hepatocellular Adenoma from Federal Health System, Rio de Janeiro, Brazil

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Open Journal of Organ Transplant Surgery 2019年第1期9卷 1-10页

作者： reinaldo Fernandes Klaus Steinbruck Danielle B. Delai Jú lia R. N. Souza Igor Duque Daniel Barbosa Marcelo Enne Renato Cano Marcelo D’Oliveira Luiza Maciel Giuliano Bento Hepatobiliary Surgery Bonsucesso Federal Hospital Health Ministry Rio de Janeiro Brazil Surgery Department Antonio Pedro University Hospital Fluminense Federal University Niter&oacute i Brazil Hepatobiliary Surgery Bonsucesso Federal Hospital Health Ministry Rio de Janeiro Brazil antonio Pedro University Hospital Fluminense Federal University Niter&oacute i Brazil Hepatobiliary Surgery Servidores do Estado Federal Hospital Health Ministry Rio de Janeiro Brazil Hepatobiliary Surgery Ipanema Federal Hospital Health Ministry Rio de Janeiro Brazil Nacional Cancer Institute Rio de Janeiro Brazil

Background: Hepatocellular adenoma is a rare liver tumor that may require surgical treatment in cases of hemorrhage or suspicion of malignant lesions. Aim: To analyze data from patients who underwent hepatectomy for hepatocellular adenoma (HCA) in Rio de Janeiro, Brazil. Methods: From January 2005 to March 2019, sixty-nine patients with HCA underwent hepatectomy at centers in Rio de Janeiro. They were included in the analysis patients undergoing hepatectomy with pathological diagnosis of hepatocellular adenoma and excluded patients with hepatectomy with anatomopathological diagnosis other than hepatocellular adenoma, mainly nodular focal hyperplasia. Data related to patients, tumor and surgery were analyzed retrospectively. Results: Sixty patients (87%) were female and nine were male. Among women, 83% had a history of contraceptive use;among men, only one had an androgen intake history. Overall mean age was 36.4 years (15 - 49), with men older than women (33.9 ± 8.14 years vs. 40.4 ± 6.27 years;P = 0.02). Forty one patients reported abdominal pain, associated or not to other symptoms;32% had an episode of hemorrhage;28 were asymptomatic with an incidental radiological finding. In total, 45 patients presented only one lesion and overall mean size was 8.1 cm (2 - 31);tumors were larger among men (mean size 12.9 ± 9.86 cm vs. 7.7 ± 4.58 cm;P = 0.009). Twenty one surgeries were laparoscopic. Hepatocellular carcinoma (HCC) was identified in three specimens and the incidence was higher among men (22.2% vs. 1.6%;P = 0.042) and in tumors larger than 20 cm (66.6% vs. 0.02%). There was no perioperative mortality. Two of the three patients with HCC died with extrahepatic recurrence;the remaining patient is well after 36 months. Overall mean follow-up time was 14.2 months (2 - 76). Conclusion: Male patients with HCA were older and had larger tumors when compared to females. Incidence of HCC was higher among men and in lesions larger than 20 cm. Male patients with HCA should be

关键词： Hepatocellular Adenoma Hepatocellular Carcinoma Hepatectomy