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卵巢肿瘤中的明胶酶及其组织抑制物;TImP-1是一个可以用以预测预后的因子

世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 36-37页

作者： rauvala m Puistola U Turpeenniemi-Hujanen T. 朱亮 Department of Obstetrics and Gynecology University Hospital of Oulu PL 24 Fin- 90029 OYS Oulu Finland

In the present study, the significance of circulating matrix metalloproteinases- 2 and- 9 (mmP- 2, mmP- 9), as well as their tissue inhibitors- 1 and- 2 (TImP- 1, TImP- 2) in ovarian cancer were studied to assess the possibility of using them in clinical decision-making. methods. We measured, prior to primary surgery, the concentrations of these proteins in serum samples of 115 patients with an ovarian tumor: 63 with cancer, 6 with a low malignant potential tumor, and 46 with a benign tumor. The measurements were performed with enzyme- linked immunosorbent assays (ELISA). The results were compared to clinicopathological data. Results. A high serum concentration of TImP- 1 at diagnosis was found to correlate with the malignant phenotype of an ovarian tumor. Within malignant neoplasias, high circulating TImP- 1 correlated to the aggressive phenotype and unfavorable prognosis. An association was found between a high serum level of TImP- 1 and an advanced stage of the disease, a residual tumor >2 cm, poor response to cytotoxic treatment, shorter recurrence free time, and shorter cancer-related overall survival. No statistically significant correlation was found between the circulating gelatinases (mmP- 2, mmP- 9) or TImP- 2 and the clinicopathological factors. However, a tendency for better survival with high serum concentration of TImP- 2 or mmP- 2 was observed. Conclusion. We conclude that an elevated preoperative serum TImP- 1 concentration correlates to the aggressive behavior of ovarian cancer.

关键词：卵巢肿瘤组织抑制物明胶酶良性肿瘤患者间质金属蛋白酶组织抑制剂临床病理学酶联免疫吸附法

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