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Chinese Science bulletin 1997年第16期42卷 1372-1377页

作者： Zhao, JS Zhao, b rao, b Chinese Acad Sci Guangzhou Inst Geochem Guangzhou 510640 Peoples R China Nanjing Univ Dept Earth Sci Nanjing 210008 Peoples R China

To counter the lack of consensus of opinion on mineralizations of Ta, Nb and W which have genetic relationship to fluorine-rich albite granite and the want of experimental evidence at present, some experiments reported in this study were carried out. The purpose of this study is to explain the genetic connection of Ta, Nb and W ore deposits and possible mechanism of their mineralization with the aid of the experimental results.

关键词： partition behaviour of Ta Nb and W process of crystallization differentiation of magma.

Weighted Probability Density Estimator with Updated bandwidths

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Journal of Systems Science & Complexity 2024年第2期37卷 886-906页

作者： WU Yi YU Wei WANG Xuejun PRAKASA rao b L S School of big Data and Artificial Intelligence Chizhou UniversityChizhou 247000China School of big Data and Statistics Anhui UniversityHefei 230601China CR rao Advanced Institute of Mathematics Statistics and Computer ScienceHyderabad 500046India

In this paper,the authors study a class of weighted version of probability density *** is shown that the weighted estimator contains some existing estimators of probability density,no matter they are recursive or *** statistical results including weak consistency,strong consistency,rate of strong consistency,and asymptotic normality are established under some mild ***,the random weighted estimator is also *** numerical simulations and a real data analysis are presented to study the numerical performances of the estimators.

关键词： Asymptotic normality consistency numerical simulation probability density real data analysis updated bandwidths weighted estimator

Identification of slot discharges in rotating machine insulation system using variable frequency PD measurement

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High Voltage 2018年第3期3卷 179-186页

作者： Ramesh P.Nair Sumangala b.Vishwanath Nageshwar b.rao Cables and Diagnostics Division Central Power Research InstituteBengaluruIndia Dr.Ambedkar Institute of Technology BengaluruIndia

Slot discharge studies are very important from the insulation diagnosis *** in practice,testing of rotating machines with power frequency requires sources which are quite bulky and *** if the diagnosis is carried out at lower frequencies( be reduced ***,it is important to know whether the study at low frequencies can be considered equivalent to study at power ***,in this study,a slot discharge phenomenon occurring in a rotating machine insulation system was investigated experimentally at different frequencies(50,10,1 and 0.1 Hz).Slot discharges are known to have a distinct phase resolved partial discharge pattern for power frequency(50/60 Hz)*** distinct patterns are useful in identifying the presence of slot discharge activity in rotating *** discharges were created on a 6.6 kV mica-epoxy stator coil and the slot discharge characteristics measured at different frequencies are *** discharge measurements were repeated by varying the air gap between the insulation surface and grounded steel *** changes in slot discharge characteristics due to the increase in air gap were found similar at all *** comparison suggests that the identification of slot discharge is also possible from the partial discharge(PD)measurement at low frequencies.

关键词： steel rotating insulation

biliary strictures complicating living donor liver transplantation:Problems,novel insights and solutions

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World Journal of Gastroenterology 2018年第19期24卷 2061-2072页

作者： Harshavardhan b rao Arjun Prakash Surendran Sudhindran Rama P Venu Department of Gastroenterology Amrita Institute of Medical SciencesAmrita UniversityKochi 682041India Department of Transplant and Vascular Surgery Amrita Institute of Medical SciencesAmrita UniversityKochi 682041India

biliary stricture complicating living donor liver transplantation(LDLT) is a relatively common complication, occurring in most transplant centres across the world. Cases of biliary strictures are more common in LDLT than in deceased donor liver transplantation. Endoscopic management is the mainstay for biliary strictures complicating LDLT and includes endoscopic retrograde cholangiography, sphincterotomy and stent placement(with or without balloon dilatation). The efficacy and safety profiles as well as outcomes of endoscopic management of biliary strictures complicating LDLT is an area that needs to be viewed in isolation, owing to its unique set of problems and attending complications; as such, it merits a tailored approach, which is yet to be well established. The diagnostic criteria applied to these strictures are not uniform and are over-reliant on imaging studies showing an anastomotic narrowing. It has to be kept in mind that in the setting of LDLT, a subjective anastomotic narrowing is present in most cases due to a mismatch in ductal diameters. However, whether this narrowing results in a functionally significant narrowing is a question that needs further study. In addition, wide variation in the endotherapy protocols practised in most centres makes it difficult to interpret the results and hampers our understanding of this topic. The outcome definition for endotherapy is also heterogenous and needs to be standardised to allow for comparison of data in this regard and establish a clinical practice guideline. There have been multiple studies in this area in the last 2 years, with novel findings that have provided solutions to some of these issues. This review endeavours to incorporate these new findings into the wider understanding of endotherapy for biliary strictures complicating LDLT, with specific emphasis on diagnosis of strictures in the LDLT setting, endotherapy protocols and outcome definitions. An attempt is made to present the best management optio

关键词： biliary strictures Endoscopic management Stenting Self-expanding metal stents Living donor liver transplantation

Investigation of antioxidant and anti-inflammatory activity of leaves of Dalbergia paniculata(Roxb)

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Asian Pacific Journal of Tropical Medicine 2012年第6期5卷 455-458页

作者： Ganga rao b Madhu Kiran P Vijaya Raju AD Pharmacognosy and Phytochemistry A.U College of Pharmaceutical SciencesAndhra UniversityVisakhapatnamA.P.India-530 003 A.U College of Pharmaceutical Sciences Andhra UniversityVisakhapatnamA.PIndia-530 003

Objective:To investigate the antioxidant and anti-inflammatory activity of orally administered methanolic leaf extract of Dalbergia paniculala(***) in Carrageenan induced inflammation in ***:In vitro antioxidant activity was evaluated for superoxide radical, Hydroxyl radical and DPPH radical scavenging *** doses 200 mg/kg,400 mg/kg and 800 mg/kg of *** were tested for anti-inflammatory activity in Carrageenan induced rat paw edema model and paw thickness was measured every one hour up to 6 h. Results:The melhanolic leaf extract of *** produced dose dependent inhibition of Superoxide radical,Hydroxyl radical and OPPH *** Carrageenan induced inflammation model,all three doses produced significant percentage inhibition of rat paw edema and 800 mg/kg dose produced maximum percent inhibition of rat paw edema(47.83%) at 3h compared to control ***:In the present study we found that methanolic leaf extract of *** showed good in vitro antioxidant activity and in vivo anti-inflammatory activity in rats.

关键词： Anti-inflammatory activity Antioxidant activity Dalbergia paniculata Free radicals Carragenan Inflammation Edema

Macrophage polarization in response to wear particles in vitro

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Cellular & Molecular Immunology 2013年第6期10卷 471-482页

作者： Joseph K Antonios Zhenyu Yao Chenguang Li Allison J rao Stuart b Goodman Orthopaedic Research Laboratories Department of Orthopaedic Surgery Stanford University School of Medicine Stanford CA USA

Total joint replacement is a highly successful surgical procedure for treatment of patients with disabling arthritis and joint dysfunction. However, over time, with high levels of activity and usage of the joint, implant wear particles are generated from the articulating surfaces. These wear particles can lead to activation of an inflammatory reaction, and subsequent bone resorption around the implant （periprosthetic osteolysis）. Cells of the monocyte/macrophage lineage orchestrate this chronic inflammatory response, which is dominated by a pro-inflammatory （M 1） macrophage phenotype rather than an anti-inflammatory pro-tissue healing （M2） macrophage phenotype. While it has been shown that interleukin-4 （IL-4） selectively polarizes macrophages towards an M2 anti-inflammatory phenotype which promotes bone healing, rather than inflammation, little is known about the time course in which this occurs or conditions in which repolarization through I L-4 is most effective. The goal of this work was to study the time course of murine macrophage polarization and cytokine release in response to challenge with combinations of polymethyl methacrylate （PMMA） particles, lipopolysaccharide （LPS） and IL-4 in vitro. Treatment of particle-challenged monocyte/macrophages with IL-4 led to an initial suppression of pro-inflammatory cytokines and inducible nitric oxide synthase （iNOS） production and subsequent polarization into an M2 anti-inflammatory phenotype. This result was optimized when IL-4 was delivered before PMMA particle challenge, to an M 1 phenotype rather than to uncommitted （MO） macrophages. The effects of this polarization were sustained over a 5-day time course. Polarization of M1 macrophages into an M2 phenotype may be a strategy to mitigate wear particle associated periprosthetic osteolysis.

关键词： IL-4 macrophage polarization osteolysis PMMA particles total joint replacement

Effect of Commiphora mukul gum resin on hepatic marker enzymes,lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats

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Asian Pacific Journal of Tropical biomedicine 2012年第11期2卷 895-900页

作者： Ramesh b Karuna R Sreenivasa Reddy S Haritha K Sai Mangala D Sasi bhusana rao b Saralakumari D Department of biochemistry Sri Venkateswara University Department of internal medicine University of Nebraska medical CentreOmahaNEUSA Department of biochemistry Sri Krishnadevaraya UniversityAnantapur-515003Andhra PradeshIndia Department of biochemistry Sri Sathya Sai Institute of Higher Medical SciencesPrasanthigramPuttaparthyPrasanthi Nilayam 515134Andhra PradeshIndia

Objective:To study the antioxidant efficacy of Commiphora mukul(***) gum resin ethanolic extract in streptozotocin(STZ) induced diabetic ***:The male Wistar albino rats were randomly divided into four groups of eight animals each:Control group(C),CM-treated control group(C_+CMEE),Diabetic control group(D),CM- treated diabetic group(D_+CMEE).Diabetes was induced by intraperitoneal injection of STZ(55 mg/kg/ bwt).After being confirmed the diabetic rats were treated with *** gum resin ethanolic extract(CMEE) for 60 *** biochemical estimations like antioxidant,oxidative stress marker enzymes and hepatic marker enzymes of tissues were ***:The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase(AST),alanine aminotransaminase(ALT) in liver and kidney and oxidative markers like lipid peroxidation(LPO) and protein oxidation(PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control *** of CMEE(200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards ***:In conclusion,our data indicate the preventive role of *** against STZ-induced diabetic oxidative stress;hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status.

关键词： Commiphora mukul Antioxidants Lipid peroxidation Streptozotocin

Development and <i>in Vitro-in Vivo</i>Evaluation of Controlled Release Matrix Tablets of Desvenlafaxine

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Pharmacology & Pharmacy 2012年第1期3卷 15-19页

作者： Shashidhar Reddy Dodda Prakash rao b 不详

The objective of this investigation was to prepare extended release tablet containing matrix granules of Desvenlafaxine succinate monohydrate and to study its in vitro release and in vivo absorption. The design of dosage form was performed by choosing hydrophilic hydroxypropyl methyl cellulose (HPMC K100M), sodium carboxyl methyl cellulose (blanose), microcrystalline cellulose (MCC) and lactose monohydrate polymers as matrix builders and polyvinyl pyrolidine (Kollidon K30) as granulating polymers. Granules were prepared by composing drug with HPMC K100M, sodium CMC, MCC and lactose monohydrate by spray drying method. Optimized formulation of Desvenlafaxine succinate monohydrate was formed by using 20% HPMC K100M, 26.6% MCC, 6.6% of sodium CMC (blanose), 13.3% of lactose monohydrate and 5% ratio of Kollidon K30 as binder. Tablets were compressed with free flowing optimized granules of uniform drug content. This extended the release period up to 24 h in vitro study. Similarity factor and mean dissolution time were also reported to compare various dissolution profiles. The network formed by HPMC, MCC and blanose had been coupled satisfactorily with the controlled resistance. biopharmaceutical study of this optimized dosage form in rabbit model showed 24 h prolonged drug release in vivo. A close correlation (R2 = 0.9833) was established between the in vitro release and the in vivo absorption of drug. The results suggested that wet granulation with spray dried technique, is a suitable method to formulate sustained release Desvenlafaxine succinate monohydrate and it can Perform therapeutically better than conventional immediate release dosage form.

关键词： Desvenlafaxine Pharmacokinetics ER Matrix Tablet In Vitro Kinetics Depressio

Studies of Climate Change with Statistical-Dynamical Models: A Review

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American Journal of Climate Change 2015年第1期4卷 57-68页

作者： Sergio H. Franchito Vadlamudi b. rao Centro de Previsao de Tempo e Estudos Climáticos CPTEC Instituto Nacional de Pesquisas Espaciais INPE Sao José dos Campos Brazil

The cause-effect relationship is not always possible to trace in GCMs because of the simultaneous inclusion of several highly complex physical processes. Furthermore, the inter-GCM differences are large and there is no simple way to reconcile them. So, simple climate models, like statistical-dynamical models (SDMs), appear to be useful in this context. This kind of models is essentially mechanistic, being directed towards understanding the dependence of a particular mechanism on the other parameters of the problem. In this paper, the utility of SDMs for studies of climate change is discussed in some detail. We show that these models are an indispensable part of hierarchy of climate models.

关键词： Simple Climate Models Statistical-Dynamical Models Climate Change

ObSERVATION OF MYO-INOSITOL CONCENTRATIONS IN bIPOLAR DISORDER PATIENTS RECEIVING SODIUM VALPROATE:An in vivo Proton MR Spectroscopy Quantitative Study

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波谱学杂志 2002年第1期19卷 96-97页

作者： R.H.WU P.SILVERSTONE J.MA H.Kim H.b.rao X.H.XU Shantou University Medical College China University of Alberta Canada University of Alberta Canada Dalian Medical University China Shantou University Medical College China

Introduction:Previous magnetic resonance spectroscopy (MRS) studies have suggested that lithium used in patients with bipolar disorder may alter brain myo-inositol concentrations.

关键词： MR ObSERVATION OF MYO-INOSITOL CONCENTRATIONS IN bIPOLAR DISORDER PATIENTS RECEIVING SODIUM VALPROATE MYO