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Adenosine A2A-dopamine D2 receptor heteromers operate striatal function:impact on Parkinson's disease pharmacotherapeutics

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Neural Regeneration Research 2018年第2期13卷 241-243页

作者： víctor fernández-duenas sergi ferré francisco ciruela unitat de farmacologia departament patologia i terapèutica experimentalfacultat de medicinaidibelluniversitat de barcelonal’hospitalet de llobregatBarcelonaSpain institut de neurociències universitat de barcelonaBarcelonaSpain integrative neurobiology section national institute on drug abuseintramural research programnational institutes of healthBaltimoreMDUSA

The basal ganglia （BG） assemble a series of deep gray matter structures forming recurrent loops that include the cortex and thalamus, and that participate in the regulation of a plethora of brain functions, including elicitation and learning of reward-and aversive stimuli-associated behaviors, motor activity control and sensorimotor gating （Brom- berg-martin et al., 2010）.

关键词： A(2A) RECEPTORS BASAL GANGLIA DOPAMINE-D-2

DNA extraction method selection for agricultural soil using TOPSIS multiple criteria decision-making model

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American Journal of Molecular Biology 2013年第4期3卷 215-228页

作者： Sepideh Pakpour Snizhana v. Olishevska Shiv O. Prasher Abbas S. Milani martin R. Chénier Department of Biology University of British Columbia Kelowna Canada Department of Bioresource Engineering McGill University Montreal Canada Department of Bioresource Engineering McGill University Montreal Canada Department of Animal Science McGill University Montreal Canada Department of Food Science and Agricultural Chemistry McGill University Montreal Canada Department of Animal Science McGill University Montreal Canada School of Engineering University of British Columbia Kelowna Canada

There is an increased interest in the extraction of nucleic acids from various environmental samples since culture-independent molecular techniques contribute to deepen and broaden the understanding of a greater portion of uncultivable microorganisms. Due to difficulties to select the optimum DNA extraction method in view of downstream molecular analyses, this article presents a straightforward mathematical framework for comparing some of the most commonly used methods. Four commercial DNA extraction kits and two physical-chemical methods (bead-beating and freeze-thaw) were compared for the extraction of DNA under several quantitative DNA analysis criteria: yield of extraction, purity of extracted DNA (A260/280 and A260/230 ratios), degradation degree of DNA, easiness of PCR amplification, duration of extraction, and cost per extraction. From a practical point of view, it is unlikely that a single DNA extraction strategy can be optimum for all selected criteria. Hence, a systematic Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) was employed to compare the methods. The PowerSoil? DNA Isolation Kit was systematically defined as the best performing method for extracting DNA from soil samples. More specifically, for soil:manure and soil:manure:biochar mixtures, the PowerSoil?DNA Isolation Kit method performed best, while for neat soil samples its alternative version gained the first rank.

关键词： DNA Extraction Agricultural Soil Biochar Poultry Manure Multiple Criteria Decision-Making Technique for Order Preference by Similarity to Ideal Solution

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肱骨干骨折后桡神经麻痹的系统评价

中华骨科杂志 2005年第10期25卷 577-582页

作者：邵云潮 Paul Harwood martin RW Grotz Peter v Giannoudis 陈统一张光健复旦大学附属中山医院骨科上海200032 Department of Trauma&Orthopaedics St James's U-niversity HospitalLeedsUK

目的采用循证医学研究方法,系统评价肱骨干骨折后桡神经麻痹(radialnervepalsy,RNP)的不同处理方法,为临床治疗决策提供证据基础。方法采用PubMed、Datastar及CochraneDatabase等互联网公共搜索引擎作为检索工具,检索过去40年中发表的... 详细信息

目的采用循证医学研究方法,系统评价肱骨干骨折后桡神经麻痹(radialnervepalsy,RNP)的不同处理方法,为临床治疗决策提供证据基础。方法采用PubMed、Datastar及CochraneDatabase等互联网公共搜索引擎作为检索工具,检索过去40年中发表的有关肱骨干骨折后桡神经麻痹的文献,再对入选文献的参考文献行手工检索,制定数据抽取问表,对入选文献进行数据抽取、汇总、归纳和荟萃分析。结果共检索到391篇原始文献,其中324篇得自电子检索,67篇得自手工检索。有35篇符合最终的入选标准,总计随访患者1045例。其中21篇文献共记录了发生于4517例肱骨干骨折中的532例桡神经麻痹,肱骨干骨折后桡神经麻痹的发生率为11.8%。肱骨干中1/5和中远1/5部位的桡神经麻痹发生率明显高于其他部位(P<0.05)。不同骨折类型中,横形和螺旋形骨折较斜形和粉碎性骨折更易于并发桡神经麻痹(P<0.0001)。肱骨干骨折后桡神经麻痹总的恢复率为88.1%,早期保守治疗的病例自发性恢复率为70.7%。观察等待组和早期手术探查组之间神经恢复的最终结果没有明显差别。结论对肱骨干骨折后桡神经麻痹采用早期保守治疗不会影响神经的最终恢复结果,可以避免许多不必要的手术。

关键词：桡神经病麻痹肱骨骨折 Meta分析桡神经麻痹肱骨干骨折系统评价骨折后 Cochrane 早期保守治疗

Investigation of Compressible Electromagnetic Flute Mode Instability in Finite Beta Plasma in Support of Z-pinch and Laboratory Astrophysics Experiments

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Communications in Computational Physics 2008年第8期4卷 611-623页

作者： v.I.Sotnikov v.v.Ivanov R.Presura J.N.Leboeuf O.G.Onishchenko B.v.Oliver B.Jones T.A.Mehlhorn C.Deeney University of Nevada at Reno NV 89523USA JNL Scientific Casa GrandeAZ 85222USA Institute of Physics of Earth 123995MoscowRussia Sandia National Laboratories NM 87123USA Department of Energy WashingtonDC 20585USA

Flute mode turbulence plays an important role in numerous applications,such as tokamak,Z-pinch,space and astrophysical *** a low beta plasma flute oscillations are electrostatic and in the nonlinear stage they produce large scale density structures co-mingling with short scale *** scale structures are responsible for the enhanced transport across the magnetic field and appearance of short scales leads to ion heating,associated with the ion *** the present paper nonlinear equations which describe the nonlinear evolution of the flute modes treated as compressible electromagnetic oscillations in a finite beta inhomogeneous plasma with nonuniform magnetic field are derived and solved *** this purpose the 2D numerical code FLUTE was *** results show that even in a finite beta plasma flute mode instability can develop along with formation of large scale structures co-existing with short scale perturbations in the nonlinear stage.

关键词： Flute instability plasma turbulence nonlinear cascades

Mucin and phospholipids determine viscosity of gallbladder bile in patients with gallstones

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World Journal of Gastroenterology 2001年第2期7卷 203-207页

作者： Dieter Jüngst Anna Niemeyer Iris Müller Benedikta Zündt Günther Meyer martin Wilhelmi Reginalddel Pozo Departments of Medicine II and Surgery Klinikum GrosshadernLudwig Maximilians-University MunichMunichGermany and Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile

AIM: An increased viscosity of gallbladder bile has been considered an important factor in the pathogenesis of gallstone disease. Besides lipids and proteins, mucin has been suggested to affect the viscosity of bile. To further clarify these issues we compared mucin, protein and the lipid componEnts of hepatic and gallbladder bile and its viscosity in patients with gallstones. METHODS: viscosity of bile (mPa.s) was measured using rotation viscosimetry in regard to the non Newtonian property of bile at low shear rates. RESULTS: Biliary viscosity was markedly higher in gallbladder bile of patients with cholesterol (5.00 +/- 0.60 mPa.s, mean +/- SEM, r= 28) and mixed stones (3.50 +/- 0.68 mPa.s; r= 8) compared to hepatic bile (0.92 +/- 0.06 mPa.s, r= 6). A positive correlation between mucin and viscosity was found in gallbladder biles (r = 0.65; P viscosity. A positive correlation was determined between phospholipid concentration and viscosity (r = 0.34, P ver, no correlation was found between total protein or the other lipid concentrations and viscosity in both gallbladder and hepatic biles. CONCLUSION: The viscosity of gallbladder bile is markedly higher than that of hepatic bile in patients with gallstones. The concentration of mucin is the major determinant of biliary viscosity and may contribute by this mechanism to the role of mucin in the pathogenesis of gallstones.

关键词： Adult Bile Cholelithiasis Female Humans Male Middle Aged Mucins Phospholipids Research Support, Non-U.S. Gov't viscosity

Anti-Melanogenesis Effect of Daniellic Acid Isolated from <i>Daniellia oliveri</i>(Rolfe) Hutch. &Dalziel (Leguminosae) Oleoresin of Burkina Faso

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Open Journal of Medicinal Chemistry 2021年第4期11卷 41-57页

作者： Aminata P. Nacoulma Moussa Compaoré Naamwin-so-Bawfu Romaric Meda Laurent Pottier véronique Megalizzi Issa Some martin Kiendrebeogo Laboratoire de Toxicologie Environnement et Santé Université Joseph KI-ZERBO Ouagadougou Burkina Faso Microbiology Bioorganic and Macromolecular Chemistry and RD3—Pharmacognosy Bioanalysis & Drug Discovery Units Université libre de Bruxelles Brussels Belgium Laboratoire de Biochimie et de Chimie Appliquées Université Joseph KI-ZERBO Ouagadougou Burkina Faso

Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, Daniellia oliveri which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from 1H-NMR, 13C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC50 going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibits tyrosinase activity with 1.20 mM as IC50. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p

关键词： Daniellia oliveri Daniellic Acid Tyrosinase Melanogenesis Cytotoxicity

Time-expanded phase-sensitive optical time-domain reflectometry

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Light(Science & Applications) 2021年第3期10卷 443-454页

作者： Miguel Soriano-Amat Hugo F.martins vicente Duran Luis Costa Sonia martin-Lopez Miguel Gonzalez-Herraez Maria R.Fernandez-Ruiz Departamento de Electronica Universidad de AlcalaEscuela Politecnica Superior28805 MadridSpain Instituto deóptica"Daza de valdes" IO-CSICC/Serrano 12128006 MadridSpain GROC-UJI Institute of New Imaging TechnologiesUniversity Jaume112071 CastellonSpain

Phase-sensitive optical time-domain reflectometry(CDOTDR)is a well-established technique that provides spatiotemporal measurements of an environmental variable in real *** unique capability is being leveraged in an everincreasing number of applications,from energy transportation or civil security to *** date,a wide number of different approaches have been implemented,providing a plethora of options in terms of performance(resolution,acquisition bandwidth,sensitivity or range).However,to achieve high spatial resolutions,detection bandwidths in the GHz range are typically required,substantially increasing the system cost and ***,we present a novel OOTDR approach that allows a customized time expansion of the received optical ***,the presented technique reaches cm-scale spatial resolutions over t km while requiring a remarkably low detection bandwidth in the MHz *** approach relies on the use of dual-comb spectrometry to interrogate the fibre and sample the backscattered *** phase-spectral coding is applied to the employed combs to maximize the signal-to-noise ratio of the sensing scheme.A comparison of the proposed method with alternative approaches aimed at similar operation features is provided,along with a thorough analysis of the new *** results demonstrate a radically novel high-resolution OOTDR scheme,which could promote new applications in metrology,borehole monitoring or aerospace.

关键词： optical phase expanded

Spontaneous liver rupture following SARS-Cov-2 infection in late pregnancy:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5042-5050页

作者： Radek Ambroz martin Stasek Ján Molnár Petr Spicka Dusan Klos Jozef Hambálek Daniela Skanderová Department of Surgery I University Hospital Olomouc and Faculty of Medicine and DentistryPalacky UniversityOlomouc 77900Czech Republic Department of Obstetrics and Gynecology University Hospital Olomouc and Faculty of Medicine and DentistryPalacky UniversityOlomouc 77900Czech Republic Department of Pathology University Hospital Olomouc and Faculty of Medicine and DentistryPalackýUniversityOlomouc 77900Czech Republic

BACKGROUND Coronavirus disease-2019(COvID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Cov-2)is characterized by systemic inflammatory response syndrome and ***-Cov-2 associated mortality ranges from 2%to 6%.Liver dysfunction was observed in 14%-53%of COvID-19 cases,especially in moderate severe ***,no cases of spontaneous hepatic rupture in pregnant women with SARS-Cov-2 have been *** SUMMARY A 32-year-old pregnant patient(gestational age:32 wk+4 d)without any remarkable medical history or long-term medication presented with ***,non-infectious,and pregnancy-related hepatopathies were *** onset of right subcostal pain with D-dimer and liver enzyme elevation was followed by shock with *** performing an emergency cesarean section,hemoperitoneum was observed,and the patient delivered a stillbirth.A 6-cm liver rupture at the edges of segments v and vI had occurred,which was sutured and ***-Cov-2 positivity on reverse transcriptionpolymerase chain reaction was *** revisions for intrahepatic hematoma with hemorrhagic shock and abdominal compartment syndrome were ***,the patient developed hemoptysis,which was treated using bronchoscopic therapy and non-invasive *** tissue biopsy revealed hemorrhagic foci and necrosis with an irregular centrilobular *** syndrome and autoimmune hepatitis were also ruled *** death was caused by acute intrauterine *** This case reveals that pregnant women with SARS-Cov-2 infection may be predisposed to liver parenchyma disease with liver rupture.

关键词： Liver rupture SARS-Cov-2 Pregnancy Abortion HELLP Case report

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非晶合金配电变压器最大限度节约能源

电气制造 2014年第5期 22-26页

作者： v.R.Ramanan martin Carlen ABB集团研究院电源技术研发中心 ABB电力产业部变压器业务单元

随着全球人口不断增长,能耗需求日益扩大,维系这个电力紧缺的世界需要靠节能产品和可靠电网的支撑。当前节能计划和能效要求的驱动力来自全球性和地区性的CO2减排倡议。谈到配电变压器,作为供电系统的一个重要组成部分,其安装量大,即便... 详细信息

随着全球人口不断增长,能耗需求日益扩大,维系这个电力紧缺的世界需要靠节能产品和可靠电网的支撑。当前节能计划和能效要求的驱动力来自全球性和地区性的CO2减排倡议。谈到配电变压器,作为供电系统的一个重要组成部分,其安装量大,即便是新型变压器,对能源的损耗从总量来看仍然是惊人的。据估计,全球此类能源损耗占总发电量的2.3%,约25 GW。每节约1 GW,大约相当于每年减少500万t的CO2排放量。作为全球领先的变压器制造商,ABB现已开发出油浸式非晶合金配电变压器和EcoDry非晶合金干式配电变压器,相对于传统铁心材料,能够减少70%的空载损耗。

关键词：非晶合金配电变压器制造领域新材料生产新工艺节约能源非晶合金变压器变压器行业铁心