Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring
大鼠孕期外源性邻苯二甲酸二丁酯和己烯雌酚暴露会改变子代雄性大鼠间质细胞发育作者机构：School of Molecular and Biomedical Science University of Adelaide Adelaide 5005 Australia FBN Leibniz Institute of Farm Animal Biology Dummerstorf 18196 Germany Centre for Reproduction and Genomics Otago School of Medical Sciences University of Otago Dunedin 9054 New Zealand School of Pharmacy and Medical Sciences University of South Australia Adelaide 5000 Australia
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2013年第15卷第2期
页 面：261-268,I0009页
核心收录：
基 金：part through an Australian Research Council (http://www.arc.gov.au) project grant to RI the University of Adelaide to KH
主 题：diethylstilbestrol (DES) INSL3 Leydig cells dibutyl phthalate (DBP) puberty testis
摘 要：Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl phthalate （DBP; from gestational day （GD） 14.5 to postnatal day （PND） 6） or diethylstilbestrol （DES; from GD14o5 to GD16.5） during a short gestationalllactational window, and male offspring subsequently analysed for various postnatal testicular parameters. All offspring remained in good health throughout the study. Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. Part of this effect appeared to be due to a treatment-specific impact on Leydig cell proliferation during puberty for both xenobiotics. Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population.
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