The role of radiation for pancreatic adenocarcinoma

作     者：Gamboa Adriana C. Lee Rachel M. Maithel Shishir K. Gamboa Adriana C.;Lee Rachel M.;Maithel Shishir K.

作者机构：Division of Surgical OncologyWinship Cancer InstituteDepartment of SurgeryEmory UniversityAtlantaUSA 

出 版 物：《Journal of Pancreatology》 (胰腺病学杂志（英文）)

年 卷 期：2020年第3卷第2期

页      面：72-80页

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

主　　题：Adjuvant radiotherapy Neoadjuvant radiotherapy Pancreatic ductal adenocarcinoma Role of radiation for pancreas cancer 

摘      要：Pancreatic cancer is an aggressive malignancy with a high recurrence rate even after curative-intent *** in survival have not been achieved in the last 25 years thus highlighting the need for effective multimodal treatment *** role of radiation therapy for pancreatic cancer remains ill-defined due to historical lack of a standard definition of resectability,and the use of antiquated radiation delivery techniques and chemotherapy *** level I data regarding neoadjuvant chemoradiotherapy for resectable and borderline resectable pancreatic adenocarcinoma(PDAC)are limited to 2 randomized controlled trials and several retrospective studies and suggest that it may lead to an increased likelihood of a margin-negative resection and certainly allows for improved patient selection for pancreaticoduodenectomy when compared to upfront *** the adjuvant setting,data are similarly lacking but suggest that chemoradiotherapy may be beneficial for patients at high risk of locoregional *** we review existing data regarding the role of radiation in PDAC.