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Human androgen deficiency： insights gained from androgen receptor knockout mouse models

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Asian Journal of Andrology 2014年第2期16卷 169-177,I0006页

作者： Kesha Rana rachel A Davey Jeffrey D Zajac Department of Medicine Austin Health University of Melbourne Heidelberg Victoria Australia.

The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor （AR） through the use of genetically modified mouse models. A number of global and tissue-specific AR knockout （ARKO） models have been generated using the Cre-loxP system which allows tissue- and/or cell-specific deletion. These ARKO models have examined a number of sites of androgen action including the cardiovascular system, the immune and hemopoetic system, bone, muscle, adipose tissue, the prostate and the brain. This review focuses on the insights that have been gained into human androgen deficiency through the use of ARKO mouse models at each of these sites of action, and highlights the strengths and limitations of these Cre-loxP mouse models that should be considered to ensure accurate interpretation of the phenotype.

关键词： androgen receptor androgen receptor knockout mouse model androgen deficiency

（1,3;1,4）-β-D-Glucans in Cell Walls of the Poaceae, Lower Plants, and Fungi： A Tale of Two Linkages

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Molecular Plant 2009年第5期2卷 873-882页

作者： rachel A. Burton Geoffrey B. Fincher The Australian Centre for Plant Functional Genomics School of Agriculture Food and Wine University of Adelaide Waite Campus Glen Osmond SA 5064Australia

（1,3;1,4）-β-D-Glucans consist of unbranched and unsubstituted chains of （1,3）- and （1,4）-β-glucosyl residues, in which the ratio of （1,4）-β-D-glucosyl residues to （1,3）-β-D-glucosyl residues appears to influence not only the physicochemical properties of the polysaccharide and therefore its functional properties in cell walls, but also its adoption by different plant species during evolution. The （1,3; 1,4）-β-D-glucans are widely distributed as non-cellulosic matrix phase polysaccharides in cell walls of the Poaceae, which evolved relatively recently and consist of the grasses and commercially important cereal species, but they are less commonly found in lower vascular plants, such as the horsetails, in algae and in fungi. The （1,3;1,4）-β-D-glucans have often been considered to be components mainly of primary cell walls, but recent observations indicate that they can also be located in secondary walls of certain tissues. Enzymes involved in the depolymerisation of （1,3;1,4）-β-D-glucans have been well characterized. In contrast, initial difficulties in purifying the enzymes responsible for （1,3;1,4）-β-D-glucan biosynthesis slowed progress in the identification of the genes that encode （1,3;1,4）-β-D-glucan synthases, but emerging comparative genomics and associated techniques have allowed at least some of the genes that contribute to （1,3;1,4）-β-D-glucan synthesis in the Poaceae to be identified. Whether similar genes and enzymes also mediate （1,3;1,4）-β-D-glucan biosynthesis in lower plants and fungi is not yet known. Here, we compare the different fine structures of （1,3;1,4）-β-D-glucans across the plant kingdom, present current information on the genes that have been implicated recently in their biosynthesis, and consider aspects of the cell biology of （1,3;1,4）-β-D-glucan biosynthesis in the Poaceae.

关键词： Cereals chemical structure glycosidic linkage analysis Poaceae polysaccharide biosynthesis wall deposition.

Energy shift： decline of easy oil and restructuring of eo-politics

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Frontiers in Energy 2016年第3期10卷 260-267页

作者： oliver R. INDERWILDI David A. KING Smith School of Enterprise and the Environment University of OxfordOxford OX1 3QY United Kingdom

This paper critically assesses the geopolitical and geo-economic impact of novel fuel resources on both resource exporters and importers. Presently, very strong political and economic forces drive the utilisation of domestic, unconventional oil and gas recovery in the West as these enhance energy security and ease balance of payment issues. The additional capacity generated by this trend has, supported by other effects such as Saudi Arabia＇s decision to maintain current production, triggered a significant reduction ofoil prices. Consequently, it is now oil exporters that struggle with the balance of payment issues and often these countries base their fiscal budget completely on fossil fuel revenues. In fact, these unconventional resources help turn the tide while oil exporters are now politically significantly weakened due to the increased energy sufficiency of the West. The catch is that the extraction of unconventional types ofoil has many environmental implications. So, internalising the environ- mental externalities have to be considered. This paper, therefore, assesses, next to geopolitics and geo-economics, the environmental implications of this trend.

关键词： energy security climatic change geo-economics geopolitics unconventional resources macroeconomics

Long-term survival of participants in the prostate ：ancer prevention trial

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Asian Journal of Andrology 2014年第3期16卷 413-414页

作者： Jonathan L Silberstein oliver Sartor Department of Urology Tulane University School of Medicine New OrleansLouisiana USA. Department of Medicine Tulane University School of Medicine New OrleansLouisiana USA.

The Prostate Cancer Prevention Trial （PCPT） is a seminal study in the field of urology. More than 10years after its initial publication, updated data from this trial continue to shape our understanding of prostate cancer. Among the major findings from the PCPT has been the demonstration that prostate cancer is common in men with prostate-specific antigen （PSA） once thought to be in the normal range,~ finasteride prevents the development of benign prostatic hypertrophy,2 it increases the sensitivity of PSA3 and digital rectal examination.4 Furthermore the PCPT helped to establish the link between erectile dysfunction and cardiovascular disease,5 and perhaps most importantly finasteride demonstrated a 25% relative risk reduction in the diagnosis of prostate cancer compared with placebo.

关键词： survival participants PCPT

Proposed framework for blockchain technology in a decentralised energy network

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Protection and Control of Modern Power Systems 2021年第1期6卷 396-406页

作者： oliver Dzobo Bessie Malila Lindokhuhle Sithole Department of Electrical&Electronic Engineering Science University of JohannesburgJohannesburgSouth Africa Department of Biomedical Engineering University of Cape TownCape TownSouth Africa

The integration of distributed renewable energy sources into the conventional power grid has become a hot research topic, all part of attempts to reduce greenhouse gas emission. There are many distributed renewable energy sources available and the network participants in energy delivery have also increased. This makes the management of the new power grid with integrated distributed renewable energy sources extremely complex. Applying the technical advantages of blockchain technology to this complex system to manage peer-to-peer energy sharing, transmission, data storage and build smart contracts between network participants can develop an optimal consensus mechanism within the new power grid. This paper proposes a new framework for the application of blockchain in a decentralised energy network. The microgrid is assumed to be private and managed by local prosumers. An overview description of the proposed model and a case study are presented in the paper.

关键词： Blockchain technology Distributed renewable energy sources Energy delivery Smart contract Distributed cloud storage system

How to derive a geovisualization from an application data model: an approach based on Semantic Web technologies

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International Journal of Digital Earth 2021年第7期14卷 874-898页

作者： Matthieu Viry Marlène Villanova.oliver Univ.Grenoble Alpes CNRSGrenoble INP(Institute of Engineering Univ.Grenoble Alpes)LIGGrenobleFrance

While ontological modelling and Semantic Web technologies are sometimes used to describe knowledge domains with a spatial component,there is still a lack of semantics to describe how to present this knowledge geovisually to the end user and how to automatize the *** this paper,we first present vocabularies to describe at a high level the elements that make up a *** then propose a method that describes at a semantic level how to obtain a geovisualization from an existing data *** method is based on our vocabularies and on a set of semantic rules encoding rich and complex operations on *** leads to the derivation of ontological knowledge,ready to be exploited to automate the creation of a *** method is implemented in a framework that uses Semantic Web *** singularity and the strength of our proposal is that it enables to describe a geovisualization through a RDF specification file,which once loaded in our system makes the geovisualization directly available for use from a Web *** result is obtained by extending a priori an application data model with ad hoc geovisualization semantics features and rules.

关键词： Knowledge representation Semantic Web geovisualization ontologies rule-based system

Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury

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Neural Regeneration Research 2015年第3期10卷 357-359页

作者： Jennifer Rodger rachel M.Sherrard Experimental and Regenerative Neuroscience School of Animal Biologythe University of Western Australia Sorbonne Universités UPMC Univ Paris 06 & CNRSInstitut de Biologie Paris Seine-B2AUMR 8256 Biological Adaptation and AgeingParis France

While it is well-known that neuronal activity promotes plasticity and connectivity, the success of activity-based neural rehabilitation programs remains extremely limited in human clinical experience because they cannot adequately control neuronal excitability and activity within the injured brain in order to induce repair. However, it is possible to non-invasively modulate brain plasticity using brain stimu- lation techniques such as repetitive transcranial （rTMS） and transcranial direct current stimulation （tDCS） techniques, which show promise for repairing injured neural circuits （Henrich-Noack et al., 2013; Lefaucher et al., 2014）. Yet we are far from having full control of these techniques to repair the brain following neurotrauma and need more fundamen- tal research （Ellaway et al., 2014; Lefaucher et al., 2014）. In this perspective we discuss the mechanisms by which rTMS may facilitate neurorehabilitation and propose experimental techniques with which magnetic stimulation may be investi- gated in order to optimise its treatment potential.

关键词： TMS Optimising repetitive transcranial magnetic stimulation for neural circuit repair following traumatic brain injury

Do females use their sexual status to gain resource access？ Investigating food-for-sex in wolves and dogs

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Current Zoology 2017年第3期63卷 323-330页

作者： rachel DALE Sarah MARSHALL-PESCINI Friederike RANGE Comparative Cognition Messerli Research Institute University of Veterinary Medicine Medical University of Vienna University of Vienna Vienna Austria Wolf Science Center Ernstbrunn Austria

While food sharing among related individuals can be explained by kin selection, food sharing be- tween unrelated individuals has been more of an evolutionary puzzle. The food-for-sex hypothesis provides an explanation for the occurrence of food sharing among nonkin. However, little is known about the socio-ecological factors that can promote such a commodity exchange. A species mating system is a factor potentially influencing food-for-sex patterns of behavior. Here, we compared wolves, which form pair-bonds, with dogs, which are typically promiscuous in freeranging contexts, to investigate the effect of reproductive stages on the behavior around a food source in 2 different contexts. Furthermore, we considered the roles of both the males and the fe- males in the potential food-for-sex exchange. Results indicate that in both species and for both sexes the breeding period promotes decreased aggression. Additionally, females were more per- sistent in their attempts to access the food and were able to monopolize the resource more when in heat as compared to outside the breeding period. Finally, in dogs, but not wolves, females spent more time in proximity to the male＇s bone and had a shorter latency to start eating it when in heat. Overall, this study demonstrates that the food-for-sex hypothesis plays a part in intersexual food sharing in canids, and highlights the role of females in the interaction. These effects were especially the case in dogs, suggesting a potential effect of mating system on food-for-sex responses

关键词： canid food-for-sex food sharing tolerance.

In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines

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World Journal of Gastroenterology 2007年第22期13卷 3063-3070页

作者： Dennis Hoffmann Wibke Bayer oliver Wildner Department of Molecular and Medical Virology Institute of Microbiology and Hygiene Ruhr-University Bochum Bldg. MA Rm. 6/40 D-44801 Bochum Germany

AIM： To evaluate whether intratumoral expression of measles virus fusogenic membrane glycoproteins H and F （MV-FMG）, encoded by an adenovirus vector ***-HI F, alone or in combination with local coexpression of cytokines （IL-2, IL-12, IL-18, IL-21 or GM-CSF）, can serve as a platform for inducing tumor-specific immune responses in colon cancer.METHODS： We used confocal laser scanning microscopy and flow cytometry to analyze cell-cell fusion after expression of MV-FMG by dye colocalization. In a syngeneic bilateral subcutaneous MC38 and Colon26 colon cancer model in C57BL/6 and BALB/c mice, we assessed the effect on both the directly vector-treated tumor as well as the contralateral, not directly vector- treated tumor. We assessed the induction of a tumorspecific cytotoxic T lymphocyte （CTL） response with a lactate dehydrogenase （LDH） release assay.RESULTS： We demonstrated in vitro that transduction of MC38 and Colon26 cells with ***-H/F resulted in dye colocalization, indicative of cell-cell fusion, in addition, in the syngeneic bilateral tumor model we demonstrated a significant regression of the directly vector-inoculated tumor upon intratumoral expression of MV-FMG alone or in combination with the tested cytokines. We observed the highest anti-neoplastic efficacy with MV-FMG and lL-21 coexpression. The degree of tumor regression of the not directly vector-treated tumor correlated with the anti-neoplastic response of the directly vector-treated tumor. This regression was mediated by a tumor-specific CTL response.CONCLUSION： Our data indicate that intratumoral expression of measles virus fusogenic membrane glycoproteins is a promising tool both for direct tumor treatment as well as for tumor vaccination approaches that can be further enhanced by cytokine coexpression.

关键词： Adenovirus vectors Measles virus fusogenic membrane glycoproteins Colorectal cancer Interleukins