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Beyond habitat structure: landscape heterogeneity explains the monito del monte (Dromiciops gliroides) occurrence and behavior at habitats dominated by exotic trees

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Integrative Zoology 2016年第5期11卷 413-421页

作者： Daniela a.salazar Francisco E.FONTÚRBEl Departamento de Ciencias Ecológicas Facultad de CienciasUniversidad de ChileSantiagoChile Instituto de Biología Facultad de CienciasPontificia Universidad Católica de ValparaísoValparaísoChile

Habitat structure determines species occurrence and ***,human activities are altering natural habitat structure,potentially hampering native species due to the loss of nesting cavities,shelter or movement *** South American temperate rainforest is experiencing an accelerated loss and degradation,compromising the persistence of many native species,and particularly of the monito del monte(Dromiciops gliroides Thomas,1894),an arboreal marsupial that plays a key role as seed *** to compare 2 contrasting habitats(a native forest and a transformed habitat composed of abandoned Eucalyptus plantations and native understory vegetation),we assessed ***’occurrence using camera traps and measured several structural features(*** and bamboo cover,deadwood presence,moss abundance)at 100 camera ***plementarily,we used radio telemetry to assess its spatial ecology,aiming to depict a more complete *** abundance was the only significant variable explaining *** occurrence between habitats,and no structural variable explained its occurrence at the transformed *** were no differences in home range,core area or inter-individual *** the transformed habitats,tracked individuals used native and Eucalyptus-associated vegetation types according to their *** locations(and,hence,nesting sites)were located exclusively in native *** landscape heterogeneity resulting from the vicinity of native and Eucalyptus-associated vegetation likely explains *** occurrence better than the habitat structure itself,as it may be use Eucalyptus-associated vegetation for feeding purposes but depend on native vegetation for nesting.

关键词： behavior fleshy fruits southern Chile spatial ecology temperate rainforest

Structural and biological engineering of 3D hydrogels for wound healing

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Bioactive Materials 2023年第6期24卷 197-235页

作者： Mohammad Hadi Norahan Sara Cristina Pedroza-gonzález Mónica Gabriela Sánchez-salazar Mario Moisés Álvarez Grissel Trujillo de Santiago Escuela de Ingeniería y Ciencias Tecnológico de MonterreyMonterreyNL64849Mexico Centro de Biotecnología-FEMSA Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico Departamento de Bioingeniería Tecnológico de MonterreyMonterreyNuevo LeónCP64849Mexico

Chronic wounds have become one of the most important issues for healthcare systems and are a leading cause of death *** dressings are necessary to facilitate wound *** wound dressings may substantially reduce healing time,reduce the risk of recurrent infections,and reduce the disability and costs *** the path of engineering of an ideal wound dressing,hydrogels have played a leading *** are 3D hydrophilic polymeric structures that can provide a protective barrier,mimic the native extracellular matrix(ECM),and provide a humid *** to their advantages,hydrogels(with different architectural,physical,mechanical,and biological properties)have been extensively explored as wound dressing *** we describe recent studies on hydrogels for wound healing applications with a strong focus on the interplay between the fabrication method used and the architectural,mechanical,and biological performance ***,we review different categories of additives which can enhance wound regeneration using 3D hydrogel *** engineering for wound healing applications promises the generation of smart solutions to solve this pressing problem,enabling key functionalities such as bacterial growth inhibition,enhanced re-epithelialization,vascularization,improved recovery of the tissue functionality,and overall,accelerated and effective wound healing.

关键词： Wound healing Wound dressing Hydrogel Tissue engineering 3D culture

Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine

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World Journal of Gastroenterology 2013年第47期19卷 9020-9033页

作者： Daniela Gordillo-Bastidas Edén Oceguera-Contreras Adriana.salazar-Montes Jaime gonzález-Cuevas luis Daniel Hernández-Ortega Juan Armendáriz-Borunda nstitute of Molecular Biology in Medicine and Gene Therapy/CUCS University of GuadalajaraGuadalajaraJalisco 44100México

AIM:To determine the molecular mechanisms involved in experimental hepatic fibrosis prevention by caffeine(CFA).METHODS:liver fibrosis was induced in Wistar rats by intraperitoneal thioacetamide or bile duct ligation and they were concomitantly treated with CFA(15 mg/kg per day).Fibrosis and inflammatory cell infiltrate were evaluated and classified by Knodell *** infiltrate was quantified by immunohistochemistry(anti-CD11b).Gene expression was analyzed by quantitative reverse transcription-polymerase chain reaction for collagenⅠ?(Col-1),connective tissue growth factor(CTGF),transforming growth factorβ1(TGF-β1),tumor necrosis factor alpha(TNF-α),interleukin-1(Il-1),Il-6,superoxide dismutase(SOD)and catalase(CAT).Activation of Nrf2 and Snail-1 was analyzed by ***-αexpression was proved by enzyme-linked immunosorbant assay,CAT activity was performed by ***:CFA treatment diminished fibrosis index in treated *** Knodell index showed both lower fibrosis and *** of profibrogenic genes CTGF,Col-1 and TGF-β1 and proinflammatory genes TNF-α,Il-6 and Il-1 was substantially diminished with CFA treatment with less CD11b positive *** lower values of transcriptional factor Snail-1 were detected in CFA treated rats compared with cirrhotic rats without treatment;in contrast Nrf2was increased in the presence of *** of SOD and CAT was greater in animals treated with CFA showing a strong correlation between mRNA expression and enzyme ***:Our results suggest that CFA inhibits the transcriptional factor Snail-1,down-regulating profibrogenic genes,and activates Nrf2 inducing antioxidant enzymes system,preventing inflammation and fibrosis.

关键词： liver fibrosis Caffeine Thioacetamide Bile duct ligation Profibrogenic genes Proinflammatory cytokines Antioxidant enzymes

Design and Implementation of a Rehabilitation Upper-limb Exoskeleton Robot Controlled by Cognitive and Physical Interfaces

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Journal of Bionic Engineering 2022年第5期19卷 1374-1391页

作者： Arturo gonzalez‑Mendoza Ivett Quinones‑Uriostegui Sergio salazar‑Cruz Alberto‑Isaac Perez‑Sanpablo Ricardo lopez‑Gutierrez Rogelio lozano lAFMIA UMI Center for Research and AdvancedStudies of National Polytechnic InstituteAv.Instituto Politecnico Nacional No.250807360 Mexico CityMexico Motion Analysis lab National Institute of Rehabilitation Luis Guillermo Ibarra IbarraCalz.Mexico Xochimilco No.28914389 Mexico CityMexico CONACYT-CINVESTAV Av.Instituto Politecnico Nacional 250807360 Mexico CityMexico UTC-CNRS UMR Sorbonne UniversitesUTC-CNRS UMR7253 HeudiasycCompiegneFrance

This paper presents an upper limb exoskeleton that allows cognitive(through electromyography signals)and physical user interaction(through load cells sensors)for passive and active exercises that can activate neuroplasticity in the rehabilitation process of people who suffer from a neurological *** the exoskeleton to be easily accepted by patients who suffer from a neurological injury,we used the ISO9241-210:2010 as a methodology design *** the first steps of the design process,design requirements were collected from previous usability tests and ***,as a second step,a technological solution is proposed,and as a third step,the system was evaluated through performance and user *** part of the technological solution and to allow patient participation during the rehabilitation process,we have proposed a hybrid admittance control whose input is load cell or electromyography *** hybrid admittance control is intended for active therapy exercises,is easily implemented,and does not need musculoskeletal modeling to ***,electromyography signals classification models and features were evaluated to identify the best settings for the cognitive human–robot interaction.

关键词： Human Robot interaction Hybrid admittance control Surface electromyography Upper-limb exoskeletal robot

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity

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Acta Pharmaceutica Sinica B 2018年第2期8卷 188-199页

作者： Eneida Turiján-Espinoza Rául Alejandro salazar-gonzález Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez laboratory of Immunology and Cellular and Molecular Biology Faculty of Chemical Science UASLP laboratory of Biopharmacy and Pharmacokinetics Faculty of Chemical Science UASLP

Arylamine N-acetyltransferase(NAT; E.C. 2.***.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPlC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins.

关键词： Arylamine N-acetyltransferase NAT Sirtuins Peripheral blood mononuclear cells Nicotinamide Resveratrol

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农民工的权利观、剥夺感与社会参考框架

学海 2013年第3期 72-84页

作者：孟慧新 Miguel a.salazar 胡晓江中国社会科学院城市发展与环境研究所北京师范大学社会发展与公共政策学院

农民工对自身处境的主观感受与他们的社会参考框架直接相关。本文基于对273位农民工的访谈,通过对资料进行逐步分类,分析概括不同层级的公民权影响农民工选择社会参考框架,及其权利意识和剥夺感的社会机制。研究发现,首先,复制到城市内... 详细信息

农民工对自身处境的主观感受与他们的社会参考框架直接相关。本文基于对273位农民工的访谈,通过对资料进行逐步分类,分析概括不同层级的公民权影响农民工选择社会参考框架,及其权利意识和剥夺感的社会机制。研究发现,首先,复制到城市内部的城乡二元结构切断了农民工与城市居民在相同能力基础上的切近比较,使城乡待遇差别呈现为能力差别;其次,巨大的城乡差距使得从乡到城的流动权利先于与城市居民平等参与劳动收益和社会资源分配的社会权利,成为农民工的首要需求;第三,隔绝于城市社会的农村和农民工群体内的社会权利状况、劳动收益核算机制,形成了农民工"自力更生"、"多劳多得"的保障责任自负的权利观念。在上述机制作用下,农民工大多将城乡差别归因于个人,与城市居民平等参与社会资源分配的权利观念及相应的相对剥夺感不强。同时,但求不被直接剥夺的农民工们也对制度和相关机构抱有疏离感和不信任感,而他们持有的基本人权观和仍旧遭受的各种直接剥夺,致使他们具有强烈的剥夺感及对制度及机构的不认同感。

关键词：公民权参照群体个人绩效城乡隔绝城乡差距

Adaptive Control for Passive Kinesiotherapy EllTIO

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Journal of Bionic Engineering 2014年第4期11卷 581-588页

作者： Ricardo lópez Hipólito Aguilar Sergio salazar Rogelio lozano laboratory UMI lAFMIA 3175 CINVESTAV-CNRS Móxico D. F. CNRS Research Director Universitb de Technologie de Compiègne 60200 Compiègne France

Exoskeletons are mechatronic devices used to increase human muscle strength and resistance. In the last decade these devices have become a very useful tool to assist active kinesiotherapy. This paper presents the design of exoskeleton focused on the rehabilitation of ankle and knee for the right leg. The construction of prototype like Exoskeleton for lower limb Training with Instrumented Orthoses （EllTIO） using Series Elastic Actuator （SEA） to reduce the effort in the human joints, and a control law to perform a rehabilitation routine using an adaptive control scheme were first implemented in simulation to verify the control strategy and make a real rehabilitation test. The adaptive control law is proposed with the intention that the exoskeleton can adapt to user parameters at the time when performing the exercise. The results show the parameters estimation and tracking trajectory for the exoskeleton were proposed, and this trajectory could be a routine rehabilitation proposed by the therapist.

关键词： exoskeleton parametric identification rehabilitation robotics adaptive control.

Spectral square moments of a resonance sum for Maass forms

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Frontiers of Mathematics in China 2017年第5期12卷 1183-1200页

作者： Nathan salazar Yangbo YE Department of Mathematics The University of Iowa Iowa City Iowa 52242-1419 USA

let f be a Maass cusp form for Г0（N） with Fourier coefficients 1 k2. λf（n） and laplace eigenvalue 1/4 ＋k2 For real α≠0 and β 〉 0, consider the sum Sx（f; α,β） = ∑n λf（n）e（αnβ）φ（n/X）, where φ is a smooth function of compact support. We prove bounds for the second spectral moment of Sx （f;α, β）, with the eigenvalue tending towards infinity. When the eigenvalue is sufficiently large, we obtain an average bound for this sum in terms of X. This implies that if f has its eigenvalue beyond X1/2＋ε, the standard resonance main term for Sx（f; ±2√q 1/2）, q ∈Z＋, cannot appear in general. The method is adopted from proofs of subconvexity bounds for rankin-Selberg l-functions for Gl（2） × Gl（2）. It contains in particular a proof of an asymptotic expansion of a well-known oscillatory integral with an enlarged range of Kε≤ l≤ K1-ε. The same bounds can be proved in a similar way for holomorphie cusp forms.

关键词： Cusp form Maass form Fourier coefficient of cusp form Kuznetsovtrace formula resonance sum first derivative test weighted stationary phase

Inverse estimation for unknown fouling geometry on inner wall of forced-convection pipe

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Applied Mathematics and Mechanics(English Edition) 2011年第1期32卷 55-68页

作者：陳文立楊俞青李浩榕 J.l.salazar Clean Energy Center Department of Mechanical EngineeringKun Shan University

A conjugate gradient method （CGM） based on the inverse algorithm is used to estimate the unknown fouling-layer profile on the inner wall of a pipe system using simulated temperature measurements taken within the pipe wall. It is assumed that no prior information is available about the functional form of the unknown profile. Therefore, the procedure is classified as the function estimation in inverse calculation. The temperature data obtained from the direct problem are used to simulate the temperature measurements. The accuracy of the inverse analysis is examined using the simulated exact and inexact temperature measurements. The results show that the excellent estimation of the fouling-layer profile can be obtained for the test case considered in this study. The technique presented in this study can be used in a warning system to call for pipe maintenance when the thickness of fouling exceeds a predefined criterion.

关键词： inverse problem fouling layer pipe system conjugate gradient method