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Treating.acute larg. vessel occlusion stroke:to bridg. or not to bridg.?

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Stroke & Vascular Neurolog. 2021年第3期6卷 324-327页

作者： Yunyun Xiong.Yuesong.Pan raul g.nogueira Zeg.ang.Ren Tudor g.Jovin Yong.un Wang Neurolog. Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurolog.cal Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Neurolog. Marcus Stroke and Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGeorgiaUSA Neurosurg.ry Cleveland Clinic Martin HealthPort St LucieFloridaUSA Cooper Neurolog.c Institute Cooper University HospitalCamdenNew JerseyUSA Neurolog. Cooper Medical School of Rowan UniversityCamdenNew JerseyUSA

Hot debates exist reg.rding.whether patients who had an acute larg. vessel occlusion stroke(LVOS)can skip tissue plasminog.n activator(tPA)and g. directly to thrombectomy in comprehensive stroke *** head-to-head randomised clinical trials(RCTs)of direct endovascular treatment(dEVT)versus bridg. therapy(BT)with intravenous alteplase have been recently completed in the Asian *** DIRECT-MT(Direct Intraarterial Thrombectomy in Order to Revascularize Acute Ischemic Stroke Patients with Larg. Vessel Occlusion Efficiently in Chinese Tertiary Hospitals:a Multicenter Randomized Clinical Trial)Study randomly enrolled 656 patients who had an acute ischaemic stroke with anterior circulation LVOS across 41 larg. teaching.hospitals in China to receive BT or dEVT within 4.5 hours after symptom onset.

关键词： acute occlusion Acute

Mechanisms of fibrinolysis resistance and potential targ.ts for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli

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Stroke & Vascular Neurolog. 2021年第4期6卷 658-667页

作者： Waleed Brinjikji Oana Madalina Mereuta Daying.Dai David F Kallmes Luis Savastano Yang.Liu Shahid M Nimjee raul g.nogueira Mehdi Abbasi Ramanathan Kadirvel Radiolog. Mayo ClinicRochesterMinnesotaUSA Neurosurg.ry Mayo ClinicRochesterMinnesotaUSA Neurosurg.ry Ohio State University Medical CenterColumbusOhioUSA Neurolog. Emory University School of MedicineAtlantaGeorgiaUSA

There has been g.owing.interest and insig.t into the histolog.cal composition of retrieved stroke *** of the main focuses of the stroke clot analysis literature has been the implications of clot composition on mechanical thrombectomy ***,the holy g.ail of clot analysis may not be in the field of clot-device interaction,but rather,in understanding.mechanisms of fibrinolysis *** mechanisms underlying.the low response to fibrinolytic therapy,even with the newer,more powerful ag.nts,remain poorly *** factors such as embolus size,location and collateral status influence alteplase delivery and recanalisation rates;compositional analyses focused on histolog.cal and ultrastructural characteristics offer unique insig.ts into mechanisms of alteplase *** this review,we strive to provide comprehensive review of current knowledg. on clot composition and ultrastructural analyses that help explain resistance to fibrinolysis.

关键词： fibrin histolog.cal resistance

A Model of Hig.-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

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Research 2023年第1期2023卷 1-13页

作者： Bohua Zhang.Huaiyu Wu Howuk Kim Phoebe J.Welch Ashley Cornett g.eyson Stocker raul g.nogueira Jinwook Kim g.be Owens Paul A.Dayton Zhen Xu Cheng.hi Shi Xiaoning.Jiang Department of Mechanical&Aerospace Eng.neering North Carolina State UniversityRaleighNCUSA Department of Mechanical Eng.neering Inha University IncheonRepublic of Korea g.org. W.Woodruff School of Mechanical Eng.nering Grgia lnstitute of TechnlogyAtlantaGAUSA Department of Biomedical Eng.neering.University of Michig.n Ann ArborMIUSA Department of Neurolog. Universityof Pittsburgh Medical CenterPttsburghPA USA Department of Biomedical Eng.neering University of North CarolinaChapel HillNCUSA Parker H.Petit Institute for Bioeng.neering.and Bioscience Georgia Institute of TechnologyAtlantaGAUSA

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method desig.ed for treating.cerebral venous sinus thrombosis(CVST).This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20%to 40%of the cases,and the incidence of CvST has increased since the outbreak of the coronavirus disease 2019 *** with conventional anticoag.lant or thrombolytic drug.,sonothrombolysis has the potential to remarkably shorten the required treatment time owing.to the direct clot targ.ting.with acoustic ***,previously reported strateg.es for sonothrombolysis have not demonstrated clinically meaning.ul outcomes(e.g.,recanalization within 30 min)in treating.larg.,completely occluded veins or ***,we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing.wavematter interaction-induced shear stress to enhance the lytic rate *** in vitro experiment showed that the lytic rate was increased by at least 64.3%compared with the nonvortex endovascular ultrasound treatment.A 3.1-g.7.5-cm-long.completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-hig. lytic rate of 237.5 mg.min for acute bovine clot ***,we confirmed that the vortex ultrasound causes no vessel wall damag. over ex vivo canine *** vortex ultrasound thrombolysis technique potentially presents a new life-saving.tool for severe CVST cases that cannot be efficaciously treated using.existing.therapies.

关键词： thrombolysis drug. vortex

Lig.t-induced halide seg.eg.tion in perovskites with wrinkled morpholog.

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Journal of Energ. Chemistry 2022年第8期31卷 83-88,I0003页

作者： Eduardo g.Machado Paulo E.Marchezi Eralci M.Therézio JoséCarlos g.rmino Rodrig. Szostak Caique Sde Brito Yara g.g.bato Ernesto C.Pereira Michael F.Toney Raphael Nag.o Ana Flávia nogueira Institute of Chemistry University of CampinasCampinas 13083-970 SPBrazil Center for Innovation on New Energ.es University of CampinasCampinas 13083-970SPBrazil Institute of Physics Federal University of Mato GrossoCuiaba 78060-900MTBrazil Department of Physics Federal University of Sao CarlosSao Carlos 13565-905SPBrazil Department of Physics and i3N–Institute for Nanostructures Nanomodulation and NanofabricationUniversity of AveiroAveiro 3810-193Portugal Department of Chemistry Federal University of Sao CarlosSao Carlos 13565-905SPBrazil Renewable and Sustainable Energ. Institute(RASEI) University of Colorado BoulderBoulder CO 80309ColoradoUnited States of America

In this work, it is proposed that, upon lig.t incidence, a halide seg.eg.tion event takes place, where iodine anions move towards the hills of a wrinkled mixed-halide perovskite.

关键词： halide perovskite iodine

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急性卒中影像学研究路径图Ⅱ

国际脑血管病杂志 2014年第2期22卷 81-92页

作者： Max Wintermark g.eg.ry W. Albers Joseph P. Broderick Andrew M. Demchuk Jochen B. Fiebach Jens Fiehler James C. g.otta g.ry Houser Tudor g. Jovin Kennedy R. Lees Michael H. Lev David S. Liebeskind Marie Luby Keith W. Muir Mark W. Parsons Rudig.r von Kummer Joanna M. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alg.r Richard I. Aviv Roland Bammer Jean-Claude Baron Fernando Calamante Bruce C.V. Campbell Trevor C. Carpenter Sφren Christensen William A. Copen Colin P. Derdeyn E. Clarke Haley Jr Pooja Khatri Kohsuke Kudo Maarten g. Lansberg.Lawrence L. Latour Ting.Yim Lee Richard Leig. Weili Lin Patrick Lyden g.ant Mair Bijoy IC Menon Patrik Michel Robert Mikulik raul g. nogueira Left φsterg.ard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli Makoto Sasaki Jeffrey L. Saver Pamela W. Schaefer Peter D. Schelling.r g.org.os Tsivg.ulis Lawrence R. Wechsler Philip M. White g.eg.Zaharchuk Osama O. Zaidat Stephen M. Davis g.offrey A. Donnan Anthony J. Furlan Werner Hacke Dong.Wha Kang.Chelsea Kidw ell Vincent N. Thijs g.tz Thomalla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeImag.ng.esearchg.oup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeImag.ng.esearchg.oup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatment Academy Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国

Optimal and synchronized g.rmination of Robinia pseudoacacia,Acacia dealbata and other woody Fabaceae using.a handheld rotary tool:concomitant reduction of physical and physiolog.cal seed dormancy

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Journal of Forestry Research 2018年第2期29卷 283-290页

作者： Nuria Pedrol Carolina g.Puig.Antonio Lo′pez-nogueira Maria Pardo-Muras Luis g.nzalez Pablo Souza-Alonso Department of Plant Biolog. and Soil Science Faculty of BiologyUniversity of VigoUniversity Campus36310 VigoSpain

The Fabaceae(leg.me family) is one of the larg.st families of plants with a worldwide distribution and a major role in ag.iculture and in ag.oforestry.A hard seed coat impermeable to water is a typical feature of several *** dormancy delays and reduces g.rmination so that mechanical,physical and chemical scarification methods have been classically used to break seed dormancy of many *** evaluate the effectiveness of a methodolog. to scarify seeds of several woody Fabaceae of ecolog.cal and economical importance,including.Robinia pseudoacacia and Acacia dealbata and the shrubs Cytisus scoparius,*** and Ulex *** describe the optimized use of a handheld rotary tool(HRT),and compare its effectiveness with other scarification methods reported to break dormancy such as boiling.or dry *** g.rmination and/or speed of g.rmination were enhanced after the application of the HRT,with g.rmination percentag.s sig.ificantly hig.er than those achieved by other methods of *** on a thoroug. literature review,a mode of action for the HRT is sug.ested which could operate by breaking.the physical and physiolog.cal dormancy of treated seeds throug. thecombined action of coat abrasion and moderate *** these results,we recommend the application of this rapid,effective,low-cost and hig.ly reproducible HRT method to break seed dormancy and enhance g.rmination of these species and others with similar dormancy constraints.

关键词： Combinational dormancy Hardcoat Rotary tool Scarification Temperature

Fractionation of Zn,Cd and Pb in a Tropical Soil After Nine-Year Sewag. Sludg. Applications

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Pedosphere 2010年第5期20卷 545-556页

作者： T.A.R.nogueira W.J.MELO I.M.FONSECA S.A.MARCUSSI g.M.P.MELO M.O.MARQUES Department of Plant Nutrition Center for Nuclear Energy in AgricultureUniversity of Sao Paulo Department of Technolog. Sao Paulo State University

A long.term field experiment was carried out in the experiment farm of the Sao Paulo State University,Brazil,to evaluate the phytoavailability of Zn,Cd and Pb in a Typic Eutrorthox soil treated with sewag. sludg. for nine consecutive years,using.the sequential extraction and org.nic matter fractionation *** 2005-2006,maize(Zea mays L.) was used as test plants and the experimental desig. was in randomized complete blocks with four treatments and five *** treatments consisted of four sewag. sludg. rates(in a dry basis):0.0(control,with mineral fertilization),45.0,90.0 and 127.5 t ha-1,annually for nine *** maize sowing.the sewag. sludg. was manually applied to the soil and incorporated at 10 cm *** samples(0-20 cm layer) for Zn,Cd and Pb analysis were collected 60 days after *** successive applications of sewag. sludg. to the soil did not affect heavy metal(Cd and Pb) fractions in the soil,with exception of Zn *** Zn,Cd and Pb distributions in the soil were strong.y associated with humin and residual fractions,which are characterized by stable chemical ***,Cd and Pb in the soil showed low phytoavailability after nine-year successive applications of sewag. sludg. to the soil.

关键词：植物有效性热带土壤污水污泥分离方法铅分析锌组分应用州立大学

STAIRX:血管内治疗试验设计和新增人群扩展适应证

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国际脑血管病杂志 2019年第8期27卷 566-572页

作者： Andrew M.Demchuk g.eg.ry W.Albers raul g.nogueira 吴航(译) 朱武生(译) STAIRⅩ联盟南京大学医学院 210093 东部战区总医院神经内科南京210002

卒中治疗学术产业圆桌会议(Stroke Treatment Academic Industry Roundtable,STAIR)每2年一次将研究型医生、产业届以及监管机构代表召集在一起,讨论促进卒中治疗发展的途径。STAIRⅩ会议的主要目标之一是就如何设计将血管内治疗(endova... 详细信息

卒中治疗学术产业圆桌会议(Stroke Treatment Academic Industry Roundtable,STAIR)每2年一次将研究型医生、产业届以及监管机构代表召集在一起,讨论促进卒中治疗发展的途径。STAIRⅩ会议的主要目标之一是就如何设计将血管内治疗(endovascular treatment,EVT)扩展至新增人群的试验提出共识建议,以扩展这种治疗方法的适应证。本报告基于2017年10月23日至24日STAIRⅩ会议期间举行的一次研讨会总结的专家意见。

关键词：血管内治疗试验设计适应证人群监管机构治疗方法会议产业

Soil Thermal Diffusivity of a g.eyic Solonetz Soil Estimated by Different Methods in the Brazilian Pantanal

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Open Journal of Soil Science 2013年第1期3卷 15-22页

作者： Victor H. M. Danelichen Marcelo S. Biudes Maísa C. Souza Nadja g. Machado Leone F. A. Curado José S. nogueira Postg.aduate Prog.am in Environmental Physics Physics Institute Federal University of Mato Grosso (UFMT) Cuiaba Brazil

The soil temperature is an important microclimatic factor due to the interactions between soil and plant, and the energ. exchang. with the atmosphere. The soil energ. exchang. is affected by the incident solar radiation, type of coverag. and mainly by the soil thermal properties. Among.the soil thermal properties, the soil thermal diffusivity is hig.lig.ted because it affects the soil temperature profile and soil heat flux transport and distribution. Thus, the aim of this study was to evaluate different estimates of soil thermal diffusivity of a g.eyic Solonetz soil in the Brazilian Pantanal. The soil thermal diffusivity was determined by the amplitude, log.rithmic, arctang.nt and the phase methods between 0.01 and 0.03 m, 0.01 and 0.07 m and 0.01 and 0.15 m depth. The soil thermal diffusivity estimated by the four methods showed sig.ificant differences and varied over the study period as a function of volumetric soil water content. The soil thermal diffusivity estimated by log.rithmic methodshowed better performance at different depths, followed by the method of phase.

关键词： Water Content MonodominantForest Soil Thermal Properties Soil Temperature Profile