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Effect of cooling media on bead geometry,microstructure,and mechanical properties of wire arc additive manufactured IN718 alloy

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Advances in Manufacturing 2024年第1期12卷 124-149页

作者： Parveen kumar Satish kumar Sharma Ratnesh kumar Raj singh Department of Mechanical Engineering Thapar Institute of Engineering and TechnologyPatialaPunjab147004India

This work aims to present and explore thermal management techniques for the wire arc additive manufacturing(WAAM)of IN718 *** heat can be mitigated via air or water *** this study,the material was deposited under four different heat-input conditions with air or water *** air cooling,the layer is deposited in a normal atmospheric air environment,whereas with water cooling,the material is deposited inside a water tank by varying the water *** validate the air and water cooling thermal management techniques,IN718 single-pass and multilayer linear walls were deposited using the bidirectional gas metal arc welding based WAAM setup under four different heat input *** the deposition of single layers,the temperature profiles were recorded,and the geometric and microstructural features were *** multilayer wall structures,the mechanical properties(hardness,tensile strength,and elongation)were determined and assessed using the corresponding microstructural features explored through scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),and electron backscatter diffraction(EBSD)*** microstructure observed through SEM analysis in the building direction was found to be nonhomogenous compared with that in the deposition ***,water cooling was found to govern bead characteristics,such as wall width and *** grain size and anisotropy of the mechanical properties also decreased in the water-cooled ***,water cooling is an economical and efficient method to mitigate excessive heat accumulation in WAAM-deposited IN718.

关键词： Air cooling Water cooling IN718 Bead characteristics Microstructure Electron backscatter diffraction(EBSD)

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Inflammation and retinal degenerative diseases

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Neural Regeneration Research 2023年第3期18卷 513-518页

作者： Geetika kaur Nikhlesh k.singh Integrative Biosciences Center Wayne State UniversityDetroitMIUSA Department of Ophthalmology Visual and Anatomical SciencesWayne State University School of MedicineDetroitMIUSA

Vision is an ability that depends on the precise structure and functioning of the *** kind of stress or injury can disrupt the retinal architecture and leads to vision impairment,vision loss,and *** system and immune response function maintain homeostasis in the *** genetic,metabolic,and environmental factors may alter retinal homeostasis,and these events may initiate various inflammatory *** prolonged inflammatory state may contribute to the initiation and development of retinal disorders such as glaucoma,age-related macular degeneration,diabetic retinopathy,and retinitis pigmentosa,which pose a threat to *** the current review,we attempted to provide sufficient evidence on the role of inflammation in these retinal ***,this review paves the way to focus on therapeutic targets of the disease,which are found to be promising.

关键词： age-related macular degeneration diabetic retinopathy glaucoma retina retinal degeneration retinitis pigmentosa

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Modulatory role of plant-derived metabolites on host-microbiota interactions:personalized therapeutics outlook

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BIOCELL 2024年第8期48卷 1127-1143页

作者： POOJA YADAV NAR singh CHAUHAN Department of Biochemistry Maharshi Dayanand University RohtakRohtakHaryanaIndia

A diverse array of microbes in and on the human body constitute the *** micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and *** biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human *** metabolites are continually being used to treat various *** metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human *** the paramount therapeutic significance of the factors affecting host-microbiota interactions,a comprehensive overview of the modulatory role of plant-derived metabolites in host-microbiota interactions is *** current review puts an effort into comprehending the role of medicinal plants in gut microbiota modulation to mitigate various human *** would develop a holistic understanding of hostmicrobiota interactions and the role of effectors in health and diseases.

关键词： Microbiome therapeutics Human gut microbiota Host-microbiota interactions Personalized therapeutics Plant metabolites Human health and diseases

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Coumarin and eugenol ameliorate LPS-induced inflammation in RAW 264.7 cells via modulating the NLRP3 inflammasome pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 40-46页

作者： Jyotsana Bakshi Somnath singh kP Mishra DRDO Defence Institute of Physiology and Allied Sciences DelhiIndia

Objective:To investigate the underlying mechanism of anti-inflammatory action of coumarin and eugenol in lipopolysaccharide(LPS)-stimulated RAW 264.7 ***:RAW 264.7 cells were treated with 2.5μg/mL of LPS,50μM of coumarin,and 50μM eugenol for 24 *** viability of the cells was assessed using MTT *** production of nitric oxide was determined using Griess reagent and DCFH-DA was used to measure the production of reactive oxygen *** protein expression of NLRP3,IL-1β,NF-κB,and cyclooxygenase 2 was assessed using Western blot ***:Coumarin and eugenol showed anti-inflammatory effects against LPS-induced inflammatory response by ameliorating the expression of NLRP3 inflammasome and NF-κB,which further led to a subsequent reduction in IL-1β,nitric oxide,and reactive oxygen ***:Coumarin and eugenol exert their anti-inflammatory activities by modulating the NLRP3 inflammasome pathway and NF-κ*** compounds may have promising therapeutic applications for the treatment of various inflammatory diseases.

关键词： Inflammation Cytokines Coumarin Eugenol NLRP3 LPS

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A Novel Multi-objective Protection Coordination Scheme for a Microgrid with Optimal Deployment of Dual-setting ROCOV Based Relays

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Protection and Control of Modern Power Systems 2024年第4期9卷 23-38页

作者： Praveen kumar Gupta Priyanshul Niranjan Niraj kumar Choudhary Nitin singh Ravindra kumar singh the Department of Electrical Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj 211004India

Relay coordination is crucial in electrical power systems to protect against malfunctions and damage caused by unexpected events like short *** address the challenge associated with the reverse direction of fault current,dual-setting(DS)directional over-current relays have evolved but failed to provide proper coordination during changes of load,generation,and *** the meantime,with the increasing number of DS relays,the total relay operating time tends to ***,this paper proposes a protection scheme based on the optimal deployment of conventional and dual-setting rate of change of voltage(DS-ROCOV)relays in distribution *** holds true for varying network topologies and is unaffected by variations in load and *** objective of the proposed scheme is to ensure reliable and efficient protection against faults in distribution systems by minimizing the overall operating time with the optimal number of DS-ROCOV *** proposed protection scheme’s performance is evaluated for different coordination time interval values as well as in different microgrid *** paper outlines the design and implementation of the proposed protection scheme which is validated on the modified IEEE 14-bus system using simulations in Matlab/Simulink.

关键词： Coordination time interval DS-ROCOV relay multi-objective optimization optimal-deployment protection coordination

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Incense smoke(IS)inhalation exposure system:Physicochemical characterization,IS particle deposition and clearance in human airway using MPPD model

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Particuology 2024年第4期87卷 271-285页

作者： Vyas kumar Hafsa Hashmi Anshita Nasreen Ghazi Ansari Jyotsna singh Inhalation Toxicology Facility Regulatory Toxicology GroupCSR-Indian Institute of Toxicology ResearchLucknow22001UPIndi Academy of Scientific and Innovative Research(AcsSIR) Ghaziabad201002UPIndia Analytical Chemistry Regulatory Toxicology GroupCSIR-Indian Institute of Toxicology ResearchLucknow226001UPIndia

Incense smoke(IS)is source of indoor air pollution and key risk for diverse human *** in-formation is available regarding controlled IS rodent inhalation exposure system and IS particulate matter(PM)deposition in human *** aimed to demonstrate stable ISPM physicochemical parameters of 10 incense products inside the customized whole body inhalation exposure chamber(without animal)connected to smoke generation unit via aerosol mixing *** analyzed for size segregated PM emission,ISPM in vitro aerodynamics(MMAD and GSD determination),fine and ultrafine particle's SEM,SEM-EDX and PAH *** real life exposure scenario by utilizing MMAD,GSD and PM concentration after Tier 1 exposure assessment as key input parameters,ISPM dosimetry in infant(3 months)and adult(21 years male and female)human airways was calculated using multiple-path particle dosimetry(MPPD 3.04)*** median aerodynamic diameter(MMAD)and geo-metric standard deviation(GSD)ranged between 0.55 and 2.10μm and 1.22 to 1.77(polydisperse)***1.0 and PM0.1 showed multiple morphology and presence of heavy and trace *** like acenaphthylene,anthracene,fluorene,naphthalene and phenanthrene were detected(0.84-143.17μg/g).MPPD results showed higher ISPM deposition in pulmonary region and lowest in trachea bronchial *** deposition in tissue was higher in lower,peripheral lung as compared to upper and central lung *** body inhalation exposure system showed stable IS atmosphere(physi-cochemical parameters)indicating the device suitability in future inhalation *** ISPM deposition fraction and clearance data showed deep lung penetrating and retention behavior with higher risk in infant followed by female and then *** modeled particle deposition and clearance data may be useful in risk assessment analysis of IS.

关键词： Inhalation Incense smoke Multiple-path particle dosimetry(MPPD) Particle deposition Particulate matter(PM) Mass median aerodynamic diameter (MMAD) Human airway

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RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4431-4432页

作者： Laura Urbach Shiv k.singh Department of Gastroenterology Gastrointestinal Oncology and EndocrinologyUniversity Medical Center GottingenGottingenGermany Clinical Research Unit 5002 KFO5002University Medical Center GöttingenGottingenGermany

A new study published in Nature by Jbara et *** identified the splicing factor“RBFOX2,”which halts metastatic spread of pancreatic ductal adenocarcinoma(PDAC)through regulating alternative splicing events.1 The results of the study provide new insights into the molecular mechanisms underlying the start of metastatic spread of PDAC *** study also indicates that pathways involved in splicing modulation could be targeted for potential therapeutic interventions in an advanced-stage PDAC.

关键词： metastasis al. metastatic

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Hopf bifurcation in a delayed prey-predator model with prey refuge involving fear effect

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International Journal of Biomathematics 2024年第5期17卷 1-32页

作者： Ankit Parwaliya Anuraj singh Ajay kumar Department of Applied Sciences ABV-Indian Institute of Information Technology and ManagementGwalior 474015India

This work investigates a prey-predator model featuring a Holling-type II functional response,in which the fear effect of predation on the prey species,as well as prey refuge,are ***,the model assumes that the growth rate of the prey population decreases as a result of the fear of ***,the detection of the predator by the prey species is subject to a delay known as the fear response delay,which is incorporated into the *** paper establishes the preliminary conditions for the solution of the delayed model,including positivity,boundedness and *** paper discusses the existence and stability of equilibrium points in the *** particular,the paper considers the discrete delay as a bifurcation parameter,demonstrating that the system undergoes Hopf bifurcation at a critical value of the delay *** direction and stability of periodic solutions are determined using central manifold and normal form ***,the global stability of the model is established at axial and positive equilibrium *** extensive numerical simulation is presented to validate the analytical findings,including the continuation of the equilibrium branch for positive equilibrium points.

关键词： Hopf bifurcation fear effect prey refuge periodic solutions time delay branch off

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kinetic Energy Recovery from the Chimney Flue Gases Using Ducted Turbine System

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Chinese Journal of Mechanical Engineering 2017年第2期30卷 472-482页

作者： Harjeet S.Mann Pradeep k.singh Department of Mechanical Engineering Sant LongowalInstitute of Engineering and TechnologyLongowalPunjab 148106India

An innovative idea of extracting kinetic energy from man-made wind resources using ducted turbine system for on-site power generation is introduced in this paper. A horizontal axis ducted turbine is attached to the top of the chimney to harness the kinetic energy of flue gases for producing electricity. The turbine system is positioned beyond the chimney outlet, to avoid any negative impact on the chimney performance. The convergentdivergent duct causes increase in the flue gas velocity and hence enhances the performance of the turbine. It also acts as a safety cover to the energy recovery system. The results from the CFD based simulation analysis indicate that sig- nificant power 34 kW can be harnessed from the chimney exhaust. The effect of airfoils NACA4412 and NACA4416 and the diffuser angle on the power extraction by the energy recovery system using a 6-bladed ducted turbine has been studied with the CFD simulation. It is observed that the average flue gas velocity in the duct section at the throat is approximately twice that of the inlet velocity, whereas maximum velocity achieved is 2.6 times the inlet velocity. The simulated results show that about power may be extracted from the chimney flue gases of 660 MW power plant. The system can be retrofitted to existing chimneys of thermal power plants, refineries and other industries.

关键词： Chimney flue gases Energy recovery system ·kinetic energy Ducted turbine CFD

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New insights into the therapeutic approaches for the treatment of tauopathies

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Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： Himanshi singh Asmita Das Mohammad Moshahid khan Tayebeh Pourmotabbed Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia Department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

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