卵巢肿瘤中的明胶酶及其组织抑制物;TIMP-1是一个可以用以预测预后的因子

作     者：Rauvala M Puistola U Turpeenniemi-Hujanen T. 朱亮 

作者机构：Department of Obstetrics and Gynecology University Hospital of Oulu PL 24 Fin- 90029 OYS Oulu Finland 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第5期

页      面：36-37页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：卵巢肿瘤 组织抑制物 明胶酶 良性肿瘤患者 间质金属蛋白酶 组织抑制剂 临床病理学 酶联免疫吸附法 

摘      要：In the present study, the significance of circulating matrix metalloproteinases- 2 and- 9 (MMP- 2, MMP- 9), as well as their tissue inhibitors- 1 and- 2 (TIMP- 1, TIMP- 2) in ovarian cancer were studied to assess the possibility of using them in clinical decision-making. Methods. We measured, prior to primary surgery, the concentrations of these proteins in serum samples of 115 patients with an ovarian tumor: 63 with cancer, 6 with a low malignant potential tumor, and 46 with a benign tumor. The measurements were performed with enzyme- linked immunosorbent assays (ELISA). The results were compared to clinicopathological data. Results. A high serum concentration of TIMP- 1 at diagnosis was found to correlate with the malignant phenotype of an ovarian tumor. Within malignant neoplasias, high circulating TIMP- 1 correlated to the aggressive phenotype and unfavorable prognosis. An association was found between a high serum level of TIMP- 1 and an advanced stage of the disease, a residual tumor 2 cm, poor response to cytotoxic treatment, shorter recurrence free time, and shorter cancer-related overall survival. No statistically significant correlation was found between the circulating gelatinases (MMP- 2, MMP- 9) or TIMP- 2 and the clinicopathological factors. However, a tendency for better survival with high serum concentration of TIMP- 2 or MMP- 2 was observed. Conclusion. We conclude that an elevated preoperative serum TIMP- 1 concentration correlates to the aggressive behavior of ovarian cancer.