检索结果-南通市图书馆

Engineered polyketides:Synergy between protein and host level engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2017年第3期2卷 147-166页

作者： Jesus f.barajas Jacquelyn M.Blake-Hedges Constance B.Bailey Samuel Curran Jay.D.Keasling Department of Energy Agile Biofoundry EmeryvilleCAUSA Department of Chemistry University of CaliforniaBerkeleyBerkeleyCA 94720USA Joint BioEnergy Institute EmeryvilleCA 94608USA Physical Biosciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Comparative Biochemistry Graduate Group University of CaliforniaBerkeleyBerkeleyCA 94720USA QB3 Institute University of CaliforniaBerkeleyEmeryvilleCA 94608USA Department of Chemical&Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA Novo Nordisk foundation Center for Biosustainability Technical University DenmarkDK2970 HorsholmDenmark

Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical *** encompass one of the largest classes of chemically diverse natural *** thousands of known polyketides,modular polyketide synthases(PKSs)share a particularly attractive biosynthetic logic for generating chemical *** engineering of modular PKSs could open access to the deliberate production of both existing and novel *** this review,we discuss PKS engineering efforts applied at both the protein and cellular level for the generation of a diverse range of chemical structures,and we examine future applications of PKSs in the production of medicines,fuels and other industrially relevant chemicals.

关键词： Polyketide Polyketide synthase Natural products Commodity chemical Metabolic engineering Synthetic biology

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第4期20卷 1081-1082页

作者： John Mitrofanis Jonathan Stone Michael r.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown rafael J.Yáñez-Muñoz Heidi r.fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Effects of rare-earth Pr3+-Dy3+ doping on structural,magnetic,optical and dielectric properties of Zn2Y hexaferrite

在线全文

学校读者我要写书评

暂无评论

Journal of rare Earths 2025年第2期43卷 329-336页

作者： Ibrahim Mohammed Mohamed E.El Sayed Ali Shawabkeh Mohammad N.Murshed Ibtehaj f.Alshdoukhi Zeinhom M.El-Bahy J.Mohammed A.K.Srivastava Department of Physics Lovely Professional University Department of Science Technology Waziri Umaru Federal Polytechnic Birnin Kebbi Physics Department Faculty of Science and ArtsKing Khalid University College of Engineering and Technology American University of the Middle East Department of Basic Sciences College of Science and Health ProfessionsKing Saud Bin Abdulaziz University for Health ScienceKing Abdullah International Medical Research Center Department of Chemistry Faculty of ScienceAl-Azhar University Department of Physics Faculty of ScienceFederal University Dutse

This study was conducted to investigate the properties of Pr3+-Dy3+doped Zn2Y-type hexaferrite for potential technological applications.X-ray diffraction（XrD）,fourier transform infrared spectroscopy（fTIr） and field-emission scanning electron microscopy（fESEM） were used to analyze structural *** crystallite size in the synthesized samples varies between 57.54 and 68.57 *** vibrational bands at 400 and 600 cm-1,common to all hexaferrites,were confirmed through *** fESEM analysis reveals an agglomeration of magnetic grains and a decrease in the average grain size from 1.24 to1.06 μ*** M-H loops show that,with x values of 0.0,0.1,and 0.2,the saturation magnetization is determined to be 34.76,34.23,and 32.52 emu/g,*** corresponding coercivity values are21.24,30.39,and 33.99 ***-visible spectroscopy using Tauc theory reveals an increase in the optical band gap from 2.32 to 2.50 eV,indicating a tunable energy band structure by incorporating Pr3+-Dy3+*** dielectric constant increases,whereas AC conductivity decreases with increased Pr3+-Dy3+*** obtained results suggest the potential suitability of these materials for various technological applications.

关键词： Dielectric constant Magnetic hysteresis Optical band gap Pr3+-Dy3+ rare earths Zn2Y-type hexaferrite

p-wave mesons emitting weak decays of bottom mesons

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2025年第02期 51-63页

作者： Maninder Kaur Supreet Pal Singh r.C.Verma Department of Physics Punjabi University

This paper is the extension of our previous work entitled "Searching a systematics for nonfactorizable contributions to B-and ■ hadronic decays".Obtaining the factorizable contributions from the spectator-quark model for Nc=3,a systematic s was identified among the iso spin reduced amplitudes for the nonfactorizable terms among ■→Dπ/D*π/Dρ decay *** systematics enables us to derive a generic formula to help predict the branching fractions for ■-*** by this observation,we extend our analysis to p-wave meson emitting decays of B-meson ■→PA/PT/PS,particularly ■→a1D/πD1/πD'1/πrD2/πD0,which have similar isospin structures and make predictions for B0-decays,for which experimental measurements are not yet available.

关键词：

Interplay between HEAT SHOCK PrOTEIN 90 and HY5 Controls PhANG Expression in response to the GUN5 Plastid Signal

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2012年第4期5卷 901-913页

作者： Peter Kindgren Louise Noren Juan de Dios barajas Lopez Jehad Shaikhali Asa Strand Umea Plant Science Centre Department of Plant Physiology Umea University S-901 87 Umea Sweden

The presence of genes encoding organellar proteins in different cellular compartments necessitates a tight coordination of expression by the different genomes of the eukaryotic cell. This coordination of gene expression is achieved by organelle-to-nucleus or retrograde communication. Stress-induced perturbations of the tetrapyrrole pathway trigger large changes in nuclear gene expression in plants. recently, we identified HSP90 proteins as ligands of the pu- tative plastid signal Mg-ProtolX. In order to investigate whether the interaction between HSP90 and Mg-ProtolX is bio- logically relevant, we produced transgenic lines with reduced levels of cytosolic HSP90 in wild-type and gun5 backgrounds. Our work reveals that HSP90 proteins respond to the tetrapyrrole-mediated plastid signal to control expres- sion of photosynthesis-associated nuclear genes （PhANG） during the response to oxidative stress. We also show that the hy5 mutant is insensitive to tetrapyrrole accumulation and that Mg-ProtolX, cytosolic HSP90, and HY5 are all part of the same signaling pathway. These findings suggest that a regulatory complex controlling gene expression that includes HSP90 proteins and a transcription factor that is modified by tetrapyrroles in response to changes in the environment is evolutionarily conserved between yeast and plants.

关键词： abiotic/environmental stress cell signaling organelle biogenesis/function.

Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第8期20卷 2218-2230页

作者： rahul Mittal Keelin McKenna Grant Keith Evan McKenna Joana r.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Historical Lesson: Environmental and Human Impacts of Cluster Bomb Use by the United States during the Second Indochina War

在线全文

学校读者我要写书评

暂无评论

Open Journal of Soil Science 2025年第1期15卷 1-21页

作者： Kenneth r. Olson College of Agricultural Consumer and Environmental Sciences University of Illinois Urbana USA

The legacy of United States cluster munition use in Laos and Cambodia during the Second Indochina War is residual bomblets that unexpectedly detonate years later, killing and injuring children, farmers, and other civilians. Cluster munitions release dozens of smaller bomblets that rain deadly ammunition on troops, armored tanks, and vegetation, effectively striking broad sections of war zone landscapes in one launch. While many bomblets detonate immediately, others fail to detonate and can lie dormant on the ground for years. The primary objectives of this study were to document the long-term consequences and impacts of the US Air force bombing of Laos and Cambodia during the Second Indochina War (1959 to 1973). The historical lessons learned by United States should be shared with russia and Ukraine governments and military. These countries need to discontinue the use of cluster bombs to prevent additional people living along the russia-Ukraine border from having to live and die with the consequences of unexploded ordnance, including cluster bombs, for the next century.

关键词： Cluster Munitions Ordnance Bombs Laos Cluster Bomblets US Air force Air America UXO

Major Asperities that ruptured in Large California Earthquakes, Surrounding Pre-Shocks, and Some Yearly to Decadal Precursory Changes in Seismic Activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Geosciences 2025年第1期16卷 99-125页

作者： Lynn r. Sykes Lamont-Doherty Earth Observatory Columbia University Palisades NY USA

Double-difference locations of forerunning shocks of seismic magnitude, M, 2 to 6 are examined in the months to decades before 11 mainshocks in California of magnitude 6 and larger. Each of the 11 had large quiet zones beforehand, which are called asperities, that break nearly entirely in large mainshocks. Their surrounding 11 zones were all sites of small to moderate-size shocks that define the approximate magnitudes of the coming large event. The latter, donuts of activity, are places to examine for precursory changes years to decades before larger earthquakes. The quiet asperities and many sites at the earth’s surface are not good places to monitor precursory changes before large mainshocks. Detecting forerunning events to large future earthquakes requires monitoring the right places. A few possible precursory changes are identified and discussed.

关键词： Active faults Plate Boundaries California Double-Difference Locations San Andreas fault Asperities forecasts Predictions Seismology