Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis

作     者：Chhabra, Kavaljit H. 

作者机构：Univ Kentucky Barnstable Brown Diabet & Obes Res Ctr Dept Pharmacol & Nutr Sci Lexington KY 40506 USA 

出 版 物：《SIGNAL TRANSDUCTION AND TARGETED THERAPY》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第1期

页      面：1-2页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：National Institutes of Health [DK124619] 

主　　题：ALPHA LATROTOXIN 

摘      要：Recently,I read with interest the research article entitled Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity published in Signal Transduction and Targeted *** report confirms and extends our findings that ADGRL1(aka latrophilin 1)regulates energy balance and glucose homeostasis.?Using affinity chromatography coupled with proteomics and electrophysiology,we showed that ADGRL1 is likely a glucose receptor in the *** findings demonstrated that lack of ADGRL1 in the hypothalamus or whole-body causes obesity and features of type 2 diabetes in *** is refreshing to see Dietzsch et al.i reached the same conclusion.