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Review: Pathogenesis of cholestatic liver diseases

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World Journal of Hepatology 2020年第8期12卷 423-435页

作者： raquel T Yokoda Eduardo A Rodriguez Department of Anatomic and Clinical Pathology Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Department of Gastroenterology Hepatology and NutritionUniversity of UtahSalt Lake CityUT 84132United States

Cholestatic liver diseases(CLD)begin to develop after an impairment of bile flow start to affect the biliary *** actively participate in the liver response to injury and repair and the intensity of this reaction is a determinant factor for the development of *** cholangiopathies may ultimately lead to end-stage liver disease requiring at the end orthotopic liver *** narrative review will discuss cholangiocyte biology and pathogenesis mechanisms involved in four intrahepatic CLD:Primary biliary cholangitis,primary sclerosing cholangitis,cystic fibrosis involving the liver,and polycystic liver disease.

关键词： Cholestasis Cholangitis Epigenomics Immunogenetics Pathogenesis Bile acid

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第一块爱因斯坦瓷砖

环球科学 2024年第3期 58-69页

作者：克雷格·S.卡普兰陶兆巍(译) 加拿大滑铁卢大学不详

2022年11月,我的一位同事不经意间问起我的研究工作。当时我正高强度地思考问题,头脑已经有些神志不清了,于是茫范然回答道:“我感觉我马上就要解决一个重大的未解难题了。”

关键词：爱因斯坦解难题思考问题高强度

The Role of the Solar Cycle in the Relationship Between the North Atlantic Oscillation and Northern Hemisphere Surface Temperatures

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Advances in Atmospheric Sciences 2007年第2期24卷 191-198页

作者： Laura DE LA TORRE Luis GIMENO Juan Antonio AEL raquel NIETO Universidad de Vigo Facultad de Ciencias de Ourense 32004OurenseSpain

The North Atlantic Oscillation （NAO） is one of the leading modes of climate variability in the Northern Hemisphere. It has been shown that it clearly relates to changes in meteorological variables, such as surface temperature, at hemispherical scales. However, recent studies have revealed that the NAO spatial pattern also depends upon solar forcing. Therefore, its effects on meteorological variables must vary depending upon this factor. Moreover, it could be that the Sun affects climate through variability patterns, a hypothesis that is the focus of this study. We find that the relationship between the NAO/AO and hemispheric temperature varies depending upon solar activity. The results show a positive significant correlation only when solar activity is high. Also, the results support the idea that solar activity influences tropospheric climate fluctuations in the Northern Hemisphere via the fluctuations of the stratospheric polar vortex .

关键词： solar activity North Atlantic Oscillation Arctic Oscillation Northern Hemisphere surface temperature

Impact of combining chlorine dioxide and chlorine on DBP formation in simulated indoor swimming pools

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Journal of Environmental Sciences 2017年第8期29卷 155-162页

作者： Daekyun Kim Nuray Ates Sehnaz Sule kaplan Bekaroglu Meric Selbes Tanju Karanfil Department of Environmental Engineering and Earth Sciences Clemson University Department of Environmental Engineering Erciyes University Water Institute Suleyman Demirel University

The main objective of this study was to assess the combined use of chlorine dioxide（ClO_2）and chlorine（Cl_2） on the speciation and kinetics of disinfection by-product（DBP） formation in swimming pools using synthetic pool waters prepared with a body fluid analog（BFA）and/or fresh natural water. At 1：25（mass ratio） of ClO_2 to Cl_2, there was no significant reduction in the formation of trihalomethanes（THMs） and haloacetic acids（HAAs） for both BFA solution and natural water compared to the application of Cl_2 alone. When the mass ratio of ClO_2 to Cl_2increased to 1：1, substantial decreases in both THMs and HAAs were observed in the natural water, while there was almost no change of DBP formations in the BFA solution. Haloacetonitriles and halonitromethanes levels in both water matrices remained similar. In the presence of bromide, the overall DBP formation increased in both BFA solution and natural water. For the DBP formation kinetics, after 72 hr of contact time,very low formation of THMs and HAAs was observed for the use of ClO_2 only. Compared to Cl_2 control, however, applying the 1：1 mixture of ClO_2/Cl_2 reduced THMs by 〉 60% and HAAs by 〉 50%. Chlorite was maintained below 1.0 mg/L, while the formation of chlorate significantly increased over the reaction time. Finally, in a bench-scale indoor pool experiment, applying ClO_2 and Cl_2simultaneously produced less THMs compared to Cl_2 control and kept chlorite at 〈 0.4 mg/L, while HAAs and chlorate accumulated over 4-week operation period.

关键词： Chlorine dioxide Chlorine Disinfection by-products Body fluid analog Natural organic matter

Influence of Pt/Ru anodic ratio on the valorization of ethanol by PEM electrocatalytic reforming towards value-added products

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Journal of Energy Chemistry 2021年第5期30卷 264-275页

作者： Alberto Rodriguez-Gomez Fernando Dorado Antonio de Lucas-Consuegra Ana raquel de la Osa Chemical Engineering Department Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha13071 Ciudad RealSpain

The ethanol electro-reforming process was studied over PtRu/C catalysts synthesized by the modified polyol method with different *** particular,this work reports the influence of anodic Pt:Ru ratio(5:1,2:1 and 1:2)on the organic product distribution(acetaldehyde,acetic acid and ethyl acetate)and pure hydrogen generation at different current densities operation *** characterization of the catalysts was made by X-ray diffraction(XRD),temperature-programmed reduction(TPR)and N_(2) adsorption-desorption *** patterns showed that Ru is introduced into the Pt structure,forming an alloy between both ***,the degree of alloy was higher by increasing the Ru *** TPR profiles Pt was found to be properly reduced while Ru was both in metallic state and forming *** electrochemical behaviour of each catalyst towards ethanol electroreforming process was investigated through electrochemical techniques in a half cell and a single proton exchange membrane(PEM)cell *** intermediate Pt:Ru ratio was found to result in high current density and electrochemical surface area(ECSA)values along with lower amounts of adsorbed ***,Ru addition seems to diminish the degree of degradation of the *** on characterization and in agreement with essays carried out in a PEM cell at mild conditions(80℃ and 1 atm),PtRu/C 2:1 anode provided the best electrocatalytic results in terms of current density(740 mA cm^(-2)),hydrogen production and selectivity toward acetic acid(up to 15%apart from acetaldehyde and ethyl acetate)while requiring the lowest energy consumption.

关键词： Ethanol electro-reforming PEM cell Pt:Ru anodic ratio Hydrogen production Value-added liquid product distribution

Forest management for optimizing soil protection:a landscape-level approach

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Forest Ecosystems 2021年第4期8卷 672-684页

作者： Ana raquel Rodrigues Susete Marques Brigite Botequim Marco Marto Jose G.Borges Forest Research Centre and Laboratory TERRA School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisbonPortugal

Background:Soil erosion is still identified as the main cause of land degradation worldwide,threatening soil functions and driving several research and policy efforts to reverse *** are commonly associated to some of the most successful land-use systems to achieve soil protection goals,but the extent to which forest ecosystems reduce erosion risks can largely depend on management decisions and associated silvicultural *** tools can assist foresters in solving the complex planning problem they face,concerning the demand for different,and often conflicting,ecosystem services.A resource capability model(RCM),based on a linear programming approach,was built and solved for a forest landscape management problem in Northwest Portugal,over a 90-years planning horizon,divided in 10-years ***:Timber provision and soil erosion were found to be in *** management alternatives included in the model were proven to be sufficiently flexible to obtain the desired level of timber yield,both in volume and even distribution along the planning horizon,while ensuring lower levels of soil loss estimates(below 35 Mg·ha^(−1)·year^(−1)).However,under climate change conditions,compatible with an increasing greenhouse gases emission scenario,potential landscape soil erosion may be enhanced up to 46 Mg·ha^(−1)·year^(−1) in critical ***:Soil conservation concerns in landscape-level forest management planning can be addressed by LPbased optimization *** providing an optimal management solution at landscape level,this approach enables a comprehensive analysis of the RCM,possible trade-offs and potential changes towards uncertainties.

关键词： Ecosystem services Erosion Optimization Silvicultural practices

Do statins reduce hepatitis C RNA titers during routine clinical use?

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World Journal of Gastroenterology 2009年第40期15卷 5020-5027页

作者： Kimberly A Forde Connie Law Rose O’Flynn David E kaplan Philadelphia Veterans Administration Medical Center Department of Medicine Division of GastroenterologyUniversity of Pennsylvania Department of Pharmacy Philadelphia Veterans Administration Medical Center

AIM: To compare hepatitis C virus (HCV) titers in patients with chronic hepatitis C with and without exposure to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins).METHODS: Medical records were reviewed for 6463 patients with documented HCV infection at a single center between March 2004 and September 2006. Patients with confi rmed viremia and meeting inclusion criteria were assigned to one of three groups: Group A (n = 50), dyslipidemic patients with statin usage during HCV RNA polymerase chain reaction (PCR) determination; Group B (n = 49), dyslipidemic patients with prior or future statin usage but not at the time of HCV RNA PCR determination; and Group C (n = 102), patients without statin usage during the study period. The primary analysis explored the effect of statin therapy on HCV viremia. Secondary analyses assessed class effect, dose response, and effect of other lipid-lowering therapies on HCV viral ***: Median HCV RNA titers did not signif icantly differ among the three groups (Group A: 4 550 000 IU/mL, Group B: 2 850 000 IU/mL, Group C: 3 055 000 IU/mL).For those subjects with longitudinal assessment of HCV viremia prior to and while on statins, there were no signif icant differences between pre- and post-HCV viral titers. Additionally, no differences in HCV titers were observed at any dose level of the most prescribed statin, simvastatin. However, hypertriglyceridemia independently correlated with HCV titers, and niacin exposure was associated with signif icantly lower viral titers (P < 0.05).CONCLUSION: There was no apparent effect of statins on HCV viral replication in this analysis. Further investigation is warranted to explore the possible antiviral properties of triglyceride-lowering agents and their potential role as adjuncts to standard HCV therapy.

关键词： Hepatitis C 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Statins Geranylgeranyl Prenylation

Boosting hydrogen and chemicals production through ethanol electro-reforming on Pt-transition metal anodes

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Journal of Energy Chemistry 2022年第7期31卷 394-406,I0011页

作者： Alberto Rodríguez-Gómez Fernando Dorado Paula Sánchez Ana raquel de la Osa Chemical Engineering Department Faculty of Chemical Sciences and TechnologyUniversity of Castilla-La Mancha

The aim of this work is to boost the combined hydrogen and added-values compounds generation(acetaldehyde, acetic acid and ethyl acetate) through ethanol electrochemical reforming using bimetallic anodes. In particular, the influence of the secondary metal on the electrochemical performance as well as on the product distribution was studied. For that purpose, Pt X/C electrocatalysts(where X corresponds to Cu, Co, Ni and Ru) were synthesized by the modified polyol method and tested in both half-cell and proton exchange membrane(PEM) cell configurations. Characterization results showed that incorporation of Ni and Co into the Pt matrix enhances the morphological properties of the material, providing smaller crystallite sizes, higher active surface areas and hence, better dispersion when comparing to Ru and Cu-based electrocatalysts. Ethanol oxidation reaction(EOR) was evaluated by cyclic, linear voltammetry and chronopotentiometry assays. Pt Co/C and Pt Ni/C exhibited the highest electrocatalytic activity at high polarization levels, which translate into an improvement of more than 30%(up to 1050 m A cm^(-2)) in the hydrogen production and chemical yields. On the other hand, Pt Ru/C results more advantageous for a lower potential interval(<0.85 V) promoting the acetic acid production despite sacrificing ethanol conversion. Pt Cu/C presented the lowest results in both electrochemical performance and product distribution. Such differences in the electrochemical performance can be rationalized in terms of the synergistic effect between both metals(particle size distribution, grade of dispersion and hydrophilic behavior), which demonstrate that the incorporation of a different secondary metal plays an essential role in the EOR development.

关键词： Ethanol electrochemical reforming Bimetallic anodic electrocatalysts PEM cell High current performance Hydrogen Chemicals production

Chlorinated paraffins in the technosphere:A review of available information and data gaps demonstrating the need to support the Stockholm Convention implementation

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Emerging Contaminants 2020年第1期6卷 143-154页

作者： Yago Guida raquel Capella Roland Weber Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas FilhoLaboratorio de Micropoluentes Jan JapengaAv.Carlos Chagas Filho373Rio de JaneiroRJ21941-902Brazil POPs Environmental Consulting Schw€abisch Gmünd73527Germany

Chlorinated paraffins(CPs)have been produced for a wide range of applications,mostly in open uses,such as metalworking fluids,lubricants,coolants or additives in consumer *** production volume is more than one million tonnes requiring control of the lifecycle of these persistent and bioaccumulative *** May 2017,the Stockholm Convention amended its Annex A to list short chain chlorinated paraffins(SCCPs)as a Persistent Organic Pollutant(POP).Additionally,a limit for the presence of SCCPs in other CP mixtures was set at 1%by *** can be released to the environment throughout their ***,the major objective of this review was to assess and compile information on SCCPs and other CPs regarding their lifecycle in the technosphere to support the Stockholm Convention implementation.A few studies have assessed CP production plants and contamination in the surrounding ***,there was no systematic investigation of release routes from production and no assessment of associated landfills,even though these are known major pollution sources at other organochlorine production *** studies have reported that industrial areas,where CPs have likely been used,have elevated levels of CPs in sediments and ***,although CPs are largely released when used as metalworking fluids or lubricants,no systematic assessment of releases has been conducted at the thousands of sites where CPs are used in high *** CPs,mainly medium chain chlorinated paraffins(MCCPs)and SCCPs,are used as additives in the production of consumer goods,resulting in exposure *** above the European Union regulation for SCCPs of 1500 mg kg^-1 and up to approx.20%are frequently *** end-of-life management of CP-containing products is difficult since no labelling requirement exists even for products containing *** Stockholm Convention prohibits the recycling of SCCP-containing products,which will result in challenges recycling the imp

关键词： SCCPs MCCPs LCCPs Lifecycle Pollution control Consumer goods Persistent organic pollutants Human exposure