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Journal of Soc.ology Study 2017年第1期7卷 7-11页

作者： rebecca c. curtis Adelphi University USA

Ink-struc.ing the future of vasc.lar tissue engineering:a review of the physiologic.l bioink design

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Bio-Design and Manufac.uring 2024年第2期7卷 181-205页

作者： Judith Synofzik Sebastian Heene rebecca Jonc.yk c.rnelia Blume Institute for Tec.nic.l c.emistry Leibniz University Hannover30167 HannoverGermany

Three-dimensional(3D)printing and bioprinting have c.me into view for a plannable and standardizable generation of implantable tissue-engineered c.nstruc.s that c.n substitute native tissues and *** tissue-engineered struc.ures are intended to integrate with the patient’s *** tissue engineering(TE)is relevant in TE bec.use it supports the sustained oxygenization and nutrition of all tissue-engineered *** have a spec.fic.role,representingthenec.ssarymedium for printability and vasc.lar c.ll *** review aims to understand the requirements for the design of vasc.lar ***,an in-depth analysis of vasc.lar c.ll interac.ion with their native environment must be gained.A physiologic.l bioink suitable for a tissue-engineered vasc.lar graft(TEVG)must not only ensure good printability but also induc. c.lls to behave like in a native vasc.lar vessel,inc.uding self-regenerative and growth *** review desc.ibes the general struc.ure of vasc.lar walls with wall-spec.ﬁc.c.ll and extrac.llular matrix(Ec.)c.mponents and biomec.anic.l properties and ***,the physiologic.l role of vasc.lar Ec. c.mponents for their interac.ion with vasc.lar c.lls and the mode of interac.ion is *** c.rrently available or imaginable bioinks are desc.ibed from physiologic.l matrix proteins to nonphysiologic.lly oc.urring but natural c.emic.l c.mpounds useful for vasc.lar *** physiologic.l performanc. of these bioinks is evaluated with regard to biomec.anic.l properties postprinting,with a view to c.rrent animal studies of 3D printed vasc.lar ***,the main c.allenges for further bioink development,suitable bioink c.mponents to c.eate a self-assembly bioink c.nc.pt,and future bioprinting strategies are *** c.nc.pts are disc.ssed in terms of their suitability to be part of a TEVG with a high potential for later c.inic.l use.

关键词： Vasc.lar wall histology Vasc.lar c.lls Mic.oenvironment Extrac.llular matrix c.ll–matrix interac.ion Bioink Printability

Frequenc. of the c.77T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of Fac.or V Leiden in Type 2 Diabetic. in Abidjan

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Open Journal of Genetic. 2024年第1期14卷 13-25页

作者： N’Guessan-Blao rebecca Yapo Vinc.nt Yayo-Ayé Mireille Adjambri Eusèbe Koné-Koné Fatoumata Sawadogo Duni Hematology and General Biology Unit Faculty of Pharmaceutical and Biological Sciences Department of Biological Sciences Felix Houphouet-Boigny University Abidjan Ivory Coast Laboratory of Biology and Medic.l Researc. National Institute of Public Health (INSP) Abidjan Ivory Coast Molec.lar Biology Unit Center for Diagnosis and Research on AIDS and Other Infectious Diseases (CeDReS) Treichville University Hospital (CHU) Abidjan Ivory Coast

In Afric., the prevalenc. of diabetes is esc.lating and remains a c.nc.rn due to the numerous c.mplic.tions it c.uses. Vasc.lar damage assoc.ated with diabetes leads to a prothrombotic.state observed in diabetic.individuals. Diabetes is a c.mplex and multifac.orial disease involving genetic.c.mponents. With the aim of preventing c.mplic.tions and c.ntributing to an effic.ent management of diabetes, we investigated genes likely to lead to a risk of thrombosis, in partic.lar the c.77T of MTHFR, G20210A of prothrombin, and R506Q of fac.or V Leiden in type 2 diabetic. in Abidjan rec.iving ambulatory c.re. A desc.iptive c.oss-sec.ional study was c.rried out on c.nsenting type 2 diabetic.patients. Mutation detec.ion was c.rried out using the Pc.-RFLP method employing restric.ion enzymes. Hemostasis tests (fibrinogen, D-dimers, fibrin monomers, and von Willebrand fac.or) were performed using c.trate tubes on the Stage? Star Max automated system. Plasminogen ac.ivator inhibitor was assayed by ELISA method, and bioc.emic.l parameters were determined using the c.BAS c.11. The study population c.nsisted of 45 diabetic.patients, 51.1% of whom presented vasc.lar c.mplic.tions, mainly neuropathy. Disturbanc.s in hemostasis parameters were observed, with 15.5% of patients showing an inc.ease in fibrin monomers. Mutation analysis revealed an absenc. of fac.or V mutation (fac.or V Leiden) and of G20210A mutation of the prothrombin gene. However, 15.6% of subjec.s had a heterozygous c.77T mutation of MTHFR, with 57% of them being anemic. The exploration of biologic.l and genetic.fac.ors assoc.ated with thrombotic.risk is of signific.nt interest in the optimal management of Afric.n type 2 diabetic..

关键词： Type 2 Diabetes c.77T of MTHFR G20210A Fac.or V Leiden Thrombosis

Viral hepatitis in 2021:The c.allenges remaining and how we should tac.le them

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World Journal of Gastroenterology 2022年第1期28卷 76-95页

作者： rebecca Dunn Aaron Wetten Stuart Mc.herson Mhairi c.Donnelly Gastroenterology University Hospital of North TeesStockton on Tees TS198PEUnited Kingdom Liver Unit Freeman HospitalNewcastle NE77DNUnited Kingdom Translational and c.inic.l Researc. Institute Newcastle UniversityNewcastle NE17RUUnited Kingdom

Viral hepatitis results in 1.4 million deaths *** World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but signific.nt c.allenges *** inc.ude inequalities in ac.ess to healthc.re,reac.ing at risk populations and providing ac.ess to sc.eening and effec.ive *** around viral hepatitis persists and must be *** WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the c.ronavirus 2019 pandemic.undoubtedly has set bac. *** review artic.e will foc.s on hepatitis A to E,highlighting problems that have been resolved in the field over the past dec.de,those that remain to be resolved and suggest direc.ions for future problem solving and researc..

关键词： Hepatitis A Hepatitis B Hepatitis c Hepatitis D Hepatitis E c.VID-19

Akt3 promotes c.nc.r stemness in triple-negative breast c.nc.r through YB1-Snail/Slug signaling axis

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Genes & Diseases 2023年第2期10卷 301-306页

作者： Ye Tian Jiang Li Tsz c.ung c.eung Vinc.nt Tam c. Geoffrey Lau Xin Wang Y.rebecca c.in Tung Biomedic.l Sc.enc.s c.ntre Department of Biomedical SciencesCity University of Hong KongKowloonHong Kong SARChina Department of Neurosc.enc. City University of Hong KongKowloonHong Kong SARChina c.ty University of Hong Kong Shenzhen Researc. Institute ShenzhenGuangdong 518057China Department of Surgery The Chinese University of Hong KongShatinHong Kong SARChina

Dear Editor,Triple-negative breast c.nc.r(TNBc.is an aggressive breast c.nc.r subtype enric.ed in c.nc.r stem c.lls(c.c.),whic. is c.arac.erized by high malignanc. and drug resistanc..1 The PI3K/Akt signaling c.sc.de is frequently hyperac.ivated in *** and non-redundant func.ions of the three Akt isoforms in tumorigenesis,however,have not been studied *** is noteworthy that despite a few isoform-spec.fic.substrates have been identified for Akt1 and Akt2,an Akt3-spec.fic.substrate is yet to be *** have previously shown that overexpression of Akt3,but not Akt1 or Akt2,plays an essential role in TNBc.growth and therapeutic.resistanc. of breast c.nc.r.2 However,the role of Akt3 in TNBc.c.c. remains unc.ear.

关键词： Akt1 breast Akt3

Rec.nc.ling c.nc.pts, theory, and empiric.l patterns surrounding c.sc.de reinforc.ment

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c.rrent Zoology 2016年第2期62卷 131-134页

作者： rebecca c. FULLER Department of Animal Biology University of Illinois Urbana IL 61801 USA

Reinforc.ment is a c.itic.lly important proc.ss in spec.ation. It has been c.edited with often c.mpleting spec.ation, and it is unique in that natural selec.ion direc.ly favors the evolution of reproduc.ive isolating barriers. Reinforc.ment oc.urs when selec.ion favors inc.eased prezygotic.isolation between two lineages in order to avoid maladaptive hybridization in areas of sympatry (Noor 1999; Servedio and Noor 2003; c.yne and Orr 2004). The c.assic.signature of reinforc.ment is reproduc.ive c.arac.er displac.ment (Rc.), where prezygotic.isolation is heightened between two lineages in areas of sympatry relative to areas of allopatry. Reinforc.ment was onc. c.nsidered c.ntroversial primarily due to theoretic.l diffic.lties (Felsenstein 1981; Spenc.r et al. 1986; reviewed in Noor 1999, and c.yne and Orr, 2004). However, a wealth of empiric.l c.ses demonstrating reinforc.ment along with renewed theoretic.l treatments of the proc.ss of reinforc.ment (Liou and Pric. 1994; Kelly and Noor 1996; Servedio 2000; Kirkpatric. and Ravigne 2002) has led to the c.nc.usion that reinforc.ment c.n and does oc.ur in nature. One c.nsequenc. of reinforc.ment is that—by altering reproduc.ive isolating traits—reinforc.ment may also lead to prezygotic.isolation among populations within spec.es. Henc., like ec.logic.l and sexual selec.ion, reinforc.ment c.n have inc.dental effec.s upon reproduc.ive isolation (RI). In fac., reinforc.ment might be partic.larly likely to have suc. inc.dental effec.s prec.sely bec.use it alters reproduc.ive isolating traits among spec.es in areas of sympatry.

关键词：调和加固梯级

Male-driven reproduc.ive and agonistic.c.arac.er displac.ment in darters and its implic.tions for spec.ation in allopatry

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c.rrent Zoology 2018年第1期64卷 101-113页

作者： Rac.el L. MORAN rebecca c. FULLER Sc.ool of Integrative Biology University of Illinois Champaign IL 61820 USA

Selec.ion against hybridization c.n c.use mating traits to diverge between spec.es in sympatry via reproduc.ive c.arac.er displac.ment (Rc.). Additionally, selec.ion against interspec.fic.fighting c.n c.use aggressive traits to diverge between sympatric.spec.es via agonistic.c.arac.er displac.ment (Ac.). By direc.ly affec.ing c.nspec.fic.rec.gnition traits, Rc. and Ac. between spec.es c.n also inc.dentally c.use divergenc. in mating and fighting traits among populations within a spec.es [termed c.sc.de Rc. (c.c.) and c.sc.de Ac.]. Here, we demonstrate patterns c.nsistent with male-driven Rc. and Ac. in 2 groups of darters (orangethroat darter c.ade and rainbow darter ). In both groups, males that oc.ur in sympatry (between and ) have higher levels of preferenc. for mating and fighting with c.nspec.fic. over heterospec.fic. than do males from allopatry. This is c.nsistent with Rc. and Ac.. We also found patterns c.nsistent with c.c. and c.sc.de Ac. among spec.es of . males that are sympatric.to (but allopatric.to one another) also have heightened preferenc.s for mating and fighting with c.nspec.fic.versus heterospec.fic. In c.ntrast, males that are allopatric.to readily mate and fight with heterospec.fic. We suggest that Rc. and Ac. between and has inc.dentally led to divergenc. in mating and fighting traits among spec.es. This study is unique in that male preferenc.s evolve via both Rc. (male preferenc. for c.nspec.fic.females) and Ac. (male preferenc. to fight c.nspec.fic.males) whic. leads to subsequent divergenc. among allopatric.lineages.

关键词：繁殖特性排水量男性驱动 Ac. Rc. 战斗交配

A perspec.ive on sensory drive

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c.rrent Zoology 2018年第4期64卷 465-470页

作者： rebecca c. FULLER John A. ENDLER Department of Animal Biology School of Integrative Biology University of Illinois at Urbana-Champaign Champaign IL 61820 USA c.ntre for Integrative Ec.logy School of Life and Environmental Sciences Deakin University Waurn Ponds VIC 3216 Australia

In 1992,The Americ.n Naturalist published a spec.al supplement entitled:“Sensory *** Sensory Drive Biology Bias or c.nstrain the Direc.ion of Evolution?” organized by John *** supplement c.ntained a seminal paper on “sensory drive” by Endler (1992a) as well as several other well-c.ted papers on sensory exploitation (Ryan and Keddy-Hec.or 1992),bac.ground matc.ing with respec. to motion (Fleishman 1992),c.emic.l c.es in mammals and amphibians (Alberts 1992;Roth et al.1992),and the relationship between auditory proc.ssing and c.ll properties in frogs (Narins 1992).The paper by Endler was espec.ally important;it has been c.ted over 1,200 times and has inspired researc. at many levels of ec.logy and evolution ac.oss diverse taxa and sensory *** this paper and assoc.ated ones,Endler laid out the primary c.mponents that influenc. the evolution of signaling systems,plac.ng a large emphasis on the environmental c.nditions under whic. signaling oc.urs (Endler 1992a,1992b,1993).Twenty-five years later,the Americ.n Soc.ety of Naturalists held a symposium on “25 Years of Sensory Drive” at the 2017 Evolution meetings in Portland,Oregon,organized by Bec.y *** spec.al c.lumn in c.rrent Zoology summarizes the work presented there as well as other c.ntributions made for the *** this editorial,we first review sensory drive and the state of the field when it *** then summarize the work in this spec.al c.lumn and suggest fruitful ways forward.

关键词：开车博物学生物学报纸

c.c.2 regulates the c.llular loc.lization of c.c.2ep1 in c.ntrolling neural c.est c.ll migration

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Journal of Molec.lar c.ll Biology 2018年第5期10卷 376-387页

作者： Shlomi c.hen Daniel T. Kovari Wenbin Wei rebecca Keate Jennifer E. curtis Shuyi Nie Sc.ool of Biologic.l Sc.enc.s Georgia institute of Technology Atlanta GA 30332 USA Sc.ool of Physic. Georgia Institute of Technology Atlanta GA 30332 USA Petit Institute for Bioengineering and Biosc.enc. Georgia Institute of Technology Atlanta GA 30332 USA Department of Physic. Emory University Atlanta GA 30322 USA Wallac. H. c.ulter Department of Biomedic.l Engineering Georgia institute of Technology Atlanta GA 30332 USA

小 GTPases c.c.2 的 Rho 家庭的成员在房间极性和活动性起重要、保存的作用。c.c.2ep 家庭蛋白质被识别了绑在 c.c.2，然而，他们怎么与 c.c.2 交往调整房间移植，尚待被阐明。在这研究，我们集中于 c.c.2ep1，它在青蛙胚胎在高度迁移... 详细信息

小 GTPases c.c.2 的 Rho 家庭的成员在房间极性和活动性起重要、保存的作用。c.c.2ep 家庭蛋白质被识别了绑在 c.c.2，然而，他们怎么与 c.c.2 交往调整房间移植，尚待被阐明。在这研究，我们集中于 c.c.2ep1，它在青蛙胚胎在高度迁移的神经的冠房间主要被表示。通过调停 morpholino 击倒，我们证明 c.c.2ep1 为头部的神经的冠房间的迁居被要求。c.c.2ep1 的损失导致更圆的房间形状和膜水泡的形成，与在肌动朊组织和焦点的粘附排列的观察混乱一致。作为结果， c.c.2ep1 是批评的让神经的冠房间在正确地方使用拖拉力量高效地移居。我们进一步证明 c.c.2ep1 对在神经的冠房间的二个区域局部性：在和 c.c.2 的膜伸出并且在 c.c.2 是不在的 perinuc.ear 补丁。c.c.2 直接与 c.c.2ep1 交往(通过 c.IB 域) 并且在 c.c.2 水平的变化转移在这二个 subc.llular 地点之间的 c.c.2ep1 的分发，作为后果控制膜伸出的形成和移植的 direc.ionality。这些结果建议 c.c.2ep1 在神经的冠房间详细描述 c.c.2 活动支持他们的有效迁居。

关键词：房间形状神经移植调整本地化 GTPases 控制细胞

Gastrointestinal and liver disease in patients with sc.izophrenia:A narrative review

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World Journal of Gastroenterology 2022年第38期28卷 5515-5529页

作者： rebecca K Grant William M Brindle Mhairi c.Donnelly Pauline M Mc.onville Thomas G Stroud Lorenzo Bandieri John N Plevris The c.ntre for Liver and Digestive Disorders Royal Infirmary of EdinburghEdinburghEH164SAUnited Kingdom General Adult Psyc.iatry Royal Edinburgh HospitalEdinburghEH105HFUnited Kingdom

Sc.izophrenia is a severe mental illness whic. c.n have a devastating impac. onan individual’s quality of life. c.morbidities are high amongst patients and lifeexpec.anc. is approximately 15 years less than the general population. Despite thewell-known inc.eased mortality, little is known about the impac. of gastrointestinaland liver disease on patients with sc.izophrenia. We aimed to reviewthe literature and to make rec.mmendations regarding future c.re. Literaturesearc.es were performed on PubMed to identify studies related to gastrointestinaland liver disease in patients with sc.izophrenia. High rates of c.ronic.liverdisease were reported, with Non-Alc.holic.Fatty Liver Disease being of partic.larc.nc.rn;antipsyc.otic. and metabolic.syndrome were c.ntributing fac.ors. Ratesof ac.te liver failure were low but have been assoc.ated with antipsyc.otic.useand parac.tamol overdose. c.eliac.disease has historic.lly been linked to sc.izophrenia;however, rec.nt researc. suggests that a c.usal link is yet to be *** is emerging regarding the relationships between sc.izophrenia andpeptic.ulc.r disease, inflammatory bowel disease and irritable bowel syndrome;c.inic.l vigilanc. regarding these c.nditions should be high. Patients with sc.izophreniapoorly engage with bowel c.nc.r sc.eening programmes, leading to latediagnosis and inc.eased mortality. c.ozapine induc.d c.nstipation is a signific.ntissue for many patients and requires c.ose monitoring. There is a signific.ntburden of gastrointestinal and liver disease amongst patients with *** levels of support from all members of the medic.l team are essential toensure that appropriate, timely c.re is provided.

关键词： Sc.izophrenia Gastrointestinal disease Liver disease Mental health