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STCf conceptual design report (Volume 1): Physics & detector

frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An r.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu f.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.f.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.f.Chen X.r.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du l.M.Duan D.Epifanov Y.l.fan S.S.fang Z.J.fang G.fedotovich C.Q.feng X.feng Y.T.feng J.l.fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng l.S.Geng A.Gilman l.Gong T.Gong B.Gou W.Gradl J.l.Gu A.Guevara l.C.Gui A.Q.Guo f.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou Y.r.Hou C.Y.Hu H.M.Hu K.Hu r.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.lei E.levichev C.H.li C.li D.Y.li f.li G.li G.li H.B.li H.li H.N.li H.J.li H.l.li J.M.li J.li l.li l.li l.Y.li N.li P.r.li r.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.r.liao l.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu f.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu l.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.l.liu Z.Q.liu Z.Y.liu Z.W.liu I.logashenko Y.long C.G.lu J.X.lu N.lu Q.f.lü Y.lu Y.lu Z.lu P.lukin f.J.luo T.luo X.f.luo Y.H.luo H.J.lyu X.r.lyu J.P.Ma P.Ma Y.Ma Y.M.Ma f.Maas S.Malde D.Matvienko Z.X.Meng r.Mitchell A.Nefediev Y.Nefedov S.l.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng l.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.f.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.rademacker C.f.redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique fédérale de lausanne(EPfl) LausanneSwitzerland fudan University Shanghai 200433China Goethe University frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCf)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCf will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCf project in China is under development with an extensive r&D *** document presents the physics opportunities at the STCf,describes conceptual designs of the STCf detector system,and discusses future plans for detector r&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCf detector conceptual design

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Attempts to restore loss of function in damaged ACD cells open the way to non-mutational oncogenesis

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Genes & Diseases 2024年第3期11卷 5-6页

作者： Vladimir f.Niculescu 86420 Diedorf Germany Kirschenweg

This correspondence to Gene&Diseases calls attention to the controversy between proponents of genetic modification in carcinogenesis and supporters of non-mutational *** from molecular cancer research and findings from evolutionary cancer cell biology support the latter claim and provide no rationale for the mutational origin of sporadic *** is more conceivable that the general susceptibility of asymmetric cell division(ACD)phenotypes to oxygen leads to irreparable DNA defects and dysregulated defective symmetric cell division(DscD)phenotypes.

关键词： rational latter finding

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Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan r.Bowman Alvaro rodríguez Echarri fatemeh Kiani fadil Iyikanat Ted V.Tsoulos Joel D.Cox ravishankar Sundararaman f.Javier García de Abajo Giulia Tagliabue laboratory of Nanoscience for Energy Technologies(lNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICfO–Institut de Ciencies fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POlIMA–Center for Polariton-driven light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICrEA–Institucio Catalana de recerca i Estudis Avancats BarcelonaSpain

luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

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Effect of radiative loss mechanisms on fIr thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.l Silva l.A.O.Nunes S.M.lima l.H.C.Andrade Optical and Photothermal Spectroscopy Group(GEOf) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(fIr)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the fIr parameters on the Nd^(3+)concentration,due to changes in the emission band pr.f.les caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)f_(5/2)→^(4)I_(9/2)/^(4)f_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass fluorescence intensity ratio Optical thermometry Judd-Ofelt rare earths

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linking Il-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2835-2836页

作者： Imke Atreya Markus f.Neurath Department of Medicine 1 University Hospital of ErlangenFriedrich-Alexander University Erlangen-NürnbergErlangenGermany Deutsches Zentrum Immuntherapie(DZI) ErlangenGermany

In a recent study published in Nature,York and coworkers identified the immunometabolic regulation of mono-unsaturated fatty acid(MUfA)pools and the subsequent increase in sphingolipid biosynthesis in Tlr2-activated macrophages as an important link between impaired Il-10 signaling and the development of intestinal inflammation.1 Thus,targeted interference with the newly identified Il-10/MUfA/sphingolipid axis appears as a promising strategy to restore immunometabolic homeostasis in the intestine of patients with inflammatory bowel diseases(IBD).

关键词： homeostasis impaired intestine

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Electron kinetic effects in back-stimulated raman scattering bursts driven by broadband laser pulses

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Matter and radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.liu l.Deng Q.Wang X.Zhang f.Q.Meng Y.P.Wang Y.Q.Gao H.B.Cai S.P.Zhu Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Shanghai Institute of laser Plasma Shanghai 201800China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China School of Physics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated raman scattering(BSrS)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity *** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the spectrum is *** asymmetry is amplified and transferred to electron phase space by high-intensity broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly influence the BSrS evolution driven by broadband lasers.

关键词： scattering kinetic simplified

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Parameter-free Shifted laplacian reconstruction for Multiple Kernel Clustering

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1072-1074页

作者： Xi Wu Zhenwen ren f.richard Yu the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010China the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010 the Guangxi Key laboratory of Machine Vision and Intelligent Control Wuzhou UniversityWuzhou 543002 the Guangdong laboratory of Artificial Intelligence and Digital Economy(SZ) Shenzhen 518060China

Dear Editor,This letter proposes a parameter-free multiple kernel clustering(MKC)method by using shifted laplacian *** MKC can effectively cluster nonlinear data,but it faces two main challenges:1)As an unsupervised method,it is up against parameter problems which makes the parameters intractable to tune and is unfeasible in real-life applications;2)Only considers the clustering information,but ignores the interference of noise within laplacian.

关键词： parameter letter Parameter

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Heat and mass transfer of a circular porous moist object located in a triangular shaped vented cavity

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Journal of Central South University 2024年第6期31卷 1956-1972页

作者： SElIMEfENDIGIl fatih OZCAN COBAN Seda OZTOP Hakan f Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa 31982Saudi Arabia Department of Mechanical Engineering Manisa Celal Bayar UniversityManisa 45140Turkey Department of Mechanical Engineering Technology FacultyFırat UniversityElazığTurkey

Heat and mass transfer of a circular-shaped porous moist object inside a two-dimensional triangle cavity is investigated by using finite element *** porous object is considered to be a moist food sample,located in the middle of the cavity with inlet and outlet ports with different configurations of inlet/outlet *** drying performance is numerically assessed for different values of reynolds numbers(between 50 and 250),dry air inlet temperature(between 40 and 80℃)and different locations of the *** is observed that changing the port locations has significant impacts on the flow recirculaitons inside the triangular chamber while convective drying performance is highly *** moisture content reduces with longer time and for higher reynolds number(re)*** P4 where inlet and outlet ports are in the middle of the walls provides the most effective configuration in terms of convective drying performance while the worst case is seen for P1 case where inlet and outlet are closer to the corners of the *** is a 192% difference between the moisture reduction of these two cases at re=250,T=80℃ and t=120 min.

关键词： convective drying porous domain cavity flow inlet/exit port finite element method

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frAP 2.0:a community engagement method applied to cervical cancer disparities among Hispanic women

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family Medicine and Community Health 2024年第S2期12卷 44-57页

作者： Autumn M Kieber-Emmons Susan E Hansen Michael Topmiller Jaskaran Grewal Carlos roberto Jaen Benjamin f Crabtree William l Miller Department of family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA College of Medicine USFTampaFloridaUSA lehigh Valley Health Network AllentownPennsylvaniaUSA American Academy of family Physicians-Health landscape CincinattiOHUSA lafayette College EastonPennsylvaniaUSA UT Health San Antonio San AntonioTexasUSA rutgers robert Wood Johnson Medical School PiscatawayNew JerseyUSA Cancer Institute of New Jersey New BrunswickNew JerseyUSA

focused rapid Assessment Process(frAP)2.0 is a community engagement approach combining geospatial mapping with rapid qualitative assessment in cyclical fashion within communities to capture multifactorial and multilevel features impacting primary care *** 2.0 offers primary care researchers a methodology framework for exploring complex community features that impact primary healthcare delivery and *** frAP 2.0 study design expands the frAP from a sequential design to a cyclical process of geospatial mapping and rapid qualitative assessment in search of modifiable contextual *** participants are stakeholders from various socioecological levels whose perspectives inform study outcomes that they may use to then become the agents of change for the very problems they helped ***,we present a proof-of-concept study for frAP 2.0 examining disparities in cervical cancer mortality rates among Hispanic women in *** primary outcomes of interest are features at the community level,medical health system level and regional government policy levels that offer opportunities for collaborative interventions to improve cervical cancer *** this study,geospatial mapping of county and ZIP code-level variables impacting postdiagnosis cervical cancer care at community,medical and policy levels were created using publicly available data and then overlaid with maps created with Texas Cancer registry data for cervical cancer cases in three of the largest population *** disparate areas were then qualitatively explored using participant observation and ethnographic field work,alongside 39 key informant *** discussion groups and stakeholder engagement existed at every phase of the *** the frAP 2.0 method,we created an action-oriented roadmap of next steps to improve cervical cancer care disparities in the three Texas counties with emphasis on the high disparity *** identified local change

关键词： cervical qualitative policy

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Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of leishmania infantum in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 199-206页

作者： lucelina S.Araújo Bruno B.Silva Eduarda N.f.N.Santos Arnaldo S.Bezerra Samuel S.frota Assis r.Montenegro Eridan O.P.T.florean Maurício fvan Tilburg Maria Izabel f.Guedes laboratory of Biotechnology and Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil faculty of Veterinary Medicine State University of CearáFortalezaBrazil

Objective:To evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)Purified recombinant K39(rK39)protein at a 20μg dose with complete freund’s adjuvant;(2)Inactivated Escherichia coli(Bl21 DE3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)Non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of TNf,IfN-γ,Il-12,Il-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of leishmania infantum showed a long-lasting immune response with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the pr.f.le of cytokines produced were indicative of the induction of a mixed-type ***:The inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune response in immunized mice,predominantly favouring a Th2 pr.f.le response.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune response Th1 Th2 leishmania infantum

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