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Chromosome 11 aneusomy in esophageal cancers and precancerous lesions-an early event in neoplastic transformation:An interphase fluorescence in situ hybridization study from south India

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World Journal of Gastroenterology 2007年第4期13卷 503-508页

作者： Vasavi mohan Shivani Ponnala Hemakumar m Reddy Radha Sistla rachel A Jesudasan Yog Raj Ahuja Qurratulain Hasan Department of Genetics & molecular medicine Kamineni Hospitals LB Nagar Hyderabad AP India Department of molecular Biology Center for Cellular and Molecular Biology Uppal Road Hyderabad AP India Department of Genetics & molecular medicine Kamineni Hospitals LB Nagar Hyderabad AP IndiaDepartment of Pathology Kamineni Hospitals Hyderabad AP India Department of Genetics Vasavi Hospital and Research Center Lakdi-ka-pul Hyderabad AP India Department of Genetics & molecular medicine Kamineni Hospitals LB Nagar Hyderabad AP IndiaDepartment of Genetics Bhagwan Mahavir Medical Research Center AC Guards Hyderabad AP India

AIm: To detect aneusomic changes with respect to chromosome 11 copy number in esophageal precancers and cancers wherein the generation of cancer-specific phenotypes is believed to be associated with specific chromosomal aneuploidies. mETHODS: We performed fluorescence in situ hybridization (FISH) on esophageal tissue paraffin sections to analyze changes in chromosome 11 copy number using apotome-generated images by optical sectioning microscopy. Sections were prepared from esophageal tumor tissue, tissues showing preneoplastic changes and histologically normal tissues (control) obtained from patients referred to the clinic for endoscopic evaluation. RESULTS: Our results demonstrated that aneusomy was seen in all the cancers and preneoplastic tissues, while none of the controls showed aneusomic cells. There was no increase in aneusomy from precancers to cancers. CONCLUSION: Our results suggest that evaluation of chromosome 11 aneusomy in esophageal tissue using FISH with an appropriate signal capture-analysis system, can be used as an ancillary molecular marker predictive of early neoplastic changes. Future studies can be directed towards the genes on chromosome 11,which may play a role in the neoplastic transformation of esophageal precancerous lesions to cancers.

关键词： Esophageal cancer Aneusomy Chromosome11 Fluorescence in situ hybridization Early detection

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Decomposition of dynamic transcriptomic responses during effector-triggered immunity reveals conserved responses in two distinct plant cell populations

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Plant Communications 2024年第8期5卷 1-17页

作者： Xiaotong Liu Daisuke Igarashi rachel A.Hillmer Thomas Stoddard You Lu Kenichi Tsuda Chad L.myers Fumiaki Katagiri Department of Plant and microbial Biology University of Minnesota-Twin CitiesSt PaulMN 55108USA Department of Computer Science and Engineering University of Minnesota-Twin CitiesMinneapolisMN 55455USA Bioinformatics and Computational Biology Graduate Program University of Minnesota-Twin CitiesMinneapolisMN 55455USA Institute for Innovation Ajinomoto Co.Inc.KawasakiJapan State Key Laboratory of Agricultural microbiology Hubei Hongshan LaboratoryHubei Key Lab of Plant PathologyCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Present address:225 S 6th St MinneapolisMN 55402USA Present address:Biotalys Inc.2520 Meridian Parkway Suite 480DurhamNC 27713USA Present address:Life Sciences Institute and Department of Cell and Developmental Biology University of Michigan Medical SchoolAnn ArborMI 48109USA

Rapid plant immune responses in the appropriate cells are needed for effective defense against *** transcriptome analysis is often used to describe overall immune responses,collection of transcriptome data with sufficient resolution in both space and time is *** reanalyzed public Arabidopsis time-course transcriptome data obtained after low-dose inoculation with a Pseudomonas syringae strain expressing the effector AvrRpt2,which induces effector-triggered immunity in ***-peak time-course patterns are prevalent among thousands of upregulated *** implemented a multicompartment modeling approach to decompose the double-peak pattern into two single-peak patterns for each *** decomposed peaks reveal an“echoing”pattern:the peak times of the first and second peaks correlate well across most upregulated *** demonstrated that the two peaks likely represent responses of two distinct cell populations that respond either cell autonomously or indirectly to ***,the peak decomposition has extracted spatial information from the time-course *** echoing pattern also indicates a conserved transcriptome response with different initiation times between the two cell populations despite different elicitor types.A gene set highly overlapping with the conserved gene set is also upregulated with similar kinetics during pattern-triggered *** of a WRKY network via different entry-point WRKYs can explain the similar but not identical transcriptome responses elicited by different elicitor *** discuss potential benefits of the properties of the WRKY activation network as an immune signaling network in light of pressure from rapidly evolving pathogens.

关键词： Arabidopsis Pseudomonas syringae plant immune response multi-compartment model WRKY transcription factors resilient immune signaling network

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Atrial tachyarrhythmia in adult congenital heart disease

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World Journal of Cardiology 2017年第6期9卷 496-507页

作者： Arsha Karbassi Krishnakumar Nair Louise Harris rachel m Wald S Lucy Roche Toronto Congenital Cardiac Center for Adults Peter Munk Cardiac Center University Health Network Division of Cardiology 5N-521 Toronto General Hospital

The adult congenital heart disease (ACHD) population continues to grow and most cardiologists, emergency room physicians and family doctors will intermittently come into contact with these patients. Oftentimes this may be in the setting of a presentation with atrial tachyarrhythmia; one of the commonest late complications of ACHD and problem with potentially serious implications. Providing appropriate initial care and ongoing management of atrial tachyarrhythmia in ACHD patients requires a degree of specialist knowledge and an awareness of certain key issues. In ACHD, atrial tachyarrhythmia is usually related to the abnormal anatomy of the underlying heart defect and often occurs as a result of surgical scar or a consequence of residual hemodynamic or electrical disturbances. Arrhythmias significantly increase mortality and morbidity in ACHD and are the most frequent reason for ACHD hospitalization. Intra-atrial reentrant tachycardia and atrial fibrillation are the most prevalent type of arrhythmia in this patient group. In hemodynamically unstable patients, urgent cardioversion is required. Acute management of the stable patient includes anticoagulation, rate control, and electrical or pharmacological cardioversion. In ACHD, rhythm control is the preferred management strategy and can often be achieved. However, in the long-term, medication side-effects can prove problematic. Electrophysiology studies and catheter ablation are important treatments modalities and in certain cases, surgical or percutaneous treatment of the underlying cardiac defect has a role. ACHD patients, especially those with complex CHD, are at increased risk of thromboembolic events and anticoagulation is usually required. Female ACHD patients of child bearing age may wish to pursue pregnancies. The risk of atrial arrhythmias is increased during pregnancy and management of atrial tachyarrhythmia during pregnancy needs specific consideration.

关键词： Congenital heart disease Arrhythmia Adult Ablation

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Extension for Community Health Outcomes-hepatitis C:Small steps carve big footprints in the allocation of scarce resources for hepatitis C virus treatment to remote developing areas

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World Journal of Hepatology 2016年第11期8卷 509-512页

作者： Veysel Tahan Ashraf Almashhrawi Ali m Kahveci rachel mutrux Jamal A Ibdah Division of Gastroenterology and Hepatology University of Missouri missouri Telehealth Network and missouri Health IT Assistance Center

Hepatitis C virus(HCV)infection is still a major health problem throughout the *** patients living in rural areas are less fortunate than their counterparts residing in populous urbanized *** lack of medical resources and properly trained medical personnel in rural regions make it especially burdensome for HCV patients seeking *** Arora at the University of New mexico Health Sciences Center took initiative to resolve the issue at hand by developing a model named Project Extension for Community Health Outcomes(ECHO).ECHO connects primary care providers(PCPs),usually family medicine physicians,in local communities with *** providers test the efficacy of treatment given using the ECHO model vs that at academic medical *** ECHO model has produced promising results such that the sustained virologic response rates for both types of sites were *** me ECHO was adapted from Project ECHO to train PCPs in missouri and equip them with the tools and skills to properly treat and diagnose HCV in a timely *** healthcare model can be implemented for treating other common infections and chronic *** is the direction healthcare is headed for the next several *** has potential to be applied in developing countries to alleviate agony and despair resulting from limited resources and lack of access to expert medical care.

关键词： Hepatitis C Treatment Community Health care Outcome Rural Primary care Extension for Community Health Outcomes

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Survey of international experts on research priorities to improve care for healthy ageing

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Family medicine and Community Health 2024年第3期12卷 36-39页

作者： matteo Cesari Yuka Sumi Hyobum Jang Jotheeswaran Amuthavalli Thiyagarajan Yejin Lee rachel Albone marco Canevelli monica R Perracini Andrew m Briggs Anshu Banerjee Department of maternal NewbornChild and Adolescent Health and AgeingWorld Health OrganizationGenevaSwitzerland Department of Clinical Sciences and Community Health University of MilanMilanItaly Department of Human Neuroscience Universitàdegli Studi di Roma La SapienzaRomeItaly Department of Neurobiology Care Sciences and SocietyStockholm UniversityStockholmSweden National Center for Disease Prevention and Health Promotion Italian National Institute of HealthRomeItaly master's and Doctoral Program in Physical Therapy Universidade Cidade de São PauloSão PauloBrazil Curtin School of Allied Health Curtin enAble InstituteCurtin UniversityPerthWAAustralia

INTRODUCTION The United Nations(UN)Decade of Healthy Ageing(2021–2030),coordinated by the World Health Organization(WHO),1 is a global collaborative initiative aimed at improving the lives of older people,their families and the communities.23 The Action Areas 3(ie,‘deliver person-centred,integrated care and primary health services responsive to older people’)and 4(ie,‘provide access to long-term care(LTC)for older people who need it’)of the Decade’s work programme focus on reorienting health and care systems to promote‘ageing in place’and the delivery of personalised interventions in a seamless continuum of care.

关键词： services ageing centre

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音乐治疗

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作者： (英)rachel Darnley-Smith (英)Helen m. Patey

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Deep learning-based analysis of macaque corneal sub-basal nerve fibers in confocal microscopy images

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Eye and Vision 2020年第1期7卷 255-265页

作者： Jonathan D.Oakley Daniel B.Russakoff megan E.mcCarron rachel L.Weinberg Jessica m.Izzi Stuti L.misra Charles N.mcGhee Joseph L.mankowski Voxeleron LLC San FranciscoCAUSA Department of molecular and Comparative Pathobiology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Ophthalmology Faculty of Medical and Health SciencesNew Zealand National Eye CentreUniversity of AucklandAucklandNew Zealand

Background:To develop and validate a deep learning-based approach to the fully-automated analysis of macaque corneal sub-basal nerves using in vivo confocal microscopy(IVCm).methods:IVCm was used to collect 108 images from 35 macaques.58 of the images from 22 macaques were used to evaluate different deep convolutional neural network(CNN)architectures for the automatic analysis of sub-basal nerves relative to manual *** remaining images were used to independently assess correlations and interobserver performance relative to three ***:Correlation scores using the coefficient of determination between readers and the best CNN averaged *** inter-observer comparison,inter-correlation coefficients(ICCs)between the three expert readers and the automated approach were 0.75,0.85 and *** ICC between all four observers was 0.84,the same as the average between the CNN and individual ***:Deep learning-based segmentation of sub-basal nerves in IVCm images shows high to very high correlation to manual segmentations in macaque data and is indistinguishable across *** quantitative measurements of corneal sub-basal nerves are important biomarkers for disease screening and management,the reported work offers utility to a variety of research and clinical studies using IVCm.

关键词： Cornea Sensory nerves macaque Deep learning In vivo confocal microscopy

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Comparison of antibody detection with <i>Blastomycesdermatitidis</i>yeast lysate antigens in serum specimens from immunized rabbits and infected dogs

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Open Journal of Immunology 2011年第3期1卷 74-79页

作者： Will Christenson rachel Horton Kayla Campbell Kelly meacham Amber Schroeder Gene m. Scalarone 不详

This present study was designed to evaluate B. dermatitidis antigens, prepared from two isolates (B5896, 597), when the yeast cells were allowed to lyse in distilled water for one day or seven days. The indirect enzyme-linked immunosorbent assay (ELISA) was used to determine the ability of the lysate reagents to detect antibodies in 30 rabbit and 30 dog serum specimens. mean absorbance values with B5896 lysate antigen ranged from 1.637 (day 1) to 1.461 (day 7) and absorbance values with 597 antigen ranged from 1.579(day 1) to 1.396 (day 7) with the serum specimens from immunized rabbits. Serum specimens from infected dogs yielded absorbance values ranging from 1.672 (day 1) to 1.763 (day 7) with the B5896 and values ranging from 1.909 (day 1) to 1.224 (day 7) with the 597. Optimal reactivity was obtained with the day 1 lysate using both lysate antigens against the rabbit sera and with the 597 antigen against the dog sera. Slightly greater reactivity was evidenced with the day 7 B5896 antigen when the dog sera was tested. Comparative studies are continuing in order to produce an optimal anti-genic preparation for antibody detection in blastomycosis.

关键词： ELISA Blastomycesdermatitidis Antibody Detection Lysate Antigens

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Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”

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World Journal of Hypertension 2016年第1期6卷 18-35页

作者： Xue Bai rachel Dee Kevin D mangum Christopher P mack Joan m Taylor Department of Pathology and Laboratory medicine Mc Allister Heart Institute University of North Carolina at Chapel Hill

Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients.

关键词： Hypertension Blood pressure RhoA Smooth muscle contraction Guanine nucleotide exchange factor GTPase activating protein Polymorphisms

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The role of radiation for pancreatic adenocarcinoma

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Journal of Pancreatology 2020年第2期3卷 72-80页

作者： Gamboa Adriana C. Lee rachel m. maithel Shishir K. Division of Surgical Oncology Winship Cancer InstituteDepartment of SurgeryEmory UniversityAtlantaUSA

Pancreatic cancer is an aggressive malignancy with a high recurrence rate even after curative-intent *** in survival have not been achieved in the last 25 years thus highlighting the need for effective multimodal treatment *** role of radiation therapy for pancreatic cancer remains ill-defined due to historical lack of a standard definition of resectability,and the use of antiquated radiation delivery techniques and chemotherapy *** level I data regarding neoadjuvant chemoradiotherapy for resectable and borderline resectable pancreatic adenocarcinoma(PDAC)are limited to 2 randomized controlled trials and several retrospective studies and suggest that it may lead to an increased likelihood of a margin-negative resection and certainly allows for improved patient selection for pancreaticoduodenectomy when compared to upfront *** the adjuvant setting,data are similarly lacking but suggest that chemoradiotherapy may be beneficial for patients at high risk of locoregional *** we review existing data regarding the role of radiation in PDAC.

关键词： Adjuvant radiotherapy Neoadjuvant radiotherapy Pancreatic ductal adenocarcinoma Role of radiation for pancreas cancer

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