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The Crop Journal 2019年第4期7卷 469-479页

作者： Abhijit Kumar Das rashmi chhabra Vignesh Muthusamy Hema Singh Chauhan Rajkumar Uttamrao Zunjare Firoz Hossain The Indian Council of Agricultural Research (ICAR)-Indian Agricultural Research Institute (IARI) New Delhi 110012 India

Deficiency of vitamin-E or tocopherol causes neurological and cardiovascular disorders in humans. Though maize kernel is rich in total tocopherol, the level of α-tocopherol possessing the highest vitamin-E activity is low. Mutant allele of ZmVTE4 with deletion of 7 bp and 118 bp (0/0: most favorable haplotype) in 5′UTR and promoter region, respectively significantly enhances α-tocopherol in maize kernel than wild type haplotype (7/118).α- tocopherol estimation in 15 diverse inbreds revealed that mean α-/γ-tocopherol and α-/ total-tocopherol was much higher in genotypes with favorable haplotype (1.51 and 0.41) than unfavorable class (0.19 and 0.13), respectively. However even within favorable class,α- tocopherol ranged from 4.76 to 30.07 μg g 1. Sequence analysis of part of 5′UTR and promoter of ZmVTE4 among the genotypes with favorable haplotype revealed 14 SNPs (SNP1 to SNP14) and eight InDels (InDel1 to InDel8). SNP7 at 606 bp (G to A), and InDels viz., InDel1 (27 bp), InDel4 (27 bp) and InDel8 (14 bp) differentiated low and high α-tocopherol accumulating inbreds with favorable haplotype. Hence the newly identified SNP and InDels in addition to the already reported InDels can be useful in selection of favorable genotypes with higher α-tocopherol in maize.

关键词： Maize Vitamin-E InDel SNP Biofortification

Adhesion G protein-coupled receptor latrophilin 1(ADGRL1):a novel regulator of glucose and energy homeostasis

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3143-3144页

作者： Kavaljit H.chhabra Department of Pharmacology and Nutritional Sciences Barnstable Brown Diabetes and Obesity Research CenterUniversity of KentuckyLexingtonKYUSA

Recently,I read with interest the research article entitled'Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity published in Signal Transduction and Targeted *** report confirms and extends our findings that ADGRL1(aka latrophilin 1)regulates energy balance and glucose homeostasis.?Using affinity chromatography coupled with proteomics and electrophysiology,we showed that ADGRL1 is likely a glucose receptor in the *** findings demonstrated that lack of ADGRL1 in the hypothalamus or whole-body causes obesity and features of type 2 diabetes in *** is refreshing to see Dietzsch et al.i reached the same conclusion.

关键词： homeostasis obesity hypothalamus

Comparison of QT Correction Methods in the Pediatric Population of a Community Hospital: A Retrospective Study

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Congenital Heart Disease 2024年第1期19卷 107-121页

作者： Koren Hyogene Kwag Ibrahim Kak Ying Li Walid Khass Alec McKechnie Oksana Nulman Brande Brown Manoj chhabra Department of Pediatrics New York Presbyterian Brooklyn Methodist HospitalBrooklyn11215USA Department of Population Health Sciences Division of BiostatisticsWeill Cornell MedicineNew York10065USA

Objective:Accurate measurement of QT interval,the ventricular action potential from depolarization to repolarization,is important for the early detection of Long QT *** most effective QT correction(QTc)formula has yet to be determined in the pediatric population,although it has intrinsically greater extremes in heart rate(HR)and is more susceptible to errors in *** authors of this study compare six dif-ferent QTc methods(Bazett,Fridericia,Framingham,Hodges,Rautaharju,and a computer algorithm utilizing the Bazett formula)for consistency against variations in HR and RR ***:Descriptive Retrospective *** included participants from a pediatric cardiology practice of a community hospital who had an ECG performed in *** participants were healthy patients with no past medical history and no regular ***:ECGs from 95 participants from one month to 21 years of age(mean 9.7 years)were included with a mean HR of 91 beats per minute(bpm).The two-sample paired t-test or Wilcoxon signed-rank test assessed for any difference between QTc methods.A statistically signiﬁcant difference was observed between every combination of two QTc *** Spearman’s rank correlation analysis explored the QTc/HR and QTc/RR relationships for each *** method was most independent of HR and RR with the lowest absolute value of correlation coefﬁ*** and Computer had moderate correlations,while Framingham and Rautaharju exhibited strong *** were positive for Bazett and Computer,reﬂecting results from prior studies demonstrating an over-correction of Bazett at higher *** the linear QTc/HR regression analysis,Bazett had the slope closest to zero,although Computer,Hodges,and Fridericia had comparable ***,Fridericia had the linear QTc/RR regression coefﬁcient closest to *** Bland-Altman method assessed for bias and the limits of agreement between correction *** an

关键词： Corrected QT interval QT prolongation long QT syndrome electrocardiogram retrospective study bazett fridericia framingham hodges rautaharju computer algorithm

Package Coupling Measurement in Object-Oriented Software

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Journal of Computer Science & Technology 2009年第2期24卷 273-283页

作者： Varun Gupta Jitender Kumar chhabra Department of Computer Engineering National Institute of TechnologyKurukshetra

The grouping of correlated classes into a package helps in better organization of modern object-oriented software. The quality of such packages needs to be measured so as to estimate their utilization. In this paper, new package coupling metrics are proposed, which also take into consideration the hierarchical structure of packages and direction of connections among package elements. The proposed measures have been validated theoretically as well as empirically using 18 packages taken from two open source software systems. The results obtained from this study show strong correlation between package coupling and understandability of the package which suggests that proposed metrics could be further used to represent other external software quality factors.

关键词： package coupling metrics object-oriented software understandability

A Survey of Dynamic Software Metrics

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Journal of Computer Science & Technology 2010年第5期25卷 1016-1029页

作者： Jitender Kumar chhabra Varun Gupta Department of Computer Engineering National Institute of TechnologyKurukshetra-136119India

Software metrics help us to make meaningful estimates for software products and guide us in taking managerial and technical ***,conventional static metrics have been found to be inadequate for modern object-oriented software due to the presence of object-oriented features such as polymorphism,dynamic binding,inheritance and unused *** fact motivates us to focus on dynamic metrics in place of traditional static ***,dynamic metrics are more precise than static metrics as they are able to capture the dynamic behaviour of the software system during *** dynamic metrics are usually obtained from the execution traces of the code or from the executable *** this paper,advantages of dynamic metrics over static metrics are discussed and then a survey of the existing dynamic metrics is carried *** metrics are characterized into different categories such as dynamic coupling metrics, dynamic cohesion *** end of the paper,potential research challenges and opportunities in the field of dynamic metrics are identified.

关键词： metrics object-oriented programming software engineering

Implementation and Validation of the Optimized Deduplication Strategy in Federated Cloud Environment

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Computers, Materials & Continua 2022年第4期71卷 2019-2035页

作者： Nipun chhabra Manju Bala Vrajesh Sharma I.K.Gujral Punjab Technical University Jalandhar144603india

Cloud computing technology is the culmination of technical advancements in computer networks,hardware and software capabilities that collectively gave rise to computing as a *** offers a plethora of utilities to its clients worldwide in a very cost-effective way and this feature is enticing users/companies to migrate their infrastructure to cloud *** by its gigantic capacity and easy access clients are uploading replicated data on cloud resulting in an unnecessary crunch of storage in *** data compression techniques came to rescue but none could serve the purpose for the capacity as large as a cloud,hence,researches were made to de-duplicate the data and harvest the space from exiting storage capacity which was going in vain due to duplicacy of *** providing better cloud services through scalable provisioning of resources,interoperability has brought many Cloud Service Providers(CSPs)under one umbrella and termed it as Cloud *** policies have been devised for private and public cloud deployment models for searching/eradicating replicated copies using hashing *** the exploration for duplicate copies is not restricted to any one type of CSP but to a set of public or private CSPs contributing to the *** was found that even in advanced deduplication techniques for federated clouds,due to the different nature of CSPs,a single file is stored at private as well as public group in the same cloud federation which can be handled if an optimized deduplication strategy be rendered for addressing this ***,this study has been aimed to further optimize a deduplication strategy for federated cloud environment and suggested a central management agent for the *** was perceived that work relevant to this is not existing,hence,in this paper,the concept of federation agent has been implemented and deduplication technique following file level has been used for the accomplishment of this approa

关键词： Federation agent deduplication in federated cloud central management agent for cloud federation interoperability in cloud computing bloom filters cloud computing cloud data storage

QoS-Aware Energy-Efficient Task Scheduling on HPC Cloud Infrastructures Using Swarm-Intelligence Meta-Heuristics

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Computers, Materials & Continua 2020年第8期64卷 813-834页

作者： Amit chhabra Gurvinder Singh Karanjeet Singh Kahlon Department of Computer Engineering&Technology Guru Nanak Dev UniversityAmritsar143005India Department of Computer Science Guru Nanak Dev UniversityAmritsar143005India

Cloud computing infrastructure has been evolving as a cost-effective platform for providing computational resources in the form of high-performance computing as a service(HPCaaS)to users for executing HPC ***,the broader use of the Cloud services,the rapid increase in the size,and the capacity of Cloud data centers bring a remarkable rise in energy consumption leading to a significant rise in the system provider expenses and carbon emissions in the *** this,users have become more demanding in terms of Quality-of-service(QoS)expectations in terms of execution time,budget cost,utilization,and *** situation calls for the design of task scheduling policy,which ensures efficient task sequencing and allocation of computing resources to tasks to meet the trade-off between QoS promises and service provider ***,the task scheduling in the Cloud is a prevalent NP-Hard *** by these concerns,this paper introduces and implements a QoS-aware Energy-Efficient Scheduling policy called as CSPSO,for scheduling tasks in Cloud systems to reduce the energy consumption of cloud resources and minimize the makespan of *** proposed multi-objective CSPSO policy hybridizes the search qualities of two robust metaheuristics *** search(CS)and particle swarm optimization(PSO)to overcome the slow convergence and lack of diversity of standard CS algorithm.A fitness-aware resource allocation(FARA)heuristic was developed and used by the proposed policy to allocate resources to tasks efficiently.A velocity update mechanism for cuckoo individuals is designed and incorporated in the proposed CSPSO ***,the proposed scheduling policy has been implemented in the CloudSim simulator and tested with real supercomputing workload *** comparative analysis validated that the proposed scheduling policy can produce efficient schedules with better performance over other well-known heuristics and meta-heuristic

关键词： HPC-as-a-Service task scheduling quality-of-service meta-heuristics and energy-efficiency

Effect of orientation on the drag of a cone settling in a Bingham plastic fluid

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Particuology 2019年第2期17卷 157-170页

作者： Pragya Mishra A.K. Tiwari R.P. chhabra Department of Chemical Engineering. Indian Institute of Technology Kanpur 208016 India M2NeT Laboratory Wilfrid Laurier University 75 University Avenue West Waterloo ON N2L 3C5 Canada

Effects of the orientation and apex angle on the settling velocity of conical particles in Bingham plas-tic fluids are numerically investigated over a Reynolds number range of 1 ≤Re ≤100, Bingham number range of 0 ≤ Bn ≤ 100, and cone angle range of 20 ≤α≤ 150°. Governing equations (of continuity and momentum) are solved numerically using the finite element method to obtain velocity and pressure fields that are postprocessed to obtain values of the drag ***, the effect of cone ori-entation on the flow field is visualized and explored in terms of streamline contours and the morphology of yielded/uny ielded regions. Finally, the obtai ned values of drag are correlated via a simple predictive expression in terms of the modified Reynolds number. The effect of the cone angle on drag is found to be moderate because the drag force acting on the lateral surface is a small fraction of the overall drag.

关键词： Bingham number Reynolds number Yielded/unyielded regions Drag

SOCS3 dictates the transition of divergent time-phased events in granulocyte TNF-a signaling

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Cellular & Molecular Immunology 2014年第1期11卷 105-116页

作者： Jasmeet Kaur chhabra Brajadulal Chattopadhyay Bhola Nath Paul Immunobiology Division CSlR-Indian Institute of Toxicology Research Lucknow India Department of Physics Faculty of Science JadavpurUniversity Kolkata India

Tumor-necrosis factor-a （TNF-a）-driven nuclear factor-KB （NF-KB） activation and apoptosis are opposing pathways; the growing recognition of these conflicting roles of TNF-a is perplexing. Here, we show that inflammation and apoptosis are time-phased events following TNF-a signaling and that emergence of suppressor of cytokine signaling 3 （SOCS3） expression limits the ongoing NF-KB activation and promotes apoptosis; further, we suggest an altered view of how inflammatory diseases are initiated and sustained. In vitro, TNF-a （50 ng/ml） induced granulocyte SOCS3 protein, inhibited nuclear accumulation of the p65NF-KB subunit and enhanced apoptosis, as shown by DNA laddering, annexin V positivity, and overexpression of caspase-3 and Bax in the late phase, whereas the early phase was marked by NF-KB activation. Conversely, SOCS3 knockdown by small interfering RNA （siRNA） inhibited granulocyte apoptosis and enhanced nuclear accumulation of p65 and 5＇ lipooxygenase expression in the late phase of TNF-a signaling. As apoptosis is associated with SOCS3 abundance, we suggest that these divergent TNF-a-driven events are time-phased, interconnected, opposing control mechanisms and one of the central features through which the immune system resolves pulmonary inflammation. Dysregulation may initiate mucosal inflammation, thus changing the landscape of asthma theraov.

关键词： apoptosis granulocytes lung inflammation NF-kB TNF-a SOCS3

Effect of Na^＋, K^＋ and Ca^2＋ Ions on Physico-chemical Properties of Thymine, Cytosine, Thymidine and Cytidine in Aqueous Urea Solution

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Chinese Journal of Chemistry 2005年第9期23卷 1157-1164页

作者： PANDEY, Jata Dhari HAROON, SHahla chhabra, Jyotsna DEY, Ranjan MISRA, Krishna Department of Chemistry University of Allahabad Allahabad 211-002 India

Experimental determination of density, ultrasonic velocity and viscosity of two pyrimidine bases thymine and cytosine along with their respective nucleosides, thymidine and cytidine has been carried out in aqueous urea solutions in the presence of different concentrations of three salts, viz. NaC1, KCl and CaCl2. The experimental data have been used for the computation of various thermodynamic parameters, viz. apparent molar volume, apparent molar compressibility, coefficients A and B of the Jones-Dole equation, internal pressure, acoustic impedance, etc. Structural studies of solutions under investigation have also been carried out by ultraviolet spectroscopy, and an at- tempt has been made to collaborate the findings of ultraviolet spectroscopy with results obtained thermodynami- cally.

关键词： interaction bivalent ion thermodynamic property ultraviolet spectroscopy ionic size