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Antiviral,immunomodulatory,and anticoagulant effects of quercetin and its derivatives:Potential role in prevention and management of COVID-19

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Journal of Pharmaceutical Analysis 2022年第1期12卷 29-34页

作者： Souparnika H.Manjunath rajesh k.thimmulappa Department of Biochemistry Jagadguru Sri Shivarathreeshwara Medical CollegeJagadguru Sri Shivarathreeshwara Academy of Higher Education&Research(JSSAHER)Mysore570015India

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has caused a devastating health crisis *** this review,we have discussed that prophylactic phytochemical quercetin supplementation in the form of foods or nutraceuticals may help manage the COVID-19 *** following evidence supports our ***,nuclear factor erythroid-derived 2-like 2(NRF2)agonists abrogate replication of SARS-CoV-2 in lung cells,and quercetin is a potent NRF2 ***,quercetin exerts antiviral activity against several zoonotic coronaviruses,including SARS-CoV-2,mainly by inhibiting the entry of virions into host ***,inflammatory pathways activated by nuclear factor kappa B,inflammasome,and interleukin-6 signals elicit cytokine release syndrome that promotes acute respiratory distress syndrome in patients with COVID-19,and quercetin inhibits these pro-inflammatory ***,patients with COVID-19 develop thrombosis,and quercetin mitigates coagulation abnormalities by inhibiting plasma protein disulfide *** review provides a strong rationale for testing quercetin for the management of COVID-19.

关键词： COVID-19 Quercetin Immunomodulation Cytokine response syndrome NRF2 Antiviral

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Nrf2 is required for normal postnatal bone acquisition in mice

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Bone Research 2014年第4期2卷 231-240页

作者： Jung-Hyun kim Vandana Singhal Shyam Biswal rajesh k thimmulappa Douglas J Di Girolamo Department of Environmental Health Sciences Johns Hopkins Bloomberg School of Public HealthBaltimoreMDUSA Department of Orthopaedic Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

A large body of literature suggests that bone metabolism is susceptible to the ill effects of reactive species that accumulate in the body and cause cellular dysfunction. One of the body＇s front lines in defense against such damage is the transcription factor, Nrf2. This transcription factor regulates a plethora of antioxidant and cellular defense pathways to protect cells from such damage. Despite the breadth of knowledge of both the function of Nrf2 and the effects of reactive species in bone metabolism, the direct role of Nrf2 in skeletal biology has yet to be thoroughly examined. Thus, in the current study, we have examined the role of Nrf2 in postnatal bone metabolism in mice. Mice lacking Nrf2 （Nrf2-/-） exhibited a marked deficit in postnatal bone acquisition, which was most severe at 3 weeks of age when osteoblast numbers were 12-fold less than observed in control animals. While primary osteoblasts from Nrf2-/- mice functioned normally in vitro, the colony forming capacity of bone marrow stromal cells （BMSCs） from these mice was significantly reduced compared to controls. This defect could be rescued through treatment with the radical scavenger N-acetyl cysteine （NAC）, suggesting that increased reactive species stress might impair early osteoblastogenesis in BMSCs and lead to the failure of bone acquisition observed in Nrf2-/- animals. Taken together, these studies suggest Nrf2 represents a key pathway in regulating bone metabolism, which may provide future therapeutic targets to treat osteoporosis.

关键词： bone Nrf2 is required for normal postnatal bone acquisition in mice

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