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Association between obesity-related adipokines and colorectal cancer:A case-control study and meta-analysis

World Journal of Gastroenterology 2014年第24期20卷 7941-7949页

作者： rakhi kumari joshi Woo Jin Kim Sang-Ah Lee Department of Preventive Medicine Kangwon National University School of MedicineChuncheon-siGangwon-do 200-701South Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon-siGangwondo 200-701South Korea

AIM: To examine the association between obesity-related adipokines (adiponectin, leptin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) and colorectal cancer (CRC) risk.

关键词： Obesity Colorectal cancer Cancer risk Adipokines Obesity-related adipokines

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Effect of Alstonia scholaris bark extract on testicular function of Wistar rats

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Asian Journal of Andrology 2002年第3期4卷 175-178页

作者： R. S. Gupta rakhi Sharma Aruna Sharma A.K. Bhatnager M.P. Dobhal Y.C. joshi M.C. Sharma Reproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302004 IndiaReproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302004 IndiaReproduction Physiology Section Department of Zoology University of Rajasthan Jaipur-302004 IndiaDepartment of Chemistry S.S. Jain Subodh P.G. College Jaipur-302004 IndiaRoswell Park Cancer Institute Elm & Carlton Streets Buffalo New York 14263 USADepartment of Chemistry University of Rajasthan Jaipur-302004 IndiaDepartment of Chemistry University of Rajasthan Jaipur-302004 India

Abstract Aim: To evaluate the antifertility effect ofAlstonia scholaris bark extract in male rats. Methods: In male Wistar rats Alstonia scholaris bark extract was given by oral route at a dose of 200 mg/day for 60 days. The fertility and testicular function were assessed by mating tests, sperm motility, sperm concentration, biochemical indices and testicular cell population dynamics. Results: Oral feeding with the extract at a dose of 200 mg/day for the period of 60 days did not cause body weight loss, while the weights of testes, epididymides, seminal vesicle and ventral prostate were significantly reduced. The production of step-19 spermatids was reduced by 79.6% in treated rats. The population of preleptotene and pachytene spermatocytes were decreased by 61.9% and 60.1%, respectively. Spermatogonia and Sertoli cell population were also affected. The seminiferous tubule and Leydig cell nuclear area were reduced significantly (P<0.01) when compared to the controls. Reduced sperm count and motility resulted in a total suppression of fertility. A significant fall in the protein and sialic acid content of the testes, epididymides, seminal vesicle and ventral prostate as well as glycogen content of testes were also noticed. The fructose content in the seminal vesicle was lowered whereas the testicular cholesterol was elevated as compared with the controls. The following compounds were obtained from the extract with chromatographic separation over Si-gel column: α-amyrin, β-amyrin, lupiol acetate, venenative, rhazine and yohimbine. Conclusion: At the dose level employed, Alstonia scholaris bark extract has a significant antifertility effect in male rats; the primary site of action may be post meiotic germ cells (Step 19 spermatids).

关键词： Alstonia scholaris testis sperm motility sialic acid Sertoli cells

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