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场地研究：场地评价中的地貌学和地质学

水文地质工程地质技术方法动态 2002年第1期 17-17页

作者： J.n.hutchinson 何雪洲

澳大利亚及新西兰新生儿网络中患严重早产儿视网膜病变的出生前危险因素研究

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 8-9页

作者： Darlow B. A. hutchinson J. L. Henderson - Smart D.J. 桑延智(译) Department of Paediatrics Christchurch School of Medicine and Health Sciences PO Box 4345 Christchurch New Zealand 不详

*** identify prenatal and perinatal risk factors for clinically severe(stage 3 or 4)retinopathy of prematurity(rOP).*** were collected prospectively as part of the ongoing Australian and new Zealand neonatal network audit of high-risk infants(birth weight of r gestational age GA of neonatal unit in Australia or new *** and perinatal factors to 1 minute of age were examined for the subset of infants with GA ofrvived to 36 weeks’ postmenstrual age and were examined for rOP(n=2105).The factors significantly associated with stage 3 or 4 rOP were entered into amultivariate logistic regression ***-hundred three infants(9.6%)had stage 3 or more *** was the dominant risk factor,with infants with GA ofng 20 times greater odds of severe rOP than infants with GA of 28 *** weight for GA also had a “ dose-response” effect;the more growthrestricted infants had greater risk,with infants below the 3rd percentile of weight for GA having 4 times greater odds of severe rOP than those between the 25th and 75th *** gender was also a significant risk factor(odds ratio:1.73;95% confidence interval:1.25-2.40).*** data,for a large,essentially population-based cohort,suggest that factors related to the degree of immaturity,intrauterine growth restriction,and male gender contribute to severe rOP.

关键词：早产儿视网膜病变危险因素研究澳大利亚网络计划新生儿出生前新西兰 logistic回归模型

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苏格兰敦雷一个核废料竖井的海岸侵蚀

水文地质工程地质技术方法动态 2003年第1期 15-15页

作者： J.n.hutchinson 何雪洲等

retinoic acid signaling acts as a rheostat to balance Treg function

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Cellular & Molecular Immunology 2022年第7期19卷 820-833页

作者： Govindarajan Thangavelu Gabriela Andrejeva Sara Bolivar-Wagers Sujeong Jin Michael C.Zaiken Michael Loschi Ethan G.Aguilar Scott n.Furlan Chrysothemis C.Brown Yu-Chi Lee Cameron McDonald Hyman Colby J.Feser Angela Panoskaltsis-Mortari Keli L.Hippen Kelli P.MacDonald William J.Murphy Ivan Maillard Geoffrey r.Hill David H.Munn robert Zeiser Leslie S.Kean Jeffrey C.rathmell Hongbo Chi randolph J.noelle Bruce r.Blazar Department of Pediatrics Center for ImmunologyUniversity of MinnesotaMinneapolisMNUSA Center for Immunobiology Vanderbilt University Medical CenterNashville TNUSA Department of Pediatrics University of WashingtonSeattleWAUSA Fred hutchinson Cancer research Center SeattleWAUSA Howard Hughes Medical Institute Immunology Program and Ludwig CenterSloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Microbiology and Immunology.Geisel School of Medicine at Dartmouth Norris Cotton Cancer CenterLebanonUSA Department of Immunology Queensland Institute of Medical Research(QIMR)Berghofer Medical Research Institute and School of MedicineUniversity of QueenslandBrisbaneQLDAustralia Departmentof Dermatology School of MedicineUniversity of California DavisSacramentoCAUSA Division of Hematology/Oncology Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPAUSA Georgia Cancer Center Augusta UniversityAugustaGAUSA Department of Haematology Oncology and Stem Cell TransplantationFaculty of MedicineFreiburg University Medical CentreFreiburgGermany Boston Children's Hospital and the Dana-Farber Cancer Institute BostonMAUSA Department of Immunology St.Jude Children's ResearchHospitalMemphisTNUSA

regulatory T cells(Tregs)promote immune homeostasis by maintaining self-tolerance and regulating inflammatory *** certain inflammatory conditions,Tregs can lose their lineage stability and *** studies have reported that ex vivo exposure to retinoic acid(rA)enhances Treg function and ***,it is unknown how rA receptor signaling in Tregs influences these processes in ***,we employed mouse models in which rA signaling is silenced by the expression of the dominant negative receptor(Dn)rArαin all T *** the fact that DnrArαconventional T cells are hypofunctional,Tregs had increased CD25 expression,STAT5 pathway activation,mTOrC1 signaling and supersuppressor ***,DnrArαTregs had increased inhibitory molecule expression,amino acid transporter expression,and metabolic fitness and decreased antiapoptotic *** function was observed when wild-type mice were treated with a pharmacologic pan-rAr ***,Treg-specific expression of DnrArαresulted in distinct phenotypes,such that a single allele of DnrArαin Tregs heightened their suppressive function,and biallelic expression led to loss of suppression and *** loss of Treg function was not cell intrinsic,as Tregs that developed in a noninflammatory milieu in chimeric mice reconstituted with DnrArαand wild-type bone marrow maintained the enhanced suppressive *** mapping suggested that maintaining Treg stability in an inflammatory milieu requires rA *** findings indicate that rA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions in a dose-dependent manner.

关键词： retinoic acid Tregulatory cells Autoimmunity Metabolism mTOrC1 STAT5

国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南

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中国微创外科杂志 2013年第9期13卷 803-805页

作者：苏远涛徐安安朱江帆 Diaz AA Arvidsson D Baker rS Basso n Bellanger D Boza C El Mourad H France M Gagner M Galvao-neto M Higa KD Himpens J hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M nguyen nT nocca D Prager G Pomp A ramos AC rosenthal rJ Shah S Vix M Wittgrove A Zundel n 同济大学附属东方医院普外科上海200120 Department of Surgery Section of Minimally Invasive SurgeryCleveland Clinic Florida2950 Cleveland Clinic Boulevard

腹腔镜胃袖状切除术（1aparoscopic sleeve gastrectomy，LSG）系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显，逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。201... 详细信息

腹腔镜胃袖状切除术（1aparoscopic sleeve gastrectomy，LSG）系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显，逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25～26日，

关键词：袖状切除术手术方式操作指南病例专家国际减重效果

Phenotypic, Cytological and Molecular (AFLP) Analyses of the Cotton Synthetic Allohexaploid Hybrid (G. hirsutum×G. longicalyx)²

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Open Journal of Genetics 2020年第2期10卷 35-49页

作者： n’Guessan Olivier Konan Jean-Marie Jacquemin Jean-Pierre Baudoin Guy Mergeai Laboratory of Crop Improvement Agroforestry Unit Jean Lorougnon Guédé University Daloa C&#244 te D’Ivoire Laboratory of Tropical Agroecology Gembloux Agro-Bio Tech Liège University Gembloux Belgium Department of Life Sciences Bioengineering Unit Walloon Agricultural Research Centre (CrAw) Gembloux Belgium

The wild cotton diploid species (2n = 2x = 26) are important sources of useful traits such as high fiber quality, resistance to biotic and abiotic stresses etc., which can be introgressed into the cultivated tetraploid cotton Gossypium hirsutum L (2n = 4x = 52), for its genetic improvement. The African wild diploid species G. longicalyx hutchinson and Lee could be used as donor of the desirable traits of fiber fineness and resistance to reniform nematode. However, hybridization of wild diploid species and cultivated tetraploid cotton encounters a sterility problem of the triploid (2n = 3x = 59), mainly due to ploidy. The restoration of the fertility can be done by creating an allohexaploid (2n = 6x = 78) through the doubling with colchicine of the sterile triploid chromosomes. With this method, a synthetic allohexaploid hybrid (G. hirsutum × G. longicalyx)2 has been obtained. This genotype was studied using phenotypic, cytological and molecular (AFLP) analyses in order to confirm its hybridity and its caryotype, and also to verify the expression of the desirable traits coming from G. longicalyx. The studied genotype showed a quite good level of pollen fertility (83%), and apart from larger seeds and some minor seedling anomalies, most of its morphological characteristics were intermediate between the two parental species. It had 78 chromosomes, proving its hexaploid status. Molecular analysis revealed 136 AFLP loci in this hexaploid, all from G. hirsutum and G. longicalyx, demonstrating its hybrid status. In addition, the hexaploid exhibited the useful traits of G. longicalyx with regard to its remarkable fiber fineness and its high resistance to the reniform nematode. This allohexaploid hybrid constitutes an interesting agronomic material, which can be used as a bridge for the transfer of useful agronomic traits from wild species to varieties of G. hirsutum.

关键词： Gossypium spp Hexaploid Hybrid Chromosomes AFLP Marker Plant Breeding

早期乳腺癌最佳辅助化疗方案与人类表皮生长因子受体2阳性乳腺癌辅助靶向治疗选择：依据 ASCO 对 CCO临床实践指南的改编

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中国全科医学 2016年第18期19卷 2113-2114页

作者： neelima Denduluri Mark r Somerfield Andrea Eisen Jamie n Holloway Arti Hurria Tari A King Gary H Lyman Ann H Partridge Melinda L Telli Maureen E Trudeau Antonio C Wolff 本刊编辑部 US Oncology network Virginia Cancer Specialists American Society of Clinical Oncology Sunnybrook Health Sciences Centre and Cancer Care Ontario City of Hope Dana-Farber/Brigham and Women' s Cancer Center Fred hutchinson Cancer research Center Dana-Farber Cancer Institute Stanford University The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HEr2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO... 详细信息

目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HEr2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO临床实践指南的严谨性与内容适用性进行回顾。结果基于对CCO临床实践指南内容的回顾,ASCO小组认为,CCO临床实践指南在整体上清晰全面,以最确切的科学证据为基础,为患者提供可接受的治疗选项。推荐关于辅助化疗方案的决定,应考虑到基线复发风险、毒性、利益可能性和宿主因素(如合并症)。对于高风险HEr2阴性的身体状况良好的人群,蒽环类和紫杉烷治疗方案是标准治疗方案。4个周期的多西他赛和环磷酰胺治疗方案是可接受的非蒽环类治疗方案。对于高风险HEr2阳性患者,推荐蒽环类与紫杉烷序贯疗法联合曲妥单抗或多西他赛、卡铂、曲妥单抗进行6个周期的治疗。对于低风险、非淋巴结转移、HEr2阳性人群,推荐每周一次的紫杉醇和曲妥单抗连续进行12个周期的替代治疗。曲妥单抗应持续使用1年。不应采用铂复合盐对三阴性人群进行常规的辅助管理,除非出现有效的生存数据加以支持。

关键词：乳腺肿瘤抗肿瘤联合化疗方案受体,表皮生长因子指南

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极早产儿慢性肺病的产前预测因子

世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 16-16页

作者： Henderson-Smart D.J. hutchinson J.L. Donoghue D.A. 郭战宏 Centre for Perinatal Health Services research University of Sydney Sydney NSW 2006 AustraliaProf

Objective: To identify prenatal risk factors for chronic lung disease (CLD) at 36 weeks postmenstrual age in very preterm infants. Population: Data were colle cted prospectively as part of the ongoing audit of the Australian and new Zealan d neonatal network (AnZnn) of all infants born at less than 32 weeks gestation a dmitted to all tertiary neonatal intensive care units in Australia and new Zeala nd. Methods: Prenatal factors up to 1 minute of age were examined in the subset of infants born at gestational ages 22-31 weeks during 1998-2001, and who surv ived to 36 weeks postmenstrual age (n=11 453). Factors that were significantly associated with CLD at 36 weeks were entered into a multivariate logistic regress ion model. results: After adjustment, low gestational age was the dominant risk factor, with an approximate doubling of the odds with each week of decreasing ge stational age from 31 to less than 25 weeks (trend P rth weight for gestational age also had a dose-response effect: the lower the birth weight for gestational age, the greater the risk, with infants below the third centile having 5.67 times greater odds of CLD than those between the 25th and 75th centile (trend P re was also a significantly increased risk for male infa nts (odds ratio 1.51 (95%confidence interval 1.36 to 1.68), P nclu sions: These population based data show that the prenatal factors low gestational age, low birth weight for gestational age, and male sex significantly predict the development of chronic respiratory insufficiency in very preterm infants and may assist clinical decision about delivery.

关键词：产前因素慢性肺病早产儿预测因子新生儿重症监护病房澳大利亚危险因素停经后新西兰出生时

低脂肪饮食模式与浸润型乳腺癌风险的妇女健康初步随机对照饮食改良试验

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 3-4页

作者： Prentice r.L. Caan B. Chlebowski r.T. 张旸 Division of Public Health Sciences Fred Hutchinson Cancer Research Center M3- A410 1100 Fairview Ave N Seattle WA 98109 United StatesDr.

Context: The hypothesis that a low- fat dietary pattern can reduce breast cancer risk has existed for decades but has never been tested in a controlled intervention trial. Objective: To assess the effects of undertaking a low- fat dietary pattern on breast cancer incidence. Design and Setting: A randomized, controlled, primary prevention trial conducted at 40 US clinical centers from 1993 to 2005. Participants: A total of 48 835 postmenopausal women, aged 50 to 79 years, without prior breast cancer, including 18.6% of minority race/ethnicity, were enrolled. Interventions: Women were randomly assigned to the dietary modification intervention group (40% [n = 19 541]) or the comparison group (60% [n = 29 294]). The intervention was designed to promote dietary change with the goals of reducing intake of total fat to 20% of energy and increasing consumption of vegetables and fruit to at least 5 servings daily and grains to at least 6 servings daily. Comparison group participants were not asked to make dietary changes. Main Outcome Measure: Invasive breast cancer incidence. results: Dietary fat intake was significantly lower in the dietary modification intervention group compared with the comparison group. The difference between groups in change from baseline for percentage of energy from fat varied from 10.7% at year 1 to 8.1% at year 6. Vegetable and fruit consumption was higher in the intervention group by at least 1 serving per day and a smaller, more transient difference was found for grain consumption. The number of women who developed invasive breast cancer (annualized incidence rate) over the 8.1- year average follow- up period was 655 (0.42% ) in the intervention group and 1072 (0.45% ) in the comparison group (hazard ratio, 0.91; 95% confidence interval, 0.83- 1.01 for the comparison between the 2 groups). Secondary analyses suggest a lower hazard ratio among adherent women, provide greater evidence of risk reduction among women having a high- fat diet at baseli

关键词：饮食模式随机对照干预试验妇女健康乳腺癌低脂肪浸润型改良风险脂肪摄入