Antiviral,immunomodulatory,and anticoagulant effects of quercetin and its derivatives:Potential role in prevention and management of COVID-19

作     者：Souparnika H.Manjunath Rajesh K.Thimmulappa Souparnika H.Manjunath;Rajesh K.Thimmulappa

作者机构：Department of BiochemistryJagadguru Sri Shivarathreeshwara Medical CollegeJagadguru Sri Shivarathreeshwara Academy of Higher Education&Research(JSSAHER)Mysore570015India 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2022年第12卷第1期

页      面：29-34页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the funding support from the Department of Biotechnology, Ramalingaswami Re-entry Fellowship (Grant No.: BT/RLF/Re-entry/37/2013) the Department of Science and Technology grant (Grant No.: DST/INT/SOUTH AFRICA/P13/2016) 

主　　题：COVID-19 Quercetin Immunomodulation Cytokine response syndrome NRF2 Antiviral 

摘      要：The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has caused a devastating health crisis *** this review,we have discussed that prophylactic phytochemical quercetin supplementation in the form of foods or nutraceuticals may help manage the COVID-19 *** following evidence supports our ***,nuclear factor erythroid-derived 2-like 2(NRF2)agonists abrogate replication of SARS-CoV-2 in lung cells,and quercetin is a potent NRF2 ***,quercetin exerts antiviral activity against several zoonotic coronaviruses,including SARS-CoV-2,mainly by inhibiting the entry of virions into host ***,inflammatory pathways activated by nuclear factor kappa B,inflammasome,and interleukin-6 signals elicit cytokine release syndrome that promotes acute respiratory distress syndrome in patients with COVID-19,and quercetin inhibits these pro-inflammatory ***,patients with COVID-19 develop thrombosis,and quercetin mitigates coagulation abnormalities by inhibiting plasma protein disulfide *** review provides a strong rationale for testing quercetin for the management of COVID-19.