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Retinoprotective compounds,current efficacy,and future prospective

Neural Regeneration Research 2023年第12期18卷 2619-2622页

作者： Rachele Marino rebecca Sappington Marco Feligioni Laboratory of Neuronal Cell Signaling EBRI Rita Levi-Montalcini FoundationRomeItaly Department of Neurobiology and Anatomy Wake Forest School of MedicineAtrium Health Wake Forest Baptist Medical CenterWinston-SalemNCUSA Department of Ophthalmology Wake Forest School of MedicineWinston-SalemNCUSA Department of Neurorehabilitation Sciences Casa di Cura IgeaMilanItaly

Retinal dysfunction is the most common cause of vision loss in several retinal *** has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,also supported by the life expectancy *** different types of retinopathies,we can account some that share causes,symptoms,and treatment including diabetic retinopathy,age-related macular degeneration,glaucoma,and retinitis *** changes,environmental factors,and genetic predisposition might be some of the main causes that drive retinal tissue to chronic inflammation and neurodegeneration in these *** treatments available on the market contain compounds that efficiently ameliorate some of the important clinical features of these pathologies like stabilization of the intraocular pressure,reduction of eye inflammation,control of eye oxidative stress which are considered the major molecular mechanisms related to retinal ***,the most commonly used drugs are antiinflammatories,such as corticosteroids,antioxidant,hypotonic molecules and natural neuroprotective ***,these drugs,which are fundamental to treating disease symptoms,are not capable to cure the pathologies and so they are not life-changing for *** review provided an overview of current treatments on the market,but more interestingly,wants to be a quick window on the new treatments that are now in clinical ***,it has been here highlighted that the recent technical enhancement of the investigation methods to identify the various retinopathies causes might be used as a sort of“precise medicine”approach to tailor the identification of molecular pathways involved and potentially study a dedicated treatment for each *** approach includes the use of cutting-edge technologies like gene therapy and metabolomics.

关键词： age-related macular degeneration anti-inflammatory drugs antioxidants diabetic retinopathy glaucoma neuroprotective compounds retinitis pigmentosa retinopathies vision loss

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Histones, histone chaperones and nucleosome assembly

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Protein & Cell 2010年第7期1卷 607-612页

作者： rebecca J.Burgess Zhiguo Zhang Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine200 First Street SWRochesterMN 55905USA

Chromatin structure governs a number of cellular processes including DNA replication,transcription,and DNA *** DNA replication,chromatin structure including the basic repeating unit of chromatin,the nucleosome,is temporarily disrupted,and then reformed immediately after the passage of the replication *** coordinated process of nucleosome assembly during DNA replication is termed replication—coupled nucleosome *** of this process can lead to genome instability,a hallmark of cancer ***,addressing how replication-coupled nucleosome assembly is regulated has been of great ***,we review the current status of this growing field of interest,highlighting recent advances in understanding the regulation of this important process by the dynamic interplay of histone chaperones and histone modifications.

关键词： nucleosome chaperones assembly

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Geographic variation in sexual selection and implications for speciation in the Barn Swallow

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Chinese Birds 2015年第1期5卷 30-42页

作者： Elizabeth SC Scordato rebecca J Safran Department of Ecology and Evolutionary Biology The University of Colorado

Barn Swallows(Hirundo rustica), a group of passerine birds comprised of six closely related subspecies, are well known throughout their nearly worldwide distribution, in part because of their close association with human settlements.A tractable species for both individual-based and population-level studies, Barn Swallows are a prominent model system in evolutionary, ecological, and behavioral research. Here we review work on sexual selection and population divergence in this species complex, focusing on comparative studies among populations and *** summarize variation in the targets of mate choice and in the information conveyed by sexually selected traits, and conclude that the benefits advertised by different traits may vary geographically. Finally, we consider the role of sexual selection as a driver of population divergence in this widespread and phenotypically variable species complex.

关键词： Barn Swallow Geographic variation Natural selection Sexual selection Speciation Tail streamers Ventral color

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Change Point Detection for Process Data Analytics Applied to a Multiphase Flow Facility

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1737-1759页

作者： rebecca Gedda Larisa Beilina Ruomu Tan Department of Mathematical Sciences Chalmers University of TechnologySE-42196GothenburgSweden and ABB Corporate Research CentreLadenburgGermany Department of Mathematical Sciences Chalmers University of Technology and University of GothenburgGothenburgSweden ABB Corporate Research Center LadenburgGermany

Change point detection becomes increasingly important because it can support data analysis by providing labels to the data in an unsupervised *** the context of process data analytics,change points in the time series of process variables may have an important indication about the process *** example,in a batch process,the change points can correspond to the operations and phases defined by the batch *** identifying change points can assist labelling the time series *** unsupervised algorithms have been developed for change point detection,including the optimisation approachwhich minimises a cost functionwith certain penalties to search for the change *** Bayesian approach is another,which uses Bayesian statistics to calculate the posterior probability of a specific sample being a change *** paper investigates how the two approaches for change point detection can be applied to process data *** addition,a new type of cost function using Tikhonov regularisation is proposed for the optimisation approach to reduce irrelevant change points caused by randomness in the *** novelty lies in using regularisation-based cost functions to handle ill-posed problems of noisy *** results demonstrate that change point detection is useful for process data analytics because change points can produce data segments corresponding to different operating modes or varying conditions,which will be useful for other machine learning tasks.

关键词： Change point detection unsupervisedmachine learning optimisation Bayesian statistics Tikhonov regularisation

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Reconciling concepts, theory, and empirical patterns surrounding cascade reinforcement

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Current Zoology 2016年第2期62卷 131-134页

作者： rebecca C. FULLER Department of Animal Biology University of Illinois Urbana IL 61801 USA

IntroductionReinforcement is a critically important process in speciation. It has been credited with often completing speciation, and it is unique in that natural selection directly favors the evolution of reproductive isolating barriers. Reinforcement occurs when selection favors increased prezygotic isolation between two lineages in order to avoid maladaptive hybridization in areas of sympatry （Noor 1999; Servedio and Noor 2003; Coyne and Orr 2004）.

关键词：调和加固梯级

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Insights into kidney stem cell development and regeneration using zebrafish

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World Journal of Stem Cells 2016年第2期8卷 22-31页

作者： Bridgette E Drummond rebecca A Wingert Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre Dame

Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research *** complexity of kidney anatomy and function,which includes the diversity of renal cell types,poses formidable challenges in the identification of methods to generate replacement *** work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney,known as nephrons,following acute ***,we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology,which may uncover important clues for regenerative medicine.

关键词： Kidney Renal stem cell Renal progenitor Regeneration Nephron Blood filter Renal corpuscle Tubule

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Edible Bird's Nest:Food or Medicine?

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Chinese Journal of Integrative Medicine 2013年第9期19卷 643-649页

作者： rebecca S.Y.Wong Faculty of Medicine SEGi University

Edible bird＇s nest （EBN） is derived from the saliva of certain types of swiflets. It is consumed in many parts of the world for its nutritional and medicinal values. Although many claims have been made on the therapeutic and health- promoting effects of EBN, scientific documentations regarding these effects are very limited in published literature. It is not until recently that the biological effects of EBN are being investigated and evidence-based studies are being conducted. Several studies have found that EBN may enhance cell proliferation and differentiation and various beneficial effects have been reported in vitro as well as in vivo. While these studies point towards the potential use of EBN in the treatment or even prevention of several diseases, the mechanisms of action of EBN remain largely unknown and more explorations are needed. This review is one of the very few scientific reviews onEBN which focuses on recent evidence-based discoveries.

关键词： edible bird's nest nutritional values composition potential health-promoting effects

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Pollinators exert positive selection on flower size on urban,but not on rural Scotch broom(Cytisus scoparius ***)

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Journal of Plant Ecology 2018年第3期11卷 493-501页

作者： Robert Frederick Bode rebecca Tong Department of Natural Sciences Saint Martin’s University405 Old Main5000 Abbey WayLaceyWA 98503USA

Aims Adaptive evolution of invasive species is both particularly exciting for the evolutionary biologist and worrisome for those interested in controlling or halting *** species often have a dis-tinct timeline and well-recorded population *** invaders encounter new environments,they undergo rapid adaptive *** aim in this study was to measure variation of floral size in the invasive shrub Cytisus scoparius(Scotch broom)and measure natural selection by pollinators on that *** research has found that this invasive plant is pollinator limited in Washington State and that declines in pollinator populations can contribute to local extinction in another invaded range(New Zealand).This plant is pollinated by both native and introduced species of bees,represent-ing a broad range of pollinator *** scoparius has a flower structure that is highly conducive to studies on pollinator choice,even in the absence of direct pollinator *** We surveyed urban and rural sites in and around the city of Olympia in Washington *** banner width,we were able to show that flower size varies substantially between plants but mini-mally within *** measuring the proportion of flowers that were‘tripped’,we could determine pollinator visitation rates and thus determine the level of selection due to pollinator choice *** Findings We found that *** is under natural selection by pollinators for increased flower ***,such positive natural selection was only seen in urban populations although it was consistent across two flowering *** populations of Scotch broom do not appear to be under selection on flower *** natural selection by pollinators on broom flowers could result in adaptive evolution into a new pollination niche by an invading species.A higher level of variation in broom flowers seen here than seen in previous works in native regions suggests that *** may be high

关键词： invasive evolution pollinator selection flower

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How the Yue Yi lun Was Lost： Calligraphy, the Cultural Legacy, and Tang Women Rulers

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第3期11卷 427-461页

作者： rebecca Doran Department of Modern Languages and Literatures College of Arts & Sciences University of Miami Coral Gables FL 33146 USA

Abstract Dating back to at least the Han dynasty, calligraphy has been a powerful object of culture and a medium of elite education, document preparation, and character evaluation. Discourses surrounding rulers and calligraphy form an important sub-strand in materials on calligraphy, and these accounts often depict calligraphy as a vehicle capable of reflecting a ruler＇s moral character. This paper explores narratives that blame early Tang women power-holders, in particular, the Taiping and Anle Princesses, for borrowing and subsequently losing precious calligraphic items that were considered the authentic work of Wang Xizhi. The analysis focuses on the ways in which the different narratives describe the physical movement or location of the Wang Xizhi pieces in relation to contemporary rule and factional politics. The narratives interpret the calligraphic manuscripts as an example of the cultural inheritance, to which the ruler should properly relate in particular ways. In this way, the fate of the Wang Xizhi artifacts is understood in terms of the complex relationship between imperial power and the court＇s cultural legacy.

关键词： calligraphy Taiping Princess Anle Princess Wu Zhao Wang Xizhi Yue Yi lun cultural legacy

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韦布望远镜揭密早期宇宙的盛筵

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中国国家天文 2024年第6期18卷 40-49页

作者：丹·科丽贝卡·拉森戴昱(译) 空间望远镜科学中心约翰斯·霍普金斯大学罗切斯特理工学院国家天文台

令天文学家欣喜的新望远镜,带来了观测宇宙最初十亿年星系无与伦比的新视角。天文学家在用韦布空间望远镜(James Webb Space Telescope,JWST)观测宇宙最初的几十亿年时,期待看到什么呢?哈勃望远镜的观测已经揭示了宇宙在不同的时期都拥... 详细信息

令天文学家欣喜的新望远镜,带来了观测宇宙最初十亿年星系无与伦比的新视角。天文学家在用韦布空间望远镜(James Webb Space Telescope,JWST)观测宇宙最初的几十亿年时,期待看到什么呢?哈勃望远镜的观测已经揭示了宇宙在不同的时期都拥有多姿多彩的星系。数十亿年前,星系是年轻、活跃,而且无序的——正等待着演化至我们现在看到的壮观的旋臂盘星系和椭圆星系。

关键词：哈勃望远镜椭圆星系盘星系旋臂空间望远镜早期宇宙韦布

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