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New VD-DIBA-Based Single-Resistance-Controlled Sinusoidal Oscillator

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Circuits and Systems 2016年第13期7卷 4145-4153页

作者： Kanhaiya Lal Pushkar rajendra kumar goel Kavya Gupta Pinky Vivek Javed Ashraf Department of Electronics and Communication Engineering Maharaja Agrasen Institute of Technology Rohini India Department of Electronics and Communication Engineering Al-Falah University Faridabad India

A new Single-Resistance-Controlled (SRC) sinusoidal oscillator using single Voltage Differencing-Differential Input Buffered Amplifier (VD-DIBA), only four passive components (two capacitors and two resistors), is presented. The proposed structure provides the following advantageous features: 1) independent control of oscillation frequency and condition of oscillation and 2) low active and passive sensitivities. The effects of non-idealities of the VD-DIBA on the proposed oscillator have also been investigated. The proposed SRC sinusoidal oscillator has been checked for robustness using Monte-Carlo simulation. SPICE simulation results have been included using 0.35 μm MIETEC technology to confirm the validity of the proposed SRC sinusoidal oscillator.

关键词： Voltage Differencing-Differential Input Buffered Amplifier Voltage-Mode Circuit Sinusoidal Oscillator

Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath Mahalingam Ashish kumar goel Uday George Zacharaiah Alok Srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials

Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh,Odisha,and Kerala in India

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 310-316页

作者： Vinay Garg Ankur Garg Shubha Garg Sudhir kumar Jain Tanzin Dikid Saurabh Jain Jitendra Manjhi Antonio Montresor Atul goel Division of Parasitic Diseases National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India National Centre for Disease Control Ministry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Epidemiology Division National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India Department of Control of Neglected Tropical Diseases(NTD) World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Department of Community&Family Medicine AIIMS KalyaniIndia Community and Primary Care-based Intervention Department of Control of Neglected Tropical Diseases(NTD)World Health Organization(WHO)Av Appia 20 CH-1211Geneva 27Switzerland Director General of Health Sciences(DGHS)&Director National Centre for Disease ControlMinistry of Health and Family WelfareGovernment of India22-Sham Nath MargCivil LinesNew Delhi-110054India

Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and ***:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were *** study was conducted in two rounds:baseline&follow up *** eligible children found positive for *** at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day *** post-treatment follow-up survey,eligible children who provided second stool sample were included in the final *** samples were examined using WHO recommended Kato-Katz *** was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up ***:328 Out of 625(52.5%)were found positive for *** in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up ***,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for *** infection at three different locations in ***,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.

关键词： Soil transmitted helminths Ascaris lumbricoides Albendazole Efficacy

Pediatric UTI research: trends, collaborations, and hotspot topics - a bibliometric analysis

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Life Research 2024年第4期7卷 9-16页

作者： Bitesh kumar Anjan kumar Dhua Prabudh goel Devendra kumar Yadav Vishesh Jain Divya Jain Department of Pediatric Surgery All India Institute of Medical SciencesDelhi 110029India Department of Ophthalmology Post Graduate Institute of Child HealthNoida 201310India

Background:Urinary tract infection(UTI)is a prevalent bacterial infection affecting adults and pediatric populations,with distinct patterns observed in *** bibliometric analysis aims to provide a comprehensive overview of the research landscape in pediatric UTI from 1990 to 2022,exploring qualitative and quantitative research output,contributing authors,institutions,countries,collaborative links,and hotspot ***:This study aims to evaluate the qualitative and quantitative research output and trends in UTI in the pediatric population through a bibliometric *** analysis covers highly cited articles,contributing authors,institutes,countries,collaborative links,and future research ***:A bibliometric analysis was conducted using the Web of Science platform with a search string focused on pediatric UTI articles published between January 1990 and December *** analysis employed the Bibliometrix R-package software and VOSviewer for collaborative networks and keyword co-occurrence ***:Out of 1399 published articles,81.7%were research *** annual growth rate of publications was 4.46%.The USA led in contributions,with the University of Pennsylvania being the most productive ***"Journal of Pediatric Urology"and"Pediatric"were prominent *** AJ from the University of Toronto was the top *** networks highlighted the significance of collaboration in pediatric UTI ***:In conclusion,this bibliometric analysis provides a detailed snapshot of the research landscape in pediatric urinary tract *** 1399 articles analyzed,the study reveals a sustained interest and growth rate of 4.46%,emphasizing ongoing efforts to address pediatric UTI *** USA dominates contributions,reflecting its pivotal role in advancing *** top institutions,journals,and authors are identified,with collaborative networks *** co-occurrence networks unve

关键词： bibliometry pediatric urinary tract infection vesicoureteric reflux

A randomized controlled trial on triamcinolone versus saline impregnated merocel post endoscopic sinus surgery:Our experience in a tertiary care centre

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 193-199页

作者： Ananya Sood Khushboo goel SSanjeev Bhagat Dimple Sahni Dinesh kumar Sharma Vishav Yadav Department of Otorhinolaryngology and Head&Neck Surgery Government Medical CollegePatialaPunjabIndia

Purpose:To assess the potential benefit of impregnating Merocel(a non-absorbable nasal dressing)with a topical steroid solution,for use as a direct and slow local delivery system of steroids after sinus surgery to improve postoperative wound ***:In this randomized controlled trial,40 patients with bilateral chronic rhinosinusitis with nasal polyposis were subjected to functional endoscopic sinus *** the completion of the surgery,Merocel packs were inserted in the bilateral nasal cavities and infiltrated with 4 mL triamcinolone(40 mg/mL)in one nasal cavity(treatment group)and 4 mL normal saline in the other(control group).Nasal packs were removed on the third postoperative day and postoperative healing assessment was done on postoperative Weeks 1,2,4,and *** findings were noted as per Lund Kennedy(LKES)and perioperative sinus endoscopy(POSE)scores and compared on both ***:Significant(P<0.05)improvement was noted in Lund Kennedy score for crusting and polyp at Week 12,for edema at Week 1,and nasal discharge at Weeks 1 and 12,but there was no significant improvement in scarring at any ***,the difference between the treatment and control arms was statistically significant at all postoperative visits except at Week ***,there was a significant improvement in POSE scores at Weeks 1,2,and 12 but not at Week ***:This study positively concludes that the nasal cavity packed with drug-soaked packs had less scarring and edema in the postoperative period and the overall wound healing was much better as compared to saline-soaked packs.

关键词： chronic rhinosinusitis functional endoscopic sinus surgery Lund Kennedy merocele perioperative sinus endoscopy triamcinolone

Surface-functionalized hole-selective monolayer for high efficiency single-junction wide-bandgap and monolithic tandem perovskite solar cells

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Journal of Energy Chemistry 2024年第1期88卷 317-326,I0008页

作者： Devthade Vidyasagar Yeonghun Yun Jae Yu Cho Hyemin Lee Kyung Won Kim Yong Tae Kim Sung Woong Yang Jina Jung Won Chang Choi Seonu Kim rajendra kumar Gunasekaran Seok Beom Kang Kwang Heo Dong Hoe Kim Jaeyeong Heo Sangwook Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering and Optoelectronics Convergence Research CenterChonnam National UniversityGwangju 61186Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea

Carbazole moiety-based 2PACz([2-(9H-carbazol-9-yl)ethyl]phosphonic acid)self-assembled monolayers(SAMs)are excellent hole-selective contact(HSC)materials with abilities to excel the charge-transferdynamics of perovskite solar cells(PSCs).Herein,we report a facile but powerful method to functionalize the surface of 2PACz-SAM,by which reproducible,highly stable,high-efficiency wide-bandgap PSCs can be *** 2PACz surface treatment with various donor number solvents improves assembly of 2PACz-SAM and leave residual surface-bound solvent molecules on 2PACz-SAM,which increases perovskite grain size,retards halide segregation,and accelerates hole *** surface functionalization achieves a high power conversion efficiency(PCE)of 17.62%for a single-junction wide-bandgap(~1.77 e V)*** also demonstrate a monolithic all-perovskite tandem solar cell using surfaceengineered HSC,showing high PCE of 24.66%with large open-circuit voltage of 2.008 V and high fillfactor of 81.45%.Our results suggest this simple approach can further improve the tandem device,when coupled with a high-performance narrow-bandgap sub-cell.

关键词： Perovskite solar cells 2PACz Monolithic tandem solar cells Wide bandgap

Artificial Intelligence for Maximizing Agricultural Input Use Efficiency: Exploring Nutrient, Water and Weed Management Strategies

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1569-1598页

作者： Sumit Sow Shivani Ranjan Mahmoud F.Seleiman Hiba M.Alkharabsheh Mukesh kumar Navnit kumar Smruti Ranjan Padhan Dhirendra kumar Roy Dibyajyoti Nath Harun Gitari Daniel O.Wasonga Department of Agronomy Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Plant Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Department of Crop Sciences Faculty of AgricultureMenoufia UniversityShibin El-Kom32514Egypt Department of Water Resources and Environmental Management Faculty of Agricultural TechnologyAl Balqa Applied UniversitySalt19117Jordan Division of Agronomy ICAR-Indian Agricultural Research InstitutePusa CampusNew Delhi110012India Department of Soil Science Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Agricultural Science and Technology School of Agriculture and Environmental SciencesKenyatta UniversityNairobi43844Kenya Department of Crop Sciences University of Illinois Urbana-ChampaignUrbanaIL 61801USA

Agriculture plays a crucial role in the economy,and there is an increasing global emphasis on automating agri-cultural *** the tremendous increase in population,the demand for food and employment has also increased signiﬁ*** methods traditionally used to meet these requirements are no longer ade-quate,requiring solutions to issues such as excessive herbicide use and the use of chemical *** of technologies such as the Internet of Things,wireless communication,machine learning,artiﬁcial intelligence(AI),and deep learning shows promise in addressing these ***,there is a lack of comprehensive documentation on the application and potential of AI in improving agricultural input efﬁ*** address this gap,a desk research approach was used by utilizing peer-reviewed electronic databases like PubMed,Scopus,Goo-gle Scholar,Web of Science,and Science Direct for relevant *** of 327 initially identiﬁed articles,180 were deemed pertinent,focusing primarily on AI’s potential in enhancing yield through better management of nutrients,water,and *** into account researchﬁndings worldwide,we found that AI technologies could assist farmers by providing recommendations on the optimal nutrients to enhance soil quality and deter-mine the best time for irrigation or herbicide *** present status of AI-driven automation in agricul-ture holds signiﬁcant promise for optimizing agricultural input utilization and reducing resource waste,particularly in the context of three pillars of crop management,i.e.,nutrient,irrigation,and weed management.

关键词： Agriculture artiﬁcial intelligence crop management nutrient irrigation weed management resource use efﬁciency

Recent progress and perspective on batteries made from nuclear waste

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Nuclear Science and Techniques 2023年第3期34卷 1-8页

作者： Nirmal kumar Katiyar Saurav goel School of Engineering London South Bank UniversityLondonSE10 AAUK University of Petroleum and Energy Studies Dehradun248007India

Sustainable energy sources are an immediate need to cope with the imminent issue of climate change the world is facing *** particular,the long-lasting miniatured power sources that can supply energy continually to power handheld gadgets,sensors,electronic devices,unmanned airborne vehicles in space and extreme mining are some of the examples where this is an acute *** is known from basic physics that radioactive materials decay over few years and some nuclear materials have their half-life until thousands of *** past five decades of research have been spent harnessing the decay energy of the radioactive materials to develop batteries that can last until the radioactive reaction ***,an emergent opportunity of industrial symbiosis to make use of nuclear waste by using radioactive waste as raw material to develop bat-teries with long shelf life presents a great opportunity for sustainable energy resource ***,the current canon of research on this topic is *** perspective draws fresh discussions on the topic while highlighting future directions in this wealthy arena of *** abstract A long-lasting miniaturised nuclear battery utilising 14C radioactive isotope as fuel.

关键词： Sustainable energy Nuclear waste battery Nano-diamond

Punjabi DeConverter for generating Punjabi from Universal Networking Language

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第3期14卷 179-196页

作者： Parteek kumar rajendra kumar SHARMA Department of Computer Science & Engineering Thapar University School of Mathematics & Computer Applications Thapar University

DeConverter is core software in a Universal Networking Language(UNL) system.A UNL system has EnConverter and DeConverter as its two major *** is used to convert a natural language sentence into an equivalent UNL expression,and DeConverter is used to generate a natural language sentence from an input UNL *** paper presents design and development of a Punjabi *** describes five phases of the proposed Punjabi DeConverter,i.e.,UNL parser,lexeme selection,morphology generation,function word insertion,and syntactic *** paper also illustrates all these phases of the Punjabi DeConverter with a special focus on syntactic linearization issues of the Punjabi *** linearization is the process of defining arrangements of words in generated *** algorithms and pseudocodes for implementation of syntactic linearization of a simple UNL graph,a UNL graph with scope nodes and a node having un-traversed parents or multiple parents in a UNL graph have been discussed in this *** cases of syntactic linearization with respect to Punjabi language for UNL relations like 'and','or','fmt','cnt',and 'seq' have also been presented in this *** paper also provides implementation results of the proposed Punjabi *** DeConverter has been tested on 1000 UNL expressions by considering a Spanish UNL language server and agricultural domain threads developed by Indian Institute of Technology(IIT),Bombay,India,as *** proposed system generates 89.0% grammatically correct sentences,92.0% faithful sentences to the original sentences,and has a fluency score of 3.61 and an adequacy score of 3.70 on a 4-point *** system is also able to achieve a bilingual evaluation understudy(BLEU) score of 0.72.

关键词： DeConverter EnConverter Machine translation Universal Networking Language(UNL) Syntactic linearization