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Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring

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Asian Journal of Andrology 2013年第2期15卷 261-268,I0009页

作者： richard ivell Kee Heng Helen Nicholson r.vinder.anand-ivell School of Molecular and Biomedical Science University of Adelaide Adelaide 5005 Australia FBN Leibniz Institute of Farm Animal Biology Dummerstorf 18196 Germany Centre for reproduction and Genomics Otago School of Medical Sciences University of Otago Dunedin 9054 New Zealand School of Pharmacy and Medical Sciences University of South Australia Adelaide 5000 Australia

Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl phthalate （DBP; from gestational day （GD） 14.5 to postnatal day （PND） 6） or diethylstilbestrol （DES; from GD14o5 to GD16.5） during a short gestationalllactational window, and male offspring subsequently analysed for various postnatal testicular parameters. All offspring remained in good health throughout the study. Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. Part of this effect appeared to be due to a treatment-specific impact on Leydig cell proliferation during puberty for both xenobiotics. Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population.

关键词： diethylstilbestrol (DES) INSL3 Leydig cells dibutyl phthalate (DBP) puberty testis

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Coarse to Fine: The role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana r Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko r Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

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Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

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重塑当代女性的轮廓孟买NEZO零售店

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室内设计与装修 2025年第1期 74-77页

作者：无 Pankaj anand(摄影) 西溪(编译) Sanjay Puri Architects 不详

NEZO创始人发现,印度市场缺乏具有西式风格样式的服装,于是决定创建这个独特的品牌,旨在汇聚来自全国的设计师,展示设计的多元化。她深信,印度的设计师代表着时尚的未来。基于这一信念,她邀请Sanjay Puri Architects建筑师事务所打造了... 详细信息

NEZO创始人发现,印度市场缺乏具有西式风格样式的服装,于是决定创建这个独特的品牌,旨在汇聚来自全国的设计师,展示设计的多元化。她深信,印度的设计师代表着时尚的未来。基于这一信念,她邀请Sanjay Puri Architects建筑师事务所打造了一个充满活力、具有前瞻性和现代感的空间。

关键词：建筑师事务所当代女性现代感展示设计多元化前瞻性

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Security Strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko Marek r.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

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Inhibition of NO emission by adding antioxidant mixture in Jatropha biodiesel on the performance and emission characteristics of a C.I. engine

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Frontiers in Energy 2015年第2期9卷 238-245页

作者： A. PrABU r. B. anand Department of Mechanical Engineering National Institute of Technol-ogy Tiruchirappalli 620015 India

In this paper, the effect of adding an antiox- idant mixture in Jatropha biodiesel as fuel, in a single cylinder, direct injection compression ignition engine was experimentally investigated and the level of pollutants in the exhaust and performance characteristics of the engine were analyzed. Nine test fuels were prepared with three antioxidants, namely, Suecinimide （C4H5NO2）, N,N-dimethyl-p-phenylenediamine-dihydrochloride （C8H14C12N2）, and N-phenyl-p-phenylenediamine （C6H5NHC6H4NH2） added to neat biodiesel at 500 parts per million （ppm）, 1000ppm and 2000ppm and the observed experimental results were compared with those of neat biodiese! and neat diesel as base fuels. The comparison showed that NO emission was reduced drastically for the test fuels with the antioxidant addition of 2000ppm. The maximum reduction of 10% of NO emission was observed for the antioxidant mixture in neat biodiesel, with a slight increase in unburned HC, CO and smoke opacity. In addition, the obtained experimental results reveal that the addition of two antioxidants as mixture in neat biodiesel caused improved NO emission reduction for all test fuels.

关键词： NO emission antioxidants Succinimide,N,N-dimethyl-p-phenylenediamine-dihydrochloride N-phenyl-p-phenylenediamine

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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural regeneration research 2025年第3期20卷 803-804页

作者： Glenn A.Harris Lauren r.Hirschfeld rainwater Charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3r) or 4-repeat(4r) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

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Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Seismic bearing capacity of strip footing on partially saturated soil using modal response analysis

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Earthquake Engineering and Engineering Vibration 2022年第3期21卷 641-662页

作者： Abhijit anand rajib Sarkar Department of Civil Engineering IIT(ISM)DhanbadDhanbad 826004India

The present study proposes a novel and simplified methodology to assess the seismic bearing capacity(SBC) of a shallow strip footing by incorporating strength non-linearity arising due to partial saturation of a soil matrix. Furthermore, developed methodology incorporates the modal response analysis of soil layers to assess SBC. A constant matric suction distribution profile has been considered throughout the depth of the soil. The Van Genuchten equation and corresponding fitting parameters have been considered to quantify matric suction in the analysis. SBC has been obtained for three different geomaterials;viz. sand, fly ash and clay, based on their predominant grain size and diverse soil water characteristics curve(SWCC) attributes. Variation of SBC with different modes of vibration and damping ratio are reported for ranges of matric suction pertinent to the geomaterials considered in the study. The relative significance of matric suction on SBC has been reported for suction values within the transition zone of each geomaterial. It is observed that the SBC of sand is drastically reduced, with matric suction reaching beyond the residual suction value. The SBC of fly ash remains constant beyond the residual suction value, whereas the SBC of clay shows an increasing trend toward the practical range of matric suction values.

关键词： seismic bearing capacity modal analysis matric suction

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