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Neural Regeneration Research 2016年第10期11卷 1545-1548页

作者： Prashanth Komirishetty Aparna Areti Ranadeep Gogoi ramakrishna sistla Ashutosh Kumar Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad BalanagarIndia Department of Biotechnology National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati Assam India Pharmacology Division Indian Institute of Chemical Technology (IICT) Hyderabad India

Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that jimit the pathological changes and improve the behavioral outcome have been well explained in different experimental models of neuropathy but translation of such strategies to clinics has been disappointing. Experimental evidences revealed the role of free radicals, especially per- oxynitrite after the nerve injury. They provoke oxidative DNA damage and consequent over-activation of the poly（ADP-ribose） polymerase （PARP） upregulates pro-inflammatory pathways, causing bioenergetic crisis and neuronal death. Along with these changes, it causes mitochondrial dysfunction leading to neu- ronal apoptosis. In related preclinical studies agents that neutralize the free radicals and pharmacological inhibitors of PARP have shown benefits in treating experimental neuropathy. This article reviews the in- volvement of PARP over-activation in trauma induced neuropathy and therapeutic significance of PARP inhibitors in the experimental neuropathy and neuropathic pain.

关键词： neuropathic pain poly(ADP-ribose) polymerase neuroinflammation oxidative stress bioenergeticcrisis

Direct injection HILIC-MS/MS analysis of darunavir in rat plasma applying supported liquid extraction

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Journal of Pharmaceutical Analysis 2015年第1期5卷 43-50页

作者： Bokka Ramesh Nemali Manjula sistla ramakrishna Potturi Sita Devi Natural Products Chemistry Division Indian Institute of Chemical TechnologyTarnakaHyderabad 500607India Medicinal Chemistry & Pharmacology Division Indian Institute of Chemical TechnologyTarnakaHyderabad 500607India

A novel bioanalytical method was developed and validated for the quantitative determination of darunavir（DRV） in rat plasma by employing hydrophilic interaction chromatography and tandem mass spectrometry（HILIC-MS/MS） with supported liquid extraction（SLE）.lrbesartan（IRB） was used as an internal standard（IS）.The analyte in rat plasma（200 μL） was isolated through SLE using ethyl acetate as the eluting *** chromatographic separation was achieved on Luna-HILIC（250 mm × 4.6 mm,5 μm）column with a mobile phase of 0.1% of formic acid in water：acetonitrile（5：95,v/v）,at a constant flow rate of 1.0mL/*** MS/MS ion transitions for DRV（548.1→392.0） and IS（429.2→207.1） were monitored on an ion trap mass spectrometer,operating in the multiple reaction monitoring（MRM） *** lower limit of quantitation（LLOQ） was 0.2 ng/mL and quantitation range was 0.2-5000 ng/*** method was validated for its selectivity,sensitivity,carryover,linearity,precision,accuracy,recovery,matrix effect and *** method was successfully applied to pharmacokinetic study in rats.

关键词： Darunavir HILIC-MS/MS Rat plasma Supported liquid extraction

Simultaneous determination of amlodipine,valsartan and hydrochlorothiazide by LC-ESIMS/MS and its application to pharmacokinetics in rats

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Journal of Pharmaceutical Analysis 2014年第6期4卷 399-406页

作者： Shankar Ganesh Gadepalli Pragney Deme Madhusudana Kuncha ramakrishna sistla Pharmacology Division Indian Institute of Chemical Technology Tcirnaka Hyderabad Andhra Pradesh 500007 India National Center for Mass Spectrometry Indian Institute of Chemical Technology Tarnaka HyderabadAndhra Pradesh 500007 India

Polypill is a fixed-dose combination that contains three or more active ingredients used as a single daily pill to achieve a large effect in preventing cardiovascular disease with minimal adverse effects.A novel and accurate liquid chromatography tandem mass spectrometry method using electrospray ionization mode has been developed and validated for the simultaneous determination of amlodipine（AMD）,valsartan（VAL） using losartan（LOS） as an internal standard（IS）,and hydrochlorothiazide（HCT） using furosemide（FSD） as an *** separation was carried on Aquasil C18（50 mm×2.1 mm,5μm） reversed phase column using acetonitrile and water containing 0.1%formic acid（50：50,v/v） as the mobile *** method was validated in terms of linearity,accuracy and precision over the concentration range of 1-1000 ng/*** intra and inter-day precision and accuracy,stability and extraction recoveries of all the analytes were in the acceptable *** method can be successfully applied to the pharmacokinetic study of AMD,VAL and HCT when given as a polypill.

关键词： Amlodipine Valsartan Hydrochlorothiazide Exforge HCT Polypill

Antioxidant and hepatoprotective effects of Boswellia ovalifoliolata bark extracts

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Chinese Journal of Natural Medicines 2014年第9期12卷 663-671页

作者： Bandari Uma Mahesh Shweta Shrivastava Rajeswara Rao Pragada V.G.M.Naidu ramakrishna sistla Department of Pharmacology A.U.College of Pharmaceutical Sciences Andhra University Vishakhapatnam Andhra Pradesh India -530003 Department of Pharmacology & Toxicology National Institute of Pharmaceutical Education & Research (NIPER-Hyderabad) Balanagar Hyderabad Andhra Pradesh India-500037 Pharmacology Division Indian Institute of Chemical Technology Habsiguda Hyderabad Andhra Pradesh ndia-500007

Paracetamol(PCM) hepatotoxicity is related to reactive oxygen species(ROS) formation and excessive oxidative stress; natural antioxidant compounds have been tested as an alternative therapy. This study evaluated the hepatoprotective activity of an alcoholic extract of Boswellia ovalifoliolata(BO) bark against PCM-induced hepatotoxicity. BO extract also demonstrated antioxidant activity in vitro, as well as scavenger activity against 2, 2-diphenyl-1-picrylhydrazyl. Administration of PCM caused a significant increase in the release of transaminases, alkaline phosphatase, and lactate dehydrogenase in serum. Significant enhancement in hepatic lipid peroxidation and marked depletion in reduced glutathione were observed after parac intoxication with severe alterations in liver histology. BO treatment was able to mitigate hepatic damage induced by acute intoxication of PCM and showed a pronounced protective effect against lipid peroxidation, deviated serum enzymatic variables, and maintained glutathione status toward control. The results clearly demonstrate the hepatoprotective effect of BO against the toxicity induced by PCM.

关键词： extracts peroxidation glutathione dehydrogenase protective alcoholic antioxidant ABTS histology curcumin

Anti-Amnesic Activity of Vitex Negundo in Scopolamine Induced Amnesia in Rats

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Pharmacology & Pharmacy 2010年第1期1卷 1-8页

作者： Abhinav Kanwal Jogender Mehla Madhusudana Kuncha Vegi Ganga Modi Naidu Yogendra Kumar Gupta ramakrishna sistla Division of Pharmacology Indian Institute of Chemical Technology (IICT) National Institute of Pharmaceutical Education and Research (NIPER) Department of Pharmacology All India Institute of Medical Sciences (AIIMS)

In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Scopolamine (3 mg/kg, i.p) was administered at different time periods on the basis of stages of memory i.e acquisition, consolidation and retention in different groups (n = 6). Effect of Vitex negundo extract was evaluated and compared to a standard drug, Donepezil. Significant (p <0.05) increase in the avoidance response on the 5th session has been observed as compared to 1st session in control group. Scopolamine treatment significantly (p <0.05) reduced the avoidance response compared to control. Extract treated groups shown significant (p <0.05) increase in number of avoidance responses as compared to scopolamine treated groups. Increased oxidative stress in brain after scopolamine treatment, as observed by increase in MDA &decrease in GSH &SOD, was lowered in the groups treated with extracts. AChE activity was also improved after V. negundo treatment. Results of the study have shown that V. negundo treated groups decrease the phenomenon of amnesia by increasing learning of memory through antioxidant effect and decreasing AChE activity.

关键词： Vitex Negundo Amnesia Acetylcholinestrase Scopolamine Learning and Memory Oxidative Stress

Anticancer Activity of Rice Callus Suspension Cultures from Aromatic Varieties and Metabolites Regulated in Treated Cancer Cell Lines

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Rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： Anuradha KUMARI Wusirika ramakrishna Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. Rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite

Engineering the axial coordination of cobalt single atom catalysts for efficient photocatalytic hydrogen evolution

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Nano Research 2024年第6期17卷 5114-5121页

作者： Ning Kang Lingwen Liao Xue Zhang Zhen He Binlu Yu Jiahong Wang Yongquan Qu Paul KChu Seeram ramakrishna Xue-Feng Yu Xin Wang Licheng Bai Materials Interfaces Center Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen 518055China Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyCAS Center for Excellence in NanoscienceInstitute of Solid State PhysicsChinese Academy of SciencesHefei 230031China Department of Chemistry City University of Hong KongKowloonHong Kong 999077China Hong Kong Branch of National Precious Metals Material Engineering Research Center(NPMM) City University of Hong KongKowloonHong Kong 999077China Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Physics and Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong 999077China National University of Singapore(NUS)Centre for Nanofibers and Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117542Singapore

Improving the catalytic activity of non-noble metal single atom catalysts(SACs)has attracted considerable attention in materials *** optimizing the local electronic structure of single atom can greatly improve their catalytic activity,it often involves in-plane modulation and requires high ***,we report a novel strategy to manipulate the local electronic structure of SACs via the modulation of axial Co-S bond anchored onto graphitic carbon nitride(C_(3)N_(4))at room temperature(RT).Each Co atom is bonded to four N atoms and one S atom(Co-(N,S)/C_(3)N_(4)).Owing to the greater electronegativity of S in the Co-S bond,the local electronic structure of the Co atoms is available to be controlled at a relatively moderate ***,when employed for the photocatalytic hydrogen evolution reaction,the adsorption energy of intermediate hydrogen(H*)on the Co atoms is remarkably *** the presence of the Co-(N,S)/C_(3)N_(4)SACs,the hydrogen evolution rates reach up to 10 mmol/(g·h),which is nearly 10 and 2.5 times greater than the rates in the presence of previously reported transition metal/C_(3)N_(4)and noble platinum nanoparticles(PtNPs)/C_(3)N_(4)catalysts,*** to the tailorable axial Co-S bond in the SAC,the local electronic structure of the Co atoms can be further optimized for other photocatalytic *** axial coordination engineering strategy is universal in catalyst designing and can be used for a variety of photocatalytic applications.

关键词： transition metal single-atom local electronic structure photocatalytic hydrogen evolution graphitic carbon nitride axial coordination environment

Electronic properties of 2D materials and their junctions

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Nano Materials Science 2024年第1期6卷 1-23页

作者： Taposhree Dutta Neha Yadav Yongling Wu Gary J.Cheng Xiu Liang Seeram ramakrishna Aoussaj Sbai Rajeev Gupta Aniruddha Mondal Zheng Hongyu Ashish Yadav Department of Chemistry Indian Institute of Engineering Science and TechnologyShibpurWest Bengal711103India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Industrial Engineering Purdue University315 N.Grant St.West LafayetteIN47907United States Birck Nanotechnology Center Purdue University1205 W State St.West LafayetteIN47907United States Advanced Materials Institute Qilu University of TechnologyShandong Academy of SciencesJinan250014PR China Nanoscience and Nanotechnology Initiative National University of Singapore10 Kent Ridge Crescent119260Singapore Faculty of Applied Phsyics and Mathematics Gdansk University of Technology Narutowicza 11/1280233GdanskPoland Department of Physics School of EngineeringUniversity of Petroleum&Energy StudiesDehradun248007UttarakhandIndia Department of Physics National Institute of Technology DurgapurDurgapur713209West BengalIndia

With an extensive range of distinctive features at nano meter-scale thicknesses,two-dimensional(2D)materials drawn the attention of the scientific *** tremendous advancements in exploratory research on 2D materials,knowledge of 2D electrical transport and carrier dynamics still in its ***,here we highlighted the electrical characteristics of 2D materials with electronic band structure,electronic transport,dielectric constant,carriers *** atomic thinness of 2D materials makes substantially scaled field-effect transistors(FETs)with reduced short-channel effects conceivable,even though strong carrier mobility required for high performance,low-voltage device *** also discussed here about factors affecting 2D materials which easily enhanced the activity of those materials for various ***,Those 2D materials used in state-of-the-art electrical and optoelectronic devices because of the extensive nature of their electronic band structure.2D materials offer unprecedented freedom for the design of novel p-n junction device topologies in contrast to conventional bulk *** also,describe the numerous 2D p-n junctions,such as homo junction and hetero junction including mixed dimensional ***,we talked about the problems and potential for the future.

关键词： 2D materials Electrical properties p-n junctions Mixed hereto junctions Homo junctions Electrical transport

Quantification of Structurally Alert Mutagenic Impurities in Meropenem Trihydrate Drug Substance by Liquid Chromatography with High Resolution Mass Spectrometer (LC-HRMS)

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American Journal of Analytical Chemistry 2024年第3期15卷 119-133页

作者： Anwar Sulaiman K. ramakrishna Reddy Vundavilli Jagadeesh Kumar Hemant Kumar Sharma REVA University Bangalore India Quality Division Aurobindo Pharma Limited Hyderabad India APL Research Centre-II Analytical Research Department Aurobindo Pharma Limited Hyderabad India

Potential mutagenic impurities in Active Pharmaceutical Ingredient, Meropenem Trihydrate were assessed and a novel analytical method for their quantification was developed and validated. This Liquid Chromatographic method using High Resolution Mass Spectrometer (LC-HRMS) technique is proved to be suitable for simultaneous quantification of all ten identified impurities with required specificity, sensitivity, resolution, precision, accuracy, and other method characteristics as per ICH Guidelines. The acceptable limit of less than 2.9 μg/g was considered for evaluations, based on drug substance dosage and duration of treatment. The method stands most sensitive with a Limit of Detection of 0.35 μg/g, considering the challenge full acceptance criteria as per current regulatory standards.

关键词： Mutagenic Impurities LC-HRMS Meropenem Trihydrate Method Validation

Basic research and industrial development status of suancai in Northeast China: History， microflora diversity， processing technology， nutrition and safety

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Food Science and Human Wellness 2024年

作者： Qianqian Wang Jingbo Yang Yuqi Wang Meiru Xie Xiaoxi Qi Ramnarain ramakrishna Libo Liu Wenkui Guo Guofang Zhang Chun Li Key Laboratory of Dairy Science， Ministry of Education， College of Food Science， Northeast Agricultural University Department of Plant Sciences， North Dakota State University Heilongjiang Institute of Green Food Science

Suancai has a lengthy history and a wide range of categories， which has some influence on the pickled diet culture around the world. Suancai production is transitioning to a large-scale， standardized production due to the growth of the market. It has a unique flavor and is rich in nutrients， and its abundance of free amino acids， vitamins and phenolics has many positive effects on the human body. This review gives the types and history of suancai， as well as its impact on the world's pickled culture. The changes in nutritional composition and flavor of suancai during fermentation are summarized. It presented the production technology and influencing factors of the northeast suancai， examined the quality and safety issues in suancai， and put forth some ideas and opinions on the standardization development of the suancai industry. It also summarized the geographic distribution and flora diversity of pickles around the world. In order to provide some knowledge and guidance for the promotion of modern industrial production in the suancai industry.

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