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印尼新几内亚巴布亚省豕蛙属4新种(两栖纲:姬蛙科)(英文)

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动物学报 2008年第4期54卷 653-674页

作者： rainer GNTHER Museum fr Naturkunde Humboldt-Universitt zu Berlin

姬蛙科豕蛙属(Choerophryne)已知5种,几乎都分布于新几内亚岛东部地区,已有物种的描述多基于较少数量的标本,由于标本贫乏,迄今无后续研究。本文针对采集于1998-2003年的50号标本,对该属进行了再研究,并描述了分布于新几内亚岛的巴布亚... 详细信息

姬蛙科豕蛙属(Choerophryne)已知5种,几乎都分布于新几内亚岛东部地区,已有物种的描述多基于较少数量的标本,由于标本贫乏,迄今无后续研究。本文针对采集于1998-2003年的50号标本,对该属进行了再研究,并描述了分布于新几内亚岛的巴布亚西北地区鲜为人知的4新种。与同属已知物种比较,新种的有效性得到来自形态、声谱以及分子数据的综合分析结果的支持。在新几内亚岛西部地区豕蛙属4新种中,至少有3种的种群密度很高,从而极大增加了对该属的了解。

关键词：两栖类无尾目姬蛙科豕蛙属新种形态生态声谱 mtDNA 新几内亚巴布亚

Potential medicinal plants involved in inhibiting 3CL^(pro) activity:A practical alternate approach to combating COVID-19

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Journal of Integrative Medicine 2022年第6期20卷 488-496页

作者： Fan Yang Xiao-lan Jiang Akash Tariq Sehrish Sadia Zeeshan Ahmed Jordi Sardans Muhammad Aleem Riaz Ullah rainer W.Bussmann The Medical Center of General Practice Sichuan Academy of Medical Science and Sichuan Provincial People’s HospitalChengdu 610041Sichuan ProvinceChina Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830041Xinjiang Uygur Autonomous RegionChina Department of Biological Sciences University of Veterinary and Animal SciencesRavi CampusPattoki 55300Pakistan Consejo Superior de Investigaciones Científicas Global Ecology UnitCentre for Ecological Research and Forestry Applications-Consejo Superior de Investigaciones Científicas-Universitat Autònoma de BarcelonaBellaterra08193 BarcelonaCataloniaSpain Centre for Ecological Research and Forestry Applications Cerdanyola del Vallès 08193CataloniaSpain Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia Department of Ethnobotany Institute of Botanyllia State UniversityTbilisi 0105Georgia

At present,a variety of vaccines have been approved,and existing antiviral drugs are being tested to find an effective treatment for coronavirus disease 2019(COVID-19).However,no standardized treatment has yet been approved by the World Health *** virally encoded chymotrypsin-like protease(3CL^(pro))from severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which facilitates the replication of SARS-CoV in the host cells,is one potential pharmacological target for the development of antiSARS *** search engines,such as Web of Science,Google Scholar,Scopus and PubMed,were used to retrieve data on the traditional uses of medicinal plants and their inhibitory effects against the SARS-CoV 3CL^(pro).Various pure compounds,including polyphenols,terpenoids,chalcones,alkaloids,biflavonoids,flavanones,anthraquinones and glycosides,have shown potent inhibition of SARS-CoV-2 3CL^(pro) activity with 50% inhibitory concentration(IC_(50))values ranging from 2-44μg/***,most of these active compounds,including xanthoangelol E(isolated from Angelica keiskei),dieckol 1(isolated from Ecklonia cava),amentoflavone(isolated from Torreya nucifera),celastrol,pristimerin,tingenone and iguesterin(isolated from Tripterygium regelii),tannic acid(isolated from Camellia sinensis),and theaflavin-3,3’-digallate,3-isotheaflav1in-3 gallate and dihydrotanshinone I(isolated from Salvia miltiorrhiza),had IC_(50)values of less than 15μg/*** mechanistic studies of several active compounds revealed that their mode of inhibition was dose-dependent and competitive,with K_(i)values ranging from 2.4-43.8μmol/*** the significance of plant-based compounds and the many promising results obtained,there is still need to explore the phytochemical and mechanistic potentials of plants and their *** medicinal plants could serve as an effective inexpensive nutraceutical for the general public to help manage COVID-19.

关键词： COVID-19 SARS-CoV-2 Coronavirus 3C proteases Medicinal plants Plant-derived compounds Drug development

Heterogeneous populations of neural stem cells contribute to myelin repair

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Neural Regeneration Research 2017年第4期12卷 509-517页

作者： rainer Akkermann Felix Beyer Patrick Küry Neuroregeneration Laboratory Department of NeurologyMedical FacultyHeinrich-Heine-University

As ingenious as nature＇s invention of myelin sheaths within the mammalian nervous system is, as fatal can be damage to this specialized lipid structure. Long-term loss of electrical insulation and of further supportive functions myelin provides to axons, as seen in demyelinating diseases such as multiple sclerosis （MS）, leads to neurodegeneration and results in progressive disabilities. Multiple lines of evidence have demon-strated the increasing inability of oligodendrocyte precursor cells （OPCs） to replace lost oligodendrocytes （OLs） in order to restore lost myelin. Much research has been dedicated to reveal potential reasons for this regeneration deficit but despite promising approaches no remyelination-promoting drugs have successfully been developed yet. In addition to OPCs neural stem cells of the adult central nervous system also hold a high potential to generate myelinating OLs. There are at least two neural stem cell niches in the brain, the subventricular zone lining the lateral ventricles and the subgranular zone of the dentate gyrus, and an additional source of neural stem cells has been located in the central canal of the spinal cord. While a substantial body of literature has described their neurogenic capacity, still little is known about the oligodendrogenic potential of these cells, even if some animal studies have provided proof of their contribution to remyelination. In this review, we summarize and discuss these studies, taking into account the different niches, the heterogeneity within and between stem cell niches and present current strategies of how to promote stem cell-mediated myelin repair.

关键词： heterogeneity oligodendrocyte neuroregeneration multiple sclerosis inhibitors intracellular proteinlocalization adult neural stem cell niche remyelination

Microstructural Damage Evaluation of High Alumina Castables with Addition of Different Dimensions of Functional Aggregates After Several Thermal Shock Cycles

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China's Refractories 2015年第1期24卷 26-31页

作者： Jonas SCHNIEDER Nicolas TRAON rainer TELLE Thorsten TONNESEN Gabrielle HAETTY Pierre SEIGNOL RWTH Aachen University Institute of Mineral Engineering ENSCI Limoges Cedex 87068France

Refractory materials are subjected to mechanical and chemical loads during application,which respectively lead to fracture and corrosion. The understanding of the mechanical fracture and the microstructural modification after progressive thermal shocks is necessary for the suitable design of high performance refractory *** fracture process zone can be divided into two areas,where different toughening mechanisms are likely to take place： the crack tip and the following process region called wake region. In this study,the emphasis is laid on the microstructural mechanisms occurring in the wake region of the crack and the crack tip. Therefore,functional aggregates,namely fused eutectic aggregates of Al2O3- ZrO 2- SiO 2and Al2O3- ZrO 2,and andalusite,are added to a model high alumina castable formulation based on tabular alumina. The discrepancy in thermal behavior between aggregates and matrix as well as phase transformation such as mullite formation favor further the nucleation of microcracks that reduce the stress field at the level of the crack tip. Two different grain fractions of tabular alumina（ 0. 2- 0. 6 mm or2. 24- 3. 00 mm） are substituted by these functional aggregates. After sintering at 1 500 ℃ for 6 h,the samplesare quenched up to 10 times in air without pressure from950 ℃ to room temperature. The resulting elastic properties are examined after each thermal shock cycle,as well as the residual bending strength after 0,1,3,5,7and 10 thermal shocks. These results are correlated with Scanning Electron Microscopy analyses after the different thermal shock cycles.

关键词： functional aggregates thermal shock resistance microcracks

Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction

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Journal of Materials Science & Technology 2021年第9期68卷 160-171页

作者： Mingjun Li Christoph Schlaich Jianguang Zhang Ievgen S.Donskyi Karin Schwibbert Frank Schreiber Yi Xi Jorg Radnik Tanja Schwerdtle rainer Haag Center for Health Science and Engineering Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologySchool of Materials Science and EngineeringHebei University of TechnologyTianjin 300130China Institut fur Chemie und Biochemie Freie Universitat BerlinBerlin 14195Germany Division Biodeterioration and Reference Organisms Federal Institute for Materials Research and Testing(BAM)Berlin 12205Germany Division of Surface Analysis and Interfacial Chemistry Federal Institute for Materials Research and Testing(BAM)Berlin 12205Germany Institute of Nutritional Science Department of Food ChemistryUniversity of PotsdamNuthetal D-14558Germany

Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles(Cu NPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol(MI-h PG) coating via a simple dip-coating *** hyperbranched polyglycerol with 10 % catechol groups’ modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone(PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated Cu NPs-incorporated PCL membrane [PCL-(MI-h PG)-Cu NPs]was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus(S. aureus), Escherichia coli(E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-h PG)-Cu NPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing Cu NPs.

关键词： Mussel-inspired coating CuNPs Multi-resistant bacteria Antibacterial Antifouling Osteogenesis

Restricting carbohydrates to fight head and neck cancer——is this realistic?

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Cancer Biology & Medicine 2014年第3期11卷 145-161页

作者： rainer J.Klement Department of Radiotherapy and Radiation Oncology Leopoldina Hospital

Head and neck cancers(HNCs) are aggressive tumors that typically demonstrate a high glycolytic rate, which results in resistance to cytotoxic therapy and poor prognosis. Due to their location these tumors specifically impair food intake and quality of life, so that prevention of weight loss through nutrition support becomes an important treatment goal. Dietary restriction of carbohydrates(CHOs) and their replacement with fat, mostly in form of a ketogenic diet(KD), have been suggested to accommodate for both the altered tumor cell metabolism and cancer-associated weight loss. In this review, I present three specific rationales for CHO restriction and nutritional ketosis as supportive treatment options for the HNC patient. These are(1) targeting the origin and specific aspects of tumor glycolysis;(2) protecting normal tissue from but sensitizing tumor tissue to radiation- and chemotherapy induced cell kill;(3) supporting body and muscle mass maintenance. While most of these benefits of CHO restriction apply to cancer in general, specific aspects of implementation are discussed in relation to HNC patients. While CHO restriction seems feasible in HNC patients the available evidence indicates that its role may extend beyond fighting malnutrition to fighting HNC itself.

关键词： Ketogenic diet(KD) head and neck neoplasms diet carbohydrate restricted(CHO restricted) nutritional support

Short wind pulses consistently change the morphology of roots,but not of shoots,across young plants of different growth forms

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Stress Biology 2023年第1期3卷 468-476页

作者： Johannes Heinze Luise Werger Michael Ogden Thilo Heinken rainer Hoefgen Ewald Weber Institute of Biochemistry and Biology Biodiversity Research and Systematic BotanyUniversity of PotsdamMaulbeerallee 1Potsdam 14469Germany Heinz Sielmann Foundation Dyrotzer Ring 4Wustermark(OT Elstal)14641Germany Department of Molecular Physiology Max Planck Institute of Molecular Plant PhysiologyAm Mühlenberg 1Potsdam-Golm 14476Germany School of Biosciences University of MelbourneMelbourneVIC 3010Australia Institute of Biochemistry and Biology General BotanyUniversity of PotsdamMaulbeerallee 3Potsdam 14469Germany

Wind is an environmental stimulus that stresses plants of all growth forms at all life-stages by influencing the development,architecture,and morphology of roots and ***,comparative studies are scarce and no study directly investigated whether shoot and root morphological traits of trees,grasses and forbs differ in their response to short wind pulses of different wind *** this study,we found that across species,wind stress by short wind pulses of increasing intensity consistently changed root morphology,but did not affect shoot morphological traits,except plant height in four *** effects in roots were generally weak in tree species but consistent across growth ***,plant height of species was correlated with changes in specific root length and average *** results indicate that short-pulse wind treatments affect root morphology more than shoot morphology across growth *** further suggest that wind stress possibly promotes root anchorage in young plants and that these effects might depend on plant height.

关键词： Wind stress Leaf traits Root traits Growth form Morphology

Brief an einen jungen Dichter

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德语人文研究 2010年第3期 19-22页

作者： rainer Maria Rilke

An Franz Xaver Kappus Paris am *** 1903 Sehr geehrter Herr, Ihr Brief hat mich erst vor einigen Tagen *** will Ihnen danken f(u|¨)r sein groβes und liebes *** kann kaum *** kann nicht auf die Art Ihrer Verse eingehen;denn mir liegt jede kritische Absicht zu *** nichts kann man ein Kunst-Werk so wenig ber(u|¨)hren als mit kritischen Worten:

关键词： der Brief an einen jungen Dichter

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Generationen

德语学习 2011年第5期 4-6页

作者： rainer Maria Rilke

In unseren Stuben riecht es am Donnerstag nach Tomaten, am Sonntag nach Gnsebraten, und jeden Montag ist Wsche. So sind die Tage: der rote, der fette, der seifige.

关键词： der Generationen