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Engineered Regeneration 2022年第3期3卷 283-291页

作者： Anju MS Athira RK ramesh Babu V Anil kumar PR Naresh Kasoju Division of Tissue Culture Department of Applied BiologyBiomedical Technology WingSree Chitra Tirunal Institute for Medical Science and TechnologyThiruvananthapuram 695012KeralaIndia Division of Precision Fabrication Department of Medical Devices EngineeringBiomedical Technology WingSree Chitra Tirunal Institute for Medical Science and TechnologyThiruvananthapuram 695012KeralaIndia

Temporary storage/shipping of cell/tissue engineering products from bench to bedside is a key aspect of re-generative *** current proof-of-concept study presents a multipurpose device for temporary storage/shipping of cell culture dishes containing cell/tissue *** device,made with readily available raw ma-terials,contains three elements viz.a specialized lid,polymeric plates having grooves and a set of nuts and *** part of the performance evaluation,the device was first subjected to a simulated storage/shipping process,wherein the leak-proof and aseptic containment of the contents was ***,the setup was used for temporary storage/shipping of dishes having(a)L929 cell monolayers cultured on treated surfaces,(b)SIRC,HaCaT and A549 cell sheets cultured on thermo-responsive surfaces,(c)HOS-cell encapsulated agar gels and(d)HOS-cell seeded silk fibroin *** results showed that the health of cell monolayers/cell sheets/tissue constructs after the process was comparable to that before the *** device was scalable,simple to handle,can be made for a single or multi-use purpose,and can be resizable to load other culture *** design of the storage/shipping device described in this report thus offers versatile features and applications.

关键词： Tissue engineering Scaffolds Tissue equivalents Translational medicine

Hepatogenous diabetes:Knowledge,evidence,and skepticism

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World Journal of Hepatology 2022年第7期14卷 1291-1306页

作者： ramesh kumar Diego García-Compeán Tanmoy Maji Department of Gastroenterology All India Institute of Medical SciencesPatna 801507BiharIndia Department of Gastroenterology University HospitalUniversidad Autónoma de Nuevo LeónMéxicoMonterrey 64700México

The diabetogenic potential of liver cirrhosis(LC)has been known for a long time,and the name"hepatogenous diabetes"(HD)was coined in 1906 to define the *** mellitus(DM)that develops as a consequence of LC is referred to as *** patients with LC,the prevalence rates of HD have been reported to vary from 21%to 57%.The pathophysiological basis of HD seems to involve insulin resistance(IR)and pancreaticβ-cell *** neurohormonal changes,endotoxemia,and chronic inflammation of LC initially create IR;however,the toxic effects eventually lead toβ-cell dysfunction,which marks the transition from impaired glucose tolerance to *** addition,a number of factors,including sarcopenia,sarcopenic obesity,gut dysbiosis,and hyperammonemia,have recently been linked to impaired glucose metabolism in *** is associated with complications and poor outcomes in patients with LC,although the individual impact of each type 2 DM and HD is unknown due to a lack of categorization of diabetes in most published *** fact,there is much skepticism within scientific organizations over the recognition of HD as a separate disease and a consequence of ***,T2DM and HD are being treated in a similar manner although no standardized guidelines are *** different pathophysiological basis of HD may have an impact on treatment *** review article discusses the existence of HD as a distinct entity with high prevalence rates,a strong pathophysiological basis,clinical and therapeutic implications,as well as widespread skepticism and knowledge gaps.

关键词： Cirrhosis Diabetes Hepatogenous diabetes Glucose intolerance Insulin resistance Metabolism

Current Status of Conventional and Molecular Interventions for Blast Resistance in Rice

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Rice science 2017年第6期24卷 299-321页

作者： Deepti srivastava Md SHAMIM Mahesh kumar Anurag MISHRA Pramila PANDEY Deepak kumar Prashant YADAV Mohammed Harrish SIDDIQUI Kapildeo Narayan SINGH Integral Institute of Agricultural Science and Technology Integral University Lucknow 226021 India Department of Molecular Biology and Genetic Engineering Dr. Kalam Agricultural College Bihar Agricultural University Sabour Bhagalpur Bihar 813210India Department of Agriculture Biotechnology Sardar Vallabhbhai Patel University of Agriculture and Technology Modipuram Meerut 250110 India Department of Plant Molecular Biology and Genetic Engineering Narendra Deva University of Agriculture and Technology Kumarganj Faizabad 224229 India Indian Council of Agricultural Research Directerate of Rapeseed mustard Research Bharatpur Rajasthan 321303 India

Pyricularia oryzae anamorph of Magnaporthe oryzae is one of the most notorious fungal pathogens causing severe economic loss in rice production worldwide. Various methods, viz. cultural, biological and molecular approaches, are utilized to counteract this pathogen. Moreover, some tolerant or resistant rice varieties have been developed with the help of breeding programmes. Isolation and molecular characterization of different blast resistance genes now open the gate for new possibilities to elucidate the actual allelic variants of these genes via various molecular breeding and transgenic approaches. However, the behavioral pattern of this fungus breakups the resistance barriers in the resistant or tolerant rice varieties. This host-pathogen barrier will be possibly countered in future research by comparative genomics data from available genome sequence data of rice and M. oryzae for durable resistance. Present review emphasized fascinating recent updates, new molecular breeding approaches, transgenic and genomics approaches(i.e. mi RNA and genome editing) for the management of blast disease in rice. The updated information will be helpful for the durable, resistance breeding programme in rice against blast pathogen.

关键词： backcross breeding gene pyramiding allele mining transgenic technology rice blast resistance CRISPR/Cas9 molecular breeding bioinformatics approach

Liquid crystal Fresnel lens display

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Chinese Physics B 2016年第9期25卷 88-90页

作者：王骁乾 srivastava Abhishek kumar 谈明威郑致刚沈冬 Chigrinov G Vladimir 郭海成 Physics Department East China University of Science and Technology State Key Laboratory on Advanced Displays and Optoelectronics Technologies HKUST

A novel see-through display with a liquid crystal lens array was proposed.A liquid crystal Fresnel lens display（LCFLD） with a holographic screen was *** proposed display system has high efficiency,simple fabrication... 详细信息

关键词： see-through display liquid crystal Fresnel lens array holographic screen

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螺旋行波管衰减器炭涂层的特性表征

新型炭材料 2008年第4期23卷 378-381页

作者： Vikas kumar Anil Vohra Vishnu srivastava Asia-Pacific Institute of Management Jasola Sarita Vihar New Delhi-110025 India Electronic Sc. Department Kurukshetra University Kurukshetra Haryana-136119 India Microwave Tubes Area CEERI Pilani Rajasthan-333031 India

分别采用热解沉积、胶体石墨涂刷和电弧放电法在行波管(TWT)刚玉支撑杆上涂覆了吸波炭涂层,以改善TWT稳定性。通过一种带孔窄频—高波—道管的实验装置,应用无向量网络解析器实施反射和透射波测量,测得6.0GHz频段涂层杆的衰减程度。并... 详细信息

分别采用热解沉积、胶体石墨涂刷和电弧放电法在行波管(TWT)刚玉支撑杆上涂覆了吸波炭涂层,以改善TWT稳定性。通过一种带孔窄频—高波—道管的实验装置,应用无向量网络解析器实施反射和透射波测量,测得6.0GHz频段涂层杆的衰减程度。并利用一种软件高频结构模拟器(HFSS)进行了模拟。结果表明:胶体石墨涂层显示出最大的损失或吸光率,是适宜的衰减器涂料。HFSS模拟的结果与实验结果吻合。

关键词：衰减器涂层行波管稳定性分析高频模拟回波损耗

Effect of processing routes on microstructure and mechanical properties of 2014 Al alloy processed by equal channel angular pressing

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Transactions of Nonferrous Metals Society of China 2010年第10期20卷 1822-1828页

作者： P.VENKATACHALAM S.ramesh kumar B.RAVISANKAR V.THOMAS PAUL M.VIJAYALAKSHMI Department of Metallurgical and Materials Engineering National Institute of Technology Physical Metallurgy Division IGCAR

Al-Cu alloy was deformed through equal channel angular pressing(ECAP) by routes A,Ba,Bc and C up to 5 *** was done using a 90° die for three different conditions,namely 1) as received,2) solutionised at 768 K for 1 h and 3) solutionised at 768 K for 1 h + aged at 468 K for 5 *** microstructure,microhardness and tensile strength were studied for all the three conditions and four *** improvement in hardness(HV 184 after five passes) and strength(602 MPa after three passes) was observed in solutionised and aged 2014 Al alloy deformed through route *** evolution was reasonably equiaxed in route Bc with aspect ratio of *** and aged 2014 Al alloy deformed through route Bc was identified to have better microstructure and mechanical property than the other processing routes and conditions.

关键词： ECAP processing route 2014 aluminium alloy

Analysis of Power in an Argon Filled Pulsed Dielectric Barrier Discharge

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Plasma Science and Technology 2013年第7期15卷 635-639页

作者： U.N.PAL Pooja GULATI Ram PRAKASH Mahesh kumar V.srivastava S.KONAR Microwave Tubes Division CSIR-Central Electronics Engineering Research Institute (CSIR-CEERI)Pilani Rajasthan-333031 India Birla Institute of Technology (BIT) Mesra Ranchi Jharkhand-835215 India

In this paper an argon filled coaxial dielectric barrier discharge （DBD） has been studied to understand the detail of power transfer from a unipolar square pulse to plasma during discharge. A dielectric barrier discharge based diffuse pulse discharge and its electrical charac-teristics are investigated. A quartz coaxial DBD tube filled at different pressures is used in the experiment. A unipolar pulse voltage of different peak voltages and frequencies has been applied to the discharge electrodes for the generation of microdischarges. Two current pulses are used for two consecutive discharges per applied voltage pulse. The second discharge, which occurs at the falling flank of the voltage pulse, is induced by the charges stored on the dielectric barrier during the first discharge. It has been deduced that the power supplied to ignite the first discharge is partly stored to ignite the second discharge when the applied voltage decays. This process ul- timately leads to much improved power transfer to the plasma. The knowledge obtained from dynamic processes of the DBDs in the discharge gap explains quantitatively the mechanism of ignition, development and extinction of the DBDs.

关键词： DBD non-equilibrium plasma non-thermal plasma diffuse pulse discharge,microdischarges

Nuclear medicine imaging in osteonecrosis of hip:Old and current concepts

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World Journal of Orthopedics 2017年第10期8卷 747-753页

作者： Kanhaiyalal Agrawal Sujit kumar Tripathy ramesh kumar Sen S Santhosh Anish Bhattacharya Department of Nuclear Medicine All India Institute of Medical Sciences Department of Orthopedics All India Institute of Medical Sciences Department of Orthopedics Fortis Hospital Institute of Nuclear Imaging and Molecular Medicine Tamilnadu Government Multi Super Specialty Hospital Department of Nuclear Medicine PGI-MER

Osteonecrosis(ON) is caused by inadequate blood supply leading to bone death, which results in the collapse of the architectural bony structure. Femoral head is the most common site involved in ON. Magnetic resonance imaging(MRI) is a commonly used imaging modality to detect early ON. When MRI is inconclusive, bone scan is helpful in detecting ON during early phase of the disease. As newer nuclear medicine equipment, like single photon emission computed tomography/computed tomography(CT) and positron emission tomography/CT, are emerging in medical science, we review the role of these imaging modalities in ON of femoral head.

关键词： Osteonecrosis Avascular necrosis Bone scan Magnetic resonance imaging Photon emission computed tomography scan Single photon emission computed tomography/computed tomography

Thermal decomposition and kinetics of plastic bonded explosives based on mixture of HMX and TATB with polymer matrices

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Defence Technology（防务技术） 2017年第1期13卷 22-32页

作者： Arjun Singh Tirupati C.Sharma Mahesh kumar Jaspreet Kaur Narang Prateek Kishore Alok srivastava Terminal Ballistics Research Laboratory Defence Research&Development OrganisationMinistry of DefenceExplosive DivisionSector 30Chandigarh(UT)160030India Department of Chemistry&Centre for Advanced Studies in Chemistry Panjab UniversityChandigarh160 014India

This work describes thermal decomposition behaviour of plastic bonded explosives(PBXs) based on mixture of 1,3,5,7-tetranitro-1,3,5,7-tetrazocane(HMX) and 2,4,6-triamino-1,3,5-trinitrobenzene(TATB)with Viton A as polymer binder. Thermal decomposition of PBXs was undertaken by applying simultaneous thermal analysis(STA) and differential scanning calorimetry(DSC) to investigate influence of the HMX amount on thermal behavior and its kinetics. Thermogravimetric analysis(TGA) indicated that the thermal decomposition of PBXs based on mixture of HMX and TATB was occurred in a three-steps. The first step was mainly due to decomposition of HMX. The second step was ascribed due to decomposition of TATB, while the third step was occurred due to decomposition of the polymer matrices. The thermal decomposition % was increased with increasing HMX amount. The kinetics related to thermal decomposition were investigated under non-isothermal for a single heating rate measurement. The variation in the activation energy of PBXs based on mixture of HMX and TATB was observed with varying the HMX amount. The kinetics from the results of TGA data at various heating rates under non-isothermal conditions were also calculated by Flynn—Wall—Ozawa(FWO) and Kissinger-Akahira-Sunose(KAS)methods. The activation energies calculated by employing FWO method were very close to those obtained by KAS method. The mean activation energy calculated by FWO and KAS methods was also a good agreement with the activation energy obtained from single heating rate measurement in the first step decomposition.

关键词： Plastic bonded explosives Thermogravimetric analysis Differential scanning calorimeter Thermal decomposition Kinetics

Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 965-970页

作者： Gollapalle Lakshminarayana shastry Viswanatha Santosh kumar Vaidya ramesh C Nandakumar Krishnadas Srinath Rangappa Department of Pharmacology PES College of PharmacyBangalore-560050 India Department of Pharmacology St.John's College of PharmacyBangalore-560040 India Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal-576104 India

Objective:The alcoholic extract of stem bark of Terminalia arjuna（ALTA） was screened for antioxidant and antimutagenic（anticlastogenic） ***:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl（DPPH） assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s *** activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 *** micronucleus test,ALTA（100 & 200 mg/kg,p.o.） showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes（PCE） and normochromatie erythrocytes（NCE） and also shown significant reduction in P/N ***:These results suggested that ALTA possess significant antioxidant and antimutagenic activity.

关键词： Terminalia arjuna Antioxidant activity Antimutagenic activity Micronuclease test