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石化译文 1994年第4期 74-76页

作者： radi.,mj 李京妮

Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD

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Genes & Diseases 2024年第3期11卷 34-38页

作者： mj Mahesh Kumar Shailendra Arindkar Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

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Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah Thuy-Tien Nguyen Warren Macdonald Anthony mj.Bull Centre for Blast Injury Studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson School of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of Methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna Mundluru mj Naidu Ravi Teja Mundluru Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative Medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of Orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADSCs)and the stromal vascular fraction(SVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating SVF and ADSCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells Stromal vascular fraction Regenerative medicine Non-enzymatic isolation Mechanical separation techniques

Evaluation of implanted perforated lacrimal punctal plugs using anterior segment optical coherence tomography

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Eye and Vision 2021年第1期8卷 366-373页

作者： Raafat Mohyeldeen Abdelrahman Abdallah Ahmed Mohamed Kamal Elshafei Heba radi.AttaAllah Ophthalmology Department Minia UniversityEl‑MiniaEgypt Ophthalmology Department Minia University HospitalEl‑MiniaEgypt

Purpose:Evaluation of the patency and position of perforated lacrimal punctal plugs implanted for treating punctal stenosis together with quantitative assessment of the precorneal tear film using anterior segment optical coherence tomography(AS-OCT).Methods:In a prospective study,the lower punctum of 54 eyes of 29 patients implanted with perforated punctal plugs were examined using AS-OCT during the early postoperative *** tear meniscus height(TMH)and tear meniscus area(TMA)were ***,the patency of the plug,its position,TMH and TMA were evaluated,and the results were correlated with postoperative *** scale was used for epiphora ***:Using AS-OCT,48(88.9%)plugs were found in proper position while 6(11.1%)were *** lumen of the plugs was completely patent in 47(87%)plugs,partially obstructed in 2(3.7%)plugs and completely occluded in 5(9.2%)*** was a statistically significant postoperative decrease of TMH and TMA(P<0.001)and postoperative epiphora Munk score(P<0.001).Conclusion:AS-OCT is a valuable,reliable,and noninvasive investigative tool that can detect the proper positioning,patency,and contents of the implanted perforated lacrimal punctal plugs in addition to measurement of TMH and TMA.

关键词： AS-OCT Perforated plugs Plugs

Correlation between corneal demarcation line depth in epithelium-off and trans-epithelium accelerated corneal cross linking and keratoconus progression

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 907-912页

作者： Mahmoud Abdel-radi.Zeiad Eldaly Hazem Abdelmotaal Reham Abdelrahman Mohamed Sayed Kamel Soliman Department of Ophthalmology Assiut UniversityAssiut 71516Egypt

AIM:To compare corneal demarcation line(DL)depth in both accelerated epithelium-off and trans-epithelium cross linking(CXL)using anterior segment optical coherence tomography(AS-OCT)and its relation to maximum keratometry(Kmax)progression in both ***:A prospective comparative interventional study where patients with mild to moderate keratoconus(KC)were classified into two groups:accelerated epitheliumoff and trans-epithelium CXL based on corneal *** of corneal DL depth was carried out after 3mo by *** readings were evaluated after one year follow up using the Scheimpflug imaging ***:Study included 74 eyes of 44 *** A underwent epithelium-off CXL(41 eyes),while Group B underwent trans-epithelium CXL(33 eyes).At 3mo follow up,mean corneal DL depth in Group A was 219.9±58.4μm while in Group B was 127.2±7.8μm(P0.05).In addition,no significant change in corneal pachymetry was found in both groups(meanchange at 1y:6.4±4.7 and-10.1±2.3μm in Groups A and B respectively).CONCLUSION:Despite a significantly deeper corneal DL depth created by accelerated epithelium-off CXL technique compared to accelerated trans-epithelium CXL,there is no significant impact on keratoconus progression.

关键词： anterior segment optical coherence tomography cross linking demarcation line keratoconus

Interference-Aware Multipath Routing Protocol for QoS Improvement in Event-Driven Wireless Sensor Networks

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Tsinghua Science and Technology 2011年第5期16卷 475-490页

作者： Marjan radi.Behnam Dezfouli Kamalrulnizam Abu Bakar Shukor Abd Razak Mohammad Ali Nematbakhsh Faculty of Computer Science and Information Systems Universiti Teknologi Malaysia Faculty of Computer Engineering University of Isfahan

The existing multipath routing protocols for wireless sensor networks demonstrate the efficacy of traffic distribution over multiple paths to fulfill the Quality of Service （QoS） requirements of different applications. However, the performance of these protocols is highly affected by the characteristics of the wireless channel and may be even inferior to the performance of single-path approaches. Specifically, when multiple adjacent paths are being used concurrently, the broadcast nature of wireless channels results in inter-path interference which significantly degrades end-to-end throughput. In this paper, we propose a Low- Interference Energy-efficient Multipath Routing protocol （LIEMRO） to improve the QoS requirements of event-driven applications. In addition, in order to optimize resource utilization over the established paths, LIEMRO employs a quality-based load balancing algorithm to regulate the amount of traffic injected into the paths. The performance gain of LIEMRO compared to the ETX-based single-path routing protocol is 85%, 80%, and 25% in terms of data delivery ratio, end-to-end throughput, and network lifetime, respectively. Furthermore, the end-to-end latency is improved more than 60%.

关键词： LIEMRO QoS load balancing interference multipath routing event-driven

Molecular mechanisms of *** associated gastric carcinogenesis

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World Journal of Gastroenterology 1999年第5期5卷 369-374页

作者： Zhang ZW Farthing mj St Bartholomew's & the Royal London School of Medicine & Dentistry 英国

Anodic voltammetric determination of gemifloxacin using screen-printed carbon electrode

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Journal of Pharmaceutical Analysis 2013年第2期3卷 132-136页

作者： Abd-Elgawad radi.Amira Khafagy Amira El-shobaky Hatem El-mezayen Department of Chemistry Faculty of ScienceDumyat University Department of Chemistry Faculty of ScienceHelwan University

The electrochemical oxidation behavior and voltammetric assay of gemifloxacin were investigated using differential-pulse and cyclic voltammetry on a screen-printed carbon *** effects of pH,scan rates,and concentration of the drug on the anodic peak current were *** of gemifloxacin in Tris-HCl buffer（pH 7.0） exhibited a well-defined single oxidation peak.A differential-pulse voltammetric procedure for the quantitation of gemifloxacin has been developed and suitably validated with respect to linearity,limits of detection and quantification,accuracy,precision,specificity,and *** calibration was linear from 0.5 to 10.0 μM,and the limits of detection and quantification were 0.15 and 5.0 μ*** ranging from 96.26% to 103.64% were *** method was successfully applied to the determination of gemifloxacin in pharmaceutical tablets without any *** present in the tablets did not interfere in the assay.

关键词： Screen-printed carbon electrode Voltammetry Gemifloxacin Pharmaceutical analysis

Increasing Equal Opportunities in Education in *** Development Programmes of the“GENIUS”Charity Foundation

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Sociology Study 2020年第1期10卷 42-51页

作者： Natália Váradi Ferenc Rákóczi II.Transcarpathian Hungarian Institute and“GENIUS”Charity Foundation BeregszászUkraine

The essential condition of the economic evolution in Transcarpathia is the assistance of young researchers,finding the young talents,supporting their development as well as finding those young people with outstanding achievements and with appropriate *** for,identifying,and developing young people with outstanding abilities is a determining key factor of the competitiveness of a given region;in such a work,a prominent role is given to different educational institutions and talent *** concerning this reason,“GENIUS”Charity Foundation has been established in *** carries out a wide range of talent management,talent development and research among the schoolchildren,students,and young *** aim is to create an integrated system of the talent support programs,to assure equal access in promoting talents,and increase the talented youth’s social *** Foundation among many others,organizes the Conference of Young Researchers,as well as the Conference of Scientific Students,and operates the nine Talent Points where more than 2,000 children,more than 300 qualified teachers,and nearly 90 schools take part.

关键词： talent development equal opportunities best practice talent management diversity management