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Journal of Pharmaceutical Analysis 2016年第5期6卷 307-312页

作者： rachel shet hui wong Mark Ashton Kalliopi Dodou Department of Pharmacy Health and Wellbeing Faculty of Applied Sciences University of Sunderland Science Complex

Acrylates have been widely used in the synthesis of pharmaceutical polymers. The quantitation of residual acrylate monomers is vital as they are strong irritants and allergens, but after polymerization, are relatively inert, causing no irritation and allergies. Poly(ethylene oxide)(PEO) hydrogels were prepared using pentaerythritol tetra-acrylate(PETRA) as UV crosslinking agent. A simple, accurate, and robust quantitation method was developed based on gas chromatographic techniques(GC), which is suitable for routine analysis of residual PETRA monomers in these hydrogels. Unreacted PETRA was initially identified using gas chromatography–mass spectrometry(GC–MS). The quantitation of analyte was performed and validated using gas chromatography equipped with a flame ionization detector(GC–FID). A linear relationship was obtained over the range of 0.0002%–0.0450%(m/m) with a correlation coefficient(r2)greater than 0.99. The recovery( 4 90%), intra-day precision(%RSD o 0.67), inter-day precision(%RSD o2.5%), and robustness(%RSD o1.62%) of the method were within the acceptable values. The limit of detection(LOD) and limit of quantitation(LOQ) were 0.0001%(m/m) and 0.0002%(m/m), *** assay provides a simple and quick way of screening for residual acrylate monomer in hydrogels.

关键词： Poly(ethylene oxide) (PEO) Residual monomer HydrogelGas chromatography–mass spectrometry (GC–MS) Gas chromatography–flame ionization detection (GC–FID)

Males armed with big weapons win fights at limited cost in ant-mimickingjumping spiders

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Current Zoology 2024年第1期70卷 98-108页

作者： Guocheng Yu Boon hui wong Christina J.Painting Hongze Li Long Yu Zengtao Zhang Shichang Zhang Daiqin Li State Key Laboratory of Biocatalysis and Enzyme Engineering and Centre for Behavioral Ecology and Evolution School of Life SciencesHubei UniversityWuhan430062China Departmentof Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Singapore Te Aka Matuatua School of Science University of WaikatoPrivate Bag 3105Hamilton 3240New Zealand

A core assumption of sexual selection theory is that sexually selected weapons,specialized morphological structures used directly in male con-tests,can improve an individual's reproductive success but only if the bearer can overcome associated costs,the negative effects on the bear-er's fitness ***,recent studies have shown that producing and wielding exaggerated weapons may not necessarily be ***,some traits can be selected for supporting,or compensating for,the expense of producing and wielding such exaggerated weapons.n the ant-mimicking jumping spider Myrmarachne gisti,exaggerated chelicerae are borne only by adult males and not females,showing sexual dimorphism and steep positive allometry with body ***,we determine the potential benefits of bearing exaggerated chelicerae during male contests and explore the potential for costs in terms of prey-capture efficiency and compensation between chelicera size and neighboring trait *** males with longer chelicerae won most of their male-male contests,we found no significant differences in prey-capture effi-ciency between males and females regardless of whether prey was winged or ***'elongated chelicerae thus do not impede their efficiency at capturing ***,we found that the sizes of all neighboring traits are positively correlated with chelicera size,suggesting that these traits may be under correlational *** together,our findings suggest that *** males armed with the exaggerated chelicerae that function as weapons win more fights at limited cost for performance in prey capture and compensate for neighboring structures.

关键词： allometry ant-mimic costs elongated chelicerae threat devices trait compensations

Cascade Catalysts Based on Colloidal Engineering

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CCS Chemistry 2024年第9期6卷 2150-2161页

作者： Chen Chen Chin Ken wong hui Chen Nicole Janoszka Giada Quintieri AndréH.Gröschel School of Chemistry and Chemical Engineering Shanghai Jiao Tong University200240 Shanghai School of Chemistry University of New South Wales(UNSW)SydneySydney NSW 2052 Physical Chemistry and Center for Soft Nanoscience University of MünsterCorrensstraße 28-3048149 Münster

We see significant progress in the preparation of nanoreactors that host incompatible catalysts for cascade reactions,yet their preparation typically requires specialized,multistep synthetic ***,we utilize core-satellite microparticles as a versatile strategy for the site isolation of catalysts in core and *** core-satellite clusters are prepared by mixing specific amounts of negatively charged core microparticles(e.g.,acid catalyst)with positively charged satellites(e.g.,base catalyst).Core and satellite are made from incompatible polymers allowing solvent-annealing of clusters into different morphologies(raspberry,patchy,and core-shell)while maintaining site isolation of the *** core-satellite microparticles show very good catalytic activity in a model one-pot acid/base cascade reaction with subtle differences regarding particle *** microparticles thereby demonstrated the highest reaction rate and yield,likely due to an alleviated diffusion pathway for the ***,we show that this colloidal engineering strategy can be extended to multifunctional microparticles suitable to perform multistep cascade reactions in one pot.

关键词： cascade catalysts compartmentalization colloidal engineering emulsion polymerization multifunctional particles

Exploring a novel class tryptophan hydroxylase 1 inhibitor derived from Sambucus williamsii Hance for the osteoporosis treatment

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Acupuncture and Herbal Medicine 2024年第1期4卷 102-112页

作者： Yu-Xin Zhu Zi-Ling Tang Lu Lu Zuo-Cheng Qiu Dabo Pan Yang Yu hui-hui Xiao Man-Sau wong State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhenChina Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine School of Traditional Chinese MedicineJinan UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhouChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHong KongChina Research Center for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHong KongChina

Objective:Gut-derived serotonin strongly inhibits bone formation by inhibiting osteoblast *** previous study demonstrated that the lignan-rich fraction prepared from Sambucus willimasii Hance,a folk herbal medicine used to treat bone fractures and joint diseases in China,exerted bone-protective effects,and its actions were modulated by suppressing the synthesis of gut-derived serotonin via the inhibition of intestinal tryptophan hydroxylase 1(TPH-1).However,there is no direct evidence for the action of lignans on *** study aimed to verify the direct action of lignans on the TPH-1 and its influence on serotonin synthesis and bone ***:Molecular docking and surface plasmon resonance were performed to determine the affinities of lignans to *** cell viability and the protein activity and expression of TPH-1 were measured in RBL2H3 *** serum serotonin level and bone mineral density upon lignan treatment in ovariectomized mice were ***:The lignans showed high binding scores and binding affinities to TPH-1,inhibited the activity and protein expression of TPH-1,suppressed the serum serotonin levels in ovariectomized mice as well as promoted bone mineral ***:This is the first study to report that lignans are novel TPH-1 inhibitors and that these lignans could be potential agents for the management of serotonin-related diseases,including osteoporosis.

关键词： Lignan Osteoporosis Sambucus williamsii Hance Serotonin TPH-1 inhibitor

Dual innervation method to preserve erectile function following prostatectomy

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 159-160页

作者： Nadia hui Shan Sim Allen Sim Dayna Sim Bien-Keem Tan Allen Wei-Jiat wong Plastic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore Department of Urology Mount Alvernia Hospital Singapore574623Singapore Department of General Surgery Sengkang General Hospital544886Singapore Department of Plastic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prostate cancer is the second most prevalent cancer in ***-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer *** the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains *** repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been *** hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve *** proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve *** VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous *** postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关键词： Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve

Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： William Chung Kevin wong Noel Ravindranayagam Lauren Tang Josephine Grace Darren wong Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic Adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(HCC).HCC-recurrence following LT is associated with reduced *** is increasing interest in chemoprophylaxis to improve HCC-related outcomes *** To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against HCC,and patient outcomes following *** This was a retrospective study of adult patients who received Deceased Donor LT for HCC from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy for≥29 days,within 24 months post-LT.A cox proportional-hazards model with time-dependent covariates was used for survival *** measures were the composite-endpoint of HCC-recurrence and all-cause mortality,HCC-recurrence and HCC-related *** analysis was performed to account for immortality time bias and statin *** Three hundred and five patients were included in this study,with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis C,73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed HCC-recurrence,48(15.74%)died,17(5.57%)from HCC-related ***,aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of HCC-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%CI:0.58-2.30;HR:1.21,95%CI:0.28-5.27;HR:0.61,95%CI:0.27-1.36],HCC-recurrence(HR:0.52,95%CI:0.20-1.35;HR:0.51,95%CI:0.14-1.93;HR 1.00,95%CI:0.37-2.72),or HCC-related mortality(HR:0.32,95%CI:0.033-3.09;HR:0.71,95%CI:0.14-3.73;HR:1.57,95%CI:0.61-4.04)*** dosing was not associated with statist-ically significant differences in HCC-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-Co-A reductase Aspirin Metformin Mammalian target of rapamycin

闪动疗法对童年创伤经历大学生焦虑情绪的干预

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中国临床心理学杂志 2024年第1期32卷 222-226页

作者：凌辉刘慧玥周雯雯颜雅琴黄锡林张建人湖南师范大学认知与人类行为湖南省重点实验室长沙410082 湖南省心理健康教育研究基地长沙410081 湖南第一师范学院心理健康教育中心长沙410205 美国加州州立大学东湾分校旧金山94707 海南医学院附属海南省妇女儿童医学中心海南省热带脑科学研究与转化重点实验室海口571199

目的:探究闪动疗法对童年创伤经历大学生焦虑情绪的干预效果。方法:采用随机对照实验设计,将16名童年创伤经历大学生分为干预组和对照组,每组8人。干预组接受每周1次,每次90分钟,共8次闪动疗法线上干预,对照组不进行任何处理。干预前后... 详细信息

目的:探究闪动疗法对童年创伤经历大学生焦虑情绪的干预效果。方法:采用随机对照实验设计,将16名童年创伤经历大学生分为干预组和对照组,每组8人。干预组接受每周1次,每次90分钟,共8次闪动疗法线上干预,对照组不进行任何处理。干预前后采用焦虑自评量表评定焦虑情绪,用定量和定性的方法评估干预效果。结果:闪动疗法可以显著缓解干预组的焦虑情绪,促进生理、心理及社会生活方面的积极改变,对照组无明显变化。结论:本研究初步证明闪动疗法对童年创伤经历大学生的焦虑情绪具有一定的干预效果。

关键词：闪动疗法童年创伤经历大学生焦虑效果评估

Rock brittleness indices and their applications to different fields of rock engineering:A review

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 221-247页

作者： Fanzhen Meng Louis Ngai Yuen wong hui Zhou College of Science Qingdao University of TechnologyQingdao266033China Department of Earth Sciences The University of Hong KongPokfulamHong KongChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Brittleness is an important parameter controlling the mechanical behavior and failure characteristics of rocks under loading and unloading conditions,such as fracability,cutability,drillability and rockburst *** such,it is of high practical value to correctly evaluate rock ***,the definition and measurement method of rock brittleness have been very diverse and not yet been *** this paper,the definitions of rock brittleness are firstly reviewed,and several representative definitions of rock brittleness are identified and briefly *** development and role of rock brittleness in different fields of rock engineering are also *** brittleness indices publicly available in rock mechanics literature are compiled,and the measurement method,applicability and limitations of some indices are *** results show that(1)the large number of brittleness indices and brittleness definitions is attributed to the different foci on the rock behavior when it breaks;(2)indices developed in one field usually are not directly applicable to other fields;and(3)the term“brittleness”is sometimes misused,and many empirically-obtained brittleness indices,which lack theoretical basis,fail to truly reflect rock *** the basis of this review,three measurement methods are identified,i.e.(1)elastic deformation before fracture,(2)shape of post-peak stressestrain curves,and(3)methods based on fracture mechanics theory,which have the potential to be further refined and unified to become the standard measurement methods of rock *** is highly beneficial for the rock mechanics community to develop a robust definition of rock *** study will undoubtedly provide a comprehensive timely reference for selecting an appropriate brittleness index for their applications,and will also pave the way for the development of a standard definition and measurement method of rock brittleness in the long term.

关键词： Rock brittleness Practical applicability Hydraulic fracturing Rockburst proneness Crack propagation Fragmentation efficiency

Basic subgroup and Reid's theorem

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Science China Mathematics 2011年第10期54卷 2249-2251页

作者： NGU Min hui wong Kok Bin wong Peng Choon Institute of Mathematical Sciences University of Malaya

We give conditions under which a torsion-free abelian group is the sum of two basic subgroups.

关键词： torsion-free abelian free abelian basic subgroup pure subgroup

This work was supported by the European Research Council Advanced Grant(ETAP-742985 to *** J.F.)and by the Ministry of Science and Technology(grant 110-2636-B-005-001 to K.-J.L.).

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Plant Communications 2024年第1期5卷 130-147页

作者： Yu Zhang Yuan Fu Wenfei Xian Xiuli Li Yong Feng Fengjiao Bu Yan Shi Shiyu Chen Robin van Velzen Kai Battenberg Alison M.Berry Marco G.Salgado hui Liu Tingshuang Yi Pascale Fournier Nicole Alloisio Petar Pujic Hasna Boubakri M.Eric Schranz Pierre-Marc Delaux Gane Ka-Shu wong Valerie Hocher Sergio Svistoonoff Hassen Gherbi Ertao Wang Wouter Kohlen Luis G.Wall Martin Parniske Katharina Pawlowski Philippe Normand Jeffrey J.Doyle Shifeng Cheng Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China Biosystematics Group Department of Plant SciencesWageningen University6708PB Wageningenthe Netherlands Department of Plant Sciences University of CaliforniaDavisDavisCA 95616USA Department of Ecology Environment and Plant SciencesStockholm University10691 StockholmSweden Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesLanhei RoadKunming 650201China Universite´de Lyon Universite´Lyon 1CNRSUMR5557Ecologie MicrobienneINRAUMR 141843 bd du 11 novembre 191869622 VilleurbanneFrance Laboratoire de Recherche en Sciences Ve´ge´tales(LRSV) Universite´de ToulouseCNRSUPS24 chemin de Borde RougeAuzevilleBP4261731326 Castanet TolosanFrance Department of Biological Sciences University of AlbertaEdmontonAB T6G 2E9Canada French National Research Institute for Sustainable Development(IRD) UMR LSTM(IRD/CIRAD/INRAe/Montpellier University/Supagro)-Campus International BaillarguetTA A-82/J34398 Montpellier Cedex 5France National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologySIBSChinese Academy of SciencesShanghaiChina Laboratory of Molecular Biology Department of Plant SciencesWageningen University6708PB Wageningenthe Netherlands Laboratory of Biochemistry Microbiology and Soil Biological InteractionsDepartment of Science and TechnologyNational University of QuilmesCONICETBernalArgentina Faculty of Biology GeneticsLMU MunichGroßhaderner Strasse 2-482152 MartinsriedGermany School of Integrative Plant Science Sections of Plant Biology and Plant Breeding&GeneticsCornell UniversityIthacaNY 14853USA State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China Univer

Plant root-nodule symbiosis(RNS)with mutualistic nitrogen-fixing bacteria is restricted to a single clade of angiosperms,the Nitrogen-Fixing Nodulation Clade(NFNC),and is best understood in the legume *** species share many commonalities,explained either by divergence from a common ancestor over 100 million years ago or by convergence following independent origins over that same time ***,comparative analyses of diverse nodulation syndromes can provide insights into constraints on nodulation—what must be acquired or cannot be lost for a functional symbiosis—and the latitude for Plant Communications Genomic landscape of nodulation variation in the ***,much remains to be learned about nodulation,especially outside of ***,we employed a large-scale phylogenomic analysis across 88 species,complemented by 151 RNA-seq libraries,to elucidate the evolution of *** phylogenomic analyses further emphasize the uniqueness of the transcription factor NIN as a master regulator of nodulation and identify key muta-tions that affect its function across the *** transcriptomic assessment revealed nodule-specific upregulated genes across diverse nodulating plants,while also identifying nodule-specific and nitrogen-response *** 70%of symbiosis-related genes are highly conserved in the four representative species,whereas defense-related and host-range restriction genes tend to be lineage *** study also identified over 900000 conserved non-coding elements(CNEs),over 300000 of which are unique to sampled NFNC ***-specific CNEs are enriched with the active H3K9ac mark and are correlated with accessible chromatin regions,thus representing a pool of candidate regula-tory elements for genes involved in ***,our results provide novel insights into the evolution of nodulation and lay a foundation for engineering of RNS traits in agriculturally important crops.

关键词： nitrogen-fixing root-nodule symbiosis two competing hypotheses phylogenomics phylotranscrip-tomics conserved non-coding elements convergence deep homology