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Lap-Shear Performance of Weld-Bonded Mg Alloy and Austenitic Stainless Steel in Three-Sheet Stack-Up

Chinese Journal of Mechanical Engineering 2024年第4期 355-366页

作者： Sunusi Marwana Manladan Mukhtar Fatihu Hamza singh ramesh Zhen Luo School of Materials Science and Engineering Tianjin University Department of Mechanical Engineering Faculty of EngineeringBayero University Department of Mechanical Engineering College of EngineeringPrince Sattam bin Abdulaziz University Department of Mechanical Engineering Faculty of EngineeringUniversity of Malaya

With the growing interest in utilizing Mg and austenitic stainless steel(ASS) in the automotive sector, joining them together in three-sheet configuration is inevitable. However, achieving this task presents considerable challenges due to the large differences in their physical, metallurgical and mechanical properties. To overcome these challenges, the feasibility of using weld-bonding to join Mg alloy/ASS/ASS was investigated. The nugget formation,interface characteristics, microstructure and mechanical properties of the joints were investigated. The results show that the connection between the Mg alloy and upper ASS was achieved through the combined effect of the cured adhesive and weld-brazing in the weld zone. On the other hand, a metallurgical bond was formed at the ASS/ASS interface. The Mg nugget microstructure exhibited fine columar grains composed predominantly of primary α-Mg grains along with a eutectic mixture of α-Mg and β-Mg17Al12. The nugget formed at the ASS/ASS interface consisted largely of columnar grains of austenite, with some equiaxed dendritic grains formed at the centerline of the *** weld-bonded joints exhibited an average peak load and energy absorption of about 8.5 kN and 17 J, respectively(the conventional RSW joints failed with minimal or no load application). The failure mode of the joints changed with increasing welding current from interfacial failure via the Mg nugget/upper ASS interface to partial interfacial failure(part of the Mg nugget was pulled out of the Mg sheet). Both failure modes were accompanied by cohesive failure in the adhesive zone.

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Chatter stability prediction in high-speed micromilling of Ti6Al4 Vvia finite element based microend mill dynamics

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Advances in Manufacturing 2018年第1期6卷 95-106页

作者： Kundan K. singh ramesh singh Department of Mechanical Engineering Indian Institute of Technology Bombay Powai Mumbai 400076 India

High-speed micromilling （spindle speeds 100 000r/min） can create complex three-dimensional microfeaturesin difficult-to-machine materials. The micromachined sur-face must be of high quatity, to meet functional require-ments. However, chatter-induced dynamic instabilitydeteriorates the surface quality and can be detrimental totool life. Chatter-free machining can be accomplished byidentifying stable process parameters via stability lobe dia-gram. To generate accurate stability lobe diagram, it isessential to determine the microend mill dynamics. Fre-quency response function is required to determine the tool-tip dynamics obtained by experimental impact *** that application of impact load at the microend mill tip（typically 100 - 500 μm） is not feasible as it would invari-ably end with tool failure. Consequently, alternative meth-ods need to be developed to identify the microend milldynamics. In the present work, the frequency responsefunction for the microend mill is obtained by finite elementmethod modal analysis. The frequency response functionobtained from modal analysis has been verified from theexperimentally obtained frequency response function. Theexperimental frequency response function was obtained byimpacting the microend mill near the taper portion with animpact hammer and measuring the vibration of the tool-tipwith a laser displacement sensor. The fundamental fre-quency obtained from finite element method modal analysisshows a difference of 6.6% from the experimental funda-mental frequency. Microend mill dynamics obtained fromthe finite element method is used for chatter prediction inhigh-speed micromilling operations. The stability lobe dia-gram predicts the stability boundary accurately at 60 000r/min and 80 000 r/min; however, a slight deviation isobserved at 100 000 r/min.

关键词： Chatter Micromilling Microend milldynamics Frequency response function Finite elementmodal analysis

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Fabrication and functional characterization of engineered features on pyrolytic carbon

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Advances in Manufacturing 2016年第2期4卷 134-141页

作者： Vivek Bajpai Bablu Prasad ramesh singh Department of Mechanical Engineering Indian Institute ofTechnology Bombay Powai Mumbai 400076 India Centre for Environmental Science and Engineering IndianInstitute of Technology Bombay Powai Mumbai 400076India

Engineered features on pyrolytic carbon （PyC） have been reported to improve the functional performance of the bio-implants. This paper is focused on the functional characterization of micro-features created on the surface of PyC. Two different types of micro-features （wide channels and arrayed holes） have been created by micro-electrical discharge machining （micro-EDM）. Two other micro-fea- tures （fine channels and micro-pillars） have been created by micromilling process. Coliform bacterial strain was iso- lated from a sample of water and grown on all four tex- tured. Cell growth was carried out on an unmachined surface to see the behavior of the isolated bacterial strain on the textured/non-textured surfaces. The samples were examined under SEM before and after wash to see cell growth and cell adhesion capability of the textures. The wide channels by micro-EDM show the maximum cell growth but poor cell adhesion. 184% higher cell growth has been observed on the wide channels in comparison with unmachined surface. The fine channels by micro-milling show comparatively lower growth but the cell adhesion on this surface was found excellent. 71% cells remain unwa- shed after washing of the surface having fine channel textures. It means that the channels structure shows the maximum cell growth and adhesion independent of machining process.

关键词： Pyrolytic carbon Micro-features Surfacetexturing Cell growth and adhesion

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Primary graft dysfunction following lung transplantation:From pathogenesis to future frontiers

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World Journal of Transplantation 2023年第3期13卷 58-85页

作者： Sanjeet singh Avtaar singh Sudeep Das De Ahmed Al-Adhami ramesh singh Peter MA Hopkins PhilipAlan Curry Department of Cardiothoracic Surgery Royal Infirmary of EdinburghEdinburgh EH164SAUnited Kingdom Institute of Cardiovascular and Medical Sciences University of GlasgowGlasgow G128QQUnited Kingdom Heart and Lung Transplant Unit Wythenshawe HospitalManchester M239NJUnited Kingdom Department of Heart and Lung Transplant Royal Papworth HospitalCambridge CB20AYUnited Kingdom Mechanical Circulatory Support Inova Health SystemFalls ChurchVA 22042United States Queensland Lung Transplant Service Prince Charles HospitalBrisbaneQLD 4032Australia Department of Cardiothoracic Surgery Golden Jubilee National HospitalGlasgow G814DYUnited Kingdom

Lung transplantation is the treatment of choice for patients with end-stage lung ***,just under 5000 lung transplants are performed worldwide ***,a major scourge leading to 90-d and 1-year mortality remains primary graft *** is a spectrum of lung injury ranging from mild to severe depending on the level of hypoxaemia and lung injury *** review aims to provide an in-depth analysis of the epidemiology,pathophysiology,risk factors,outcomes,and future frontiers involved in mitigating primary graft *** current diagnostic criteria are examined alongside changes from the previous *** also highlight the issues surrounding chronic lung allograft dysfunction and identify the novel therapies available for ex-vivo lung *** primary graft dysfunction remains a significant contributor to 90-d and 1-year mortality,ongoing research and development abreast with current technological advancements have shed some light on the issue in pursuit of future diagnostic and therapeutic tools.

关键词： Primary graft dysfunction Lung transplantation Pathophysiology Risk factors Extracorporeal membranous oxygenation

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Diurnal characteristics of geoelectric fields and their changes associated with the Alxa Zuoqi M_S5.8 earthquake on 15 April 2015(Inner Mongolia)

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Earthquake Science 2018年第1期31卷 35-43页

作者： Qing Ye Ye Fan Xuebin Du Tengfa Cui Kechang Zhou ramesh P.singh China Earthquake Network Center China Earthquake Administration Lanzhou Institute of Seismology China Earthquake Administration Institute of Geology China Earthquake Administration School of Life and Environmental Sciences Schmid College of Science and Technology Chapman University One University Drive

In China, efforts are being made to monitor geoelectric fields through a large network of stations deployed and managed by the China Earthquake Administration. The diurnal variations in the geoelectric field waveforms were similar in the quiet magnetic periods when K〈5 （generally, K〈3 indicates a quiet time）. The arrival time points of the maxima in the geoelectric field waveforms exhibited differences in local time related to geographic longitude. The amplitude of diurnal variation was several to 16.6 mV/km and decreased with increasing latitude. Further, the amplitude of diurnal variation, which was related to seasonal changes, was larger in summer and autumn than in spring and winter. The periods of diurnal changes during quiet days were 24, 12, 8, 6, 4 hours and several minutes over large areas. Finally, the observed diurnal variations in geoelectric field prior to the Alxa Zuoqi Ms5.8 earthquake on 15 April 2015 were studied, and pronounced changes in the spectral values of the geoelectric fields were found to be associated with the Alxa Zuoqi earthquake in Inner Mongolia.

关键词： Geoelectrical field Diurnal variation Period Alxa Zuoqi earthquake

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Effects of Atmospheric Pollutants on Agricultural Crop Yield in China

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Journal of Earth Science 2020年

作者： Lunche Wang Yisen Chen Xinzhong Liang ramesh P.singh Xinxin Chen Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information Engineering China University of Geosciences Department of Atmospheric and Oceanic Science University of Maryland College Park Earth System Science Interdisciplinary Center University of Maryland College Park School of Life and Environmental Sciences Schmid College of Science and Technology Chapman University One University Drive

Recent studies have shown decline in crop production due to changes in climate associated with the increasing greenhouse emissions. It is difficult to reduce the emissions in a short period of time, however, the short-lived climate pollutants (SLCPs) are more likely to be controlled. In present study, a statistical panel model was established to investigate the national-level effects of SLCPs on five crops (early-, middle-late-season rice, spring wheat, and winter wheat) in China. Observed national yields during 1980-2009 were 6%-18% lower than values modeled while excluding variations in climate and pollutants, with larger biases in some of the most heavily polluted provinces such as the Sichuan-Chongqing region. Overall, the impacts of climate and SLCPs on agricultural production have increased over the past three decades. SLCPs have been responsible for more than 80% of the impacts, while the changing climate is of secondary importance. So controlling regional SLCPs can dramatically reduce the negative impacts on the agricultural yields, which is easier than changing the climate. This analysis provides a scientific basis for policy making to improve future agriculture in China.

关键词： crop yield climate change pollution SLCPs rice and wheat

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反复张力下V形切口圆条的表面裂纹的疲劳扩展(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第11期15卷 873-882页

作者： Devi CHANDRA Judha PURBOLAKSONO Yusoff NUKMAN Haw-ling LIEW singh ramesh Mohsen-abdel HASSAN Center of Advanced Manufacturing and Materials Processing Department of Mechanical EngineeringFaculty of EngineeringUniversity of Malaya Department of Mechanical Engineering Faculty of Engineering University of Andalas Center of Manufacturing System Integration Department of Mechanical EngineeringFaculty of Engineering University of Malaya

研究目的:在相同的反复张力下,研究V形切口圆条表面裂纹的疲劳扩展规律。研究方法:1.构建V形切口圆条模型(图1),基于线性二次元将模型表面离散成一个个网格点(图2);2.以AZ-6A-T5镁合金为例,利用J积分计算应力强度因数,利用NASGRO裂纹增... 详细信息

研究目的:在相同的反复张力下,研究V形切口圆条表面裂纹的疲劳扩展规律。研究方法:1.构建V形切口圆条模型(图1),基于线性二次元将模型表面离散成一个个网格点(图2);2.以AZ-6A-T5镁合金为例,利用J积分计算应力强度因数,利用NASGRO裂纹增长率模拟裂纹的疲劳扩展;3.通过研究不同的裂纹纵横比和对应的应力强度因数之间的相关性来研究裂纹的扩展。重要结论:1.在裂纹扩展时裂纹纵横比的初始值对断裂形状的发展有重要影响;2.裂纹纵横比对疲劳负荷寿命的作用比缺口半径更加明显;3.当裂纹前缘演变成一条直线形时可观察到不稳定的裂纹扩展;4.裂纹深度一定时,断裂纵横比越小,疲劳负荷寿命越短;5.当裂纹纵横比为0.6–0.7时,出现了不稳定的裂纹扩展。

关键词：疲劳裂纹扩展裂纹纵横比边界元法应力强度因数

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Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition:Harnessing the power of nanotheranostics

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 79-101页

作者： Sagnik Nag Oishi Mitra Bhanu Maturi Simran Preet Kaur Ankita Saini Muskan Nama Soumik Roy Souvik Samanta Leena Chacko Rohan Dutta Suresh Babu Sayana Vetriselvan Subramaniyan Jasvinder singh Bhatti ramesh Kandimalla Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia Department of Bio-Sciences School of Bio-Sciences&Technology(SBST)Vellore Institute of Technology(VIT)Tiruvalam RoadVellore 632014Tamil NaduIndia Department of Internal Medicine University of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Delhi(South Campus)Benito Juarez RoadNew Delhi 110021India Department of Biotechnology Indian Institute of TechnologyHyderabad(IIT-H)SangareddyTelangana 502284India BioAnalytical Lab Meso Scale Discovery1601 Research BlvdRockvilleMDUSA Department of Pharmacology Government Medical CollegeSuryapetTelanganaIndia Laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathindaIndia Department of Biochemistry Kakatiya Medical CollegeWarangal 506007India

Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition(DHC),which encompasses a complex range of cardiovascular issues linked to diabetes and associated *** significant progress in reducing mortality rates from cardiovascular diseases(CVDs),heart failure remains a major cause of increased morbidity among diabetic *** cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components,and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and *** a variety of conventional diagnostic and therapeutic strategies are available,DHC continues to present a significant ***-of-care diagnostics,supported by nanobiosensing techniques,offer a promising alternative for these complex *** conventional medications have been widely used in DHC patients,they raise several concerns regarding various physiological *** medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DHC,offering a promising approach to deliver drugs beyond the limitations of traditional *** article aims to explore the potential connections between autophagy,mitophagy and DHC,while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.

关键词： Autophagy Diabetes Diabetic heart condition Mitophagy Nanotheranostics Nanomedicine

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Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa2X4（X=S and Se）:A first-principles study

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Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： Aparna Dixit Inas A.Ahmed Jisha Annie Abraham Zeinhom M.El-Bahy Mumtaz Manzoor Sajad Ahmad Dar ramesh Sharma Department of Basic Science and Humanities Pranveer Singh Institute of Technology Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics National Defence Academy Department of Chemistry Faculty of ScienceAl-Azhar University Institute of Physics Slovak Academy of Sciences Department of Physics Motilal Vigyan Mahavidyalya College Department of Applied Science Feroze Gandhi Institute of Engineering and Technology

We investigated spinel chalcogenides HgLa2（S/Se）4by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa2（S/Se）4spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential（TB-mBJ）.Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa2S4and *** were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit（more than unity）,as well as Seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Power factor Semiconductors Thermoelectric

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco Arun Upadhyay ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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